Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9651 - 9700 OF 15583 RESULTS

Overview and clinical applications of VEGF-A
Angiogenesis: An Integrative Approach From Science to Medicine,
Napoleone Ferrara
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Gene therapy offers HD patients relief from some symptoms
Managed Care, ISSN: 10623388
Thomas Morrow
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The development of avastin
Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy,
Robert Mass
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Meniscectomy alters the dynamic deformational behavior and cumulative strain of tibial articular cartilage in knee joints subjected to cyclic loads
Osteoarthritis and Cartilage, ISSN: 10634584
Song; Joan M. Greve; Carter; Giori
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Crucial roles of robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing
Neural Development, ISSN: 17498104
Atsushi Tamada; Tatsuro Kumada; Yan Zhu; Tomoko Matsumoto; Yumiko Hatanaka; Keiko Muguruma; Zhe Chen; Yasuto Tanabe; Makio Torigoe; Kenta Yamauchi; Hiroshi Oyama; Kazuhiko Nishida; Fujio Murakami
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Recent developments in microwave-assisted protein chemistries - can this be integrated into the drug discovery and validation process?
Drug Discovery Today, ISSN: 13596446
Wendy N. Sandoval; Victoria Pham; Jennie R. Lill
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Bayesian adaptive design for targeted therapy development in lung cancer - A step toward personalized medicine
Clinical Trials, ISSN: 17407745 17407753
Xian Zhou; Suyu Liu; Edward S. Kim; Roy S. Herbst; J. Jack J. Lee
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Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways
PLoS Medicine, ISSN: 15491277 15491676
Charles W. Lees; William J. Zacharias; Mark Tremelling; Colin L. Noble; Elaine R. Nimmo; Albert Tenesa; Jennine Cornelius; Leif Torkvist; John Kao; Susan Farrington; Hazel E. Drummond; Gwo-Tzer Ho; Ian Arnott; Henry D. Appelman; Laurie Diehl; Harry Campbell; Malcolm G. Dunlop; Miles Parkes; Sarah Howie; Deborah L. Gumucio; Jack Satsangi
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Pathophysiology and clinical implications of vascular endothelial growth factor
Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy,
Napoleone Ferrara
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MFAM29A promotes microtubule amplification via recruitment of the NEDDI-γ-tubuIin complex to the mitotic spindle
Journal of Cell Biology, ISSN: 00219525 00219525
Hui Zhu; Judith A. Coppinger; Chang-Young Jang; John R. Yates; Guowei Fang
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Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies
Drug Resistance Updates, ISSN: 13687646
Farbod Shojaei; Napoleone Ferrara
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Proteomic analysis of breast cancer molecular subtypes and biomarkers of response to targeted kinase inhibitors using reverse-phase protein microarrays
Molecular Cancer Therapeutics, ISSN: 15357163
Zachary Boyd; Jenny Q. Wu; Carol O'Brien; Jill M. Spoerke; Heidi Savage; Fielder; Lukas Amler; Yibing Yan; Lackner
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Establishing the credibility of a biotech simulation model
Proceedings - Winter Simulation Conference, ISSN: 08917736
Lenrick Johnston; Lee Schruben; Arden Yang; David Zhang
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Triple light chain antibodies in thiomabs
AIChE Annual Meeting, Conference Proceedings,
Natalia Gomez; Abigail R Vinson; Jun Ouyang; Inn H. Yuk
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Harnessing the power of statistical design and the efficiency of a high throughput system for Cho media development
AIChE Annual Meeting, Conference Proceedings,
Sonali Nigam; Robb Shawley; Martin Gawlitzek; Louis Cheung; Christina Bevilacqua
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Automated de novo protein sequencing of monoclonal antibodies
Nature Biotechnology, ISSN: 10870156 15461696
Nuno Bandeira; Victoria Pham; Pavel A. Pevzner; David Arnott; Jennie R. Lill
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Monitoring and control of cell culture bioreactors using on-line scanning dielectric spectroscopy
AIChE Annual Meeting, Conference Proceedings,
Cary F. Opel; Ashraf Amanullah
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How Do You Classify Asthma by Severity?
