Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6601 - 6650 OF 16048 RESULTS

January 1, 2015

Essentials of Mouse Genetics and Nomenclature

Pathology of the Developing Mouse: A Systematic Approach,

Oded Foreman; Brad N. Bolon

January 1, 2015

Orchestrating high-throughput genomic analysis with Bioconductor

Nature Methods, ISSN: 15487105 15487091

Wolfgang Huber; Vincent J. Carey; Robert Gentleman; Simon Anders; Marc Carlson; Benilton S. Carvalho; Hector Corrada Bravo; Sean Davis; Laurent Gatto; Thomas Girke; Raphael Gottardo; Florian Hahne; Kasper D. Hansen; Rafael A. Irizarry; Michael Lawrence; Michael I. Love; James MacDonald; Valerie Obenchain; Andrzej K. Oles̈; Hervé Pagès; Alejandro Reyes; Paul Shannon; Gordon K. Smyth; Dan Tenenbaum; Levi Waldron; Martin Morgan

January 1, 2015

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

Immunity, ISSN: 10974180 10747613

Natalia B. Pikor; Jillian L. Astarita; Leslie Summers-Deluca; Georgina Galicia; Joy Qu; Lesley A. Ward; Susan Armstrong; Claudia X. Dominguez; Deepali Malhotra; Brendan Heiden; Robert Kay; Valera Castanov; Hanane Touil; Louis Boon; Paul O'Connor; Amit Bar-Or; Alexandre Prat; Valeria Ramaglia; Samuel Ludwin; Shannon J. Turley; Jennifer L. Gommerman

January 1, 2015

Expanded change protocols: Benefits, cost considerations, and regulatory views

BioProcess International, ISSN: 15426319

Nadine Ritter; Julia Edwards; Stefanie Pluschkell; Suzanne Stella; Rebekah Logan; Chana Fuchs; Wassim Nashabeh; Rohin Mahtre

January 1, 2015

United States comparative costs and absenteeism of diabetic ophthalmic conditions

Postgraduate Medicine, ISSN: 19419260 00325481

Richard A. Brook; Nathan L. Kleinman; Sunil Patel; Jim E. Smeeding; Ian A. Beren; Adam Turpcu

January 1, 2015

Enhancing efficiency of trace metals analysis using a validated generic ICP-OES method

American Pharmaceutical Review, ISSN: 10998012

Ila Patel; Venkatramani; Colin D. Medley; Kavita Mistry; Larry Wigman; Nik P. Chetwyn

January 1, 2015

Creating a specialist protein resource network: A meeting report for the protein bioinformatics and community resources retreat

Database, ISSN: 17580463

Patricia C. Babbitt; Pantelis G. Bagos; Amos Bairoch; Alex Bateman; Arnaud Chatonnet; Mark J. Chen; David J. Craik; Robert D. Finn; David Gloriam; Daniel H. Haft; Bernard Henrissat; Gemma L. Holliday; Vignir Isberg; Quentin Kaas; David Landsman; Nicolas Lenfant; Gerard Manning; Nozomi Nagano; Narayanaswamy Srinivasan; Claire O'Donovan; Kim D. Pruitt; Ramanathan Sowdhamini; Neil D. Rawlings; Milton H. Saier Jr.; Joanna L. Sharman; Michael Spedding; Konstantinos D. Tsirigos; Ake Vastermark; Gerrit Vriend

January 1, 2015

The authors explore and define common industry approaches and practices when applying GMPs in early development

Pharmaceutical Technology, ISSN: 21507376 15432521

Q. Chan Li; Jackson D. Pellett; Michael Szulc; Mark D. Trone; Kirby Wong-Moon

January 1, 2015

A biopharmaceutical industry perspective on single-use sensors for biological process applications

BioPharm International, ISSN: 19391862 1542166X

Bradley H. Diehl; Mark A. Lapack; Tony Y. Wang; Robert E. Kottmeier; Stacey M. Kaneshiro; Michael C. Brandenstein; Yongchun Zhang; Yuk Chun Chiu; Seongkyu Yoon; Victor Saucedo

