Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7851 - 7900 OF 15805 RESULTS

Can quality solve the equation? ↓ pricing ↓ a health authority expectations ↑ a supply chain complexity ↑ a counterfeiting ↑ quality drugs to patients + an engaged workforce
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440 19482124
Jennifer Magnani; Anders Vinther
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A strategy for risk mitigation of antibodies with fast clearance
mAbs, ISSN: 19420862 19420870
Isidro Hötzel; Frank-Peter Theil; Lisa J. Bernstein; Saileta Prabhu; Rong Deng; Leah Quintana; Jeff Lutman; Renuka Sibia; Pamela Chan; Daniela Bumbaca; Fielder; Paul J. Carter; Robert F. Kelley
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Long-term outcomes after high dose therapy and autologous haematopoietic cell rescue for refractory/relapsed Hodgkin lymphoma
British Journal of Haematology, ISSN: 00071048 13652141
Ann Y. Minn; Elyn Riedel; Jerry Halpern; Laura J. Johnston; Sandra J. Horning; Richard T. Hoppe; Karyn A. Goodman
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Characterization of ML-IAP protein stability and physiological role in vivo
Biochemical Journal, ISSN: 02646021 14708728
Eugene Varfolomeev; Elham Moradi; Jasmin N. Dynek; Jiping Zha; Anna V. Fedorova; Deshayes; Wayne J. Fairbrother; Kim Newton; Jennifer Le Couter; Domagoj Vucic
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Robustness of iCIEF methodology for the analysis of monoclonal antibodies: An interlaboratory study
Journal of Separation Science, ISSN: 16159306 16159314
Oscar Salas-Solano; Babu Kennel; Park; Kelly Roby; Zoran Sosic; Boris Boumajny; Sarah Free; Angelia Reed-Bogan; David A. Michels; Will McElroy; Pauline Bonasia; Mingfang Hong; Xiaoping Z. He; Margaret Ruesch; Frank Moffatt; Steffen Kiessig; Brian Nunnally
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Characterization of Hepatitis C Virus (HCV) quasispecies dynamics upon short-term dual therapy with the HCV NS5B nucleoside polymerase inhibitor mericitabine and the NS3/4 protease inhibitor danoprevir
Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596
Sophie Le Pogam; Yan; Chhabra; Ilnicka; Kang; Kosaka; Ali; Chin; Nancy Shulman; Patrick F. Smith; Klumpp; Nájera
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Impact of disease severity on healthcare costs in patients with chronic hepatitis C (CHC) virus infection
Hepatology, ISSN: 02709139 15273350
Gordon; Pockros; Terrault; Hoop; Buikema; David Nerenz; Hamzeh
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Quantitation and characterization of process impurities and extractables in protein-containing solutions using proton NMR as a general tool
Biotechnology Progress, ISSN: 87567938 15206033
Ken Skidmore; Daniel Hewitt; Kao
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Treatment rationale study design for the MetLung trial: A randomized, double-blind phase III study of onartuzumab (MetMAb) in combination with erlotinib versus erlotinib alone in patients who have received standard chemotherapy for stage IIIB or IV met-positive non-small-cell lung cancer
Clinical Lung Cancer, ISSN: 15257304 19380690
David Spigel; Martin J. Edelman; Tony Mok; Kenneth O'Byrne; Luis Paz-Ares; Wei Yu; Karen Rittweger; Holger Thurm
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Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: A translational toxicokinetic/toxicodynamic analysis
Toxicological Sciences, ISSN: 10966080 10960929
Harvey Wong; Nageshwar Budha; Kristina West; Elizabeth M. Blackwood; Joseph A. Ware; Ron Yu; Darbonne; Stephen Gould; Ronald Steigerwalt; Rebecca Erickson; Cornelis E. Hop; Patricia M. LoRusso; Gail Eckhardt; Andrew Wagner; Iris Chan; Michael Mamounas; Flygare; Wayne J. Fairbrother
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A DNA-conjugated magnetic nanoparticle assay for assessing genotoxicity
