Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

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February 28, 2008

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

New England Journal of Medicine, ISSN: 15334406 00284793

Geoffrey Hom; Robert R. Graham; Barmak Modrek; Kimberly E. Taylor; Ward Ortmann; Sophie Garnier; Annette T. Lee; Sharon A. Chung; Ricardo C. Ferreira; P. V. Krishna Pant; Dennis G. Ballinger; Kosoy; F. Yesim Demirci; M. Ilyas Kamboh; Amy H. Kao; Tian; Iva Gunnarsson; Anders A. Bengtsson; Solbritt Rantapää-Dahlqvist; Michelle Petri; Manzi; Michael F. Seldin; Lars Rönnblom; Ann-Christine Syvänen; Lindsey A. Criswell; Peter K. Gregersen; Timothy W. Behrens

February 20, 2008

Vesicle priming and recruitment by ubMunc13-2 are differentially regulated by calcium and calmodulin

Journal of Neuroscience, ISSN: 02706474 02706474

Dragoslav Zikich; Aviv Mezer; Frederique Varoqueaux; Anton Sheinin; Harald Junge; Esther Nachliel; Rely Melamed; Nils Brose; Menachem Gutman; Uri Ashery

February 20, 2008

Are Phase 2 screening trials in Oncology obsolete?

Statistics in Medicine, ISSN: 02776715 10970258

Holmgren

February 19, 2008

Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Farbod Shojaei; Mallika Singh; Jennifer D. Thompson; Napoleone Ferrara

February 15, 2008

A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior

Analytical Biochemistry, ISSN: 10960309 00032697

Quan; Emily W. Alcala; Irena Petkovska; Domenic Matthews; Eleanor Canova-Davis; Ron Taticek; Stacey Ma

February 14, 2008

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

New England Journal of Medicine, ISSN: 15334406 00284793

Stephen L. Hauser; Waubant; Douglas L. Arnold; Timothy Vollmer; Jack Antel; Robert J. Fox; Amit Bar-Or; Michael Panzara; Neena Sarkar; Sunil Agarwal; Annette Langer-Gould; Craig H. Smith

February 8, 2008

Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Pierre A. Barthelemy; Helga Raab; Brent A. Appleton; Christopher J. Bond; Ping Wu; Wiesmann; Sachdev S. Sidhu

February 5, 2008

pH dependent effect of glycosylation on protein stability

European Journal of Pharmaceutical Sciences, ISSN: 09280987

Wei Wang; Kris Antonsen; Y. John Wang; Wang

February 5, 2008

Engineering and Overproduction of Polyketide Natural Products

Modern Biopharmaceuticals: Design, Development and Optimization,

Martha Lovato Tse; Chaitan Khosla

February 1, 2008

Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling

Immunology and Cell Biology, ISSN: 08189641 14401711

Nicholas S. Wilson; Louise J. Young; Fiona Kupresanin; Shalin H. Naik; David Vremec; William R. Heath; Shizuo Akira; Ken Shortman; Jeff Boyle; Eugene Maraskovsky; Gabrielle T Belz; Jose A. Villadangos

February 1, 2008

Effect of food on the pharmacokinetics of erlotinib, an orally active epidermal growth factor receptor tyrosine-kinase inhibitor, in healthy individuals

Anti-Cancer Drugs, ISSN: 09594973

Jie Ling; Scott Fettner; Bert L. Lum; Myriam Riek; Ashok Rakhit

February 1, 2008

Interaction between bevacizumab and murine VEGF-A: A reassessment

Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783

Lanlan Yu; Xiumin Wu; Zhiyong Cheng; Chingwei V. Lee; Jennifer Lecouter; Claudio Campa; Fuh; Henry B. Lowman; Napoleone Ferrara

February 1, 2008

Economic evaluation of rituximab plus cyclophosphamide, vincristine and prednisolone for advanced follicular lymphoma