January 1, 2015

Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: Addressing methodologic issues of plasma membrane isolation and expression-activity relationship

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Vineet Kumar; Bhagwat Prasad; Gabriela Patilea; Anshul Gupta; Laurent Salphati; Raymond Evers; Cornelis E. Hop; Jashvant D. Unadkat

January 1, 2015

Development and implementation of a double-blind corticosteroid-tapering regimen for a clinical trial

International Journal of Rheumatology, ISSN: 16879279 16879260

Neil Collinson; Katie Tuckwell; Frank Habeck; Monique Chapman; Micki Klearman; John H. Stone

January 1, 2015

First million-dollar syringe could be a sight for sore eyes

Managed Care, ISSN: 10623388

Thomas Morrow

January 1, 2015

Predictors of early discontinuation of pegylated interferon for reasons other than lack of efficacy in United States veterans with chronic hepatitis c

Gastroenterology Nursing, ISSN: 15389766 1042895X

Joanne Lafleur; Hoop; Korner; Scott L. Duvall; Timothy Morgan; Prashant K. Pandya; Jian Han; Kristin Knippenberg; Richard E. Nelson

January 1, 2015

Evaluation of detection sensitivity in comprehensive two-dimensional liquid chromatography separations of an active pharmaceutical ingredient and its degradants

Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642

Dwight R. Stoll; Eric S. Talus; David C. Harmes; Kelly Zhang

January 1, 2015

Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells

Oncotarget, ISSN: 19492553

Nitu Bansal; Prasun J. Mishra; Mark Stein; Robert S. DiPaola; Joseph R. Bertino

January 1, 2015

Anemia Predicts Sustained Virological Response in Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C Treated with Peginterferon Alfa-2a and Ribavirin

Current Hepatitis Reports, ISSN: 15410706 15403416

Reau; Korner; Jian Han; Donald Jensen

January 1, 2015

Safety, virology and pharmacokinetics of oseltamivir in infants with laboratory-confirmed influenza: A Phase I/II, prospective, open-label, multicentre clinical trial

Antiviral Therapy, ISSN: 20402058 13596535

Barbara A. Rath; Jerzy Brzostek; Sara Guillén; Vis Niranjan; Colombe Chappey; Craig R. Rayner; Barry Clinch

January 1, 2015

Validation of a method for the determination of thiocyanate in human plasma by UV/VIS spectrophotometry and application to a Phase I clinical trial of GDC-0425

Translational and Clinical Pharmacology, ISSN: 22890882

Young G. Shin; Henri Meijering; Fred H. van Heuveln; Jaap Wieling; Jason S Halladay; Srikumar Sahasranaman; Cornelis E. Hop

January 1, 2015

The BioMart community portal: An innovative alternative to large, centralized data repositories

