Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9851 - 9900 OF 15583 RESULTS

The Intrinsic Contributions of Tyrosine, Serine, Glycine and Arginine to the Affinity and Specificity of Antibodies
Journal of Molecular Biology, ISSN: 00222836
Sara Birtalan; Yingnan Zhang; Frederic A. Fellouse; Lily Shao; Gabriele Schaefer; Sachdev S. Sidhu
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The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
Immunity, ISSN: 10747613
Wenjun Ouyang; Jay K. Kolls; Yan Zheng
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Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis
Cancer Cell, ISSN: 15356108
Maresa Caunt; Judy Mak; Wei-Ching Liang; Scott Stawicki; Qi Pan; Raymond K. Tong; Joe Kowalski; Calvin Ho; Hani Bou-Reslan; Ross; Berry; Ian Kasman; Constance Zlot; Zhiyong Cheng; Jennifer Le Couter; Ellen H. Filvaroff; Greg D. Plowman; Franklin V. Peale Jr.; French; Richard A. D. Carano; Alexander W. Koch; Yan Wu; Ryan J. Watts; Marc Tessier-Lavigne; Anil Bagri
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Natural selection of protein structural and functional properties: A single nucleotide polymorphism perspective
Genome Biology, ISSN: 14747596 1474760X
Jinfeng Liu; Yan Zhang; Xingye Lei; Zemin Zhang
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To help or not to help? The Good Samaritan effect and the love of money on helping behavior
Journal of Business Ethics, ISSN: 15730697 01674544
Thomas Li-Ping Tang; Toto Sutarso; Grace Mei-Tzu Wu Davis; Dariusz Dolinski; Abdul Hamid Safwat Ibrahim; Sharon Lynn Wagner
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In the world of tomorrow's medicine, a single physician makes a difference.
Managed Care, ISSN: 10623388
Thomas Morrow
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Pharmacokinetics and safety of bevacizumab administered in combination with cisplatin and paclitaxel in cynomolgus monkeys
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Lu Xu; Christina L. Zuch; Yvonne S. Lin; Modi; Bert L. Lum
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Characterization of structurally distinct, isoform-selective phosphoinositide 3′-kinase inhibitors in combination with radiation in the treatment of glioblastoma
Molecular Cancer Therapeutics, ISSN: 15357163
Jack S. Chen; Linda J. Zhou; Michal Entin-Meer; Xiaodong Yang; Mila Donker; Zachary A. Knight; William Weiss; Kevan Shokat; Daphne A. Haas-Kogan; David Stokoe
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Interstitial granulomatous dermatitis in a patient with rheumatoid arthritis on etanercept
Cutis, ISSN: 00114162
Stephanie Hu; Darel Cohen; George Murphy; Elinor Mody; Abrar A. Qureshi
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Budget impact model of adding erlotinib to a regimen of gemcitabine for the treatment of locally advanced, nonresectable or metastatic pancreatic cancer
Clinical Therapeutics, ISSN: 01492918 1879114X
Mark Danese; Carolina Reyes; Kelly Northridge; Deborah Lubeck; Chin-Yu Lin; Paula O'Connor
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Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5
Cell Death and Differentiation, ISSN: 13509047 14765403
Cam Adams; Klara Totpal; David Lawrence; Scot A. Marsters; Pitti; Sharon Fong Yee; Ross; Laura DeForge; Koeppen; Meredith Sagolla; Deanne M. Compaan; Henry B. Lowman; Sarah G. Hymowitz; Avi Ashkenazi
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Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models
Journal of Immunotherapy, ISSN: 15249557
Rebecca E. Sadun; Wen-En Hsu; Nan Zhang; Yu-Chih Nien; Scott A. Bergfeld; Helen Sabzevari; M. E. Christine Lutsiak; Leslie A. Khawli; Peisheng Hu; Alan L. Epstein
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B cell receptor basal signaling regulates antigen-induced ig light chain rearrangements
Journal of Immunology, ISSN: 15506606 00221767
Brian R. Schram; Lina E. Tze; Laura B. Ramsey; Jiabin Liu; Lydia Najera; Amanda L. Vegoe; Richard R. Hardy; Keli Hippen; Farrar; Timothy W. Behrens
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Unveiling a glycation hot spot in a recombinant humanized monoclonal antibody
Analytical Chemistry, ISSN: 00032700
Boyan Zhang; Yi Yang; Inn H. Yuk; Roger Pai; McKay; Eigenbrot; Dennis; Viswanatham Katta; Kathleen Francissen
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Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation
European Journal of Immunology, ISSN: 00142980
Martijn S. Bijker; Susan J.F. van den Eeden; Kees Franken; Cornelis J. M. Melief; Sjoerd H. van der Burg; Rienk Offringa
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Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma
Modern Pathology, ISSN: 08933952 15300285
Ines Gütgemann; Norman L. Lehman; Peter K Jackson; Teri A. Longacre
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PTEN in brain tumors
Expert Review of Neurotherapeutics, ISSN: 14737175 17448360
Daphne A. Haas-Kogan; David Stokoe
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TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I IFN
Journal of Interferon and Cytokine Research, ISSN: 10799907
Jon R. Inglefield; Calin Dumitru; Sefik S. Alkan; Sheila J. Gibson; Kenneth E. Lipson; Mark A. Tomai; Chris J. Larson; John P. Vasilakos
