Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9651 - 9700 OF 15805 RESULTS

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
Trends in Pharmacological Sciences, ISSN: 01656147
Suzie J. Scales; Frederic J. De Sauvage
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Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: Human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG Cells
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Dermot F. McGinnity; George Zhang; Jane R. Kenny; Geraldine A. Hamilton; Sara Otmani; Karen R. Stams; Suzzette Haney; Patrick Brassil; David M Stresser; Robert J. Riley
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Analysis of charge heterogeneities in mAbs using imaged CE
Electrophoresis, ISSN: 01730835 15222683
Xiaoping Z. He; Amy H. Que; Jim J. Mo
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Review of recent genome-wide association scans in lupus
Journal of Internal Medicine, ISSN: 09546820 13652796
Robert R. Graham; Geoffrey Hom; Ward Ortmann; Timothy W. Behrens
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Assessment of a sixteen-week training program on strength, pain, and function in rheumatoid arthritis patients
Journal of Clinical Rheumatology, ISSN: 10761608
Hilary G. Flint-Wagner; Jeffrey Lisse; Timothy G. Lohman; Scott B. Going; Terri Guido; Ellen Cussler; Donald Gates; David E. Yocum
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Phase I study of the effect of gastric acid pH modulators on the bioavailability of oral dasatinib in healthy subjects
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Timothy Eley; Feng R. Luo; Shruti Agrawal; Ashish Sanil; James Manning; Tong Li; Anne Blackwood-Chirchir; Richard Bertz
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PET of glial metabolism using 2-18F-fluoroacetate
Journal of Nuclear Medicine, ISSN: 01615505
Jan Marik; Annie Ogasawara; Baby Martin-McNulty; Ross; Judith E. Flores; Herman S. Gill; Jeff N. Tinianow; Alexander N. Vanderbilt; Merry C. Nishimura; Franklin V. Peale Jr.; Cinthia V Pastuskovas; Joan M. Greve; Nicholas Van Bruggen; Simon P. Williams
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Non-invasive monitoring provides fast payback
Chemical Processing, ISSN: 00092630
Chris Stubbs
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Characterization of multiple stable conformers of the EC5 domain of E-cadherin and the interaction of EC5 with E-cadherin peptides
Chemical Biology and Drug Design, ISSN: 17470277
Kai Zheng; Jennifer S. Laurence; Krzysztof Kuczera; Gennady Verkhivker; C. Russell Middaugh; Teruna J. Siahaan
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A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B
Journal of Medicinal Chemistry, ISSN: 00222623
Ignacio Aliagas; Burdick; Laura B. Corson; Jennafer Dotson; Jason H. Drummond; Carter Fields; Oscar W Huang; Thomas Hunsaker; Tracy L. Kleinheinz; Elaine B. Krueger; Jun Liang; John Moffat; Gail L. Phillips; Rebecca Pulk; Thomas E. Rawson; Ultsch; Leslie Walker; Wiesmann; Birong Zhang; Bing-Yan Zhu; Andrea G Cochran
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Primary Sjögren's Syndrome: Health experiences and predictors of health quality among patients in the United States
Health and Quality of Life Outcomes, ISSN: 14777525
Barbara Segal; Simon J. Bowman; Philip C. Fox; Frederick B. Vivino; Nandita Murukutla; Jeff Brodscholl; Sarika Ogale; Lachy McLean
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Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors
PLoS ONE, ISSN: 19326203
Bijay S. Jaiswal; Vasantharajan Janakiraman; Noelyn Kljavin; Jeffrey Eastham-Anderson; James Cupp; Yuxin Liang; David P. Davis; Klaus P. Hoeflich; Somasekar Seshagiri
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MBX-102/JNJ39659100, a novel non-TZD selective partial PPAR-γ agonist lowers triglyceride independently of PPAR-α activation
PPAR Research, ISSN: 16874757 16874765
Francine M. Gregoire; Apurva Chandalia; Holly J. Clarke; L. Edward Clemens; Bindu Pandey; Vic Vicena; Paul Lee; Brian E. Lavan
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Development of a rapid sanitization solution for silica-based protein A affinity adsorbents
Journal of Chromatography A, ISSN: 00219673
Marc Rogers; Hiraoka-Sutow; Polly Mak; Fred Mann; Lebreton
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ATP-citrate lyase links cellular metabolism to histone acetylation
Science, ISSN: 00368075 10959203
Kathryn E. Wellen; Georgia Hatzivassiliou; Uma M. Sachdeva; Thi V. Bui; Justin R. Cross; Craig B. Thompson
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Effect of EDTA and methionine on preventing loss of viscosity of cellulose-based topical gel
