Genentech: Publications

July 24, 2009

Two-dimensional liquid chromatographic methods to examine phenylboronate interactions with recombinant antibodies

Journal of Chromatography A, ISSN: 00219673

Boyan Zhang; Sean Mathewson; Huifen Chen

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July 23, 2009

Navigating the Deubiquitinating Proteome with a CompPASS

Cell, ISSN: 00928674

Peter K Jackson

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July 22, 2009

Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus

Arthritis Research and Therapy, ISSN: 14786354 14786362

Donna L. Thibault; Kareem L. Graham; Lowen Y. Lee; Imelda Balboni; Paul J. Hertzog; Paul J. Utz

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July 17, 2009

IL-33 Raises Alarm

Immunity, ISSN: 10747613

Lamkanfi; Vishva M. Dixit

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July 17, 2009

Imaging the lipidome: ω-alkynyl fatty acids for detection and cellular visualization of lipid-modified proteins

ACS Chemical Biology, ISSN: 15548929

Rami N. Hannoush; Natalia Arenas-Ramirez

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July 17, 2009

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists

ACS Chemical Biology, ISSN: 15548929

Chudi O. Ndubaku; Eugene Varfolomeev; Lan Wang; Zobel; Kevin Lau; Linda O. Elliott; Brigitte Maurer; Anna V. Fedorova; Jasmin N. Dynek; Michael F. T. Koehler; Sarah G. Hymowitz; Vickie Tsui; Deshayes; Wayne J. Fairbrother; Flygare; Domagoj Vucic

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July 17, 2009

Assigning large proteins in the solid state: A MAS NMR resonance assignment strategy using selectively and extensively 13C-labelled proteins

Journal of Biomolecular NMR, ISSN: 09252738 15735001

Victoria A. Higman; Jeremy Flinders; Matthias Hiller; Stefan Jehle; Stefan Markovic; Sebastian Fiedler; Barth-Jan van Rossum; Hartmut Oschkinat

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July 15, 2009

Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis

Arthritis Care and Research, ISSN: 21514658

Michael M. Ward; Matthew R. Hendrey; James D. Malley; Thomas J. Learch; John C. Davis; John D. Reveille; Michael Weisman

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July 15, 2009

Fear of commitment: Hes1 protects quiescent fibroblasts from irreversible cellular fates

Cell Cycle, ISSN: 15514005 15384101

Liyun Sang; Hilary A. Coller

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July 10, 2009

Wnt signaling is regulated by endoplasmic reticulum retention

PLoS ONE, ISSN: 19326203

J. Susie Zoltewicz; Amir M. Ashique; Youngshik Choe; Gena Lee; Stacy Taylor; Khanhky Phamluong; Mark J. Solloway; Andrew S. Peterson

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July 10, 2009

CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Mari Nojiri; Kelly M. Loyet; Vadim A. Klenchin; Gregory Kabachinski; Thomas F.J. Martin; Thomas F.J. Martin

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July 10, 2009

CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Mari Nojiri; Kelly M. Loyet; Vadim A. Klenchin; Gregory Kabachinski; Thomas F.J. Martin

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July 8, 2009

Scalable total synthesis and biological evaluation of haouamine A and its atropisomer

Journal of the American Chemical Society, ISSN: 00027863

Noah Z. Burns; Irina N. Krylova; Rami N. Hannoush; Phil S. Baran

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July 8, 2009

Reassessment of corticospinal tract regeneration in Nogo-deficient mice

Journal of Neuroscience, ISSN: 02706474 15292401

Jae K. Lee; Andrea F. Chan; Sen M. Luu; Yuhong Zhu; Carole Ho; Marc Tessier-Lavigne; Binhai Zheng

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July 6, 2009

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

Journal of Experimental Medicine, ISSN: 00221007 15409538

Geethanjali Pickert; Clemens Neufert; Moritz Leppkes; Yan Zheng; Nadine Wittkopf; Moritz Warntjen; Hans-Anton Lehr; Sebastian Hirth; Benno Weigmann; Stefan Wirtz; Wenjun Ouyang; Markus F. Neurath; Christoph Becker

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July 6, 2009

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

Nature Immunology, ISSN: 15292908 15292916

Sara Trifari; Charles D. Kaplan; Elise H. Tran; Natasha K Crellin; Hergen Spits

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July 6, 2009

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

Journal of Experimental Medicine, ISSN: 00221007 15409538

Wei Cao; Laura Bover; Minkwon Cho; Xiaoxia Wen; Shino Hanabuchi; Musheng Bao; David B. Rosen; Yi-Hong Wang; Joanne L. Shaw; Qiumei Du; Chun Li; Naoko Arai; Zhengbin Yao; Lewis L. Lanier; Yong-Jun Liu

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July 6, 2009

Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice

Journal of Thrombosis and Haemostasis, ISSN: 15387933 15387836

Jian-Guo Wang; Manly; Daniel Kirchhofer; Rafal Pawlinski; Nigel Mackman

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July 1, 2009

Homeless women's personal networks: Implications for understanding risk behavior

Human Organization, ISSN: 00187259

Joan Tucker; David Kennedy; Gery Ryan; Suzanne Wenzel; Daniela Golinelli; James L. Zazzali

