Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9501 - 9550 OF 15805 RESULTS

November 3, 2009

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

John D. Rioux; Philippe Goyette; Timothy J. Vyse; Lennart Hammarström; Michelle M.A. Fernando; Todd Green; Philip L. De Jager; Sylvain Foisy; Joanne Wang; Paul I. W. De Bakker; Stephen Leslie; Gilean McVean; Leonid Padyukov; Lars Alfredsson; Vito Annese; David A. Hafler; Qiang Pan-Hammarström; Ritva Matell; Stephen J. Sawcer; Alastair D. Compston; Bruce A. C. Cree; Daniel B. Mirel; Mark J. Daly; Timothy W. Behrens; Lars Klareskog; Peter K. Gregersen; Jorge R. Oksenberg; Stephen L. Hauser

November 1, 2009

Multiproduct high-resolution monoclonal antibody charge variant separations by pH gradient ion-exchange chromatography

Analytical Chemistry, ISSN: 00032700

Dell Farnan; G. Tony Moreno

November 1, 2009

Monitoring Ocular Drug Therapy by Analysis of Aqueous Samples

Ophthalmology, ISSN: 01616420

Peter A. Campochiaro; David F. Choy; Diana V. Do; Gulnar Hafiz; Syed Mahmood Shah; Quan Dong Nguyen; Roman G. Rubio; Joseph R. Arron

November 1, 2009

Pegylated Kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis

Cancer Research, ISSN: 00085472 15387445

Wei Li; Bu-Er Wang; Paul Moran; Michael T. Lipari; Rajkumar Ganesan; Corpuz; Mary J. C. Ludlam; Alvin Gogineni; Koeppen; Bunting; Gao; Daniel Kirchhofer

November 1, 2009

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Nature Genetics, ISSN: 10614036 15461718

Vesela Gateva; Johanna K. Sandling; Geoffrey Hom; Kimberly E. Taylor; Sharon A. Chung; Xin Sun; Ward Ortmann; Kosoy; Ricardo C. Ferreira; Gunnel Nordmark; Iva Gunnarsson; Elisabet Svenungsson; Leonid Padyukov; Gunnar Sturfelt; Andreas Jönsen; Anders A. Bengtsson; Solbritt Rantapää-Dahlqvist; Emily C. Baechler; Elizabeth E. Brown; Graciela S. Alarcõn; Jeffrey C. Edberg; Robert P. Kimberly; Gerald McGwin; John D. Reveille; Luis M. Vilá; Robert P. Kimberly; Manzi; Michelle Petri; Annette T. Lee; Peter K. Gregersen; Michael F. Seldin; Lars Rönnblom; Lindsey A. Criswell; Ann-Christine Syvänen; Timothy W. Behrens; Robert R. Graham

November 1, 2009

Recent asthma exacerbations predict future exacerbations in children with severe or difficult-to-treat asthma

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Tmirah Haselkorn; Robert S. Zeiger; Bradley E. Chipps; David R. Mink; Stanley J. Szefler; F. Estelle R. Simons; Marc Massanari; James E. Fish

November 1, 2009

Comparison of asthma exacerbations in pediatric and adult patients with severe or difficult-to-treat asthma

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Robert S. Zeiger; Bradley E. Chipps; Tmirah Haselkorn; Lawrence Rasouliyan; F. Estelle R. Simons; James E. Fish

November 1, 2009

Oral bioavailability of polychlorinated dibenzo-p-dioxins/dibenzofurans in industrial soils

Human and Ecological Risk Assessment, ISSN: 10807039 15497860

Brent Finley; Kurt Fehling; John Warmerdam; Eric Morinello

November 1, 2009

Economic outcomes in patients diagnosed with systemic lupus erythematosus with versus without nephritis: Results from an analysis of data from a US claims database

Clinical Therapeutics, ISSN: 01492918 1879114X

Elise M. Pelletier; Sarika Ogale; Elaine B. Yu; Paul Brunetta; Jay Garg

November 1, 2009

Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung

Pediatric Pulmonology, ISSN: 87556863 10990496

Fernando Urrego; Mario Scuri; Alexander Auais; Lida Mohtasham; Giovanni Piedimonte

November 1, 2009

Targeting inhibitor of apoptosis proteins for therapeutic intervention

Future Medicinal Chemistry, ISSN: 17568919

Chudi O. Ndubaku; Frederick Cohen; Eugene Varfolomeev; Domagoj Vucic

November 1, 2009

Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance

Journal of Virology, ISSN: 0022538X

Madhavi Kolli; Eric Stawiski; Colombe Chappey; Celia A. Schiffer

November 1, 2009

Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4- (methylsulfonyl)benzamide), an orally bioavailable systemic hedgehog signalling pathway inhibitor

