Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10851 - 10900 OF 15805 RESULTS

Angiogenic inhibitors: A new therapeutic strategy in oncology
Nature Clinical Practice Oncology, ISSN: 17434254 17434262
Giampietro Gasparini; Raffaele Longo; Masakazu Toi; Napoleone Ferrara
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Involvement of α4 integrins in maintenance of cardiac sympathetic axons
Autonomic Neuroscience: Basic and Clinical, ISSN: 15660702
Kevin L. Wingerd; William C. Wayne; Jackson; Dennis O. Clegg
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Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
New England Journal of Medicine, ISSN: 00284793 15334406
Edward H. Romond; Edith A. Perez; John Bryant; Vera J. Suman; Charles E. Geyer Jr.; Nancy E. Davidson; Elizabeth Tan-Chiu; Silvana Martino; Soonmyung Paik; Peter A. Kaufman; Sandra M. Swain; Thomas M. Pisansky; Louis Fehrenbacher; Leila A. Kutteh; Victor G. Vogel; Daniel W. Visscher; Greg Yothers; Robert B. Jenkins; Ann M. Brown; Shaker R. Dakhil; Eleftherios P. Mamounas; Wilma L. Lingle; Pam Klein; James N. Ingle; Norman Wolmark
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Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
Journal of Experimental Medicine, ISSN: 00221007 00221007
Sanjeev Mariathasan; David S. Weiss; Vishva M. Dixit; Denise M. Monack
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Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin
Journal of Biological Chemistry, ISSN: 00219258
Bin Fan; Thomas D Wu; Wei Li; Daniel Kirchhofer
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Neuroscience: EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans
Science, ISSN: 00368075 10959203
Vuk Koprivica; Kin-Sang Cho; Jong Bae Park; Glenn Yiu; Jasvinder K. Atwal; Bryan B. Gore; Jieun A. Kim; Estelle Lin; Marc Tessier-Lavigne; Dong Feng Chen; Zhigang He
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Achieving door-to-balloon times that meet quality guidelines: How do successful hospitals do it?
Journal of the American College of Cardiology, ISSN: 07351097
Elizabeth H. Bradley; Sarah A. Roumanis; Martha J. Radford; Tashonna R. Webster; Robert L. McNamara; Jennifer A. Mattera; Barbara A. Barton; David N. Berg; Edward L. Portnay; Harry Moscovitz; Janet Parkosewich; Eric S. Holmboe; Martha Blaney; Harlan M. Krumholz
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Pathogen recognition: TLRs throw us a curve
Immunity, ISSN: 10747613
Peter Kirk; J.Fernando Bazan
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Population pharmacokinetics of trastuzumab in patients with HER2+ metastatic breast cancer
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Rene Bruno; Carla Washington; Jian-Feng Lu; Lieberman; Ludger Banken; Pam Klein
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The septin-binding protein anillin is overexpressed in diverse human tumors
Clinical Cancer Research, ISSN: 10780432
Peter A. Hall; Christopher B. Todd; Paula L. Hyland; Simon S. McDade; Grabsch; Mit Dattani; Kenneth J. Hillan; S. E. Hilary Russell
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The external RNA controls consortium: A progress report
Nature Methods, ISSN: 15487091 15491676
Shawn C. Baker; Steven R. Bauer; Richard P. Beyer; James D. Brenton; Bud Bromley; John Burrill; Helen Causton; Michael P. Conley; Rosalie Elespuru; Michael Fero; Carole Foy; James Fuscoe; Xiaolian Gao; David Lee Gerhold; Patrick Gilles; Federico Goodsaid; Xu Guo; Joe Hackett; Richard D. Hockett; Pranvera Ikonomi; Rafael A. Irizarry; Ernest S. Kawasaki; Tamma Kaysser-Kranich; Kathleen Kerr; Gretchen Kiser; Walter H. Koch; Kathy Y. Lee; Chunmei Liu; Z. Lewis Liu; Anne Lucas; Chitra F. Manohar; Garry Miyada; Zora Modrusan; Helen Parkes; Raj K. Puri; Laura Reid; Thomas B. Ryder; Marc Salit; Raymond R. Samaha; Uwe Scherf; Timothy J. Sendera; Robert A. Setterquist; Leming Shi; Richard Shippy; Jesus V. Soriano; Elizabeth A. Wagar; Janet A. Warrington; Mickey Williams; Frederike Wilmer; Mike Wilson; Paul K. Wolber; Xiaoning Wu; Renata Zadro
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TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice
Immunology and Cell Biology, ISSN: 08189641
Erika Cretney; Jonathan L. McQualter; Nobuhiko Kayagaki; Hideo Yagita; Claude C.A. Bernard; Iqbal S. Grewal; Avi Ashkenazi; Mark J. Smyth
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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
Cell, ISSN: 00928674
Sophie Pattingre; Amina Tassa; Xueping Qu; Rita Garuti; Huan Liang Xiao; Noboru Mizushima; Milton Packer; Michael D. Schneider; Beth Levine
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Inhibitory effects of interferon-γ on myocardial hypertrophy
Cytokine, ISSN: 10434666
Hongkui Jin; Wei Li; Renhui Yang; Annie Ogasawara; Hsienwie Lu; Nicholas F. Paoni
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Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
