Genentech: Publications

September 17, 2009

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

New England Journal of Medicine, ISSN: 15334406 00284793

Charles M. Rudin; Christine L. Hann; John Laterra; Robert Yauch; Christopher Callahan; Ling Fu; Thomas Holcomb; Stinson; Stephen Gould; Barbara Coleman; Patricia M. LoRusso; Daniel D. Von Hoff; Frederic J. De Sauvage; Low

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September 17, 2009

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

New England Journal of Medicine, ISSN: 15334406 00284793

Daniel D. Von Hoff; Patricia M. LoRusso; Charles M. Rudin; Josina C. Reddy; Robert Yauch; Raoul Tibes; Glen J. Weiss; Mitesh J. Borad; Christine L. Hann; Julie Brahmer; Howard M. Mackey; Bert L. Lum; Darbonne; James C. Marsters Jr.; Frederic J. De Sauvage; Low

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September 15, 2009

Local Guidance of Emerging Vessel Sprouts Requires Soluble Flt-1

Developmental Cell, ISSN: 15345807

John C. Chappell; Sarah M. Taylor; Napoleone Ferrara; Victoria L. Bautch

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September 14, 2009

Genomic DNA microarray comparison of gene expression patterns in Paracoccidioides brasiliensis mycelia and yeasts in vitro

Microbiology, ISSN: 13500872

Jomar P. Monteiro; Karl V. Clemons; Laurence F. Mirels; John A. Coller Jr.; Thomas D Wu; Jata Shankar; Catalina R. Lopes; David A. Stevens

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September 10, 2009

Estimating variance parameters from multivariate normal variables subject to limits of detection: MLE, REML, or Bayesian approaches?

Statistics in Medicine, ISSN: 02776715 10970258

Lei Nie; Haitao Chu; Shibao Feng

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September 9, 2009

A modular platform for the rapid site-specific radiolabeling of proteins with 18F exemplified by quantitative positron emission tomography of human epidermal growth factor receptor 2

Journal of Medicinal Chemistry, ISSN: 00222623

Herman S. Gill; Jeff N. Tinianow; Annie Ogasawara; Judith E. Flores; Alexander N. Vanderbilt; Helga Raab; Justin M. Scheer; Richard L. Vandlen; Simon P. Williams; Jan Marik

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September 8, 2009

Science signaling podcast: 8 September 2009

Science Signaling, ISSN: 19450877 19379145

Sachdev S. Sidhu; Annalisa M. VanHook

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September 8, 2009

Rapid evolution of functional complexity in a domain family

Science Signaling, ISSN: 19450877 19379145

Andreas Ernst; Stephen L. Sazinsky; Shirley Hui; Bridget Currell; Moyez Dharsee; Somasekar Seshagiri; Gary D. Bader; Sachdev S. Sidhu

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September 1, 2009

Single-use technology and the carbon and water footprints of biopharm manufacturing

American Pharmaceutical Review, ISSN: 10998012

Lindsay Leveen

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September 1, 2009

Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers

Molecular Cancer Research, ISSN: 15417786

Eva Lin; Li Li; Yinghui Guan; Robert Soriano; Rivers; Sankar Mohan; Ajay Pandita; Zhijun Tang; Zora Modrusan

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September 1, 2009

Converting cancer mutations into therapeutic opportunities

EMBO Molecular Medicine, ISSN: 17574676 17574684

Thomas O'Brien; David Stokoe

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September 1, 2009

Design, synthesis and discovery of 1-(2-(6-chloro-3-methylsulfonyl)- naphthyl)-1H-pyrazole-5-carboxylamides as highly potent factor Xa inhibitors

Chemical and Pharmaceutical Bulletin, ISSN: 00092363 13475223

Zhaozhong J. Jia; Robert M. Scarborough; Penglie Zhang; Sherin Halfon; Ann Elizabeth Arfsten; Uma Sinha; Bing-Yan Zhu

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September 1, 2009

Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: The BRiTE observational cohort study