Analytical and Bioanalytical Chemistry, ISSN: 16182642 16182650
Colin D. Medley; Joshua E. Smith; Larry Wigman; Nik P. Chetwyn
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Pretreatment synovial transcriptional profile is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab
Annals of the Rheumatic Diseases, ISSN: 00034967 14682060
Vanessa E. Hogan; Cécile T.J. Holweg; David F. Choy; Sarah K. Kummerfeld; Jason A. Hackney; Y. K. Onno Teng; Michael J. Townsend; Jacob M. Van Laar
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Non-clinical toxicological considerations for pharmaceutical salt selection
Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255 17447607
Evan A Thackaberry
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Multi-temporal globally-optimal dense 3-D cell segmentation and tracking from multi-photon time-lapse movies of live tissue microenvironments
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), ISSN: 03029743 16113349
Arunachalam Narayanaswamy; Amine Merouane; Antonio Peixoto; Ena Ladi; Paul Herzmark; Ulrich H. von Andrian; Ellen Robey; Badrinath Roysam
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Compensatory dendritic cell development mediated by BATF-IRF interactions
Nature, ISSN: 00280836 14764687
Roxane Tussiwand; Wan-Ling Lee; Theresa L. Murphy; Mona Mashayekhi; Wumesh Kc; Jörn C. Albring; Ansuman T. Satpathy; Jeffrey A. Rotondo; Brian T. Edelson; Nicole M. Kretzer; Xiaodi Wu; Leslie A. Weiss; Elke Glasmacher; Peng Li; Wei Liao; Michael Behnke; Samuel S. K. Lam; Cora T. Aurthur; Warren J. Leonard; Harinder Singh; Christina L. Stallings; David Sibley; Schreiber; Kenneth M. Murphy
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Phosphorylation of NLRC4 is critical for inflammasome activation
Nature, ISSN: 00280836 14764687
Yan Qu; Shahram Misaghi; Anita Izrael-Tomasevic; Kim Newton; Laurie L. Gilmour; Lamkanfi; Salina Louie; Nobuhiko Kayagaki; Jinfeng Liu; László Kömüves; James Cupp; David Arnott; Denise M. Monack; Vishva M. Dixit
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Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
James J. Crawford; Peter W. Kenny; Jonathan Bowyer; Calum R. Cook; Jonathan E. Finlayson; Christine Heyes; Adrian J. Highton; Julian A. Hudson; Anja Jestel; Stephan Krapp; Scott Martin; Philip A. MacFaul; Benjamin P. McDermott; Thomas M. McGuire; Andrew D. Morley; Jeffrey J. Morris; Ken M. Page; Lyn Rosenbrier Ribeiro; Helen Sawney; Stefan Steinbacher; Caroline Smith; Alexander G. Dossetter
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Residual Tumor Cells That Drive Disease Relapse after Chemotherapy Do Not Have Enhanced Tumor Initiating Capacity
PLoS ONE, ISSN: 19326203
Ganapati V. Hegde; Cecile C. de la Cruz; Jeffrey Eastham-Anderson; Yanyan Zheng; E. Alejandro Sweet-Cordero; Erica L. Jackson
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Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: A correlative study from the E2496 Intergroup trial
Blood, ISSN: 15280020 00064971
King L. Tan; David W. Scott; Fangxin Hong; Brad Kahl; Richard I. Fisher; Nancy L. Bartlett; Ranjana H. Advani; Rena Buckstein; Lisa M. Rimsza; Joseph M. Connors; Christian Steidl; Leo I. Gordon; Sandra J. Horning; Randy D. Gascoyne
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Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: A correlative study from the E2496 Intergroup trial
Blood, ISSN: 15280020 00064971
King L. Tan; David W. Scott; Fangxin Hong; Wojciech Jurczak; Richard I. Fisher; Nancy L. Bartlett; Ranjana H. Advani; Rena Buckstein; Lisa M. Rimsza; Joseph M. Connors; Christian Steidl; Leo I. Gordon; Sandra J. Horning; Randy D. Gascoyne
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Functional anatomy of neural circuits regulating fear and extinction
