Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10101 - 10150 OF 15805 RESULTS

March 1, 2008

Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets

Genome Research, ISSN: 10889051 15495469

David S. Johnson; Wei Li; D. Benjamin Gordon; Arindam Bhattacharjee; Bo Curry; Jayati Ghosh; Leonardo Brizuela; Jason S. Carroll; Myles Brown; Paul Flicek; Christoph M. Koch; Ian Dunham; Mark Bieda; Xiaoqin Xu; Farnham; Philipp Kapranov; David A. Nix; Thomas R. Gingeras; Xinmin Zhang; Heather Holster; Nan Jiang; Roland D. Green; Jun S. Song; Scott A. McCuine; Elizabeth Anton; Loan Nguyen; Nathan D. Trinklein; Zhen Ye; Keith Ching; David Hawkins; Bing Ren; Peter C. Scacheri; Joel Rozowsky; Alexander Karpikov; Ghia Euskirchen; Sherman Weissman; Mark Gerstein; Michael Snyder; Annie Yang; Zarmik Moqtaderi; Heather Hirsch; Hennady P. Shulha; Yutao Fu; Zhi-Ping Weng; Kevin Struhl; Richard M. Myers; Jason D. Lieb; X. Shirley Liu

March 1, 2008

Effects of an Anti-VEGF-A monoclonal antibody on laser-induced choroidal neovascularization in mice: Optimizing methods to quantify vascular changes

Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783

Claudio Campa; Ian Kasman; Weilan Ye; Wyne P. Lee; Fuh; Napoleone Ferrara

March 1, 2008

Current Cancer Drug Targets: Editorial

Current Cancer Drug Targets, ISSN: 15680096

Domagoj Vucic

March 1, 2008

Global regulatory expectations for process changes, versions and multiple manufacturing sites

American Pharmaceutical Outsourcing, ISSN: 15296318

Shelley Suggett

March 1, 2008

Rituximab in relapsing-remitting multiple sclerosis: A 72-week, open-label, phase I trial

Annals of Neurology, ISSN: 03645134

Amit Bar-Or; Peter A Calabresi; Douglas Arnlod; Clyde Markowitz; Stuart Shafer; Lloyd H. Kasper; Waubant; Suzanne Gazda; Robert J. Fox; Michael Panzara; Neena Sarkar; Sunil Agarwal; Craig H. Smith

March 1, 2008

Reducing bias in parameter estimates from stepwise regression in proportional hazards regression with right-censored data

Lifetime Data Analysis, ISSN: 13807870

Chang-Heok Soh; David P. Harrington; Alan M. Zaslavsky

March 1, 2008

The mitochondrial serine protease HtrA2/Omi: An overview

Cell Death and Differentiation, ISSN: 13509047 14765403

Vande Walle; Lamkanfi; Vandenabeele

March 1, 2008

Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells

Journal of Immunology, ISSN: 15506606 00221767

Marcel Batten; Noelyn Kljavin; Ji Li; Michael J. Walter; Frederic J. De Sauvage; Nico Ghilardi

March 1, 2008

A new ELISA for use in a 3-ELISA system to assess concentrations of VEGF splice variants and VEGF110 in ovarian cancer tumors

Clinical Chemistry, ISSN: 00099147

Johnny Gutierrez; Gottfried E. Konecny; Kyu Hong; Alexander Burges; Timothy D. Henry; Pier D. Lambiase; Lee Wong Wai; Meng

March 1, 2008

Gene signatures reflect the marked heterogeneity of tissue-resident macrophages

Immunology and Cell Biology, ISSN: 08189641 14401711

Nick N. Gorgani; Yan Ma; Hilary F. Clark

March 1, 2008

Tumor necrosis factor: Renaissance as a cancer therapeutic?