Xenobiotica, ISSN: 00498254 13665928

Harvey Wong; Jacob Z. Chen; Bilin Chou; Jason S Halladay; Jane R. Kenny; Hank La; James C. Marsters Jr.; Emile G. Plise; Patrick J. Rudewicz; Kirk D. Robarge; Young G. Shin; Susan C. Wong; Chenghong Zhang; S. Cyrus Khojasteh

November 1, 2009

Human monomeric antibody fragments to TRAIL-R1 and TRAIL-R2 that display potent in vitro agonism

mAbs, ISSN: 19420862

Claire L. Dobson; Sarah Main; Philip Newton; Matthieu Chodorge; Karen Cadwallader; Robin Humphreys; Albert; Tristan J. Vaughan; Ralph R. Minter; Bryan M. Edwards

November 1, 2009

Multivariate analysis of the sequence dependence of asparagine deamidation rates in peptides

Pharmaceutical Research, ISSN: 07248741 1573904X

Andrew Kosky; Vasumathi Dharmavaram; Gayathri Ratnaswamy; Mark C. Manning

November 1, 2009

Carboxylate-dependent gelation of a monoclonal antibody

Pharmaceutical Research, ISSN: 07248741 1573904X

Osigwe Esue; Sonoko Kanai; Jun Liu; Thomas W. Patapoff; Steven J. Shire

November 1, 2009

Charge-based analysis of antibodies with engineered cysteines: From multiple peaks to a single main peak

mAbs, ISSN: 19420862

Xiaoying Chen; Mary D. H. Nguyen; Fred Jacobson; Jun Ouyang

November 1, 2009

Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: Insights from imaging

Clinical Cancer Research, ISSN: 10780432

James P.B. O'Connor; Richard A. D. Carano; Andrew R. Clamp; Ross; Calvin Ho; Alan Jackson; Geoff J. M. Parker; Chris J. Rose; Franklin V. Peale Jr.; Michel Friesenhahn; Claire L. Mitchell; Yvonne Watson; Caleb Roberts; Lynn Hope; Sue Cheung; Hani Bou-Reslan; MaryAnn Go; Glenn Pacheco; Xiumin Wu; Tim C. Cao; Ross; Giovanni A. Buonaccorsi; Karen Davies; Jurjees Hasan; Paula Thornton; Olivia Del Puerto; Napoleone Ferrara; Nicholas Van Bruggen; Gordon C. Jayson

November 1, 2009

A novel alginate hollow fiber bioreactor process for cellular therapy applications

Biotechnology Progress, ISSN: 87567938

Corinne A. Hoesli; Minh Luu; James M. Piret

October 30, 2009

Retinoic Acid from the Meninges Regulates Cortical Neuron Generation

Cell, ISSN: 00928674

Julie A. Siegenthaler; Amir M. Ashique; Konstantinos Zarbalis; Katelin P. Patterson; Jonathan H. Hecht; Maureen A. Kane; Alexandra E. Folias; Youngshik Choe; Scott R. May; Tsutomu Kume; Joseph L. Napoli; Andrew S. Peterson; Samuel J. Pleasure

October 29, 2009

Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors

Journal of Medicinal Chemistry, ISSN: 00222623

Michael B. Plewe; Scott L. Butler; Klaus R. Dress; Qiyue Hu; Ted W. Johnson; Jon E. Kuehler; Atsuo Kuki; Hieu Lam; Wen Liu; Dawn Nowlin; Qinghai Peng; Sadayappan V. Rahavendran; Steven P. Tanis; Khanh T. Tran; Hai Wang; Anle Yang; Junhu Zhang

October 26, 2009

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

Journal of Experimental Medicine, ISSN: 00221007 15409538

David K. Finlay; Linda V. Sinclair; Carmen Feijoo; Caryll M. Waugh; Thijs Hagenbeek; Hergen Spits; Doreen A. Cantrell

October 26, 2009

Masking MALT1: The paracaspase's potential for cancer therapy

Journal of Experimental Medicine, ISSN: 00221007 15409538

Domagoj Vucic; Vishva M. Dixit

October 23, 2009

Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma

Science, ISSN: 00368075 10959203

Robert Yauch; Gerrit J. P. Dijkgraaf; Bruno Alicke; Thomas Januario; Christina Ahn; Thomas Holcomb; Kanan Pujara; Stinson; Christopher Callahan; Tracy Tzu-Ling Tang; J.Fernando Bazan; Zhengyan Kan; Somasekar Seshagiri; Christine L. Hann; Stephen Gould; Low; Charles M. Rudin; Frederic J. De Sauvage

