Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 6851 - 6900 OF 16285 RESULTS

Development and implementation of a double-blind corticosteroid-tapering regimen for a clinical trial
International Journal of Rheumatology, ISSN: 16879279 16879260
Neil Collinson; Katie Tuckwell; Frank Habeck; Monique Chapman; Micki Klearman; John H. Stone
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First million-dollar syringe could be a sight for sore eyes
Managed Care, ISSN: 10623388
Thomas Morrow
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Predictors of early discontinuation of pegylated interferon for reasons other than lack of efficacy in United States veterans with chronic hepatitis c
Gastroenterology Nursing, ISSN: 15389766 1042895X
Joanne Lafleur; Hoop; Korner; Scott L. Duvall; Timothy Morgan; Prashant K. Pandya; Jian Han; Kristin Knippenberg; Richard E. Nelson
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Evaluation of detection sensitivity in comprehensive two-dimensional liquid chromatography separations of an active pharmaceutical ingredient and its degradants
Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642
Dwight R. Stoll; Eric S. Talus; David C. Harmes; Kelly Zhang
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Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells
Oncotarget, ISSN: 19492553
Nitu Bansal; Prasun J. Mishra; Mark Stein; Robert S. DiPaola; Joseph R. Bertino
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Anemia Predicts Sustained Virological Response in Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C Treated with Peginterferon Alfa-2a and Ribavirin
Current Hepatitis Reports, ISSN: 15410706 15403416
Reau; Korner; Jian Han; Donald Jensen
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Safety, virology and pharmacokinetics of oseltamivir in infants with laboratory-confirmed influenza: A Phase I/II, prospective, open-label, multicentre clinical trial
Antiviral Therapy, ISSN: 20402058 13596535
Barbara A. Rath; Jerzy Brzostek; Sara Guillén; Vis Niranjan; Colombe Chappey; Craig R. Rayner; Barry Clinch
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Validation of a method for the determination of thiocyanate in human plasma by UV/VIS spectrophotometry and application to a Phase I clinical trial of GDC-0425
Translational and Clinical Pharmacology, ISSN: 22890882
Young G. Shin; Henri Meijering; Fred H. van Heuveln; Jaap Wieling; Jason S Halladay; Srikumar Sahasranaman; Cornelis E. Hop
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Recommendations for adaptation and validation of commercial kits for biomarker quantification in drug development
Bioanalysis, ISSN: 17576199 17576180
Masood U. Khan; Ronald Bowsher; Mark Cameron; Viswanath Devanarayan; Steve Keller; Lindsay King; Jean W. Lee; Alyssa M. Morimoto; Paul Rhyne; Laurie Stephen; Yuling Wu; Tim Wyant; D Richard Lachno
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A comprehensive transcriptional portrait of human cancer cell lines
Nature Biotechnology, ISSN: 15461696 10870156
Christiaan N. Klijn; Durinck; Eric Stawiski; Matthias Peter; Zhaoshi Jiang; Hanbin Liu; Jeremiah D. Degenhardt; Oleg Mayba; Florian Gnad; Jinfeng Liu; Gregoire Pau; Jens Reeder; Yi Cao; Kiran Mukhyala; Suresh K Selvaraj; Mamie Yu; Gregory J Zynda; Matthew J. Brauer; Thomas D Wu; Robert Gentleman; Gerard Manning; Robert Yauch; Richard Bourgon; David Stokoe; Zora Modrusan; Richard M. Neve; Frederic J. De Sauvage; Jeffrey Settleman; Somasekar Seshagiri; Zemin Zhang
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Symptoms and toxicity of rituximab maintenance relative to observation following immunochemotherapy in patients with follicular Lymphoma
