Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10401 - 10450 OF 15632 RESULTS

Targeting the Hedgehog pathway in cancer
Nature Reviews Drug Discovery, ISSN: 14741776 14741784
Lee L. Rubin; Frederic J. De Sauvage
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Sensitive detection of KIT D816V in patients with mastocytosis
Clinical Chemistry, ISSN: 00099147
Tan; David Westerman; McArthur; Kevin Lynch; Waring; Dobrovic
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Development and validation of a preference weight multiattribute health outcome measure for rheumatoid arthritis
Journal of Rheumatology, ISSN: 0315162X
Chiun-Fang Chiou; Maria E. Suarez-Almazor; Cathy D. Sherbourne; Chih-Hung Chang; Carolina Reyes; Michelle Dylan; Joshua Ofman; Daniel J. Wallace; Wesley Mizutani; Michael Weisman
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Bringing science to cancer therapy
Yale Journal of Biology and Medicine, ISSN: 00440086
Ira Mellman
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TENOR risk score predicts healthcare in adults with severe or difficult-to-treat asthma
European Respiratory Journal, ISSN: 09031936
Mary K. Miller; June H. Lee; Paul D. Blanc; David J. Pasta; Gujrathi; Hal V. Barron; Sally E. Wenzel; Weiss
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Selectivity improvements in highly charged UF membranes
Desalination, ISSN: 00119164
Alex Xenopoulos; Charkoudian; Robert Van Reis
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Protein NMR Spectroscopy: Principles and Practice
Protein NMR Spectroscopy: Principles and Practice,
John Cavanagh; Wayne J. Fairbrother; Arthur G. Palmer III; Mark Rance; Nicholas J. Skelton
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Boc is a receptor for sonic hedgehog in the guidance of commissural axons
Nature, ISSN: 14764687 00280836
Ami Okada; Frédéric Charron; Steves Morin; David S. Shin; Karen G. Wong; Pierre J. Fabre; Marc Tessier-Lavigne; Susan K. McConnell
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Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest
EMBO Journal, ISSN: 02614189 14602075
George B. Kyei; Isabelle Vergne; Jennifer Chua; Esteban Roberts; James Harris; Jagath R. Junutula; Vojo Deretic
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Structure of C3b in complex with CRIg gives insights into regulation of complement activation
Nature, ISSN: 14764687 00280836
Wiesmann; Kenneth J. Katschke Jr.; Jianping Yin; Karim Y. Helmy; Micah Steffek; Wayne J. Fairbrother; Scott A. McCallum; Lizette Sturgeon; Laura DeForge; Hass; Menno Van Lookeren Campagne
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Allowing for missing data at highly polymorphic genes when testing for maternal, offspring and maternal-fetal genotype incompatibility effects
Human Heredity, ISSN: 00015652
Hsin-Ju Hsieh; Christina G.S. Palmer; Janet S. Sinsheimer
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Inhibitory effect of carboxylic acid group on hERG binding
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Bing-Yan Zhu; Zhaozhong J. Jia; Penglie Zhang; Ting Su; Wenrong Huang; Erick Goldman; Daniel B. Tumas; Vic Kadambi; Priya Eddy; Uma Sinha; Robert M. Scarborough; Yonghong Song
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Human immunodeficiency virus persistence and production in T-cell development
Clinical and Vaccine Immunology, ISSN: 15566811
Kevin B. Gurney; Christel H. Uittenbogaart
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Rapid redistribution of synaptic PSD-95 in the neocortex in vivo
PLoS Biology, ISSN: 15457885 15457885
Noah W. Gray; Robby M. Weimer; Ingrid Bureau; Karel Svoboda
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Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis
Molecular and Cellular Biology, ISSN: 02707306
Zhaoyu Jin; Wafik S. El-Deiry
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Magnetic resonance angiography reveals therapeutic enlargement of collateral vessels induced by VEGF in a murine model of peripheral arterial disease
Journal of Magnetic Resonance Imaging, ISSN: 10531807 15222586
Joan M. Greve; Chico; Hope Goldman; Bunting; Franklin V. Peale Jr.; Daugherty; Nicholas Van Bruggen; Simon P. Williams
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Preclinical pharmacokinetics and metabolism of 6-(4- (2,5-Difluorophenyl)oxazol-5-yk)-3-isopropyl-[1,2,4]-triazolo[4,3- a]pyridine, a novel and selective p38α inhibitor: Identification of an active metaboline in preclinical species and human liver microsomes
Biopharmaceutics and Drug Disposition, ISSN: 01422782 1099081X
Amit S. Kalgutkar; Heather L. Hatch; Frederick Kosea; Hang T. Nguyen; Edna F. Choo; Kim F. McClure; Timothy J. Taylor; Kirk R. Henne; Alexander V. Kuperman; Mark A. Dombroski; Michael A. Letavic
