Genentech: Publications

January 1, 2010

Poor disease control among insured users of high-dose combination therapy for asthma

Allergy and Asthma Proceedings, ISSN: 10885412 15396304

Michael S. Broder; Eunice Chang; Tripthi V. Kamath; Sandhya Sapra

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January 1, 2010

Purification and characterization of a motility initiating protein from caprine epididymal plasma

Journal of Cellular Physiology, ISSN: 00219541

Bijay S. Jaiswal; Kaushik Das; Sudipta Saha; Sandhya Rekha Dungdung; Gopal C. Majumder

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January 1, 2010

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

British Journal of Pharmacology, ISSN: 14765381 00071188

Joel R. Gever; Rothschild Soto; Robert A. Henningsen; Renee S. Martin; David Hackos; Sandip Panicker; Rubas; Ian B. Oglesby; Michael P. Dillon; Marcos E. Milla; Geoffrey Burnstock; Anthony P. D. W. Ford

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January 1, 2010

Local tissue distribution and cellular fate of vascular endothelial growth factor (VEGF) following intramuscular injection

Journal of Drug Targeting, ISSN: 1061186X 10292330

Daugherty; Mrsny

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January 1, 2010

Structural characterization of intact antibodies by high-resolution LTQ Orbitrap mass spectrometry

Journal of Mass Spectrometry, ISSN: 10765174 10969888

Jennifer Zhang; Hongbin Liu; Viswanatham Katta

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January 1, 2010

Mechanism-based receptor-binding model to describe the pharmacokinetic and pharmacodynamic of an anti-α5β1 integrin monoclonal antibody (volociximab) in cancer patients

Cancer Chemotherapy and Pharmacology, ISSN: 03445704

Chee Ng; Shuang Bai; Takimoto; Meina Tao Tang; Anthony W. Tolcher

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January 1, 2010

Prospects for personalized medicine with inhibitors targeting the RAS and PI3K pathways

Expert Review of Molecular Diagnostics, ISSN: 14737159 17448352

Lackner

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January 1, 2010

Cell culture monitoring via an auto-sampler and an integrated multi-functional off-line analyzer

Biotechnology Progress, ISSN: 87567938 15206033

Gayle E. Derfus; Daniel Abramzon; Meg Tung; David Chang; Robert Kiss; Ashraf Amanullah

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January 1, 2010

Guidelines for reporting the use of capillary electrophoresis in proteomics

Nature Biotechnology, ISSN: 15461696 10870156

Paula J. Domann; Satoko Akashi; Coral Barbas; Lihua Huang; Wendy Lau; Cristina Legido-Quigley; Stephen McClean; Christian Neusü; David Perrett; Milena Quaglia; Erdmann Rapp; Lance Smallshaw; Norman W. Smith; W Franklin Smyth; Chris Taylor

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January 1, 2010

Phase 1 study of aflibercept administered subcutaneously to patients with advanced solid tumors

Clinical Cancer Research, ISSN: 10780432

William P. Tew; Michael S. Gordon; John Murren; Jakob Dupont; Sandra Pezzulli; Carol Aghajanian; Paul Sabbatini; David Mendelson; Lawrence Schwartz; Scott Gettinger; Amanda Psyrri; Jesse M. Cedarbaum; David R. Spriggs

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January 1, 2010

Immunization responses in rheumatoid arthritis patients treated with rituximab: Results from a controlled clinical trial

Arthritis and Rheumatism, ISSN: 00043591 15290131

Bingham; R. John Looney; Deodhar; Neal Halsey; Maria Greenwald; Christine Codding; Benjamin L. Trzaskoma; Flavius Martin; Sunil Agarwal; Ariella Kelman

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January 1, 2010

A two-stage algorithm for designing phase I cancer clinical trials for two new molecular entities