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STAT3-mediated Up-regulation of BLIMP1 is coordinated with BCL6 down-regulation to control human plasma cell differentiation
Journal of Immunology, ISSN: 15506606 00221767
Sean A. Diehl; Heike Schmidlin; Maho Nagasawa; Simon D. Van Haren; Mark J. Kwakkenbos; Etsuko Yasuda; Tim Beaumont; Ferenc A. Scheeren; Hergen Spits
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Developing and promoting an intranet site for a drug information service
American Journal of Health-System Pharmacy, ISSN: 10792082
Emily C. Costerison; Graham
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Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs
Journal of Immunological Methods, ISSN: 00221759
Jagath R. Junutula; Sunil Bhakta; Helga Raab; Karen E. Ervin; Eigenbrot; Richard L. Vandlen; Richard H. Scheller; Henry B. Lowman
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Identification of direct target genes using joint sequence and expression likelihood with application to DAF-16
PLoS ONE, ISSN: 19326203
Ron X. Yu; Jie Liu; Nick True; Wei Wang
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Intestinal epithelial cell up-regulation of LY6 molecules during colitis results in enhanced chemokine secretion
Journal of Immunology, ISSN: 15506606 00221767
Ken Flanagan; Zora Modrusan; Jennine Cornelius; Arvind Chavali; Ian Kasman; László Kömüves; Lian Mo; Laurie Diehl
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Immunoglobulin dynamics, conformational fluctuations, and nonlinear elasticity and their effects on stability
Journal of Physical Chemistry B, ISSN: 15206106
Tim J. Kamerzell; Joshua D. Ramsey; C. Russell Middaugh
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VEGF inhibition and renal thrombotic microangiopathy
New England Journal of Medicine, ISSN: 15334406 00284793
Vera Eremina; J. Ashley Jefferson; Jolanta Kowalewska; Hochster; Mark Haas; Joseph Weisstuch; Catherine Richardson; Jeffrey B. Kopp; M. Golam Kabir; Peter H. Backx; Hans-Peter Gerber; Napoleone Ferrara; Laura Barisoni; Charles E. Alpers; Susan E. Quaggin
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A Trigger Squeezed
Structure, ISSN: 09692126
Eigenbrot
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Regulation of a Late Phase of T Cell Polarity and Effector Functions by Crtam
Cell, ISSN: 00928674
Jung-Hua Yeh; Sachdev S. Sidhu; Andrew A. Chan
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Conservation of inner domain modules in the surface envelope glycoproteins of an ancient rabbit lentivirus and extant lentiviruses and betaretroviruses
Virology, ISSN: 00426822 10960341
Isidro Hötzel
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Multi-step variance minimization in sequential tests
Statistics and Computing, ISSN: 09603174
Zheng Su; Jiaqiao Hu; Wei Zhu
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Subcutaneous efalizumab is not effective in the treatment of alopecia areata
Journal of the American Academy of Dermatology, ISSN: 01909622
Vera H. Price; Maria K. Hordinsky; Elise A. Olsen; Janet L. Roberts; Elaine C. Siegfried; Elyse S. Rafal; Neil J. Korman; Basel Altrabulsi; Hoi M. Leung; Marvin Garovoy; Ivor Caro; David A. Whiting
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Targeting IAP (inhibitor of apoptosis) proteins for therapeutic intervention in tumors
Current Cancer Drug Targets, ISSN: 15680096
Domagoj Vucic
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Egfl7 knockdown causes defects in the extension and junctional arrangements of endothelial cells during Zebrafish vasculogenesis
Developmental Dynamics, ISSN: 10588388 10970177
Ann De Mazière; Leon Parker; Suzanne Van Dijk; Weilan Ye; Judith Klumperman
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The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis
Molecular Biology of the Cell, ISSN: 10591524
Elsa N. N'Diaye; Aylin C. Hanyaloglu; Kimberly K. Kajihara; Manojkumar A. Puthenveedu; Ping Wu; Mark Von Zastrow; Eric J. Brown
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Combination intravitreal triamcinolone injection and cryotherapy for exudative retinal detachments in severe coats disease
Retina, ISSN: 0275004X
Chris S. Bergstrom; G. Baker Hubbard III
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Effect of food or antacid on pharmacokinetics and pharmacodynamics of febuxostat in healthy subjects
British Journal of Clinical Pharmacology, ISSN: 03065251 13652125
Reza Khosravan; Brian Grabowski; Jing-Tao Wu; Nancy Joseph-Ridge; Laurent Vernillet
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Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: Support for a crucial role of intron 1 polymorphisms
Arthritis and Rheumatism, ISSN: 00043591
Aya Kawasaki; Chieko Kyogoku; Jun Ohashi; Risa Miyashita; Koki Hikami; Makio Kusaoi; Katsushi Tokunaga; Yoshinari Takasaki; Hiroshi Hashimoto; Timothy W. Behrens; Naoyuki Tsuchiya
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Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug
Xenobiotica, ISSN: 00498254 13665928
S. Cyrus Khojasteh; Douglas Leipold; Lai; Hank La; Matthew Baumgardner; Desino; Gudmundsson; Duane C. Bloedow; Bodary; Mark E. Reynolds; Thomas Gadek; Sara Kenkare-Mitra
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Tumor necrosis factor: Renaissance as a cancer therapeutic?