Journal of Experimental Medicine, ISSN: 00221007
Kyle I. Happel; Patricia J. Dubin; Mingquan Zheng; Nico Ghilardi; Christie Lockhart; Lee J. Quinton; Anthony R. Odden; Judd E. Shellito; Gregory J. Bagby; Steve Nelson; Jay K. Kolls
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Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40
Cancer Research, ISSN: 00085472
Che-Leung Law; Kristine A. Gordon; John Collier; Kerry Klussman; Julie A. McEarchern; Charles G. Cerveny; Bruce J. Mixan; Wyne P. Lee; Zhonghau Lin; Patricia A. Valdez; Alan Wahl; Iqbal S. Grewal
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Novel method of generating prostate-specific Cre-loxP gene switching via intraductal delivery of adenovirus
Prostate, ISSN: 02704137
Ching Ching Leow; Xi-De Wang; Gao
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A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging
Biochemical Journal, ISSN: 02646021
Stanley W. Botchway; Ignasi Barba; Randolf Jordan; Rebecca Harmston; Peter M. Haggie; Simon P. Williams; Alexandra M. Fulton; Anthony W. Parker; Kevin M. Brindle
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Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Roland H. Friedel; Andrew Plump; Lu; Kerri Spilker; Christine Jolicoeur; Karen G. Wong; Tadmiri R. Venkatesh; Avraham Yaron; Mary Hynes; Bin Chen; Ami Okada; Susan K. McConnell; Helen Rayburn; Marc Tessier-Lavigne
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Mutations increasing exposure of a receptor binding site epitope in the soluble and oligomeric forms of the caprine arthritis-encephalitis lentivirus envelope glycoprotein
Virology, ISSN: 00426822
Isidro Hötzel; William P. Cheevers
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NMR methods for studying the structure and dynamics of RNA
ChemBioChem, ISSN: 14394227
Michael P. Latham; Darin J. Brown; Scott A. McCallum; Arthur Pardi
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Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis
Protein Science, ISSN: 09618368 1469896X
Gábor Pál; Shun-Yin Fong; Anthony A. Kossiakoff; Sachdev S. Sidhu
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Separation of genomic DNA from plasmid DNA by selective renaturation with immobilized metal affinity capture
Biotechnology Progress, ISSN: 87567938
Tony Cano; Jason C. Murphy; George E. Fox; Richard C. Willson
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Alcohol as a risk factor for plaque-type psoriasis
Cutis, ISSN: 00114162
Shahrad M. Behnam; Shahdad E. Behnam; John Y. Koo
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Partial remission of psoriasis following rituximab therapy for non-hodgkin lymphoma
Cutis, ISSN: 00114162
Fiza Singh; Jeffrey M. Weinberg
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Technical report # 39: Cold chain guidance for medicinal products: Maintaining the quality of temperature-sensitive medicinal products through the transportation environment
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Rafik H. Bishara; Jim Antonopoulos; Mari Bakken; Daniel Colton; Laura Fontan; Derrick Gallagher; Paul Harber; Kelly Klien; Chris Landauer; Teresa Lucas; Sarvang Mishra; Kevin O'Donnell; Oumer Salim; Jeff Seeley; Bob Seevers; Edward G. Smith; Douglas Staruk; Donald Wilson
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Effect of statin use within the first 24 hours of admission for acute myocardial infarction on early morbidity and mortality
American Journal of Cardiology, ISSN: 00029149
Gregg C. Fonarow; R. Scott Wright; Frederick A. Spencer; Paul D. Fredrick; Wei Dong; Nathan R. Every; William J. French
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Recombinant tissue plasminogen activator for minor strokes: The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study experience
Annals of Emergency Medicine, ISSN: 01960644
Steven R. Levine; Joseph P. Broderick; Thomas Brott; Thomas DeGraba; Susan C. Fagan; Michael R. Frankel; James C. Grotta; E. Clarke Haley Jr.; Scott Hamilton; Thomas Kwiatkowski; Christopher A. Lewandowski; Yan Lin; Richard Libman; Mei Lu; Patrick Lyden; John R. Marler; Lewis Morgenstern; Suresh Patel; Corsee Sanders; Barbara C. Tilley
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Portfolio management by late-phase design
Good Clinical Practice Journal, ISSN: 13500961
Susan Morris; Elizabeth Tschosik
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Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab
Breast Cancer Research and Treatment, ISSN: 01676806
Noel Dybdal; Grazyna Leiberman; Steven M. Anderson; Bryan McCune; Alex Bajamonde; Robert L. Cohen; Robert Mass; Corsee Sanders; Michael F. Press
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Protein-interaction mapping in search of effective drug targets
BioEssays, ISSN: 02659247
Amitabha Chaudhuri; John Chant