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CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway
Cellular Signalling, ISSN: 08986568
Simon Rousseau; Ignacio Dolado; Victoria Beardmore; Natalia Shpiro; Rodolfo Marquez; Angel R. Nebreda; J. Simon C. Arthur; Lauren C Case; Marc Tessier-Lavigne; Matthias Gaestel; Ana Cuenda; Philip Cohen
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Reply to Challenges to the report of Nogo antibody effects in primates [4]
Nature Medicine, ISSN: 10788956 1546170X
Carole Ho; Marc Tessier-Lavigne
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Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells
Blood, ISSN: 00064971 00064971
Chingwei V. Lee; Sarah G. Hymowitz; Heidi J. A. Wallweber; Nathaniel C. Gordon; Karen L Billeci; Siao Ping Tsai; Deanne M. Compaan; Jianping Yin; Qian Gong; Robert F. Kelley; Laura DeForge; Flavius Martin; Melissa A. Starovasnik; Fuh
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Loss of T-cell protein tyrosine phosphatase induces recycling of the platelet-derived growth factor (PDGF) β-receptor but not the PDGF α-receptor
Molecular Biology of the Cell, ISSN: 10591524
Susann Karlsson; Katarzyna Kowanetz; Åsa Sandin; Camilla Persson; Arne Östman; Carl-Henrik Heldin; Carina Hellberg
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The process engineer's role in technology transfers to CMOs
American Pharmaceutical Outsourcing, ISSN: 15296318
Bender
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Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration: Year 1 results of the FOCUS study
Archives of Ophthalmology, ISSN: 00039950 00039950
Jeffrey S. Heier; David S. Boyer; Thomas A. Ciulla; Philip J. Ferrone; J. Michael Jumper; Ronald C. Gentile; Debbie Kotlovker; Carol Chung; Robert Kim
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Quality by design, validation, and PAT: Operational, statistical, and engineering perspectives
Pharmaceutical Engineering, ISSN: 02738139
Ron Branning; Lynn Torbeck; Cliff Campbell
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Alteplase for the treatment of central venous catheter occlusion in children: Results of a prospective, open-label, single-arm study (The Cathflo Activase Pediatric Study)
Journal of Vascular and Interventional Radiology, ISSN: 10510443
Martha Blaney; Violet Shen; John A. Kerner; Brian R. Jacobs; Sarah Gray; Jennifer Armfield; Charles P. Semba
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Technical considerations in the development of prefilled syringes for protein products
American Pharmaceutical Review, ISSN: 10998012
David E. Overcashier; Edwin K. Chan; Chung C. Hsu
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Reply to Challenges to the report of Nogo antibody effects in primates [4]
Nature Medicine, ISSN: 10788956 1546170X
Carole Ho; Marc Tessier-Lavigne
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Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration: Year 1 results of the FOCUS study
Archives of Ophthalmology, ISSN: 00039950 00039950
Jeffrey S. Heier; David S. Boyer; Thomas A. Ciulla; Philip J. Ferrone; J. Michael Jumper; Ronald C. Gentile; Debbie Kotlovker; Carol Y. Chung; Robert Kim
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Corneal avascularity is due to soluble VEGF receptor-1
Nature, ISSN: 14764687 00280836
Balamurali K. Ambati; Miho Nozaki; Nirbhai Singh; Atsunobu Takeda; Pooja D. Jani; Tushar Suthar; Romulo J. C. Albuquerque; Elizabeth Richter; Eiji Sakurai; Michael T. Newcomb; Mark E. Kleinman; Ruth Caldwell; Qing Lin; Yuichiro Ogura; Angela Orecchia; Don A. Samuelson; Dalen W. Agnew; Judy St. Leger; W. Richard Green; Parameshwar J. Mahasreshti; David T. Curiel; Donna Kwan; Helene Marsh; Sakae Ikeda; Lucy J. Leiper; J. Martin Collinson; Sasha Bogdanovich; Tejvir S. Khurana; Masabumi Shibuya; Megan E. Baldwin; Napoleone Ferrara; Hans-Peter Gerber; Sandro De Falco; Jassir Witta; Judit Z. Baffi; Brian J. Raisler; Jayakrishna Ambati
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Polyclonal resistance in gastrointestinal stromal tumor treated with sequential kinase inhibitors [3]
Clinical Cancer Research, ISSN: 10780432
Loughrey; Waring; Dobrovic; George Demetri; Kovalenko; McArthur
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The Hedgehog signaling pathway in cancer
Clinical Cancer Research, ISSN: 10780432
Marie Evangelista; Hua Tian; Frederic J. De Sauvage
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A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo
Clinical Cancer Research, ISSN: 10780432
Tobias Martens; Nils-Ole Schmidt; Carmen Eckerich; Regina Filibrandt; Mark Merchant; Ralph H. Schwall; Manfred Westphal; Katrin Lamszus