AAPS PharmSciTech, ISSN: 15309932
Junyan A. Ji; Erika Ingham; John Wang
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Ubiquilins accelerate autophagosome maturation and promote cell survival during nutrient starvation
Autophagy, ISSN: 15548635 15548627
Elsa N. N'Diaye; Jayanta Debnath; Eric J. Brown
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A therapeutic antibody and its antigen form different complexes in serum than in phosphate-buffered saline: A study by analytical ultracentrifugation
Analytical Biochemistry, ISSN: 10960309 00032697
Barthélemy Demeule; Steven J. Shire; Jun Liu
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Characterization of deamidated peptide variants by micro-preparative capillary electrophoresis and mass spectrometry
Journal of Chromatography A, ISSN: 00219673
Lynn Gennaro; Oscar Salas-Solano
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Erratum: Erythropoietin dosing in children with chronic kidney disease: Based on body size or on hemoglobin deficit? (Pediatric Nephrology (2009) 10.1007/s00467-008-0955-2)
Pediatric Nephrology, ISSN: 0931041X
Ruediger E. Port; Otto Mehls
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Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling
Cell, ISSN: 00928674
Zhaoyu Jin; Yun Li; Pitti; David Lawrence; Victoria Pham; Jennie R. Lill; Avi Ashkenazi
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Surface extenders and an optimal pore size promote high dynamic binding capacities of antibodies on cation exchange resins
Journal of Chromatography A, ISSN: 00219673
David S. Hart; Chithkala Harinarayan; Gunnar Malmquist; Andreas Axén; Mandakini Sharma; Robert Van Reis
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Ion exchange chromatography of monoclonal antibodies: Effect of resin ligand density on dynamic binding capacity
Journal of Chromatography A, ISSN: 00219673
Ann Marie Hardin; Chithkala Harinarayan; Gunnar Malmquist; Andreas Axén; Robert Van Reis
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A developmentally regulated Myb domain protein regulates expression of a subset of stage-specific genes in Entamoeba histolytica
Cellular Microbiology, ISSN: 14625814 14625822
Gretchen M. Ehrenkaufer; Jason A. Hackney; Upinder Singh
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The effects of c-Abl mutation on developing B cell differentiation and survival
International Immunology, ISSN: 09538178 14602377
Hans D. Brightbill; Mark S. Schlissel
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A nanocube plasmonic sensor for molecular binding on membrane surfaces
Nano Letters, ISSN: 15306984
William J. Galush; Sarah A. Shelby; Martin J. Mulvihill; Andrea Tao; Peidong Yang; Jay T. Groves
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Analytical methods for inferring functional effects of single base pair substitutions in human cancers
Human Genetics, ISSN: 03406717 14321203
William Lee; Peng Yue; Zemin Zhang
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Small-molecule inhibitors of store-operated calcium entry
ChemMedChem, ISSN: 18607179 18607187
Zachary K. Sweeney; Ana Minatti; Donald Button; Silvia Patrick
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Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941
Cancer Cell, ISSN: 15356108
Teemu T. Junttila; Robert W. Akita; Kathryn Parsons; Carter Fields; Gail L. Phillips; Lori S. Friedman; Deepak Sampath; Mark X. Sliwkowski
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Pharmacokinetic analysis of irinotecan plus bevacizumab in patients with advanced solid tumors
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Crystal S. Denlinger; Rebecca Blanchard; Lu Xu; Coen A. Bernaards; Samuel Litwin; Cynthia Spittle; Daniel J. Berg; Susan McLaughlin; Maryann Redlinger; Andrew Dorr; Julie Hambleton; Scott N. Holden; Anne Kearns; Sara Kenkare-Mitra; Bert L. Lum; Neal J. Meropol; Peter J. O'Dwyer
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Docking for fragment inhibitors of AmpC β-lactamase
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Denise G. Teotico; Kerim Babaoglu; Gabriel J. Rocklin; Rafaela S. Ferreira; Anthony M. Giannetti; Brian K. Shoichet
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Molecular mechanisms of mTOR-mediated translational control
Nature Reviews Molecular Cell Biology, ISSN: 14710072 14710080
Xiaoju Max Ma; John Blenis
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Regulating laboratory-developed tests
Nature Biotechnology, ISSN: 10870156 15461696
Hal V. Barron
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Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice