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Ewelina Knapska; Matylda Macias; Marta Mikosz; Aleksandra Nowak; Dorota Owczarek; Marcin Wawrzyniak; Marcelina Pieprzyk; Iwona A. Cymerman; Tomasz Werka; Morgan Sheng; Stephen Maren; Jacek Jaworski; Leszek Kaczmarek
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S1P1 inhibits sprouting angiogenesis during vascular development
Development (Cambridge), ISSN: 09501991 14779129
Adi Ben Shoham; Guy Malkinson; Sharon Krief; Yulia Shwartz; Yona Ely; Napoleone Ferrara; Karina Yaniv; Elazar Zelzer
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Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function
Cell, ISSN: 10974172 00928674
Jing Jin; Karen Sison; Chengjin Li; Ruijun Tian; Monika Wnuk; Hoon-Ki Sung; Marie Jeansson; Cunjie Zhang; Monika Tucholska; Nina Jones; Dontscho Kerjaschki; Masabumi Shibuya; I. George Fantus; Andras Nagy; Hans-Peter Gerber; Napoleone Ferrara; Tony Pawson; Susan E. Quaggin
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Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
Nature, ISSN: 00280836 14764687
Petr Broz; Thomas Ruby; Kamila Belhocine; Donna M. Bouley; Nobuhiko Kayagaki; Vishva M. Dixit; Denise M. Monack
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The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site
Structure, ISSN: 09692126 18784186
Gladys De Leon Boenig; Krista K. Bowman; Jianwen A. Feng; Terry Crawford; Christine Everett; Yvonne Franke; Angela Oh; Mark S. Stanley; Steven T. Staben; Melissa A. Starovasnik; Heidi J. A. Wallweber; Jiansheng Wu; Lawren C. Wu; Adam R. Johnson; Sarah G. Hymowitz
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Ectopic expression of select innexins in individual central neurons couples them to pre-existing neuronal or glial networks that express the same innexin
Journal of Neuroscience, ISSN: 02706474 15292401
Constantine P. Firme; Ryan G. Natan; Neema Yazdani; Eduardo R. Macagno; Michael W. Baker
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Role of myeloid cells in tumor angiogenesis
Milestones in Drug Therapy,
Napoleone Ferrara
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Calcium-independent inhibition of PCSK9 by affinity-improved variants of the LDL receptor EGF(A) domain
Journal of Molecular Biology, ISSN: 10898638 00222836
Yingnan Zhang; Lijuan Zhou; Monica Kong-Beltran; Wei Li; Paul Moran; Jianyong Wang; Quan; Jeffrey Tom; Ganesh Kolumam; J. Michael Elliott; Nicholas J. Skelton; Andrew S. Peterson; Daniel Kirchhofer
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Population genetic inference from personal genome data: Impact of ancestry and admixture on human genomic variation
American Journal of Human Genetics, ISSN: 00029297 15376605
Jeffrey M. Kidd; Gravel; Jake Byrnes; Andres Moreno-Estrada; Shaila Musharoff; Katarzyna Bryc; Jeremiah D. Degenhardt; Abra Brisbin; Vrunda Sheth; Rong Chen; Stephen F. McLaughlin; Heather E. Peckham; Larsson Omberg; Christina A. Bormann Chung; Sarah Stanley; Kevin Pearlstein; Elizabeth Levandowsky; Suehelay Acevedo-Acevedo; Adam Auton; Alon Keinan; Victor Acuña-Alonzo; Rodrigo Barquera-Lozano; Samuel Canizales-Quinteros; Celeste Eng; Esteban G. Burchard; Archie Russell; Andy Reynolds; Andrew G. Clark; Martin G. Reese; Stephen E. Lincoln; Atul J. Butte; Francisco M. De La Vega; Carlos D. Bustamante
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Novel nanoparticles formulation for cassette dosing via intravenous injection in rats for high throughput pharmacokinetic screening and potential applications
Journal of Nanoscience and Nanotechnology, ISSN: 15334880 15334899
Po-Chang Chiang; Yuzhong Deng; Savita Ubhayakar; Hank La; Yong Cui; Kang-Jye Chou; Yingqing Ran; Harvey Wong
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Improvements in health-related quality of life after treatment with tocilizumab in patients with rheumatoid arthritis refractory to tumour necrosis factor inhibitors: Results from the 24-week randomized controlled radiate study