Nucleic Acids Research, ISSN: 13624962 03051048

Damian Smedley; Syed Haider; Durinck; Luca Pandini; Paolo Provero; James Allen; Olivier Arnaiz; Mohammad H.amza Awedh; Richard Baldock; Giulia Barbiera; Philippe Bardou; Tim Beck; Andrew Blake; Merideth Bonierbale; Anthony J. Brookes; Gabriele Bucci; Iwan Buetti; Sarah Burge; Cédric Cabau; Joseph W. Carlson; Claude Chelala; Charalambos Chrysostomou; Davide Cittaro; Olivier Collin; Raul Cordova; Rosalind J. Cutts; Erik Dassi; Alex Di Genova; Anis Djari; Anthony Esposito; Heather Estrella; Eduardo Eyras; Julio Fernandez-Banet; Simon Forbes; Robert C. Free; Takatomo Fujisawa; Emanuela Gadaleta; Jose M. Garcia-Manteiga; David Goodstein; Kristian Gray; José Afonso Guerra-Assunção; Bernard Haggarty; Dong-Jin Han; Byung Woo Han; Todd Harris; Jayson Harshbarger; Robert K. Hastings; Richard D. Hayes; Claire Hoede; Shen Hu; Zhi-Liang Hu; Lucie Hutchins; Zhengyan Kan; Hideya Kawaji; Aminah Keliet; Arnaud Kerhornou; Sunghoon Kim; Rhoda Kinsella; Christophe Klopp; Lei Kong; Daniel Lawson; Dejan Lazarevic; Ji-Hyun Lee; Thomas Letellier; Chuan-Yun Li; Pietro Lio; Chu-Jun Liu; Jie Luo; Alejandro Maass; Jerome Mariette; Thomas Maurel; Stefania Merella; Azza Mostafa Mohamed; Francois Moreews; Ibounyamine Nabihoudine; Nelson Ndegwa; Céline Noirot; Cristian Perez-Llamas; Michael Primig; Alessandro Quattrone; Hadi Quesneville; Davide Rambaldi; James Reecy; Michela Riba; Steven Rosanoff; Amna Ali Saddiq; Elisa Salas; Olivier Sallou; Rebecca Shepherd; Reinhard Simon; Linda Sperling; William Spooner; Daniel M. Staines; Delphine Steinbach; Kevin Stone; Elia Stupka; Jon W. Teague; Abu Z. Dayem Ullah; Jun Wang; Doreen Ware; Marie Wong-Erasmus; Ken Youens-Clark; Amonida Zadissa; Shi-Jian Zhang; Arek Kasprzyk

January 1, 2015

Molecular assessment of monoclonal antibody-based therapeutics enabling lead selection for clinical development

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Vikas Sharma; Robert F. Kelley

January 1, 2015

Pharmacokinetics/pharmacodynamics and disposition of antibody-drug conjugates

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Siddharth Sukumaran; Kedan Lin

January 1, 2015

Application of QbD principles to late-stage formulation development for biological liquid products

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Alavattam Sreedhara; Wong; Yvonne Lentz; Karin Schoenhammer; Christoph Stark

January 1, 2015

Application of quality by design principles to the drug product technology transfer process

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Fred Lim; Jagannathan Sundaram; Alavattam Sreedhara

January 1, 2015

Drug substance frozen storage and thawing

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Philippe Lam; Fred Lim; Samir Sane

January 1, 2015

Challenges and considerations for development of therapeutic proteins in pediatric patients

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Yi Zhang; Xiaohui Wei; Gaurav Bajaj; Jeffrey S. Barrett; Bernd Meibohm; Amita Joshi; Manish Gupta

January 1, 2015

Oxidative degradation of polysorbate surfactants studied by liquid chromatography-mass spectrometry

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Oleg V. Borisov; Junyan A. Ji; Y. John Wang

January 1, 2015

Sensitive and direct determination of lithium by mixed-mode chromatography and charged aerosol detection

Journal of Chromatography A, ISSN: 18733778 00219673

Lulu Dai; Larry Wigman; Kelly Zhang

January 1, 2015

Effect of individual fc methionine oxidation on FcRn binding: Met252 oxidation impairs fcrn binding more profoundly than Met428 oxidation

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Xuan Gao; Junyan A. Ji; Karthik Veeravalli; Y. John Wang; Taylor Zhang; William Mcgreevy; Kai Zheng; Robert F. Kelley; Mike Laird; Jun Liu; Cromwell

January 1, 2015

Solid state considerations for early development

American Pharmaceutical Review, ISSN: 10998012

Jeffrey Stults

December 30, 2014

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Vikas Sharma; Thomas W. Patapoff; Bruce Kabakoff; Satyan Pai; Eric Hilario; Boyan Zhang; Charlene Li; Oleg V. Borisov; Robert F. Kelley; Ilya Chorny; Joe Zhongxiang Zhou; Ken A. Dill; Trevor E. Swartz

December 30, 2014

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

T. Justin Rettenmaier; Jack D. Sadowsky; Nathan D. Thomsen; Steven C. Chen; Allison K. Doak; Michelle R. Arkin; James A. Wells