Hematology, ISSN: 16078454 10245332
Zhou; Jianmin Wang; Jessica Zhang; Catherine Copley-Merriman; Yasuhiro Torigoe; Carolina Reyes; John F. Seymour; Fritz C. Offner; Marek Trneny; Gilles Salles
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Metal ion interactions with mAbs: Part 1 pH and conformation modulate copper-mediated site-specific fragmentation of the IgG1 hinge region
mAbs, ISSN: 19420870 19420862
Zephania Kwong Glover; Basa; Benjamin Moore; Jennifer S. Laurence; Alavattam Sreedhara
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John T. Stults
The Encyclopedia of Mass Spectrometry: Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry,
Stults
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In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Vikas Sharma; Thomas W. Patapoff; Bruce Kabakoff; Satyan Pai; Eric Hilario; Boyan Zhang; Charlene Li; Oleg V. Borisov; Robert F. Kelley; Ilya Chorny; Joe Zhongxiang Zhou; Ken A. Dill; Trevor E. Swartz
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A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
T. Justin Rettenmaier; Jack D. Sadowsky; Nathan D. Thomsen; Steven C. Chen; Allison K. Doak; Michelle R. Arkin; James A. Wells
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Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Giovanni Cervi; Paola Magnaghi; Daniela Asa; Nilla Avanzi; Alessandra Badari; Daniela Borghi; Michele Caruso; Alessandra Cirla; Liviana Cozzi; Eduard Felder; Arturo Galvani; Fabio Gasparri; Antonio Lomolino; Steven Magnuson; Beatrice Malgesini; Ilaria Motto; Maurizio Pasi; Simona Rizzi; Barbara Salom; Graziella Sorrentino; Sonia Troiani; Barbara Valsasina; Thomas O'Brien; Antonella Isacchi; Daniele Donati; Roberto D'Alessio
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Identification of the WNT1 residues required for palmitoylation by Porcupine
FEBS Letters, ISSN: 18733468 00145793
Miranda; Lisa M. Galli; Enriquez; Linda A. Szabo; Xinxin Gao; Rami N. Hannoush; Laura W. Burrus
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Depletion of the Central Metabolite NAD leads to oncosismediated cell death
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Christopher J. Del Nagro; Yang Xiao; Linda Rangell; Mike Reichelt; Thomas O'Brien
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Synthesis of Akt inhibitor ipatasertib. part 1. Route scouting and early process development of a challenging cyclopentylpyrimidine intermediate
Organic Process Research and Development, ISSN: 1520586X 10836160
Jonathan W. Lane; Keith L. Spencer; Sagar R. Shakya; Nicholas C. Kallan; Peter J. Stengel; Travis Remarchuk
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Synthesis of Akt inhibitor ipatasertib. part 2. Total synthesis and first kilogram scale-up
Organic Process Research and Development, ISSN: 1520586X 10836160
Travis Remarchuk; Frederic St-Jean; Diane Carrera; Scott Savage; Herbert M. Yajima; Brian Wong; Srinivasan Babu; Alan Deese; Jeffrey Stults; Michael W. Dong; David Askin; Jonathan W. Lane; Keith L. Spencer
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Preclinical efficacy of MEK inhibition in NRAS-mutant AML
Blood, ISSN: 15280020 00064971
Michael R. Burgess; Eugene Hwang; Ari J. Firestone; Tannie Huang; Jin Xu; Johannes Zuber; Natacha Bohin; Tiffany Wen; Scott C. Kogan; Kevin M. Haigis; Deepak Sampath; Scott W. Lowe; Kevin Shannon; Qing Li
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Preclinical efficacy of MEK inhibition in NRAS-mutant AML