Clinical Asthma,
James E. Fish
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Recombinant protein production in escherichia coli
AIChE Annual Meeting, Conference Proceedings,
Jane Gunson; Mike Laird
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Trends in presenting characteristics and hospital mortality among patients with ST elevation and non-ST elevation myocardial infarction in the National Registry of Myocardial Infarction from 1990 to 2006
American Heart Journal, ISSN: 00028703 10976744
William J. Rogers; Paul D. Frederick; Edna Stoehr; John G. Canto; Joseph P. Ornato; C.Michael Gibson; Charles V. Pollack Jr.; Joel M. Gore; Nisha C. Chandra; Eric D. Peterson; William J. French
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Some features of the kinetics and equilibrium of drug binding to plasma proteins
Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255
Leonid M. Berezhkovskiy
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High throughput ADME screening: Practical considerations, impact on the portfolio and enabler of in silico ADME models
Current Drug Metabolism, ISSN: 13892002
Cornelis E. Hop; Mark J. Cole; Ralph E. Davidson; David B. Duignan; James Federico; John S. Janiszewski; Kelly Jenkins; Suzanne Krueger; Rebecca Lebowitz; Theodore E. Liston; Walter Mitchell; Mark Snyder; Stefan J. Steyn; John R. Soglia; Christine Taylor; Troutman; John Umland; Michael West; Kevin M. Whalen; Veronica Zelesky; Sabrina X. Zhao
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The p85α subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration
Molecular and Cellular Biology, ISSN: 02707306
Veerendra Munugalavadla; Sasidhar Vemula; Emily Sims; Subha Krishnan; Shi Chen; Jincheng Yan; Huijie Li; Paul J. Niziolek; Clifford Takemoto; Alexander G. Robling; Feng-Chun Yang; Reuben Kapur
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Automated monitoring of mammalian cell cultures via an auto-sampler and an integrated multi-functional off-line analyzer
AIChE Annual Meeting, Conference Proceedings,
Gayle E. Derfus; Daniel Abramzon; Meg Tung; Robert Kiss; Ashraf Amanullah
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Are health-care relationships important for mammography adherence in Latinas?
Journal of General Internal Medicine, ISSN: 08848734 15251497
Vanessa B. Sheppard; Judy Wang; Bin Yi; Toni Michelle Harrison; Shibao Feng; Elmer E. Huerta; Jeanne S. Mandelblatt
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Cooperation of the agonistic DR5 antibody apomab with chemotherapy to inhibit orthotopic lung tumor growth and improve survival
Clinical Cancer Research, ISSN: 10780432
Hongkui Jin; Renhui Yang; Ross; Fong; Richard A. D. Carano; Klara Totpal; David Lawrence; Zhong Zheng; Koeppen; Howard M. Stern; Ralph H. Schwall; Avi Ashkenazi
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Startle reactivity in children at risk for migraine
Clinical Neurophysiology, ISSN: 13882457
Roman Duncko; Lihong Cui; Jeffrey Hille; Christian Grillon; Kathleen R. Merikangas
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Analysis of the nucleotide sequence of the guinea pig cytomegalovirus (GPCMV) genome
Virology Journal, ISSN: 1743422X
Mark R. Schleiss; Alistair McGregor; K Yeon Choi; Shailesh V. Date; Xiaohong Cui; Michael A. McVoy
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Effects of cell culture conditions on antibody N-glycosylation- What causes high mannose 5 glycoform
AIChE Annual Meeting, Conference Proceedings,
Efren Pacis; Feng Li; Darren Brown; Robert Bayer
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Erratum: PCSK9 function and physiology (Journal of Lipid Research)
Journal of Lipid Research, ISSN: 00222275 15397262
Andrew S. Peterson; Loren G. Fong; Stephen G. Young
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Chirality vs. HOMFLY and Kauffman polynomials
Journal of Knot Theory and its Ramifications, ISSN: 02182165
Sandy Ganzell; Amy V. Kapp
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Independent development of hydrolysate-containing and hydrolysate-free cho cell culture processes yields different optimal conditions
AIChE Annual Meeting, Conference Proceedings,
Diane M. Wuest; Polina Rapoport; Deborah E. Pascoe
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Erratum: FGF15 promotes neurnogenesis and opposes FGF8 function during neocortical development (Neural Development (2008) 3 (31))
Neural Development, ISSN: 17498104
Ugo Borello; Inma Cobos; Jason E. Long; John R. McWhirter; Cornelis Murre; John L. R. Rubenstein
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The semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development