Current Cancer Drug Targets, ISSN: 15680096

Dylan Daniel; Nicholas S. Wilson

March 1, 2008

Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug

Xenobiotica, ISSN: 00498254 13665928

S. Cyrus Khojasteh; Douglas Leipold; Lai; Hank La; Matthew Baumgardner; Desino; Gudmundsson; Duane C. Bloedow; Bodary; Mark E. Reynolds; Thomas Gadek; Sara Kenkare-Mitra

March 1, 2008

Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: Support for a crucial role of intron 1 polymorphisms

Arthritis and Rheumatism, ISSN: 00043591

Aya Kawasaki; Chieko Kyogoku; Jun Ohashi; Risa Miyashita; Koki Hikami; Makio Kusaoi; Katsushi Tokunaga; Yoshinari Takasaki; Hiroshi Hashimoto; Timothy W. Behrens; Naoyuki Tsuchiya

March 1, 2008

Effect of food or antacid on pharmacokinetics and pharmacodynamics of febuxostat in healthy subjects

British Journal of Clinical Pharmacology, ISSN: 03065251 13652125

Reza Khosravan; Brian Grabowski; Jing-Tao Wu; Nancy Joseph-Ridge; Laurent Vernillet

March 1, 2008

Combination intravitreal triamcinolone injection and cryotherapy for exudative retinal detachments in severe coats disease

Retina, ISSN: 0275004X

Chris S. Bergstrom; G. Baker Hubbard III

March 1, 2008

The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis

Molecular Biology of the Cell, ISSN: 10591524

Elsa N. N'Diaye; Aylin C. Hanyaloglu; Kimberly K. Kajihara; Manojkumar A. Puthenveedu; Ping Wu; Mark Von Zastrow; Eric J. Brown

March 1, 2008

Egfl7 knockdown causes defects in the extension and junctional arrangements of endothelial cells during Zebrafish vasculogenesis

Developmental Dynamics, ISSN: 10588388 10970177

Ann De Mazière; Leon Parker; Suzanne Van Dijk; Weilan Ye; Judith Klumperman

March 1, 2008

Targeting IAP (inhibitor of apoptosis) proteins for therapeutic intervention in tumors

Current Cancer Drug Targets, ISSN: 15680096

Domagoj Vucic

March 1, 2008

Subcutaneous efalizumab is not effective in the treatment of alopecia areata

Journal of the American Academy of Dermatology, ISSN: 01909622

Vera H. Price; Maria K. Hordinsky; Elise A. Olsen; Janet L. Roberts; Elaine C. Siegfried; Elyse S. Rafal; Neil J. Korman; Basel Altrabulsi; Hoi M. Leung; Marvin Garovoy; Ivor Caro; David A. Whiting

March 1, 2008

Multi-step variance minimization in sequential tests

Statistics and Computing, ISSN: 09603174

Zheng Su; Jiaqiao Hu; Wei Zhu

March 1, 2008

Conservation of inner domain modules in the surface envelope glycoproteins of an ancient rabbit lentivirus and extant lentiviruses and betaretroviruses

Virology, ISSN: 00426822 10960341

Isidro Hötzel

February 28, 2008

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

New England Journal of Medicine, ISSN: 15334406 00284793

Geoffrey Hom; Robert R. Graham; Barmak Modrek; Kimberly E. Taylor; Ward Ortmann; Sophie Garnier; Annette T. Lee; Sharon A. Chung; Ricardo C. Ferreira; P. V. Krishna Pant; Dennis G. Ballinger; Kosoy; F. Yesim Demirci; M. Ilyas Kamboh; Amy H. Kao; Tian; Iva Gunnarsson; Anders A. Bengtsson; Solbritt Rantapää-Dahlqvist; Michelle Petri; Manzi; Michael F. Seldin; Lars Rönnblom; Ann-Christine Syvänen; Lindsey A. Criswell; Peter K. Gregersen; Timothy W. Behrens

February 28, 2008

Stem Cell Factor Functions as an Outgrowth-Promoting Factor to Enable Axon Exit from the Midline Intermediate Target

Neuron, ISSN: 08966273

Bryan B. Gore; Karen G. Wong; Marc Tessier-Lavigne

February 20, 2008

Are Phase 2 screening trials in Oncology obsolete?