Leukemia and Lymphoma, ISSN: 10428194 10292403

John Hornberger; Carolina Reyes; Deborah Lubeck; Nancy Valente

February 1, 2008

Cleaning validation for biopharmaceutical manufacturing at Genentech

BioPharm International, ISSN: 1542166X

A. Hamid Mollah

February 1, 2008

Transplantation: It may take two to tango and to treat

Immunology and Cell Biology, ISSN: 08189641 14401711

Flavius Martin

February 1, 2008

Allergen skin tests and free IgE levels during reduction and cessation of omalizumab therapy

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Jonathan Corren; Gail Shapiro; Reimann; Yamo Deniz; Dennis A. Wong; Daniel C. Adelman; Alkis Togias

February 1, 2008

Duration of chronic toxicity studies for biotechnology-derived pharmaceuticals: Is 6 months still appropriate?

Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295

Janet Clarke; Christopher Hurst; Pauline L. Martin; John Vahle; Rafael Ponce; Barbara Mounho; Shawn Heidel; Laura Andrews; Theresa Reynolds; Joy A. Cavagnaro

February 1, 2008

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

Nature Genetics, ISSN: 10614036 15461718

John B. Harley; Marta E. Alarcón-Riquelme; Lindsey A. Criswell; Chaim O. Jacob; Robert P. Kimberly; Kathy L. Moser; Betty P. Tsao; Timothy J. Vyse; Carl D. Langefeld; Swapan K. Nath; Joel M. Guthridge; Beth L. Cobb; Daniel B. Mirel; Miranda C. Marion; Adrienne H. Williams; Jasmin Divers; Wei Wang; Summer G. Frank; Bahram Namjou; Stacey B. Gabriel; Annette T. Lee; Peter K. Gregersen; Timothy W. Behrens; Kimberly E. Taylor; Michelle M.A. Fernando; Raphael Zidovetzki; Patrick M. Gaffney; Jeffrey C. Edberg; John D. Rioux; Joshua O. Ojwang; Judith A. James; Merrill; Gary S. Gilkeson; Michael F. Seldin; Hong Yin; Emily C. Baechler; Quan-Zhen Li; Edward K. Wakeland; Gail R. Bruner; Kenneth M. Kaufman; Jennifer A. Kelly

February 1, 2008

Racial variation in the incidence, care, and outcomes of severe sepsis: Analysis of population, patient, and hospital characteristics

American Journal of Respiratory and Critical Care Medicine, ISSN: 1073449X 15354970

Amber E. Barnato; Sherri L. Alexander; Walter T. Linde-Zwirble; Derek C. Angus

January 30, 2008

Netrin-1 is a novel myelin-associated inhibitor to axon growth

Journal of Neuroscience, ISSN: 02706474 02706474

Karin Löw; Maya Culbertson; Frank Bradke; Marc Tessier-Lavigne; Mark H. Tuszynski

January 23, 2008

SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system

EMBO Journal, ISSN: 02614189 14602075

Vikki M. Weake; Kenneth K. Lee; Sebastián Guelman; Chia-Hui Lin; Christopher Seidel; Susan M. Abmayr; Jerry L. Workman

January 22, 2008

Dual effects of Tween 80 on protein stability

International Journal of Pharmaceutics, ISSN: 03785173

Wei Wang; Y. John Wang; Wang

January 15, 2008

Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer

Clinical Cancer Research, ISSN: 10780432

Peisheng Hu; Robyn S. Arias; Rebecca E. Sadun; Yu-Chih Nien; Nan Zhang; Helen Sabzevari; M. E. Christine Lutsiak; Leslie A. Khawli; Alan L. Epstein

January 15, 2008

Role for lysosomal enzyme β-hexosaminidase in the control of mycobacteria infection

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Ingrid Chou Koo; Yamini M. Ohol; Ping Wu; J. Hiroshi Morisaki; Jeffery S. Cox; Eric J. Brown