Contemporary Clinical Trials, ISSN: 15517144

Zheng Su

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January 1, 2010

B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity

Annals of Neurology, ISSN: 15318249 03645134

Martin Weber; Thomas Prod'homme; Juan C. Patarroyo; Nicolas Molnarfi; Tara Karnezis; Klaus Lehmann-Horn; Dimitry Danilenko; Jeffrey Eastham-Anderson; Anthony J. Slavin; Christopher Linington; Claude C.A. Bernard; Flavius Martin; Scott S. Zamvil

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January 1, 2010

The conserved bardet-biedl syndrome proteins assemble a coat that traffics membrane proteins to Cilia

Cell, ISSN: 00928674

Hua Jin; Susan Roehl White; Toshinobu Shida; Stefan Schulz; Mike Aguiar; Steven P. Gygi; J.Fernando Bazan; Maxence V. Nachury

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January 1, 2010

Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia

Journal of Immunology, ISSN: 15506606 00221767

Lamkanfi; Anasuya Sarkar; Vande Walle; Alberto C. Vitari; Amal O. Amer; Mark D. Wewers; Kevin J. Tracey; Thirumala-Devi Kanneganti; Vishva M. Dixit

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January 1, 2010

Statistical techniques to construct assays for identifying likely responders to a treatment under evaluation from cell line genomic data.

BMC Cancer, ISSN: 14712407

Erich P. Huang; Jane Fridlyand; Nicholas Lewin-Koh; Peng Yue; Xiaoyan Shi; David Dornan; Bart Burington

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January 1, 2010

Targeting inhibitor of apoptosis (IAP) proteins in cancer

Apoptosis: Modern Insights into Disease from Molecules to Man,

Eugene Varfolomeev; Domagoj Vucic

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January 1, 2010

Cancer: MiRNA addiction - Depending on life's little things

Current Biology, ISSN: 09609822

David Dornan; Jeffrey Settleman

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January 1, 2010

A generic headspace GC method for residual solvents in pharmaceuticals: Benefits, rationale, and adaptations for new chemical entities

LCGC North America, ISSN: 15275949

Lulu Dai; Amanda C. Quiroga; Kelly Zhang; Heather B. Runes; Derrick T. Yazzie; Kavita Mistry; Nik P. Chetwyn; Michael W. Dong

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January 1, 2010

An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Satish K. Singh; Nataliya Afonina; Michel Awwad; Karoline Bechtold-Peters; Jeffrey T. Blue; Danny Chou; Cromwell; Hans-Juergen Krause; Hanns-Christian Mahler; Brian K. Meyer; Linda O. Narhi; Doug P. Nesta; Thomas Spitznagel

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January 1, 2010

Single-use technology and its carbon and water footprints, part 2: "Bioreactors - To be or not to be: That is the question"

American Pharmaceutical Review, ISSN: 10998012

Lindsay Leveen

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January 1, 2010

Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using in vivo imaging model

British Journal of Dermatology, ISSN: 13652133 00070963

Wang; Fujita; Prado; Tousson; Hsu; Arndt J Schottelius; Kelly; Yang; Wu; Chen; Xu; Elmets; Mountz; Edwards Iii

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January 1, 2010

Pharmaceutical Medical Information Contact Centers: Results of Three Benchmarking Surveys

Therapeutic Innovation and Regulatory Science, ISSN: 21684790

Pete Guillot; Stacey M. Fung

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January 1, 2010

Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture

PLoS Computational Biology, ISSN: 15537358 1553734X

Ju Han; Hang Chang; Orsi Giricz; Genee Y. Lee; Frederick L. Baehner; Joe W. Gray; Mina J. Bissell; Paraic A. Kenny; Bahram Parvin