Oncologist, ISSN: 10837159 1549490X

Kozloff; Marianne Ulcickas Yood; Jordan Berlin; Patrick J. Flynn; Fairooz F. Kabbinavar; David M. Purdie; Ashby; Wei Dong; Mary M. Sugrue; Grothey

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September 1, 2009

SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition

Cell Cycle, ISSN: 15514005 15384101

Lin Fang; Akiko Seki; Guowei Fang

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September 1, 2009

T-helper type 2-driven inflammation defines major subphenotypes of asthma

American Journal of Respiratory and Critical Care Medicine, ISSN: 1073449X 15354970

Prescott G. Woodruff; Barmak Modrek; David F. Choy; Guiquan Jia; Abbas Alexander; Almut Ellwanger; Joseph R. Arron; Laura L. Koth; John V. Fahy

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September 1, 2009

Stimulant medication use and response to growth hormone therapy: An NCGS database analysis

Hormone Research, ISSN: 03010163

J. Paul Frindik; Alba Morales; John Fowlkes; Stephen F. Kemp; Kathryn Thrailkill; Barbara M. Lippe; Ken Dana

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September 1, 2009

Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents

British Journal of Pharmacology, ISSN: 00071188 14765381

Florio; Loh; Huang; Iwamaye; Kitto; Fowler; Treiberg; Hayflick; Walker; Fairbanks; Lai

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September 1, 2009

Development of a high throughput protein a well-plate purification method for monoclonal antibodies

Biotechnology Progress, ISSN: 87567938

Jennifer Hopp; Ross Pritchett; Maria R. Darlucio; Junfen Ma; Judy H. Chou

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September 1, 2009

Response to Charlton et al.

Birth Defects Research Part A - Clinical and Molecular Teratology, ISSN: 15420752 15420760

Angela E. Scheuerle; Vani X. Vannappagari; Mary K. Miller

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September 1, 2009

Laplace's approximation for relative risk frailty models

Lifetime Data Analysis, ISSN: 13807870

Shibao Feng; Lei Nie; Robert A. Wolfe

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September 1, 2009

The prioritization of cancer antigens: A National Cancer Institute pilot project for the acceleration of translational research

Clinical Cancer Research, ISSN: 10780432

Martin A. Cheever; James P. Allison; Andrea Stern Ferris; Olivera J. Finn; Benjamin M. Hastings; Toby T. Hecht; Ira Mellman; Sheila A. Prindiville; Jaye L. Viner; Louis M. Weiner; Lynn M. Matrisian

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September 1, 2009

A Phase IIIb Study to Evaluate the Safety of Ranibizumab in Subjects with Neovascular Age-related Macular Degeneration

Ophthalmology, ISSN: 01616420

David S. Boyer; Jeffrey S. Heier; David M. Brown; Steve Francom; Tsontcho Ianchulev; Roman G. Rubio

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September 1, 2009

Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents

British Journal of Pharmacology, ISSN: 00071188 14765381

Florio; Christine Loh; Huang; Iwamaye; Kitto; Fowler; Treiberg; Hayflick; Walker; Fairbanks; Lai

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August 31, 2009

Techniques for time-efficient isolation of human skin dendritic cell subsets and assessment of their antigen uptake capacity

Journal of Immunological Methods, ISSN: 00221759

Emily Bond; William C. Adams; Anna Smed-Sörensen; Kerrie J. Sandgren; Leif Perbeck; Anette Hofmann; Jan Andersson; Karin Loré

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August 24, 2009

Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2

PLoS ONE, ISSN: 19326203

Wendy R. Gordon; Didem Vardar-Ulu; Sarah L'Heureux; Todd Ashworth; Michael J. Malecki; Cheryll Sanchez-Irizarry; Debbie G. McArthur; Gavin Histen; Jennifer L. Mitchell; Jon C. Aster; Stephen C. Blacklow