January 11, 2008

Laboratory evolution of Escherichia coli thioredoxin for enhanced catalysis of protein oxidation in the periplasm reveals a phylogenetically conserved substrate specificity determinant

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Lluis Masip; Daniel Klein-Marcuschamer; Shu Quan; James C. A. Bardwell; George Georgiou

January 10, 2008

Response-independent survival benefit in metastatic colorectal cancer: A comparative analysis of N9741 and AVF2107

Journal of Clinical Oncology, ISSN: 0732183X

Grothey; Eric Hedrick; Robert Mass; Somnath Sarkar; Sam Suzuki; Ramesh K. Ramanathan; Herbert Hurwitz; Richard M. Goldberg; Daniel J. Sargent

January 8, 2008

Synthetic antibodies for specific recognition and crystallization of structured RNA

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Jing-Dong Ye; Valentina Tereshko; John K. Frederiksen; Akiko Koide; Frederic A. Fellouse; Sachdev S. Sidhu; Shohei Koide; Anthony A. Kossiakoff; Joseph A. Piccirilli

January 3, 2008

Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models

Oncogene, ISSN: 09509232 14765594

Luc Desnoyers; Rama Pai; Ron Ferrando; Kathy Hötzel; Tom Le; Ross; Richard A. D. Carano; Aloma L. D'Souza; Jing Qing; Iman Mohtashemi; Avi Ashkenazi; French

January 1, 2008

Accounting for interim analyses in the assessment of program expected net present value

Drug Information Journal, ISSN: 00928615

Lee D. Kaiser; Jeffrey D. Helterbrand; Hal V. Barron

January 1, 2008

Cytokine, chemokine, and co-stimulatory fusion proteins for the immunotherapy of solid tumors

Handbook of Experimental Pharmacology, ISSN: 18650325 01712004

Leslie A. Khawli; Peisheng Hu; Alan L. Epstein

January 1, 2008

DNA microarray gene expression profile of marginal zone versus follicular B cells and idiotype positive marginal zone B cells before and after immunization with Streptococcus pneumoniae

Journal of Immunology, ISSN: 15506606 00221767

Nicholas W. Kin; Dianna Crawford; Jiabin Liu; Timothy W. Behrens; John F. Kearney

January 1, 2008

Oral involvement in primary Sjögren syndrome

Journal of the American Dental Association, ISSN: 00028177

Philip C. Fox; Simon J. Bowman; Barbara Segal; Frederick B. Vivino; Murukutla; Karen Choueiri; Sarika Ogale; Lachy McLean

January 1, 2008

Therapeutic anti-VEGF antibodies

Handbook of Experimental Pharmacology, ISSN: 18650325 01712004

Samantha Lien; Henry B. Lowman

January 1, 2008

Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities

Journal of Immunology, ISSN: 15506606 00221767

Mary M. Tomayko; Shannon M. Anderson; Catherine E. Brayton; Saheli Sadanand; Natalie C. Steinel; Timothy W. Behrens; Mark J. Shlomchik

January 1, 2008

Influence of race on tolerance of platinum-based chemotherapy and clinical outcomes in women with advanced and recurrent cervical cancer: a pooled analysis of 3 Gynecologic Oncology Group studies

American Journal of Obstetrics and Gynecology, ISSN: 00029378

Steven C. Plaxe; Sandra E. Brooks; Chunquiao Tian; Jeffrey D. Bloss; David H. Moore; Harry J. Long

January 1, 2008

Neuromyelitis optica and the optic neuritis treatment trial - Reply

Archives of Neurology, ISSN: 15383687 00039942

Craig H. Smith

January 1, 2008

Recognition of genetic factors influencing the progression of hepatitis C: Potential for personalized therapy

Molecular Diagnosis and Therapy, ISSN: 11771062

Julie R. Jonsson; David M. Purdie; Andrew D. Clouston; Elizabeth E. Powell

January 1, 2008

A role of macrophage complement receptor crig in immune clearance and inflammation

