Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10651 - 10700 OF 15632 RESULTS

December 1, 2005

Predicting clinical benefit in non-small-cell lung cancer patients treated with epidermal growth factor tyrosine kinase inhibitors

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

Lukas Amler; Goddard; Kenneth J. Hillan

December 1, 2005

Inhibition of collagen gene expression in systemic sclerosis dermal fibroblasts by mithramycin

Annals of the Rheumatic Diseases, ISSN: 00034967

Sandorfi; Louneva; Hitraya; Hajnoczky; Saitta; Sergio A. Jimenez

December 1, 2005

UV microscopy at 280 nm is effective in screening for the growth of protein microcrystals

Journal of Applied Crystallography, ISSN: 00218898 16005767

Christopher S. Lunde; Shahab Rouhani; Jonathan P. Remis; Steven E. Ruzin; James A. Ernst; Robert M. Glaeser

December 1, 2005

Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer

Journal of Clinical Oncology, ISSN: 0732183X

David B. Agus; Michael S. Gordon; Charles Taylor; Ronald B. Natale; Beth Karlan; David Mendelson; Michael F. Press; David E. Allison; Mark X. Sliwkowski; Grade Lieberman; Stephen Kelsey; Gwendolyn Fyfe

December 1, 2005

Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer

Journal of Clinical Oncology, ISSN: 0732183X

Fairooz F. Kabbinavar; Julie Hambleton; Robert Mass; Herbert Hurwitz; Emily Bergsland; Somnath Sarkar

December 1, 2005

Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer

Journal of Clinical Oncology, ISSN: 0732183X

Kathy Miller; Linnea I. Chap; Frankie Ann Holmes; Melody A. Cobleigh; P. Kelly Marcom; Louis Fehrenbacher; Maura N. Dickler; Beth A. Overmoyer; Reimann; Amy Sing; Virginia K. Langmuir; Hope S. Rugo

December 1, 2005

Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer

Journal of Clinical Oncology, ISSN: 0732183X

Agus; Michael S. Gordon; Charles Taylor; Ronald B. Natale; Beth Karlan; David Mendelson; Michael F. Press; David E. Allison; Mark X. Sliwkowski; Grade Lieberman; Stephen Kelsey; Gwendolyn Fyfe

December 1, 2005

Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib

Journal of Clinical Oncology, ISSN: 0732183X

Eberhard; Bruce E. Johnson; Lukas Amler; Goddard; Sherry Heldens; Roy S. Herbst; William L. Ince; Pasi A. Jänne; Thomas Januario; David H. Johnson; Pam Klein; Vincent A. Miller; Michael Ostland; David A. Ramies; Dragan Sebisanovic; Stinson; Zhang; Somasekar Seshagiri; Kenneth J. Hillan

December 1, 2005

Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial

Journal of Clinical Oncology, ISSN: 0732183X

Fairooz F. Kabbinavar; Joseph Schulz; Michael McCleod; Taral Patel; John T. Hamm; Joel Randolph Hecht; Robert Mass; Brent Perrou; Betty Nelson; Novotny

December 1, 2005

Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib

Journal of Clinical Oncology, ISSN: 0732183X

Eberhard; Bruce E. Johnson; Lukas Amler; Goddard; Sherry Heldens; Roy S. Herbst; William Ince; Pasi A. Jänne; Thomas Januario; David H. Johnson; Pam Klein; Vincent A. Miller; Michael Ostland; David A. Ramies; Dragan Sebisanovic; Stinson; Zhang; Somasekar Seshagiri; Kenneth J. Hillan

November 25, 2005

Attenuating lymphocyte activity: The crystal structure of the BTLA-HVEM complex

Journal of Biological Chemistry, ISSN: 00219258

Deanne M. Compaan; Lino C. Gonzalez Jr.; Irene Tom; Kelly M. Loyet; Dan L. Eaton; Sarah G. Hymowitz

November 22, 2005

Isolation and characterization of the B-cell marker CD20

Biochemistry, ISSN: 00062960

James A. Ernst; Hong Li; Hok Seon Kim; Nakamura; Yansura; Richard L. Vandlen

November 21, 2005

Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation

Journal of Experimental Medicine, ISSN: 00221007 00221007

Honglin Zhou; Denise M. Monack; Nobuhiko Kayagaki; Ingrid E. Wertz; Jianping Yin; Beni B. Wolf; Vishva M. Dixit