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August 20, 2009

A highly annotated whole-genome sequence of a Korean individual

Nature, ISSN: 00280836 14764687

Jong-Il Kim; Young Seok Ju; Hansoo Park; Sheehyun Kim; Seonwook Lee; Jae-Hyuk Yi; Joann Mudge; Neil A. Miller; Dongwan Hong; Callum J. Bell; Hye-Sun Kim; In-Soon Chung; Woo-Chung Lee; Ji-Sun Lee; Seung-Hyun Seo; Ji-Young Yun; Hyun Nyun Woo; Heewook Lee; Dongwhan Suh; Seungbok Lee; Hyun-Jin Kim; Maryam Yavartanoo; Minhye Kwak; Ying Zheng; Mi Kyeong Lee; Hyunjun Park; Jeong Yeon Kim; Omer Gokcumen; Ryan E. Mills; Alexander Wait Zaranek; Joseph Thakuria; Xiaodi Wu; Ryan W. Kim; Jim J. Huntley; Shujun Luo; Gary P. Schroth; Thomas D Wu; Hyeran Kim; Kap-Seok Yang; Woong-Yang Park; Hyungtae Kim; George M. Church; Charles Lee; Stephen F. Kingsmore; Jeong-Sun Seo

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August 18, 2009

Validation of tangential flow filtration in biopharmaceutical applications task force

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440

Chris Antoniou; Neil Bingham; Glen Bolton; Chris Bussineau; Michael Dosmar; Chithkala Harinarayan; Robert W. Juffras; James Klein; Peter Levy; Richard V. Levy; Mike Mulcare; Jon Petrone; Jon Romero; Ganesh Vedantham; Robert Velcheck

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August 15, 2009

Investigation of sample preparation artifacts formed during the enzymatic release of N-linked glycans prior to analysis by capillary electrophoresis

Analytical Chemistry, ISSN: 00032700

Yong Liu; Oscar Salas-Solano; Lynn Gennaro

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August 15, 2009

Identification of cell culture conditions to control N-glycosylation site-occupancy of recombinant glycoproteins expressed in CHO cells

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Martin Gawlitzek; Michael Estacio; Tobias Fürch; Robert Kiss

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August 15, 2009

BCL6 cooperates with CD40 stimulation and loss of p53 function to rapidly transform primary B cells

International Journal of Cancer, ISSN: 00207136 10970215

Saritha Kusam; Veerendra Munugalavadla; Deepali Sawant; Alexander Dent

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August 12, 2009

A multi-tiered analytical approach for the analysis and quantitation of high-molecular-weight aggregates in a recombinant therapeutic glycoprotein

AAPS Journal, ISSN: 15507416

Heather Hughes; Charles Morgan; Elizabeth Brunyak; Kristen Barranco; Emily Cohen; Tim Edmunds; Karen Lee

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August 11, 2009

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

Current Biology, ISSN: 09609822

Setsu Endoh-Yamagami; Marie Evangelista; Deanna G. Wilson; Xiaohui Wen; Jan-Willem Theunissen; Khanhky Phamluong; Matti Davis; Suzie J. Scales; Mark J. Solloway; Frederic J. De Sauvage; Andrew S. Peterson

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August 5, 2009

Microarray analysis of RNA extracted from formalin-fixed, paraffin-embedded and matched fresh-frozen ovarian adenocarcinomas

BMC Medical Genomics, ISSN: 17558794

Grazyna Fedorowicz; Steve Guerrero; Thomas D Wu; Zora Modrusan

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August 5, 2009

High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors

BMC Medical Genomics, ISSN: 17558794

Matthias Peter; Lawrence S. Hon; Joshua S. Kaminker; John Chant; Zemin Zhang

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August 1, 2009

Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer

Molecular Cancer Therapeutics, ISSN: 15357163

Jiping Zha; Carol O'Brien; Heidi Savage; Huw; Fiona Zhong; Berry; Gail L. Phillips; Luis; Guy Cavet; Xiaolan Hu; Lukas Amler; Lackner

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August 1, 2009

Health benefit costs and absenteeism due to insomnia from the employer's perspective: A retrospective, case-control, database study

Journal of Clinical Psychiatry, ISSN: 01606689

Nathan L. Kleinman; Richard A. Brook; Justin Doan; Arthur K. Melkonian; Robert W. Baran