December 26, 2014

Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Giovanni Cervi; Paola Magnaghi; Daniela Asa; Nilla Avanzi; Alessandra Badari; Daniela Borghi; Michele Caruso; Alessandra Cirla; Liviana Cozzi; Eduard Felder; Arturo Galvani; Fabio Gasparri; Antonio Lomolino; Steven Magnuson; Beatrice Malgesini; Ilaria Motto; Maurizio Pasi; Simona Rizzi; Barbara Salom; Graziella Sorrentino; Sonia Troiani; Barbara Valsasina; Thomas O'Brien; Antonella Isacchi; Daniele Donati; Roberto D'Alessio

December 20, 2014

Identification of the WNT1 residues required for palmitoylation by Porcupine

FEBS Letters, ISSN: 18733468 00145793

Miranda; Lisa M. Galli; Enriquez; Linda A. Szabo; Xinxin Gao; Rami N. Hannoush; Laura W. Burrus

December 19, 2014

Depletion of the Central Metabolite NAD leads to oncosismediated cell death

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Christopher J. Del Nagro; Yang Xiao; Linda Rangell; Mike Reichelt; Thomas O'Brien

December 19, 2014

Synthesis of Akt inhibitor ipatasertib. part 1. Route scouting and early process development of a challenging cyclopentylpyrimidine intermediate

Organic Process Research and Development, ISSN: 1520586X 10836160

Jonathan W. Lane; Keith L. Spencer; Sagar R. Shakya; Nicholas C. Kallan; Peter J. Stengel; Travis Remarchuk

December 19, 2014

Synthesis of Akt inhibitor ipatasertib. part 2. Total synthesis and first kilogram scale-up

Organic Process Research and Development, ISSN: 1520586X 10836160

Travis Remarchuk; Frederic St-Jean; Diane Carrera; Scott Savage; Herbert M. Yajima; Brian Wong; Srinivasan Babu; Alan Deese; Jeffrey Stults; Michael W. Dong; David Askin; Jonathan W. Lane; Keith L. Spencer

December 18, 2014

Preclinical efficacy of MEK inhibition in NRAS-mutant AML

Blood, ISSN: 15280020 00064971

Michael R. Burgess; Eugene Hwang; Ari J. Firestone; Tannie Huang; Jin Xu; Johannes Zuber; Natacha Bohin; Tiffany Wen; Scott C. Kogan; Kevin M. Haigis; Deepak Sampath; Scott W. Lowe; Kevin Shannon; Qing Li

December 18, 2014

Preclinical efficacy of MEK inhibition in NRAS-mutant AML

Blood, ISSN: 15280020 00064971

Michael R. Burgess; Eugene Hwang; Ari J. Firestone; Tannie Huang; Jin Xu; Johannes Zuber; Natacha Bohin; Tiffany Wen; Scott Kogan; Kevin M. Haigis; Deepak Sampath; Scott W. Lowe; Kevin Shannon; Qing Li

December 16, 2014

Effect of gastric pH on erlotinib pharmacokinetics in healthy individuals: Omeprazole and ranitidine

Anti-Cancer Drugs, ISSN: 14735741 09594973

Heidemarie Kletzl; Mylene Giraudon; Patricia Sanwald Ducray; Markus Abt; Marta Hamilton; Bert L. Lum

December 15, 2014

MMP-1 and Pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Xiangnan Du; Benjamin C. Lin; Qian-Rena Wang; Hao Li; Ellen Ingalla; Janet Y. Tien; Isabelle Rooney; Avi Ashkenazi; Elicia M. Penuel; Jing Qing

December 15, 2014

A reversed sulfonamide series of selective RORc inverse agonists

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Monique B. Van Niel; Benjamin P. Fauber; Matthew W. Cartwright; Simon Gaines; Jonathan C. Killen; Olivier René; Stuart I. Ward; Gladys De Leon Boenig; Yuzhong Deng; Celine Eidenschenk; Christine Everett; Emanuela Gancia; Arunima Ganguli; Alberto Gobbi; Julie Hawkins; Adam R. Johnson; James R. Kiefer; Hank La; Peter Lockey; Maxine Norman; Wenjun Ouyang; Ann R. Qin; Nicole Wakes; Bohdan Waszkowycz; Harvey Wong