November 15, 2005

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

Developmental Biology, ISSN: 00121606

Scott R. May; Amir M. Ashique; Mattias Karlen; Baolin Wang; Yiguo Shen; Konstantinos Zarbalis; Jeremy Reiter; Johan Ericson; Andrew S. Peterson

November 15, 2005

Immune thrombocytopenia associated with efalizumab therapy for psoriasis [7]

Annals of Internal Medicine, ISSN: 00034819

Theodore E. Warkentin; Paul Kwon

November 11, 2005

Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking

Journal of Biological Chemistry, ISSN: 00219258

Mark Larance; Georg Ramm; Jacqueline Stöckli; Ellen M. Van Dam; Stephanie Winata; Valerie Wasinger; Fiona Simpson; Michael Graham; Jagath R. Junutula; Michael Guilhaus; David E. James

November 9, 2005

Concomitant administration of bevacizumab, irinotecan, 5-fluorouracil, and leucovorin: Nonclinical safety and pharmacokinetics

International Journal of Toxicology, ISSN: 10915818 1092874X

Jacques Gaudreault; Vanessa Shiu; Ann Bricarello; Brian J. Christian; Christina L. Zuch; Barbara Mounho

November 1, 2005

Angiogenic inhibitors: A new therapeutic strategy in oncology

Nature Clinical Practice Oncology, ISSN: 17434254 17434262

Giampietro Gasparini; Raffaele Longo; Masakazu Toi; Napoleone Ferrara

November 1, 2005

Aspirin sensitivity and severity of asthma: Evidence for irreversible airway obstruction in patients with severe or difficult-to-treat asthma

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Kimberly Mascia; Tmirah Haselkorn; Yamo Deniz; Dave P. Miller; Eugene R. Bleecker; Larry Borish

November 1, 2005

The ATPase motif in RAD51D is required for resistance to DNA interstrand crosslinking agents and interaction with RAD51C

Mutagenesis, ISSN: 02678357 14643804

Aaron M. Gruver; Kristi A. Miller; Changanamkandath Rajesh; Phillip G. Smiraldo; Saravanan Kaliyaperumal; Rachel Balder; Katie M. Stiles; Joanna S. Albala; Douglas L. Pittman

November 1, 2005

A causal inference approach for constructing transcriptional regulatory networks

Bioinformatics, ISSN: 13674803 14602059

Biao Xing; Mark J. van der Laan

November 1, 2005

Risk-based cleaning validation in biopharmaceutical API manufacturing

BioPharm International, ISSN: 1542166X

A. Hamid Mollah; Edward K. White

November 1, 2005

VEGF as a therapeutic target in cancer

Oncology, ISSN: 00302414

Napoleone Ferrara

November 1, 2005

Rapid on-membrane proteolytic cleavage for Edman sequencing and mass spectrometric identification of proteins

Electrophoresis, ISSN: 01730835

Victoria Pham; William J. Henzel; Jennie R. Lill

November 1, 2005

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

Immunity, ISSN: 10747613

Jochen Schmitz; Alexander M. Owyang; Elizabeth Oldham; Yaoli Song; Erin Murphy; Terrill McClanahan; Gerard Zurawski; Mehrdad Moshrefi; Jinzhong Qin; Xiaoxia Li; Daniel M. Gorman; J.Fernando Bazan; Robert A. Kastelein

November 1, 2005

Cutting edge: TRAIL deficiency accelerates hematological malignancies

Journal of Immunology, ISSN: 00221767

Nadeen Zerafa; Jennifer A. Westwood; Erika Cretney; Sally Mitchell; Waring; Manuela Iezzi; Mark J. Smyth

November 1, 2005

Severity assessment in asthma: An evolving concept

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Mary K. Miller; Charles A. Johnson; Dave P. Miller; Yamo Deniz; Eugene R. Bleecker; Sally E. Wenzel

November 1, 2005

Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers

Cancer Research, ISSN: 00085472

Daniel C. Gray; Adrian M. Jubb; Deborah A. Hogue; Patrick Dowd; Noelyn Kljavin; Sothy Yi; Wei Bai; Gretchen D. Frantz; Zemin Zhang; Koeppen; Frederic J. De Sauvage; David P. Davis