October 20, 2009

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Richard G. Jenner; Michael J. Townsend; Ian Jackson; Kaiming Sun; Russell D. Bouwman; Richard A. Young; Laurie H. Glimcher; Graham M. Lord

October 20, 2009

A Role for C. elegans Eph RTK Signaling in PTEN Regulation

Developmental Cell, ISSN: 15345807

Sarah Brisbin; Jun Liu; Jeff Boudreau; Jimmy Peng; Marie Evangelista; Ian Chin-Sang

October 20, 2009

The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta

Developmental Cell, ISSN: 15345807

Boris Strilić; Tomáš Kučera; Jan Eglinger; Michael R. Hughes; Kelly M. McNagny; Sachiko Tsukita; Elisabetta Dejana; Napoleone Ferrara; Eckhard Lammert

October 19, 2009

Promising bone-related therapeutic targets for rheumatoid arthritis

Nature Reviews Rheumatology, ISSN: 17594790 17594804

Yongwon Choi; Joseph R. Arron; Michael J. Townsend

October 16, 2009

TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling

Cell, ISSN: 00928674

Harald Junge; Stacey Yang; Jeremy B. Burton; Kim Paes; Xiao Shu; French; Michael Costa; Dennis S. Rice; Weilan Ye

October 15, 2009

Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y+, proopiomelanocortin+, and tyrosine hydroxylase+ neurons in neonatal and adult mice

Journal of Comparative Neurology, ISSN: 00219967 10969861

Cindy Yee; Yanling Wang; Stewart Anderson; Marc Ekker; John L. R. Rubenstein

October 15, 2009

Revving the throttle on an oncogene: CDK8 takes the driver seat

Cancer Research, ISSN: 00085472 15387445

Ron Firestein; William C. Hahn

October 14, 2009

Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors-Insight into Heterotrimeric IL-1 Signaling Complexes

Structure, ISSN: 09692126

Andreas Lingel; Thomas M. Weiss; Marc Niebuhr; Borlan Pan; Brent A. Appleton; Wiesmann; J.Fernando Bazan; Wayne J. Fairbrother

October 14, 2009

Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: A validation study

Arthritis and Rheumatism, ISSN: 00043591 15290131

Jason W. Bauer; Michelle Petri; Franak Batliwalla; Thearith Koeuth; Joseph Wilson; Catherine A. Slattery; Angela Panoskaltsis-Mortari; Peter K. Gregersen; Timothy W. Behrens; Emily C. Baechler

October 14, 2009

Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells

PLoS ONE, ISSN: 19326203

Junichi Soh; Naoki Okumura; William W. Lockwood; Hiromasa Yamamoto; Hisayuki Shigematsu; Wei Zhang; Raj Chari; David S. Shames; Ximing Tang; Calum MacAulay; Marileila Varella-Garcia; Tõnu Vooder; Ignacio I. Wistuba; Stephen Lam; Rolf Brekken; Shinichi Toyooka; Minna; Wan L. Lam; Adi Gazdar

October 12, 2009

Engineering surfaces for substrate-mediated gene delivery using recombinant proteins

Biomacromolecules, ISSN: 15257797

Jennifer C. Rea; Romie F. Gibly; Nicolynn E. Davis; Annelise E. Barron; Lonnie D. Shea

October 9, 2009

DNA spike studies for demonstrating improved clearance on chromatographic media

Journal of Chromatography A, ISSN: 00219673

Michelle D. Butler; Brian Kluck; Tracy Bentley

October 5, 2009

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

Journal of Cell Biology, ISSN: 00219525 00219525

Lamkanfi; James L. Mueller; Alberto C. Vitari; Shahram Misaghi; Anna V. Fedorova; Deshayes; Wyne P. Lee; Hal M. Hoffman; Vishva M. Dixit

October 5, 2009

Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus

Lupus, ISSN: 09612033

Michelle Petri; Singh; Tesfasyone; Russell L Dedrick; Fry; Preeti Lal; Williams; Jason W. Bauer; Peter K. Gregersen; Timothy W. Behrens; Emily C. Baechler

October 1, 2009

Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins

PLoS Biology, ISSN: 15449173 15457885

Raffi Tonikian; Xiaofeng Xin; Christopher P. Toret; David Gfeller; Christiane Landgraf; Simona Panni; Serena Paoluzi; Luisa Castagnoli; Bridget Currell; Somasekar Seshagiri; Haiyuan Yu; Barbara Winsor; Marc Vidal; Mark Gerstein; Gary D. Bader; Rudolf Volkmer; Gianni Cesareni; Drubin; Philip M. Kim; Sachdev S. Sidhu; Charles Boone