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Pro-urokinase-type plasminogen activator is a substrate for hepsin
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Paul Moran; Wei Li; Bin Fan; Rajesh Vij; Eigenbrot; Daniel Kirchhofer
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2005 AAPS Biotechnology Conference Open Forum on Aggregation of Protein Therapeutics - Panel discussion June 5-8, 2005 San Francisco, CA
AAPS Journal, ISSN: 15507416
Steven J. Shire
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Ranibizumab versus Verteporfin Photodynamic Therapy for Neovascular Age-Related Macular Degeneration: Two-Year Results of the ANCHOR Study
Ophthalmology, ISSN: 01616420
David M. Brown; Mark Michels; Peter K. Kaiser; Jeffrey S. Heier; Judy P. Sy; Tsontcho Ianchulev
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Ranibizumab versus verteporfin for neovascular age-related macular degeneration
New England Journal of Medicine, ISSN: 00284793 15334406
David M. Brown; Peter K. Kaiser; Mark Michels; Gisele Soubrane; Jeffrey S. Heier; Robert Kim; Judy P. Sy; Susan Schneider
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Ranibizumab for neovascular age-related macular degeneration
New England Journal of Medicine, ISSN: 00284793 15334406
Philip J. Rosenfeld; David M. Brown; Jeffrey S. Heier; David S. Boyer; Peter K. Kaiser; Carol Chung; Robert Kim
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Ranibizumab for neovascular age-related macular degeneration
New England Journal of Medicine, ISSN: 00284793 15334406
Philip J. Rosenfeld; David M. Brown; Jeffrey S. Heier; David S. Boyer; Peter K. Kaiser; Carol Y. Chung; Robert Kim
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Structure of SAP18: A ubiquitin fold in histone deacetylase complex assembly
Biochemistry, ISSN: 00062960
Scott A. McCallum; J.Fernando Bazan; Mark Merchant; Jianping Yin; Borlan Pan; Frederic J. De Sauvage; Wayne J. Fairbrother
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Imaging tumor angiogenesis
Journal of Clinical Investigation, ISSN: 00219738 15588238
Kristy Red-Horse; Napoleone Ferrara
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Early coronary revascularization diminishes the risk of ischemic stroke with acute myocardial infarction
Stroke, ISSN: 00392499
Eric Van De Graaff; Monisha Dutta; Pranab Das; Eric A. Shry; Paul D. Frederick; Martha Blaney; David J. Pasta; Steven R. Steinhubl
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Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
Retina, ISSN: 0275004X
Napoleone Ferrara; Lisa A. Damico; Naveed Shams; Henry B. Lowman; Robert Kim
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Ophthalmological and otological problems in Turner syndrome
International Congress Series, ISSN: 05315131
Saenger; Nussbaum; Barbara M. Lippe
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The lack of cardiotrophin-1 alters expression of interleukin-6 and leukemia inhibitory factor mRNA but does not impair cardiac injury response
Cytokine, ISSN: 10434666
Kurt Gritman; Donna M. Van Winkle; Christina U. Lorentz; Diane Pennica; Beth A. Habecker
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A review of malignancies observed during efalizumab (Raptiva®) clinical trials for plaque psoriasis
Dermatology, ISSN: 10188665
Craig Leonardi; Darryl P. Toth; Jennifer C. Cather; Richard G. B. Langley; Winifred Werther; Peter Compton; Paul Kwon; Graham Wetherill; Francois Curtin; Alan Menter
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The inhibitor of apoptosis protein fusion c-IAP2·MALT1 stimulates NF-κB activation independently of TRAF1 and TRAF2
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eugene Varfolomeev; Sarah M. Wayson; Vishva M. Dixit; Wayne J. Fairbrother; Domagoj Vucic
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Monopolar Attachment of Sister Kinetochores at Meiosis I Requires Casein Kinase 1
Cell, ISSN: 00928674
Mark Petronczki; Joao Matos; Saori Mori; Juraj Gregan; Aliona Bogdanova; Martin Schwickart; Karl Mechtler; Katsuhiko Shirahige; Wolfgang Zachariae; Kim Nasmyth
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A critical review of analytical ultracentrifugation and field flow fractionation methods for measuring protein aggregation
AAPS Journal, ISSN: 15507416
Jun Liu; Andya; Steven J. Shire
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SNAREs - Engines for membrane fusion
Nature Reviews Molecular Cell Biology, ISSN: 14710072 14710080
Reinhard Jahn; Richard H. Scheller
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Using genetically engineered mouse models of cancer to aid drug development: An industry perspective
Clinical Cancer Research, ISSN: 10780432
Mallika Singh; Leisa Johnson
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