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July 1, 2009

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling

Nature Structural and Molecular Biology, ISSN: 15459993 15459985

Ivan Bosanac; Henry R. Maun; Suzie J. Scales; Xiaohui Wen; Andreas Lingel; J.Fernando Bazan; Frederic J. De Sauvage; Sarah G. Hymowitz; Lazarus

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July 1, 2009

Removal of endogenous retrovirus-like particles from CHO-cell derived products using Q sepharose fast flow chromatography

Biotechnology Progress, ISSN: 87567938

Daniel M. Strauss; Scott Lute; Kurt Brorson; Gregory S. Blank; Qi Chen; Bin Yang

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July 1, 2009

Development of prophylactic and therapeutic vaccines using the ISCOMATRIX adjuvant

Immunology and Cell Biology, ISSN: 08189641 14401711

Eugene Maraskovsky; Max Schnurr; Nicholas S. Wilson; Neil C Robson; Jeff Boyle; Debbie Drane

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July 1, 2009

MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema

Molecular Endocrinology, ISSN: 08888809

Francine M. Gregoire; Fang Zhang; Holly J. Clarke; Thomas A. Gustafson; Dorothy D. Sears; Svetlana Favelyukis; James Lenhard; Dennis Rentzeperis; L. Edward Clemens; Yi Mu; Brian E. Lavan

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July 1, 2009

Second International Conference on Accelerating Biopharmaceutical Development March 9-12, 2009, Coronado, CA, USA

Biotechnology Progress, ISSN: 87567938

Janice M. Reichert; Nitya M. Jacob; Ashraf Amanullah

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July 1, 2009

Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus

PLoS ONE, ISSN: 19326203

Abbas Alexander; Kristen Wolslegel; Dhaya Seshasayee; Zora Modrusan; Hilary F. Clark

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July 1, 2009

Differential roles of Netrin-1 and its receptor DCC in inferior olivary neuron migration

Molecular and Cellular Neuroscience, ISSN: 10447431

Séverine Marcos; Stéphanie Backer; Frédéric Causeret; Marc Tessier-Lavigne; Evelyne Bloch-Gallego

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July 1, 2009

Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways

Cerebral Cortex, ISSN: 10473211 14602199

Jason E. Long; Inma Cobos; Gregory B. Potter; John L. R. Rubenstein

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July 1, 2009

Preclinical evaluation of carcinoembryonic cell adhesion molecule (CEACAM) 6 as potential therapy target for pancreatic adenocarcinoma

Journal of Pathology, ISSN: 00223417 10969896

Laura A. Strickland; Ross; Simon P. Williams; Ross; Maria Romero; Spencer; Erickson; Julie Sutcliffe; Caroline Verbeke; Paul G. Polakis; Nicholas Van Bruggen; Koeppen

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July 1, 2009

Player RanKings: Using coefficient of variation to measure MLB players' worth

Quality Progress, ISSN: 0033524X

Julia E. Seaman; Elaine Allen

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July 1, 2009

Measurements of birth defect prevalence: Which is most useful as a comparator group for pharmaceutical pregnancy registries?

Birth Defects Research Part A - Clinical and Molecular Teratology, ISSN: 15420752 15420760

Angela E. Scheuerle; Vani X. Vannappagari; Mary K. Miller

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July 1, 2009

Targeted depletion of lymphotoxin-α-expressing T H 1 and T H 17 cells inhibits autoimmune disease

Nature Medicine, ISSN: 10788956 1546170X

Eugene Y. Chiang; Ganesh Kolumam; Xin Yu; Michelle Francesco; Ivelja; Ivan Peng; Gribling; Jean Shu; Wyne P. Lee; Refino; Mercedesz Balazs; Andres Paler Martinez; Allen Nguyen; Judy Young; Kai H. Barck; Richard A. D. Carano; Ron Ferrando; Laurie Diehl; Devavani Chatterjea; Jane L. Grogan

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July 1, 2009

Unbound brain concentration determines receptor occupancy: A correlation of drug concentration and brain serotonin and dopamine reuptake transporter occupancy for eighteen compounds in rats

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Xingrong Liu; Olga Vilenski; Joyce Kwan; Subbu Apparsundaram; Robert Weikert

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July 1, 2009

Immunogenicity of biologically-derived therapeutics: Assessment and interpretation of nonclinical safety studies

Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295

Rafael Ponce; Leslie Abad; Lakshmi Amaravadi; Thomas R. Gelzleichter; Elizabeth Gore; Green; Shalini Gupta; Danuta Herzyk; Christopher Hurst; Inge A. Ivens; Thomas Kawabata; Curtis Maier; Barbara Mounho; Bonita Rup; Gopi Shankar; Holly W. Smith; Peter Thomas; Daniel Wierda

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July 1, 2009

Differential role of the Ca2+ sensor synaptotagmin VII in macrophages and dendritic cells