Molecular Immunology, ISSN: 18729142 01615890

Jeannie Q. He; Wiesmann; Menno Van Lookeren Campagne

January 1, 2008

Reversible self-association of a concentrated monoclonal antibody solution mediated by fab-fab interaction that impacts solution viscosity

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Sonoko Kanai; Jun Liu; Thomas W. Patapoff; Steven J. Shire

January 1, 2008

Racial disparities in asthma-related health outcomes in severe or difficult-to-treat asthma

Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206

Tmirah Haselkorn; June H. Lee; David R. Mink; Weiss

January 1, 2008

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

Nature Genetics, ISSN: 15461718 10614036

Robert R. Graham; Chris Cotsapas; Leela R. L. Davies; Rachel Hackett; Christopher J. Lessard; Joanlise M. Leon; Noel Burtt; Candace Guiducci; Melissa Parkin; Casey Gates; Robert M. Plenge; Timothy W. Behrens; Joan E. Wither; John D. Rioux; Fortin; Deborah S. Cunninghame Graham; Andrew K. Wong; Timothy J. Vyse; Mark J. Daly; David Altshuler; Kathy L. Moser; Patrick M. Gaffney

January 1, 2008

The safety of bone allografts used in dentistry: A review

Journal of the American Dental Association, ISSN: 00028177

Dan Holtzclaw; Nicholas Toscano; Lisa Eisenlohr; Don Callan

January 1, 2008

The complex inter-relationships between protein flexibility and stability

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Tim J. Kamerzell; C. Russell Middaugh

January 1, 2008

Anti-CD22-MCC-DM1 and MC-MMAF conjugates: Impact of assay format on pharmacokinetic parameters determination

Bioconjugate Chemistry, ISSN: 10431802

Jean-Philippe Stephan; Pamela Chan; Chien C. Lee; Nelson; J. Michael Elliott; Charity Bechtel; Helga Raab; David Xie; Jon Akutagawa; Jakub Baudys; Ola M. Saad; Saileta Prabhu; Wai Lee T. Wong; Richard L. Vandlen; Fred Jacobson; Allen Ebens

January 1, 2008

15 Capillary electrophoresis and bioanalysis

Separation Science and Technology, ISSN: 01496395

Oscar Salas-Solano; Chantal Felten

January 1, 2008

The Notch pathway in prostate development and cancer

Differentiation, ISSN: 14320436 03014681

Kevin G. Leong; Gao

January 1, 2008

Evaluation of hydrate-screening methods

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Yonc Cui; Erica Yao

January 1, 2008

Synthesis of a cross-bridged cyclam derivative for peptide conjugation and 64Cu radiolabeling

Bioconjugate Chemistry, ISSN: 10431802

C. Andrew Boswell; Celeste A. S. Regino; Kwamena E. Baidoo; Karen J. Wong; Ambika Bumb; Heng Xu; Diane E. Milenic; James A. Kelley; Christopher C. Lai; Martin W. Brechbiel

January 1, 2008

Stopping replication, at the beginning

Nature Chemical Biology, ISSN: 15524469 15524450

Peter K Jackson

January 1, 2008

Summary statement novel agents in the treatment of lung cancer: Fifth Cambridge conference assessing opportunities for combination therapy

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Thomas J. Lynch; George R. Blumenschein; Jeff A. Engelman; Igor Espinoza-Delgado; Ramaswamy Govindan; Jeffrey H. Hanke; Nasser H. Hanna; John V. Heymach; Fred R. Hirsch; Pasi A. Jänne; Rogerio C. Lilenbaum; Ronald B. Natale; Gregory J. Riely; Lecia V. Sequist; Geoffrey I. Shapiro; Alice T. Shaw; Frances A. Shepherd; Mark A. Socinski; A Gregory Sorensen; Heather A. Wakelee; Aaron Weitzman

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