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August 1, 2009

Antibody binding to a tethered vesicle assembly using QCM-D

Analytical Chemistry, ISSN: 00032700

Ankit Patel; Kay K. Kanazawa; Curtis W. Frank

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August 1, 2009

Churg-Strauss syndrome in patients treated with omalizumab

Chest, ISSN: 19313543 00123692

Michael E. Wechsler; Dennis A. Wong; Mary K. Miller; Lisa Lawrence-Miyasaki

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August 1, 2009

Paracrine hedgehog signaling in cancer

Cancer Research, ISSN: 00085472 15387445

Jan-Willem Theunissen; Frederic J. De Sauvage

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August 1, 2009

Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling

FEBS Journal, ISSN: 1742464X 17424658

Niko Föger; Silvia Bulfone-Paus; Andrew A. Chan; Kyeong-Hee Lee

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August 1, 2009

European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus

Arthritis and Rheumatism, ISSN: 00043591 15290131

Sharon A. Chung; Tian; Kimberly E. Taylor; Annette T. Lee; Ward Ortmann; Geoffrey Hom; Robert R. Graham; Joanne Nititham; Jennifer A. Kelly; Jean Morrisey; Hui Wu; Hong Yin; Marta E. Alarcón-Riquelme; Betty P. Tsao; John B. Harley; Patrick M. Gaffney; Kathy L. Moser; Manzi; Michelle Petri; Peter K. Gregersen; Carl D. Langefeld; Timothy W. Behrens; Michael F. Seldin; Lindsey A. Criswell

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August 1, 2009

A phase IB trial of intravenous INO-1001 plus oral temozolomide in subjects with unresectable stage-III or IV melanoma

Cancer Investigation, ISSN: 07357907 15324192

Agop Y. Bedikian; Nicholas E. Papadopoulos; Kevin B. Kim; Wen-Jen Hwu; Jade Homsi; Michelle R. Glass; Suzanne Cain; Patrick J. Rudewicz; Laurent Vernillet; Patrick Hwu

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August 1, 2009

Oncogenic activating mutations are associated with local copy gain

Molecular Cancer Research, ISSN: 15417786

Barmak Modrek; Lin Ge; Ajay Pandita; Eva Lin; Sankar Mohan; Peng Yue; Steve Guerrero; William M. Lin; Thinh Q. Pham; Zora Modrusan; Somasekar Seshagiri; Howard M. Stern; Waring; Levi A. Garraway; John Chant; David Stokoe; Guy Cavet

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August 1, 2009

Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer

Molecular Cancer Therapeutics, ISSN: 15357163

Jiping Zha; Carol O'Brien; Heidi Savage; Huw; Fiona Zhong; Berry; Gail L. Phillips; Luis; Guy Cavet; Hu; Lukas Amler; Lackner

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August 1, 2009

FAM29A, a target of Plk1 regulation, controls the partitioning of NEDD1 between the mitotic spindle and the centrosomes

Journal of Cell Science, ISSN: 00219533

Hui Zhu; Kayleen Fang; Guowei Fang

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July 31, 2009

Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Ching Ching Leow; Bu-Er Wang; Ross; Sara M. Chan; Jiping Zha; Richard A. D. Carano; Gretchen D. Frantz; Michael M. Shen; Frederic J. De Sauvage; Gao

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July 28, 2009

Development of a microarray platform for FFPET profiling: Application to the classification of human tumors

Journal of Translational Medicine, ISSN: 14795876

Sven Duenwald; Mingjie Zhou; Yanqun Wang; Serguei Lejnine; Amit Kulkarni; Jaime Graves; Ryan Smith; John C. Castle; George Tokiwa; Bernard M. Fine; Hongyue Dai; Thomas Fare; Matthew Marton

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July 28, 2009

Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation

Biochemistry, ISSN: 00062960

Eric Bourhis; Andreas Lingel; Qui Phung; Wayne J. Fairbrother; Andrea G Cochran

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July 28, 2009

Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity

PLoS ONE, ISSN: 19326203

Galia Blum; Robby M. Weimer; Laura E. Edgington; Walter Adams; Matthew Bogyo

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July 27, 2009