Rheumatology, ISSN: 14620324 14620332
Vibeke Strand; Gerd R. Burmester; Sarika Ogale; Jenny Devenport; Ani John; Paul Emery
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Studying host cell protein interactions with monoclonal antibodies using high throughput protein A chromatography
Biotechnology Journal, ISSN: 18606768 18607314
Vikram N. Sisodiya; Joshua Lequieu; Maricel Rodriguez; Paul McDonald; Kathlyn P. Lazzareschi
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Hepatitis C virus induces epidermal growth factor receptor activation via CD81 binding for viral internalization and entry
Journal of Virology, ISSN: 0022538X 10985514
Jingyu Diao; Homer Pantua; Hai Ngu; László Kömüves; Laurie Diehl; Gabriele Schaefer; Sharookh B. Kapadia
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Omalizumab and the risk of malignancy: Results from a pooled analysis
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
William W. Busse; Roland Buhl; Carlos Fernandez Vidaurre; Martin Blogg; Jin Zhu; Mark D. Eisner; Janice Canvin
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Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
Nature Genetics, ISSN: 10614036 15461718
Charles M. Rudin; Durinck; Eric Stawiski; John T. Poirier; Zora Modrusan; David S. Shames; Emily A. Bergbower; Yinghui Guan; James Shin; Joseph Guillory; Rivers; Catherine K. Foo; Deepali Bhatt; Stinson; Florian Gnad; Matthias Peter; Robert Gentleman; Subhra Chaudhuri; Vasantharajan Janakiraman; Bijay S. Jaiswal; Chaitali Parikh; Yuan; Zemin Zhang; Koeppen; Thomas D Wu; Howard M. Stern; Robert Yauch; Kenneth E. Huffman; Diego D. Paskulin; Peter B. Illei; Marileila Varella-Garcia; Adi Gazdar; Frederic J. De Sauvage; Richard Bourgon; Minna; Malcolm V. Brock; Somasekar Seshagiri
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European genetic ancestry is associated with a decreased risk of lupus nephritis
Arthritis and Rheumatism, ISSN: 00043591 15290131
Ilana B. Richman; Kimberly E. Taylor; Sharon A. Chung; Laura Trupin; Michelle Petri; Edward Yelin; Robert R. Graham; Annette T. Lee; Timothy W. Behrens; Peter K. Gregersen; Michael F. Seldin; Lindsey A. Criswell
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Cost utility of palivizumab prophylaxis among pre-term infants in the United States: A national policy perspective
Journal of Medical Economics, ISSN: 13696998 1941837X
Parthiv J. Mahadevia; Anthony Masaquel; Mark J. Polak; Leonard B. Weiner
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Risk of Significant Infection in Rheumatoid Arthritis Patients Switching Anti-Tumor Necrosis Factor-α Drugs
Seminars in Arthritis and Rheumatism, ISSN: 00490172 1532866X
Bao-Anh Nguyen-Khoa; Earl L. Goehring; Kimberly Alexander; Wei Dong; Pavel Napalkov; Judith K. Jones
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The genetics of type I interferon in systemic lupus erythematosus
Current Opinion in Immunology, ISSN: 09527915 18790372
Paola G. Bronson; Christina Chaivorapol; Ward Ortmann; Timothy W. Behrens; Robert R. Graham
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Mycobacterium marinum SecA2 promotes stable granulomas and induces tumor necrosis factor alpha in Vivo
Infection and Immunity, ISSN: 00199567 10985522
Brigitte Y. Watkins; Shilpa A. Joshi; David A. Ball; Hadley Leggett; Summer Park; Janice Kim; Cary D. Austin; Andres Paler Martinez; Min Xu; Kenneth H. Downing; Eric J. Brown
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Genomic landscape of liver cancer
Nature Genetics, ISSN: 10614036 15461718
Zemin Zhang
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Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model
Thrombosis Research, ISSN: 00493848 18792472
Anna L. Hampton; Jose A. Diaz; Angela E. Hawley; Shirley K. Wrobleski; Jian-Guo Wang; Rebecca D. Lee; Daniel Kirchhofer; Robert E. Sigler; Thomas W. Wakefield; Nigel Mackman; Daniel D. Myers Jr.