November 1, 2005

Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes

Molecular Biology of the Cell, ISSN: 10591524

Alexander C. Theos; Danièle Tenza; José A. Martina; Ilse Hurbain; Andrew A. Peden; Elena V. Sviderskaya; Abigail Stewart; Margaret S. Robinson; Dorothy C. Bennett; Daniel F. Cutler; Juan S. Bonifacino; Michael S. Marks; Graça Raposo

October 30, 2005

Involvement of α4 integrins in maintenance of cardiac sympathetic axons

Autonomic Neuroscience: Basic and Clinical, ISSN: 15660702

Kevin L. Wingerd; William C. Wayne; Jackson; Dennis O. Clegg

October 20, 2005

Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer

New England Journal of Medicine, ISSN: 00284793 15334406

Edward H. Romond; Edith A. Perez; John Bryant; Vera J. Suman; Charles E. Geyer Jr.; Nancy E. Davidson; Elizabeth Tan-Chiu; Silvana Martino; Soonmyung Paik; Peter A. Kaufman; Sandra M. Swain; Thomas M. Pisansky; Louis Fehrenbacher; Leila A. Kutteh; Victor G. Vogel; Daniel W. Visscher; Greg Yothers; Robert B. Jenkins; Ann M. Brown; Shaker R. Dakhil; Eleftherios P. Mamounas; Wilma L. Lingle; Pam Klein; James N. Ingle; Norman Wolmark

October 17, 2005

Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis

Journal of Experimental Medicine, ISSN: 00221007 00221007

Sanjeev Mariathasan; David S. Weiss; Vishva M. Dixit; Denise M. Monack

October 14, 2005

Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin

Journal of Biological Chemistry, ISSN: 00219258

Bin Fan; Thomas D Wu; Wei Li; Daniel Kirchhofer

October 7, 2005

Neuroscience: EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans

Science, ISSN: 00368075 10959203

Vuk Koprivica; Kin-Sang Cho; Jong Bae Park; Glenn Yiu; Jasvinder K. Atwal; Bryan B. Gore; Jieun A. Kim; Estelle Lin; Marc Tessier-Lavigne; Dong Feng Chen; Zhigang He

October 4, 2005

Achieving door-to-balloon times that meet quality guidelines: How do successful hospitals do it?

Journal of the American College of Cardiology, ISSN: 07351097

Elizabeth H. Bradley; Sarah A. Roumanis; Martha J. Radford; Tashonna R. Webster; Robert L. McNamara; Jennifer A. Mattera; Barbara A. Barton; David N. Berg; Edward L. Portnay; Harry Moscovitz; Janet Parkosewich; Eric S. Holmboe; Martha Blaney; Harlan M. Krumholz

October 1, 2005

TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice

Immunology and Cell Biology, ISSN: 08189641

Erika Cretney; Jonathan L. McQualter; Nobuhiko Kayagaki; Hideo Yagita; Claude C.A. Bernard; Iqbal S. Grewal; Avi Ashkenazi; Mark J. Smyth

October 1, 2005

The external RNA controls consortium: A progress report

Nature Methods, ISSN: 15487091 15491676

Shawn C. Baker; Steven R. Bauer; Richard P. Beyer; James D. Brenton; Bud Bromley; John Burrill; Helen Causton; Michael P. Conley; Rosalie Elespuru; Michael Fero; Carole Foy; James Fuscoe; Xiaolian Gao; David Lee Gerhold; Patrick Gilles; Federico Goodsaid; Xu Guo; Joe Hackett; Richard D. Hockett; Pranvera Ikonomi; Rafael A. Irizarry; Ernest S. Kawasaki; Tamma Kaysser-Kranich; Kathleen Kerr; Gretchen Kiser; Walter H. Koch; Kathy Y. Lee; Chunmei Liu; Z. Lewis Liu; Anne Lucas; Chitra F. Manohar; Garry Miyada; Zora Modrusan; Helen Parkes; Raj K. Puri; Laura Reid; Thomas B. Ryder; Marc Salit; Raymond R. Samaha; Uwe Scherf; Timothy J. Sendera; Robert A. Setterquist; Leming Shi; Richard Shippy; Jesus V. Soriano; Elizabeth A. Wagar; Janet A. Warrington; Mickey Williams; Frederike Wilmer; Mike Wilson; Paul K. Wolber; Xiaoning Wu; Renata Zadro