December 15, 2014

Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Giancarlo Trani; John J. Barker; Steven M. Bromidge; Frederick A. Brookfield; Jason D. Burch; Yuan Chen; Eigenbrot; Alexander Heifetz; Moulay Hicham Alaoui Ismaili; Adam R. Johnson; Thomas M. Krülle; Colin H. Mackinnon; Rosemary Maghames; Paul A. McEwan; Christian A.G.N. Montalbetti; Daniel F. Ortwine; Yolanda Pérez-Fuertes; Darshan G. Vaidya; Xiaolu Wang; Ali A. Zarrin; Zhonghua Pei

December 15, 2014

Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Benjamin P. Fauber; Peter Dragovich; Jinhua Chen; Laura B. Corson; Charles Z. Ding; Eigenbrot; Sharada Labadie; Shiva Malek; David Peterson; Hans E. Purkey; Kirk D. Robarge; Steve Sideris; Ultsch; Binqing Wei; Ivana Yen; Qin Yue; Aihe Zhou

December 15, 2014

Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Lewis Gazzard; Brent A. Appleton; Kerry Chapman; Huifen Chen; Clark; Joy Drobnick; Simon Goodacre; Jason S Halladay; Joseph P. Lyssikatos; Stephen Schmidt; Steve Sideris; Wiesmann; Karen Williams; Ping Wu; Ivana Yen; Shiva Malek

December 11, 2014

8-tetrahydropyran-2-yl chromans: Highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Allen A. Thomas; Kevin W. Hunt; Bradley J. Newhouse; Ryan J. Watts; Xingrong Liu; Guy Vigers; Darin Smith; Susan P. Rhodes; Karin D. Brown; Jennifer N. Otten; Michael Burkard; April Cox; Mary K. Geck Do; Darrin Dutcher; Sumeet Rana; Robert K. Delisle; Kelly Regal; Albion D. Wright; Robert Groneberg; Jiangpeng Liao; Kimberly Scearce-Levie; Michael Siu; Hans E. Purkey; Joseph P. Lyssikatos

December 11, 2014

Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Emily J. Hanan; Eigenbrot; Marian C. Bryan; Burdick; Bryan K. Chan; Yuan Chen; Jennafer Dotson; Robert Heald; Philip Jackson; Hank La; Michael Lainchbury; Shiva Malek; Hans E. Purkey; Gabriele Schaefer; Stephen Schmidt; Eileen Seward; Steve Sideris; Christine Tam; Shumei Wang; Siew Kuen Yeap; Ivana Yen; Jianping Yin; Christine Yu; Inna Zilberleyb; Timothy P. Heffron

December 11, 2014

The IL-20 subfamily of cytokines-from host defence to tissue homeostasis

Nature Reviews Immunology, ISSN: 14741741 14741733

Sascha Rutz; Xiaoting Wang; Wenjun Ouyang

December 11, 2014

Internal motions prime cIAP1 for rapid activation

Nature Structural and Molecular Biology, ISSN: 15459985 15459993

Aaron H. Phillips; Allyn J. Schoeffler; Tsutomu Matsui; Thomas M. Weiss; John W. Blankenship; Zobel; Anthony M. Giannetti; Erin C. Dueber; Wayne J. Fairbrother

December 10, 2014

A septin-dependent diffusion barrier at dendritic spine necks

PLoS ONE, ISSN: 19326203

Helge Ewers; Tomoko Tada; Jennifer D. Petersen; Bence Racz; Morgan Sheng; Daniel Choquet

December 8, 2014

The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+ T Cell Effector Function

Cancer Cell, ISSN: 18783686 15356108

Robert J. Johnston; Laetitia Comps-Agrar; Jason A. Hackney; Xin Yu; Mahrukh Huseni; Yagai Yang; Summer Park; Vincent Javinal; Chiu; Bryan Irving; Dan L. Eaton; Jane L. Grogan

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