Journal of Neuroscience, ISSN: 02706474 02706474
Ayal Ben-Zvi; Osnat Manor; Melitta Schachner; Avraham Yaron; Marc Tessier-Lavigne; Oded Behar
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Chapter 6 Mouse Models to Investigate Anti-Cancer Effects of VEGF Inhibitors
Methods in Enzymology, ISSN: 00766879
Yongping Crawford; Napoleone Ferrara
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Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
Cancer Research, ISSN: 00085472 15387445
Gail L. Phillips; Guangmin Li; Dugger; Lisa Crocker; Kathryn Parsons; Elaine Mai; Walter A. Blättler; John M. Lambert; Ravi Chari; Robert J. Lutz; Wai Lee T. Wong; Fred Jacobson; Koeppen; Ralph H. Schwall; Sara Kenkare-Mitra; Spencer; Mark X. Sliwkowski
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Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Manisha Tripathi; Srinivas Nandana; Hironobu Yamashita; Rajkumar Ganesan; Daniel Kirchhofer; Vito Quaranta
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Directing cancer cells to self-destruct with pro-apoptotic receptor agonists
Nature Reviews Drug Discovery, ISSN: 14741776 14741784
Avi Ashkenazi
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PirB is a functional receptor for myelin inhibitors of axonal regeneration
Science, ISSN: 00368075 10959203
Jasvinder K. Atwal; Julie Pinkston-Gosse; Josh Syken; Scott Stawicki; Yan Wu; Carla J. Shatz; Marc Tessier-Lavigne
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Reflections
Neuron, ISSN: 08966273
Richard H. Scheller; John R. Nambu
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Formation of the blood - Brain barrier: Wnt signaling seals the deal
Journal of Cell Biology, ISSN: 00219525 00219525
Paul G. Polakis
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Coordinated protein sorting, targeting and distribution in polarized cells
Nature Reviews Molecular Cell Biology, ISSN: 14710072 14710080
Ira Mellman; W. James Nelson
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Effect of therapeutic integrin (CD11a) blockade with efalizumab on immune responses to model antigens in humans: Results of a randomized, single blind study
Journal of Investigative Dermatology, ISSN: 0022202X 15231747
James G. Krueger; Hans D. Ochs; Piyush Patel; Ellen Gilkerson; Emma Guttman-Yassky; Wolfgang Dummer
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Increased plasma concentrations of cytoskeletal and Aa2+-binding proteins and their peptides in psoriasis patients
Clinical Chemistry, ISSN: 00099147
Tatiana Plavina; Marina Hincapie; Eric Wakshull; Subramanyam; William S. Hancock
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BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4
Genes and Development, ISSN: 08909369 15495477
Milena B. Furtado; Mark J. Solloway; Vanessa J. Jones; Mauro W. Costa; Christine Biben; Orit Wolstein; Jost I. Preis; Duncan B. Sparrow; Yumiko Saga; Sally Dunwoodie; Elizabeth J. Robertson; Patrick P. L. Tam; Richard P. Harvey
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Evidence for an asialoglycoprotein receptor on nonparenchymal cells for O-linked glycoproteins
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565 15210103
Stefanich; Song Ren; Dimitry Danilenko; Lim; An Song; Suhasini Iyer; Fielder
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Pharmacokinetics, metabolism, and excretion of torcetrapib, a cholesteryl ester transfer protein inhibitor, in humans
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Deepak Dalvie; Weichao Chen; Chenghong Zhang; Alfin D. Vaz; Teresa Smolarek; Loretta M. Cox; Jian Lin; R. Scott Obach
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The environmental impact of disposable technologies
BioPharm International, ISSN: 1542166X
Andrew Sinclair; Lindsay Leveen; Miriam Monge; Janice Lim; Stacey Cox
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Metabolic engineering of the non-sporulating, non-solventogenic Clostridium acetobutylicum strain M5 to produce butanol without acetone demonstrate the robustness of the acid-formation pathways and the importance of the electron balance
Metabolic Engineering, ISSN: 10967176 10967184
Ryan Sillers; Alison Chow; Bryan Tracy; Eleftherios T. Papoutsakis
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The response to combination therapy treatment regimens in severe/difficult-to-treat asthma
European Respiratory Journal, ISSN: 09031936 13993003
Campbell; Larry Borish; Tmirah Haselkorn; Lawrence Rasouliyan; June H. Lee; Sally E. Wenzel; Sean D. Sullivan
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