October 1, 2005

The septin-binding protein anillin is overexpressed in diverse human tumors

Clinical Cancer Research, ISSN: 10780432

Peter A. Hall; Christopher B. Todd; Paula L. Hyland; Simon S. McDade; Grabsch; Mit Dattani; Kenneth J. Hillan; S. E. Hilary Russell

October 1, 2005

Population pharmacokinetics of trastuzumab in patients with HER2+ metastatic breast cancer

Cancer Chemotherapy and Pharmacology, ISSN: 03445704

Rene Bruno; Carla Washington; Jian-Feng Lu; Lieberman; Ludger Banken; Pam Klein

October 1, 2005

Pathogen recognition: TLRs throw us a curve

Immunity, ISSN: 10747613

Peter Kirk; J.Fernando Bazan

September 23, 2005

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

Cell, ISSN: 00928674

Sophie Pattingre; Amina Tassa; Xueping Qu; Rita Garuti; Huan Liang Xiao; Noboru Mizushima; Milton Packer; Michael D. Schneider; Beth Levine

September 21, 2005

Inhibitory effects of interferon-γ on myocardial hypertrophy

Cytokine, ISSN: 10434666

Hongkui Jin; Wei Li; Renhui Yang; Annie Ogasawara; Hsienwie Lu; Nicholas F. Paoni

September 19, 2005

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae

Journal of Experimental Medicine, ISSN: 00221007

Kyle I. Happel; Patricia J. Dubin; Mingquan Zheng; Nico Ghilardi; Christie Lockhart; Lee J. Quinton; Anthony R. Odden; Judd E. Shellito; Gregory J. Bagby; Steve Nelson; Jay K. Kolls

September 15, 2005

A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging

Biochemical Journal, ISSN: 02646021

Stanley W. Botchway; Ignasi Barba; Randolf Jordan; Rebecca Harmston; Peter M. Haggie; Simon P. Williams; Alexandra M. Fulton; Anthony W. Parker; Kevin M. Brindle

September 15, 2005

Novel method of generating prostate-specific Cre-loxP gene switching via intraductal delivery of adenovirus

Prostate, ISSN: 02704137

Ching Ching Leow; Xi-De Wang; Gao

September 15, 2005

Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40

Cancer Research, ISSN: 00085472

Che-Leung Law; Kristine A. Gordon; John Collier; Kerry Klussman; Julie A. McEarchern; Charles G. Cerveny; Bruce J. Mixan; Wyne P. Lee; Zhonghau Lin; Patricia A. Valdez; Alan Wahl; Iqbal S. Grewal

September 13, 2005

Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Roland H. Friedel; Andrew Plump; Lu; Kerri Spilker; Christine Jolicoeur; Karen G. Wong; Tadmiri R. Venkatesh; Avraham Yaron; Mary Hynes; Bin Chen; Ami Okada; Susan K. McConnell; Helen Rayburn; Marc Tessier-Lavigne

September 1, 2005

Bioanalytical method validation for macromolecules in support of pharmacokinetic studies

Pharmaceutical Research, ISSN: 07248741 1573904X

JoMarie Smolec; Binodh DeSilva; Wendell Smith; Russell Weiner; Marian Kelly; Ben Lee; Masood Khan; Richard Tacey; Howard Hill; Abbie Celniker; Vinod Shah; Ronald Bowsher; Mire-Sluis; John W. A. Findlay; Mary Saltarelli; Quarmby; David Lansky; Robert Dillard; Martin Ullmann; Steve Keller; H. Thomas Karnes

September 1, 2005

Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab

Journal of Surgical Oncology, ISSN: 00224790

Frank A. Scappaticci; Louis Fehrenbacher; Cartwright; John Hainsworth; William Heim; Jordan Berlin; Fairooz F. Kabbinavar; Novotny; Somnath Sarkar; Herbert Hurwitz

September 1, 2005

Protein-interaction mapping in search of effective drug targets

BioEssays, ISSN: 02659247

Amitabha Chaudhuri; John Chant

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