Blood, ISSN: 15280020 00064971
Michael R. Burgess; Eugene Hwang; Ari J. Firestone; Tannie Huang; Jin Xu; Johannes Zuber; Natacha Bohin; Tiffany Wen; Scott Kogan; Kevin M. Haigis; Deepak Sampath; Scott W. Lowe; Kevin Shannon; Qing Li
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Effect of gastric pH on erlotinib pharmacokinetics in healthy individuals: Omeprazole and ranitidine
Anti-Cancer Drugs, ISSN: 14735741 09594973
Heidemarie Kletzl; Mylene Giraudon; Patricia Sanwald Ducray; Markus Abt; Marta Hamilton; Bert L. Lum
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MMP-1 and Pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer
Clinical Cancer Research, ISSN: 15573265 10780432
Xiangnan Du; Benjamin C. Lin; Qian-Rena Wang; Hao Li; Ellen Ingalla; Janet Y. Tien; Isabelle Rooney; Avi Ashkenazi; Elicia M. Penuel; Jing Qing
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A reversed sulfonamide series of selective RORc inverse agonists
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Monique B. Van Niel; Benjamin P. Fauber; Matthew W. Cartwright; Simon Gaines; Jonathan C. Killen; Olivier René; Stuart I. Ward; Gladys De Leon Boenig; Yuzhong Deng; Celine Eidenschenk; Christine Everett; Emanuela Gancia; Arunima Ganguli; Alberto Gobbi; Julie Hawkins; Adam R. Johnson; James R. Kiefer; Hank La; Peter Lockey; Maxine Norman; Wenjun Ouyang; Ann R. Qin; Nicole Wakes; Bohdan Waszkowycz; Harvey Wong
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Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Giancarlo Trani; John J. Barker; Steven M. Bromidge; Frederick A. Brookfield; Jason D. Burch; Yuan Chen; Eigenbrot; Alexander Heifetz; Moulay Hicham Alaoui Ismaili; Adam R. Johnson; Thomas M. Krülle; Colin H. Mackinnon; Rosemary Maghames; Paul A. McEwan; Christian A.G.N. Montalbetti; Daniel F. Ortwine; Yolanda Pérez-Fuertes; Darshan G. Vaidya; Xiaolu Wang; Ali A. Zarrin; Zhonghua Pei
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Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Benjamin P. Fauber; Peter Dragovich; Jinhua Chen; Laura B. Corson; Charles Z. Ding; Eigenbrot; Sharada Labadie; Shiva Malek; David Peterson; Hans E. Purkey; Kirk D. Robarge; Steve Sideris; Ultsch; Binqing Wei; Ivana Yen; Qin Yue; Aihe Zhou
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Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Lewis Gazzard; Brent A. Appleton; Kerry Chapman; Huifen Chen; Clark; Joy Drobnick; Simon Goodacre; Jason S Halladay; Joseph P. Lyssikatos; Stephen Schmidt; Steve Sideris; Wiesmann; Karen Williams; Ping Wu; Ivana Yen; Shiva Malek
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8-tetrahydropyran-2-yl chromans: Highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Allen A. Thomas; Kevin W. Hunt; Bradley J. Newhouse; Ryan J. Watts; Xingrong Liu; Guy Vigers; Darin Smith; Susan P. Rhodes; Karin D. Brown; Jennifer N. Otten; Michael Burkard; April Cox; Mary K. Geck Do; Darrin Dutcher; Sumeet Rana; Robert K. Delisle; Kelly Regal; Albion D. Wright; Robert Groneberg; Jiangpeng Liao; Kimberly Scearce-Levie; Michael Siu; Hans E. Purkey; Joseph P. Lyssikatos
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Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Emily J. Hanan; Eigenbrot; Marian C. Bryan; Burdick; Bryan K. Chan; Yuan Chen; Jennafer Dotson; Robert Heald; Philip Jackson; Hank La; Michael Lainchbury; Shiva Malek; Hans E. Purkey; Gabriele Schaefer; Stephen Schmidt; Eileen Seward; Steve Sideris; Christine Tam; Shumei Wang; Siew Kuen Yeap; Ivana Yen; Jianping Yin; Christine Yu; Inna Zilberleyb; Timothy P. Heffron