Statistics in Medicine, ISSN: 02776715 10970258

Holmgren

February 20, 2008

Vesicle priming and recruitment by ubMunc13-2 are differentially regulated by calcium and calmodulin

Journal of Neuroscience, ISSN: 02706474 02706474

Dragoslav Zikich; Aviv Mezer; Frederique Varoqueaux; Anton Sheinin; Harald Junge; Esther Nachliel; Rely Melamed; Nils Brose; Menachem Gutman; Uri Ashery

February 19, 2008

Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Farbod Shojaei; Mallika Singh; Jennifer D. Thompson; Napoleone Ferrara

February 15, 2008

A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior

Analytical Biochemistry, ISSN: 10960309 00032697

Quan; Emily W. Alcala; Irena Petkovska; Domenic Matthews; Eleanor Canova-Davis; Ron Taticek; Stacey Ma

February 14, 2008

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

New England Journal of Medicine, ISSN: 15334406 00284793

Stephen L. Hauser; Waubant; Douglas L. Arnold; Timothy Vollmer; Jack Antel; Robert J. Fox; Amit Bar-Or; Michael Panzara; Neena Sarkar; Sunil Agarwal; Annette Langer-Gould; Craig H. Smith

February 8, 2008

Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Pierre A. Barthelemy; Helga Raab; Brent A. Appleton; Christopher J. Bond; Ping Wu; Wiesmann; Sachdev S. Sidhu

February 5, 2008

Engineering and Overproduction of Polyketide Natural Products

Modern Biopharmaceuticals: Design, Development and Optimization,

Martha Lovato Tse; Chaitan Khosla

February 5, 2008

pH dependent effect of glycosylation on protein stability

European Journal of Pharmaceutical Sciences, ISSN: 09280987

Wei Wang; Kris Antonsen; Y. John Wang; Wang

February 1, 2008

Racial variation in the incidence, care, and outcomes of severe sepsis: Analysis of population, patient, and hospital characteristics

American Journal of Respiratory and Critical Care Medicine, ISSN: 1073449X 15354970

Amber E. Barnato; Sherri L. Alexander; Walter T. Linde-Zwirble; Derek C. Angus

February 1, 2008

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

Nature Genetics, ISSN: 10614036 15461718

John B. Harley; Marta E. Alarcón-Riquelme; Lindsey A. Criswell; Chaim O. Jacob; Robert P. Kimberly; Kathy L. Moser; Betty P. Tsao; Timothy J. Vyse; Carl D. Langefeld; Swapan K. Nath; Joel M. Guthridge; Beth L. Cobb; Daniel B. Mirel; Miranda C. Marion; Adrienne H. Williams; Jasmin Divers; Wei Wang; Summer G. Frank; Bahram Namjou; Stacey B. Gabriel; Annette T. Lee; Peter K. Gregersen; Timothy W. Behrens; Kimberly E. Taylor; Michelle M.A. Fernando; Raphael Zidovetzki; Patrick M. Gaffney; Jeffrey C. Edberg; John D. Rioux; Joshua O. Ojwang; Judith A. James; Merrill; Gary S. Gilkeson; Michael F. Seldin; Hong Yin; Emily C. Baechler; Quan-Zhen Li; Edward K. Wakeland; Gail R. Bruner; Kenneth M. Kaufman; Jennifer A. Kelly

February 1, 2008

Duration of chronic toxicity studies for biotechnology-derived pharmaceuticals: Is 6 months still appropriate?

Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295

Janet Clarke; Christopher Hurst; Pauline L. Martin; John Vahle; Rafael Ponce; Barbara Mounho; Shawn Heidel; Laura Andrews; Theresa Reynolds; Joy A. Cavagnaro

February 1, 2008

Allergen skin tests and free IgE levels during reduction and cessation of omalizumab therapy

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Jonathan Corren; Gail Shapiro; Reimann; Yamo Deniz; Dennis A. Wong; Daniel C. Adelman; Alkis Togias

February 1, 2008

Transplantation: It may take two to tango and to treat

Immunology and Cell Biology, ISSN: 08189641 14401711

Flavius Martin

February 1, 2008

Cleaning validation for biopharmaceutical manufacturing at Genentech

BioPharm International, ISSN: 1542166X

A. Hamid Mollah

February 1, 2008

Economic evaluation of rituximab plus cyclophosphamide, vincristine and prednisolone for advanced follicular lymphoma