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Cerebrovascular accidents in patients treated for choroidal neovascularization with ranibizumab in randomized controlled trials
Retina, ISSN: 0275004X 15392864
Neil M. Bressler; David S. Boyer; David F. Williams; Steven Butler; Steve Francom; Benton Brown; Flavia Di Nucci; Timothy Cramm; Lisa Tuomi; Tsontcho Ianchulev; Roman G. Rubio
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Immuno-PET of the hepatocyte growth factor receptor met using the 1-armed antibody onartuzumab
Journal of Nuclear Medicine, ISSN: 01615505
Elaine M. Jagoda; Lixin Lang; Veerendra Bhadrasetty; Stephanie Histed; Mark Williams; Gabriela Kramer-Marek; Esther Mena; Lauren Rosenblum; Jan Marik; Jeff N. Tinianow; Mark Merchant; Lawrence Szajek; Chang Paik; Fabiola Cecchi; Kristen Raffensperger; Joe-Marie Jose-Dizon; Donald P. Bottaro; Peter Choyke
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A phase i study of subcutaneously administered aflibercept (VEGF trap) in a new formulation in patients with advanced solid tumors
Investigational New Drugs, ISSN: 01676997 15730646
Andrea Wang-Gillam; William P. Tew; MacE L. Rothenberg; Jakob Dupont; Wendy Cooper; Lars Sternas; Giliane Buzenet; Jeffrey A. Sosman; David R. Spriggs; Albert Craig Lockhart
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Semi-mechanistic population pharmacokinetic model of multivalent trastuzumab emtansine in patients with metastatic breast cancer
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Chudasama; Franziska Schaedeli-Stark; Harrold; Jay Tibbitts; Sandhya Girish; Manish Gupta; Frey; Donald E. Mager
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Intracellular-signaling tumor-regression modeling of the pro-apoptotic receptor agonists dulanermin and conatumumab
Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 1567567X 15738744
Brittany P. Kay; Cheng-Pang Hsu; Jian-Feng Lu; Sun; Shuang Bai; Yan Xin; David Z. D'Argenio
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Modulation of caenorhabditis elegans infection sensitivity by the LIN-7 cell junction protein
Cellular Microbiology, ISSN: 14625814 14625822
Xiaohui Sem; Jason F. Kreisberg; Trupti Kawli; Man-Wah Tan; Mikael Rhen; Patrick Tan
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TBC1D13 is a RAB35 Specific GAP that Plays an Important Role in GLUT4 Trafficking in Adipocytes
Traffic, ISSN: 13989219 16000854
Jonathan R. Davey; Sean J. Humphrey; Jagath R. Junutula; Ashwini K. Mishra; David G. Lambright; David E. James; Jacqueline Stöckli
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Pyrazolopyridine inhibitors of B-RafV600E. Part 4: Rational design and kinase selectivity profile of cell potent type II inhibitors
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Steve Wenglowsky; David Moreno; Ellen R. Laird; Susan L. Gloor; Li Ren; Tyler Risom; Joachim Rudolph; Hillary L. Sturgis; Walter C. Voegtli
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