Immunobiology, ISSN: 01712985

Steven M. Becker; Lélia Delamarre; Ira Mellman; Norma W. Andrews

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July 1, 2009

In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models

Clinical Cancer Research, ISSN: 10780432

Klaus P. Hoeflich; Carol O'Brien; Zachary Boyd; Guy Cavet; Steve Guerrero; Kenneth Jung; Thomas Januario; Heidi Savage; Elizabeth A. Punnoose; Tom Truong; Wei Zhou; Berry; Lesley J. Murray; Lukas Amler; Marcia Belvin; Lori S. Friedman; Lackner

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June 30, 2009

Technology comparisons for anti-therapeutic antibody and neutralizing antibody assays in the context of an anti-TNF pharmacokinetic study

Journal of Immunological Methods, ISSN: 00221759

Kelly M. Loyet; Rong Deng; Wei-Ching Liang; Yan Wu; Henry B. Lowman; Laura DeForge

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June 28, 2009

Expression and activity of the efflux transporters ABCB1, ABCC2 and ABCG2 in the human colorectal carcinoma cell line LS513

European Journal of Pharmaceutical Sciences, ISSN: 09280987

Laurent Salphati; Emile G. Plise; Guangmin Li

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June 26, 2009

Novel therapeutic targets along the Th17 pathway

European Journal of Immunology, ISSN: 00142980 15214141

Wenjun Ouyang; Ellen H. Filvaroff; Yan Hu; Jane L. Grogan

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June 17, 2009

Finding and achieving value in cancer care

JNCCN Journal of the National Comprehensive Cancer Network, ISSN: 15401405 15401413

Clifford Goodman; Joseph S. Bailes; Stephen B. Edge; A. Mark Fendrick; Scott Gottlieb; Robert Mass; Lee N. Newcomer; Lynn Zonakis

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June 17, 2009

Development of novel drugs targeting inhibitors of apoptosis

Future Oncology, ISSN: 14796694 17448301

Flygare; Domagoj Vucic

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June 15, 2009

Engineering human IgG1 affinity to human neonatal Fc receptor: Impact of affinity improvement on pharmacokinetics in primates

Journal of Immunology, ISSN: 00221767 15506606

Yik Andy Yeung; Maya Leabman; Jonathan S. Marvin; Julia Qiu; Adams; Samantha Lien; Melissa A. Starovasnik; Henry B. Lowman

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June 15, 2009

Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab

Clinical Cancer Research, ISSN: 10780432

Evelyn Yao; Wei Zhou; Si Tuen Lee-Hoeflich; Tom Truong; Matthias Peter; Jeffrey Eastham-Anderson; Nicholas Lewin-Koh; Bert Gunter; Marcia Belvin; Lesley J. Murray; Lori S. Friedman; Mark X. Sliwkowski; Klaus P. Hoeflich

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June 15, 2009

Multi-round virus filter integrity test sensitivity

Biotechnology and Bioengineering, ISSN: 00063592 10970290

Chris Dowd

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June 15, 2009

Toward an effective targeted chemotherapy for multiple myeloma

Clinical Cancer Research, ISSN: 10780432

Andrew G. Polson; Mark X. Sliwkowski

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June 9, 2009

Interaction of IF2 with the ribosomal GTPase-associated center during 70S initiation complex formation

Biochemistry, ISSN: 00062960

Haiou Qin; Christina Grigoriadou; Barry S. Cooperman

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June 5, 2009

Hedgehog Signaling Is Dispensable for Adult Murine Hematopoietic Stem Cell Function and Hematopoiesis

Cell Stem Cell, ISSN: 19345909

Inga Hofmann; Elizabeth H. Stover; Dana E. Cullen; Junhao Mao; Kelly J. Morgan; Benjamin H. Lee; Michael G. Kharas; Peter G. Miller; Melanie G. Cornejo; Rachel Okabe; Scott A. Armstrong; Nico Ghilardi; Stephen Gould; Frederic J. De Sauvage; Andrew P. McMahon; D. Gary Gilliland

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June 5, 2009

Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of Hepatitis C virus

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Julie Qi Hang; Yanli Yang; Seth F. Harris; Vincent J.P. Leveque; Hannah J. Whittington; Sonal Rajyaguru; Gloria Ao-Leong; Matthew F. McCown; April Wong; Anthony M. Giannetti; Sophie Le Pogam; Francisco Talamás; Nick Cammack; Nájera; Klumpp

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June 5, 2009

Targeting interferon alpha subtypes in serum: A comparison of analytical approaches to the detection and quantitation of proteins in complex biological matrices

Journal of Proteome Research, ISSN: 15353893

Anita Izrael-Tomasevic; Lilian Phu; Qui Phung; Jennie R. Lill; David Arnott

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June 3, 2009

Axotomy-induced smad1 activation promotes axonal growth in adult sensory neurons

Journal of Neuroscience, ISSN: 02706474 15292401

Hongyan Zou; Carole Ho; Karen G. Wong; Marc Tessier-Lavigne

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June 1, 2009