Leukemia and Lymphoma, ISSN: 10428194 10292403

John Hornberger; Carolina Reyes; Deborah Lubeck; Nancy Valente

February 1, 2008

Interaction between bevacizumab and murine VEGF-A: A reassessment

Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783

Lanlan Yu; Xiumin Wu; Zhiyong Cheng; Chingwei V. Lee; Jennifer Lecouter; Claudio Campa; Fuh; Henry B. Lowman; Napoleone Ferrara

February 1, 2008

Effect of food on the pharmacokinetics of erlotinib, an orally active epidermal growth factor receptor tyrosine-kinase inhibitor, in healthy individuals

Anti-Cancer Drugs, ISSN: 09594973

Jie Ling; Scott Fettner; Bert L. Lum; Myriam Riek; Ashok Rakhit

February 1, 2008

Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling

Immunology and Cell Biology, ISSN: 08189641 14401711

Nicholas S. Wilson; Louise J. Young; Fiona Kupresanin; Shalin H. Naik; David Vremec; William R. Heath; Shizuo Akira; Ken Shortman; Jeff Boyle; Eugene Maraskovsky; Gabrielle T Belz; Jose A. Villadangos

January 30, 2008

Netrin-1 is a novel myelin-associated inhibitor to axon growth

Journal of Neuroscience, ISSN: 02706474 02706474

Karin Löw; Maya Culbertson; Frank Bradke; Marc Tessier-Lavigne; Mark H. Tuszynski

January 23, 2008

SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system

EMBO Journal, ISSN: 02614189 14602075

Vikki M. Weake; Kenneth K. Lee; Sebastián Guelman; Chia-Hui Lin; Christopher Seidel; Susan M. Abmayr; Jerry L. Workman

January 22, 2008

Dual effects of Tween 80 on protein stability

International Journal of Pharmaceutics, ISSN: 03785173

Wei Wang; Y. John Wang; Wang

January 15, 2008

Role for lysosomal enzyme β-hexosaminidase in the control of mycobacteria infection

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Ingrid Chou Koo; Yamini M. Ohol; Ping Wu; J. Hiroshi Morisaki; Jeffery S. Cox; Eric J. Brown

January 15, 2008

Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer

Clinical Cancer Research, ISSN: 10780432

Peisheng Hu; Robyn S. Arias; Rebecca E. Sadun; Yu-Chih Nien; Nan Zhang; Helen Sabzevari; M. E. Christine Lutsiak; Leslie A. Khawli; Alan L. Epstein

January 11, 2008

Laboratory evolution of Escherichia coli thioredoxin for enhanced catalysis of protein oxidation in the periplasm reveals a phylogenetically conserved substrate specificity determinant

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Lluis Masip; Daniel Klein-Marcuschamer; Shu Quan; James C. A. Bardwell; George Georgiou

January 10, 2008

Response-independent survival benefit in metastatic colorectal cancer: A comparative analysis of N9741 and AVF2107

Journal of Clinical Oncology, ISSN: 0732183X

Grothey; Eric Hedrick; Robert Mass; Somnath Sarkar; Sam Suzuki; Ramesh K. Ramanathan; Herbert Hurwitz; Richard M. Goldberg; Daniel J. Sargent

January 8, 2008

Synthetic antibodies for specific recognition and crystallization of structured RNA

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Jing-Dong Ye; Valentina Tereshko; John K. Frederiksen; Akiko Koide; Frederic A. Fellouse; Sachdev S. Sidhu; Shohei Koide; Anthony A. Kossiakoff; Joseph A. Piccirilli

January 3, 2008

Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models

Oncogene, ISSN: 09509232 14765594

Luc Desnoyers; Rama Pai; Ron Ferrando; Kathy Hötzel; Tom Le; Ross; Richard A. D. Carano; Aloma L. D'Souza; Jing Qing; Iman Mohtashemi; Avi Ashkenazi; French

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