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The IL-20 subfamily of cytokines-from host defence to tissue homeostasis
Nature Reviews Immunology, ISSN: 14741741 14741733
Sascha Rutz; Xiaoting Wang; Wenjun Ouyang
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Internal motions prime cIAP1 for rapid activation
Nature Structural and Molecular Biology, ISSN: 15459985 15459993
Aaron H. Phillips; Allyn J. Schoeffler; Tsutomu Matsui; Thomas M. Weiss; John W. Blankenship; Zobel; Anthony M. Giannetti; Erin C. Dueber; Wayne J. Fairbrother
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A septin-dependent diffusion barrier at dendritic spine necks
PLoS ONE, ISSN: 19326203
Helge Ewers; Tomoko Tada; Jennifer D. Petersen; Bence Racz; Morgan Sheng; Daniel Choquet
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The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+ T Cell Effector Function
Cancer Cell, ISSN: 18783686 15356108
Robert J. Johnston; Laetitia Comps-Agrar; Jason A. Hackney; Xin Yu; Mahrukh Huseni; Yagai Yang; Summer Park; Vincent Javinal; Chiu; Bryan Irving; Dan L. Eaton; Jane L. Grogan
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Gutsy moves in mice: Cellular and molecular dynamics of endoderm morphogenesis
Philosophical Transactions of the Royal Society B: Biological Sciences, ISSN: 14712970 09628436
Manuel Viotti; Ann C. Foley; Anna-Katerina Hadjantonakis
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Rituximab (Rituxan®)
Handbook of Therapeutic Antibodies: Second Edition,
Axel Böhnke; Michael Wenger
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Obinutuzumab (Gazyva®), a Novel Glycoengineered Type II CD20 Antibody for the Treatment of Chronic Lymphocytic Leukemia and Non-Hodgkin's Lymphoma
Handbook of Therapeutic Antibodies: Second Edition,
Christian Klein; Marina Bacac; Pablo Umaña; Michael Wenger
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Ultra-high-pressure liquid chromatography (UHPLC) in method development
TrAC - Trends in Analytical Chemistry, ISSN: 18793142 01659936
Michael W. Dong; Kelly Zhang
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TNFR1-activated NF-κB signal transduction: Regulation by the ubiquitin/proteasome system
Current Opinion in Chemical Biology, ISSN: 18790402 13675931
Ingrid E. Wertz
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A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease
PLoS ONE, ISSN: 19326203
Kareem L. Graham; Jian V. Zhang; Susanna Lewén; Thomas M. Burke; Ton Dang; Maria Zoudilova; Raymond A. Sobel; Eugene C. Butcher; Brian A. Zabel
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Willingness to pay to avoid metastatic breast cancer treatment side effects: results from a conjoint analysis
SpringerPlus, ISSN: 21931801
Deepa Lalla; Rashad Carlton; Eduardo Santos; Thomas Bramley; Anna D’Souza
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Complement inhibition in cynomolgus monkeys by anti-factor D antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration
Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103 00223565
Kelly M. Loyet; Jeremy Good; Teresa Davancaze; Lizette Sturgeon; Xiangdan Wang; Yang; Kha Le; Maureen Wong; Hass; Menno Van Lookeren Campagne; Peter Haughney; Alyssa M. Morimoto; Lisa A. Damico; Laura DeForge
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2014 White Paper on recent issues in bioanalysis: A full immersion in bioanalysis (Part 2-hybrid LBA/LCMS, ELN & regulatory agencies' input)
Bioanalysis, ISSN: 17576199 17576180