October 1, 2009

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions

PLoS Genetics, ISSN: 15537390 15537404

Lisa F. Barcellos; Suzanne L. May; Ramsay; Hong L. Quach; Lane; Joanne Nititham; Janelle A. Noble; Kimberly E. Taylor; Diana L. Quach; Sharon A. Chung; Jennifer A. Kelly; Kathy L. Moser; Timothy W. Behrens; Michael F. Seldin; Glenys Thomson; John B. Harley; Patrick M. Gaffney; Lindsey A. Criswell

October 1, 2009

Axl as a potential therapeutic target in cancer: Role of Axl in tumor growth, metastasis and angiogenesis

Oncogene, ISSN: 09509232 14765594

Li; Ye; Christine Tan; Hongo; Jiping Zha; Liu; Dara Y. Kallop; Mary J. C. Ludlam; Lin Pei

October 1, 2009

GDC-0449-A potent inhibitor of the hedgehog pathway

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Kirk D. Robarge; Shirley A. Brunton; Georgette M. Castanedo; Yong Cui; Dina; Richard Goldsmith; Stephen Gould; Oivin Guichert; Janet Gunzner; Jason S Halladay; Wei Jia; S. Cyrus Khojasteh; Michael F. T. Koehler; Karen Kotkow; Hank La; Rebecca L. LaLonde; Kevin Lau; Leslie Lee; Derek Marshall; James C. Marsters Jr.; Lesley J. Murray; Changgeng Qian; Lee L. Rubin; Laurent Salphati; Mark S. Stanley; John H.A. Stibbard; Daniel P. Sutherlin; Savita Ubhayakar; Shumei Wang; Susan C. Wong; Minli Xie

October 1, 2009

Systematic genetic nomenclature for type VII secretion systems

PLoS Pathogens, ISSN: 15537366 15537374

Wilbert Bitter; Edith N. G. Houben; Daria Bottai; Priscille Brodin; Eric J. Brown; Jeffery S. Cox; Keith Derbyshire; Sarah M. Fortune; Lian-Yong Gao; Jun Liu; Nicolaas C. Gey Van Pittius; Alexander S. Pym; Eric J. Rubin; David R. Sherman; Stewart T. Cole; Roland Brosch

October 1, 2009

In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates

Molecular Cancer Therapeutics, ISSN: 15357163

Bing Zheng; Reina N. Fuji; Kristi Elkins; Shang-Fan Yu; Franklin Fuh; Josefa Chuh; Christine Tan; Hongo; Helga Raab; Katherine R. Kozak; Marna Williams; Elena McDorman; Dan L. Eaton; Allen Ebens; Andrew G. Polson

October 1, 2009

Biomanufacturing process analytical technology (PAT) application for downstream processing: Using dissolved oxygen as an indicator of product quality for a protein refolding reaction

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Shelly A. Pizarro; Rachel Dinges; Rachel Adams; Ailen M. Sánchez; Charles Winter

October 1, 2009

Multiplex RT Q-PCR assay for simultaneous quantification of three viruses used for validation of virus clearance by biopharmaceutical production

Biologicals, ISSN: 10451056 10958320

Scott Lute; Hua Wang; Davonie Sanchez; Janet Barletta; Qi Chen; Kurt Brorson

October 1, 2009

Understanding the mechanism of virus removal by Q sepharose fast flow chromatography during the purification of CHO-cell derived biotherapeutics

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Daniel M. Strauss; Scott Lute; Zinaida Tebaykina; Douglas D. Frey; Cintia Ho; Gregory S. Blank; Kurt Brorson; Qi Chen; Bin Yang

October 1, 2009

The N-terminal domain of DDA3 regulates the spindle-association of the microtubule depolymerase Kif2a and controls the mitotic function of DDA3

Cell Cycle, ISSN: 15514005 15384101

Chang-Young Jang; Guowei Fang

September 18, 2009

Structural Ties between Cholesterol Transport and Morphogen Signaling

Cell, ISSN: 00928674

J.Fernando Bazan; Frederic J. De Sauvage

September 18, 2009

The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Hiroaki Uranishi; Andrei S. Zolotukhin; Susan Lindtner; Søren Warming; Gen-Mu Zhang; Jenifer Bear; Neal G. Copeland; Nancy A. Jenkins; George N. Pavlakis; Barbara K. Felber

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