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January 1, 2010

Foreword

Separation Science and Technology, ISSN: 15205754 01496395

James M. van Alstine; Philip M. Lester

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December 29, 2009

Robust preparation of novel imidazo[5,1-b][1,3,4]oxadiazoles

Organic and Biomolecular Chemistry, ISSN: 14770520

Tuan P. Tran; Nandini C. Patel; Brian Samas; Jacob B. Schwarz

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December 21, 2009

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

Journal of Experimental Medicine, ISSN: 00221007 15409538

Melba Muñoz; Markus Heimesaat; Kerstin Danker; Daniela Struck; Uwe Lohmann; Rita Plickert; Stefan Bereswill; André Fischer; Ildikò Rita Dunay; Kerstin Wolk; Christoph Loddenkemper; Hans-Willi Krell; Claude Libert; Leif R. Lund; Oliver Frey; Christoph Hölscher; Yoichiro Iwakura; Nico Ghilardi; Wenjun Ouyang; Thomas Kamradt; Robert Sabat; Oliver Liesenfeld

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December 18, 2009

Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Bing Li; Hongkang Xi; Laurie Diehl; Wyne P. Lee; Lizette Sturgeon; Jason Chinn; Laura DeForge; Robert F. Kelley; Wiesmann; Menno Van Lookeren Campagne; Sachdev S. Sidhu

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December 18, 2009

Interlaced size exclusion liquid chromatography of monoclonal antibodies

Journal of Chromatography A, ISSN: 00219673

Dell Farnan; G. Tony Moreno; Stults; Andreas Becker; Guillaume Tremintin; Mark van Gils

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December 15, 2009

Cutting edge: Depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice

Journal of Immunology, ISSN: 00221767 15506606

Kim; Katharina Lahl; Shohei Hori; Christoph Loddenkemper; Ashutosh Chaudhry; Paul DeRoos; Alexander Y. Rudensky; Tim Sparwasser

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December 15, 2009

IL-23 is required for protection against systemic infection with Listeria monocytogenes

Journal of Immunology, ISSN: 00221767 15506606

Karen D. Meeks; Amy N. Sieve; Jay K. Kolls; Nico Ghilardi; Rance E. Berg

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December 11, 2009

X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Eugene Varfolomeev; Bruno Alicke; J. Michael Elliott; Zobel; Kristina West; Harvey Wong; Justin M. Scheer; Avi Ashkenazi; Stephen Gould; Wayne J. Fairbrother; Domagoj Vucic

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December 9, 2009

Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody

Structure, ISSN: 09692126

Rajkumar Ganesan; Eigenbrot; Yan Wu; Wei-Ching Liang; Steven Shia; Michael T. Lipari; Daniel Kirchhofer

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December 8, 2009

Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation

Cancer Cell, ISSN: 15356108

Bijay S. Jaiswal; Vasantharajan Janakiraman; Noelyn Kljavin; Subhra Chaudhuri; Howard M. Stern; Weiru Wang; Zhengyan Kan; Hashem A. Dbouk; Brock A. Peters; Waring; Trisha Dela Vega; Denise M. Kenski; Krista K. Bowman; Maria N. Lorenzo; Hong Li; Jiansheng Wu; Zora Modrusan; Stinson; Mike Eby; Peng Yue; Joshua S. Kaminker; Frederic J. De Sauvage; Jonathan M. Backer; Somasekar Seshagiri

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December 8, 2009

Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy

Breast Cancer Research, ISSN: 14655411 1465542X

Nancy Dumont; Yongping Crawford; Mahvash Sigaroudinia; Shefali S. Nagrani; Matthew B. Wilson; Gertrude C. Buehring; Gulisa Turashvili; Samuel A. Aparicio; Mona L. Gauthier; Colleen A. Fordyce; Kimberly M. McDermott; Thea D. Tlsty

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December 7, 2009

Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2

Molecular Pharmaceutics, ISSN: 15438384 15438392

Henriette E. Meyer Zu Schwabedissen; Joseph A. Ware; Rommel G. Tirona; Richard B. Kim