Journal of Clinical Investigation, ISSN: 00219738 15588238
Jing Qing; Xiangnan Du; Yongmei Chen; Pamela Chan; Hao Li; Ping Wu; Scot A. Marsters; Scott Stawicki; Janet Y. Tien; Klara Totpal; Ross; Susanna Y. Stinson; David Dornan; French; Qian-Rena Wang; Jean-Philippe Stephan; Yan Wu; Wiesmann; Avi Ashkenazi
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Second International Conference on Accelerating Biopharmaceutical Development: March 9-12, 2009, Coronado, CA USA
mAbs, ISSN: 19420862
Janice M. Reichert; Nitya M. Jacob; Ashraf Amanullah
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Estimating glomerular filtration rate: Cockcroft-gault and modification of diet in renal disease formulas compared to renal inulin clearance
Clinical Journal of the American Society of Nephrology, ISSN: 15559041 1555905X
Rossini Botev; Jean-Pierre Mallié; Cecilé Couchoud; Otto Schück; Jean-Pierre Fauvel; Jack F. M. Wetzels; Nelson Lee; Natale G. De Santo; Massimo Cirillo
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Plk1 and aurora A regulate the depolymerase activity and the cellular localization of Kif2a
Journal of Cell Science, ISSN: 00219533
Chang-Young Jang; Judith A. Coppinger; Akiko Seki; John R. Yates; Guowei Fang
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Atg5-independent sequestration of ubiquitinated mycobacteria
PLoS Pathogens, ISSN: 15537366 15537374
Cathleen A. Collins; Ann De Mazière; Suzanne Van Dijk; Fredric Carlsson; Judith Klumperman; Eric J. Brown
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High-throughput generation of tagged stable cell lines for proteomic analysis
Proteomics, ISSN: 16159853 16159861
Jorge Z. Torres; Julie J. Miller; Peter K Jackson
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Some notable properties of the standard oncology phase i design
Journal of Biopharmaceutical Statistics, ISSN: 10543406 15205711
Gregory J. Hather; Howard M. Mackey
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Microtubule amplification in the assembly of mitotic spindle and the maturation of kinetochore fibers
Communicative and Integrative Biology, ISSN: 19420889
Hui Zhu; Kayleen Fang; Guowei Fang
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Predictive biomarkers in the development of oncology drugs: A therapeutic industry perspective
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Bernard M. Fine; Lukas Amler
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Efficacy and safety of erlotinib in patients with locally advanced or metastatic breast cancer
Breast Cancer Research and Treatment, ISSN: 01676806 15737217
Maura N. Dickler; Melody A. Cobleigh; Kathy Miller; Pam Klein; Eric P. Winer
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Variation in the upstream region of P-Selectin (SELP) is a risk factor for SLE
Genes and Immunity, ISSN: 14664879 14765470
David L. Morris; Robert R. Graham; Erwig; Patrick M. Gaffney; Kathy L. Moser; Timothy W. Behrens; Timothy J. Vyse; Deborah S. Cunninghame Graham
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How can we improve the translational landscape for a faster cure of type 1 diabetes?
Journal of Clinical Investigation, ISSN: 00219738 15588238
Matthias von Herrath; Andrew A. Chan
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The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility
Arthritis and Rheumatism, ISSN: 00043591 15290131
Yvonne C. Lee; Soumya Raychaudhuri; Jing Cui; Immaculata De Vivo; Bo Ding; Lars Alfredsson; Leonid Padyukov; Karen H. Costenbader; Mark Seielstad; Robert R. Graham; Lars Klareskog; Peter K. Gregersen; Robert M. Plenge; Elizabeth W. Karlson
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How can we improve the translational landscape for a faster cure of type 1 diabetes?
Journal of Clinical Investigation, ISSN: 00219738 15588238
Matthias von Herrath; Andrew Chan
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Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis
Oncogene, ISSN: 09509232 14765594
Kwek; Roy; Zhou; Climent; Martinez-Climent; Jane Fridlyand; Albertson
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Increasing IgG concentration modulates the conformational heterogeneity and bonding network that influence solution properties
Journal of Physical Chemistry B, ISSN: 15206106
Tim J. Kamerzell; Sonoko Kanai; Jun Liu; Steven J. Shire; Y. John Wang
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G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Farbod Shojaei; Xiumin Wu; Xueping Qu; Marcin Kowanetz; Lanlan Yu; Martha Tan; Meng; Napoleone Ferrara
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