Dawn Dufield; Hendrik Neubert; Fabio Garofolo; Leo Kirkovsky; Lauren Stevenson; Isabelle Dumont; Surinder Kaur; Keyang Xu; Stephen C. Alley; Matthew Szapacs; Mark Arnold; Surendra Bansal; Sam Haidar; Jan Welink; Olivier Le Blaye; Jason Wakelin-Smith; Emma Whale; Akiko Ishii-Watabe; Mark Bustard; Noriko Katori; Lakshmi Amaravadi; Anne-Françoise Aubry; Chris Beaver; Annik Bergeron; Xiao-Yan Cai; Laura Cojocaru; Binodh DeSilva; Jeff Duggan; Eric Fluhler; Boris Gorovits; Swati Gupta; Roger Hayes; Stacy Ho; Benno Ingelse; Lindsay King; Ann Lévesque; Steve Lowes; Mark Ma; Adrien Musuku; Heather Myler; Timothy Olah; Shefali Patel; Mark Rose; Gary Schultz; John Smeraglia; Steven J. Swanson; Albert Torri; Faye Vazvaei; Amanda Wilson; Eric Woolf; Li Xue; Tong-Yuan Yang
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Impact of symptom burden on work-related abilities in patients with locally recurrent or metastatic breast cancer: Results from a substudy of the VIRGO observational cohort study
Breast, ISSN: 15323080 09609776
Charles S. Cleeland; Musa Mayer; Nancy A. Dreyer; Yeun Mi Yim; Elaine B. Yu; Zhaohui Su; Yong Mun; Jeff A. Sloan; Peter A. Kaufman
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2014 White Paper on recent issues in bioanalysis: A full immersion in bioanalysis (Part 3-LBA and immunogenicity)
Bioanalysis, ISSN: 17576199 17576180
Lauren Stevenson; Lakshmi Amaravadi; Heather Myler; Laura Salazar-Fontana; Boris Gorovits; Susan Kirshner; Li Xue; Fabio Garofolo; Stephen C. Alley; Theingi Thway; Alison Joyce; Surendra Bansal; Chris Beaver; Annik Bergeron; Xiao-Yan Cai; Laura Cojocaru; Binodh DeSilva; Isabelle Dumont; Eric Fluhler; Stephanie Fraser; Dominique Gouty; Swati Gupta; Sam Haidar; Roger Hayes; Benno Ingelse; Akiko Ishii-Watabe; Surinder Kaur; Lindsay King; Omar Laterza; Sheldon Leung; Ann Lévesque; Mark Ma; Corinne Petit-Frere; Renuka Pillutla; Mark Rose; Gary Schultz; John Smeraglia; Steven J. Swanson; Albert Torri; Faye Vazvaei; Jason Wakelin-Smith; Amanda Wilson; Eric Woolf; Tong-Yuan Yang
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Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular amd
British Journal of Ophthalmology, ISSN: 14682079 00071161
Robert L. Avery; Alessandro A. Castellarin; Nathan C. Steinle; Dilsher S. Dhoot; Dante Joseph Pieramici; Robert See; Stephen Couvillion; MA'An A. Nasir; Melvin D. Rabena; Kha Le; Mauricio Maia; Jennifer Visich
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Vision-related function after ranibizumab treatment for diabetic macular edema: Results from RIDE and RISE
Ophthalmology, ISSN: 15494713 01616420
Neil M. Bressler; Rohit Varma; Ivan J. Suñer; Chantal M. Dolan; James Ward; Jason S. Ehrlich; Shoshana Colman; Adam Turpcu
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Visualization of protein sequence features using JavaScript and SVG with pViz.js
Bioinformatics, ISSN: 14602059 13674803
Kiran Mukhyalay; Alexandre Masselot
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Practical permeability-based hepatic clearance classification system (HepCCS) in drug discovery
Future Medicinal Chemistry, ISSN: 17568927 17568919
Peter W. Fan; Yang Song; Leonid M. Berezhkovskiy; Jonathan Cheong; Emile G. Plise; S. Cyrus Khojasteh
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Proteome-wide light/dark modulation of thiol oxidation in cyanobacteria revealed by quantitative site-specific redox proteomics
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Jia Guo; Amelia Y. Nguyen; Ziyu Dai; Dian Su; Matthew J. Gaffrey; Ronald J. Moore; Jon M. Jacobs; Matthew E. Monroe; Richard D. Smith; David W. Koppenaal; Himadri B. Pakrasi; Wei-Jun Qian
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