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December 7, 2009

Transport-metabolism interplay

Molecular Pharmaceutics, ISSN: 15438384 15438392

Laurent Salphati

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December 4, 2009

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Martin L. Sos; Stefanie Fischer; Roland Ullrich; Martin Peifer; Johannes M. Heuckmann; Mirjam Koker; Stefanie Heynck; Isabel Stückrath; Jonathan Weiss; Florian Fischer; Kathrin Michel; Aviva Goel; Lucia Regales; Katerina Politi; Samanthi Perera; Matthäus Getlik; Lukas C. Heukamp; Sascha Ansén; Thomas Zander; Rameen Beroukhim; Hamid Kashkar; Kevan Shokat; William R. Sellers; Daniel Rauh; Christine Orr; Klaus P. Hoeflich; Lori S. Friedman; Kwok-Kin Wong; William Pao; Roman K. Thomas

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December 4, 2009

Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells

Carcinogenesis, ISSN: 01433334 14602180

Cho S. Aung; Weilan Ye; Greg D. Plowman; Amelia A. Peters; Gregory R. Monteith; Sarah J. Roberts-Thomson

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December 2, 2009

Identification of codon-specific serine to asparagine mistranslation in recombinant monoclonal antibodies by high-resolution mass spectrometry

Analytical Chemistry, ISSN: 00032700

X. Christopher Yu; Oleg V. Borisov; Melissa Alvarez; David A. Michels; Yajun Jennifer Wang; Victor Ling

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December 1, 2009

The effects of paroxetine on the pharmacokinetics of paliperidone extended-release tablets

Pharmacopsychiatry, ISSN: 01763679 14390795

Berwaerts; Cleton; Herben; I. Van De Vliet; Chang; P. Van Hoek; Eerdekens

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December 1, 2009

Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies

Trends in Pharmacological Sciences, ISSN: 01656147

Yongping Crawford; Napoleone Ferrara

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December 1, 2009

Unison: An integrated platform for computational biology discovery

Pacific Symposium on Biocomputing 2009, PSB 2009,

Reece K. Hart; Kiran Mukhyala

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December 1, 2009

Bi-directional SIFT predicts a subset of activating mutations

PLoS ONE, ISSN: 19326203

William Lee; Yan Zhang; Kiran Mukhyala; Lazarus; Zemin Zhang

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December 1, 2009

Formulation and manufacturability of biologics

Current Opinion in Biotechnology, ISSN: 09581669

Steven J. Shire

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December 1, 2009

VEGF-A: A critical regulator of blood vessel growth

European Cytokine Network, ISSN: 11485493

Napoleone Ferrara

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December 1, 2009

Protease expression colocalizes to regions of abdominal aortic expansion and stiffening in a murine aneurysm model

Proceedings of the ASME Summer Bioengineering Conference, SBC2008,

Craig J. Goergen; Dara Y. Kallop; Charles A. Taylor; Robby M. Weimer; Joan M. Greve

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December 1, 2009

Polysorbate 20 prevents the precipitation of a monoclonal antibody during shear Viscosity of monoclonal antibodies under shear

Pharmaceutical Development and Technology, ISSN: 10837450 10979867

Thomas W. Patapoff; Osigwe Esue

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December 1, 2009

Safety of biological therapies following rituximab treatment in rheumatoid arthritis patients

Annals of the Rheumatic Diseases, ISSN: 00034967 14682060

Mark C. Genovese; Ferdinand Breedveld; Paul Emery; Stanley B. Cohen; Edward Keystone; Matteson; Baptiste; Akiko Chai; Laura Burke; William Reiss; Marianne Sweetser; Tim Shaw

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December 1, 2009

Recovery from hind limb ischemia is less effective in type 2 than in type 1 diabetic mice: Roles of endothelial nitric oxide synthase and endothelial progenitor cells

Journal of Vascular Surgery, ISSN: 07415214

Jinglian Yan; Guodong Tie; Brian Park; Yagai Yang; Philip T. Nowicki; Louis M. Messina

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