Current Cancer Drug Targets, ISSN: 15680096
Dylan Daniel; Nicholas S. Wilson
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Gene signatures reflect the marked heterogeneity of tissue-resident macrophages
Immunology and Cell Biology, ISSN: 08189641 14401711
Nick N. Gorgani; Yan Ma; Hilary F. Clark
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A new ELISA for use in a 3-ELISA system to assess concentrations of VEGF splice variants and VEGF110 in ovarian cancer tumors
Clinical Chemistry, ISSN: 00099147
Johnny Gutierrez; Gottfried E. Konecny; Kyu Hong; Alexander Burges; Timothy D. Henry; Pier D. Lambiase; Lee Wong Wai; Meng
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Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells
Journal of Immunology, ISSN: 15506606 00221767
Marcel Batten; Noelyn Kljavin; Ji Li; Michael J. Walter; Frederic J. De Sauvage; Nico Ghilardi
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The mitochondrial serine protease HtrA2/Omi: An overview
Cell Death and Differentiation, ISSN: 13509047 14765403
Vande Walle; Lamkanfi; Vandenabeele
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Reducing bias in parameter estimates from stepwise regression in proportional hazards regression with right-censored data
Lifetime Data Analysis, ISSN: 13807870
Chang-Heok Soh; David P. Harrington; Alan M. Zaslavsky
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Rituximab in relapsing-remitting multiple sclerosis: A 72-week, open-label, phase I trial
Annals of Neurology, ISSN: 03645134
Amit Bar-Or; Peter A Calabresi; Douglas Arnlod; Clyde Markowitz; Stuart Shafer; Lloyd H. Kasper; Waubant; Suzanne Gazda; Robert J. Fox; Michael Panzara; Neena Sarkar; Sunil Agarwal; Craig H. Smith
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Global regulatory expectations for process changes, versions and multiple manufacturing sites
American Pharmaceutical Outsourcing, ISSN: 15296318
Shelley Suggett
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Current Cancer Drug Targets: Editorial
Current Cancer Drug Targets, ISSN: 15680096
Domagoj Vucic
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Effects of an Anti-VEGF-A monoclonal antibody on laser-induced choroidal neovascularization in mice: Optimizing methods to quantify vascular changes
Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783
Claudio Campa; Ian Kasman; Weilan Ye; Wyne P. Lee; Fuh; Napoleone Ferrara
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Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets
Genome Research, ISSN: 10889051 15495469
David S. Johnson; Wei Li; D. Benjamin Gordon; Arindam Bhattacharjee; Bo Curry; Jayati Ghosh; Leonardo Brizuela; Jason S. Carroll; Myles Brown; Paul Flicek; Christoph M. Koch; Ian Dunham; Mark Bieda; Xiaoqin Xu; Farnham; Philipp Kapranov; David A. Nix; Thomas R. Gingeras; Xinmin Zhang; Heather Holster; Nan Jiang; Roland D. Green; Jun S. Song; Scott A. McCuine; Elizabeth Anton; Loan Nguyen; Nathan D. Trinklein; Zhen Ye; Keith Ching; David Hawkins; Bing Ren; Peter C. Scacheri; Joel Rozowsky; Alexander Karpikov; Ghia Euskirchen; Sherman Weissman; Mark Gerstein; Michael Snyder; Annie Yang; Zarmik Moqtaderi; Heather Hirsch; Hennady P. Shulha; Yutao Fu; Zhi-Ping Weng; Kevin Struhl; Richard M. Myers; Jason D. Lieb; X. Shirley Liu
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Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
Nature Medicine, ISSN: 10788956 1546170X
Yan Zheng; Patricia A. Valdez; Dimitry Danilenko; Yan Hu; Susan Sa; Qian Gong; Abbas Alexander; Zora Modrusan; Nico Ghilardi; Frederic J. De Sauvage; Wenjun Ouyang
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Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): A potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Amrita Kamath; Jian Wang; Francis Y. F. Lee; Punit H. Marathe
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