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Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab
Journal of Surgical Oncology, ISSN: 00224790
Frank A. Scappaticci; Louis Fehrenbacher; Cartwright; John Hainsworth; William Heim; Jordan Berlin; Fairooz F. Kabbinavar; Novotny; Somnath Sarkar; Herbert Hurwitz
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Bioanalytical method validation for macromolecules in support of pharmacokinetic studies
Pharmaceutical Research, ISSN: 07248741 1573904X
JoMarie Smolec; Binodh DeSilva; Wendell Smith; Russell Weiner; Marian Kelly; Ben Lee; Masood Khan; Richard Tacey; Howard Hill; Abbie Celniker; Vinod Shah; Ronald Bowsher; Mire-Sluis; John W. A. Findlay; Mary Saltarelli; Quarmby; David Lansky; Robert Dillard; Martin Ullmann; Steve Keller; H. Thomas Karnes
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ERM is required for transcriptional control of the spermatogonial stem cell niche
Nature, ISSN: 00280836
Chen Chen; Wenjun Ouyang; Vadim Grigura; Qing Zhou; Kay Carnes; Hyunjung J. Lim; Guang-Quan Zhao; Silvia Arber; Natasza Kurpios; Theresa L. Murphy; Alec M. Cheng; John A. Hassell; Varadaraj Chandrashekar; Marie-Claude Hofmann; Rex A. Hess; Kenneth M. Murphy
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Sex and racial differences in the management of acute myocardial infarction, 1994 through 2002
New England Journal of Medicine, ISSN: 00284793
Viola Vaccarino; Saif S. Rathore; Nanette K. Wenger; Paul D. Frederick; Jerome L. Abramson; Hal V. Barron; Ajay Manhapra; Susmita Mallik; Harlan M. Krumholz
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Relationship between time of day, day of week, timeliness of reperfusion, and in-hospital mortality for patients with acute ST-segment elevation myocardial infarction
JAMA - Journal of the American Medical Association, ISSN: 00987484
David J. Magid; Yongfei Wang; Jeph Herrin; Robert L. McNamara; Elizabeth H. Bradley; Jeptha P. Curtis; Charles V. Pollack Jr.; William J. French; Martha Blaney; Harlan M. Krumholz
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Relationship between time of day, day of week, timeliness of reperfusion, and in-hospital mortality for patients with acute ST-segment elevation myocardial infarction
JAMA - Journal of the American Medical Association, ISSN: 15383598 00987484
David J. Magid; Yongfei Wang; Jeph Herrin; Robert L. McNamara; Elizabeth H. Bradley; Jeptha P. Curtis; Charles V. Pollack Jr.; William J. French; Martha Blaney; Harlan M. Krumholz
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APC-independent NK cell activation [1] (multiple letters)
Journal of Immunology, ISSN: 00221767
Zhongjun Dong; Zhigang Tian; Kerstin N. Schmidt; Beatrice Leung; Mandy Kwong; Kol A. Zarember; Sanjeev Satyal; Tony A. Navas; Fay Wang; Godowski
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Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers
Biochemical Journal, ISSN: 02646021
Sylvia Herter; Derek E. Piper; Wade Aaron; Timothy Gabriele; Cutler; Ping Cao; Ami S. Bhatt; Youngchool Choe; Charles S. Craik; Nigel Walker; David Meininger; Timothy Hoey; Richard J. Austin
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Unambiguous assignment of intramolecular chemical cross-links in modified mammalian membrane proteins by Fourier transform-tandem mass spectrometry
Analytical Chemistry, ISSN: 00032700
Petr Novak; William E. Haskins; Marites J. Ayson; Richard B. Jacobsen; Joseph S. Schoeniger; Michael D. Leavell; Malin M. Young; Gary H. Kruppa
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Phosphorylation of FADD at serine 194 by CKIα regulates its nonapoptotic activities
Molecular Cell, ISSN: 10972765
Elizabeth C. Alappat; Christine Feig; Benjamin Boyerinas; Jörg Volkland; Martin Samuels; Andrea E. Murmann; Andrew Thorburn; Vincent J. Kidd; Clive A. Slaughter; Stephanie L. Osborn; Astar Winoto; Wei-Jen Tang; Marcus E. Peter
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Unraveling TACIt functions
Nature Genetics, ISSN: 10614036
Flavius Martin; Vishva M. Dixit
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Safety and tolerability of omalizumab (Xolair®), a recombinant humanized monoclonal anti-IgE antibody
Clinical Reviews in Allergy and Immunology, ISSN: 10800549
Yamo Deniz; Niroo Gupta
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Loss of the serine/threonine kinase Fused results in postnatal growth defects and lethality due to progressive hydrocephalus
Molecular and Cellular Biology, ISSN: 02707306
Mark Merchant; Marie Evangelista; Shiuh-Ming Luoh; Gretchen D. Frantz; Sreedevi Chalasani; Richard A. D. Carano; Marjie Van Hoy; Julio Ramirez; Annie Ogasawara; Leanne McFarland; Ellen H. Filvaroff; French; Frederic J. De Sauvage
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Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)
Journal of Pathology, ISSN: 00223417
Laura A. Strickland; Adrian M. Jubb; Hongo; Fiona Zhong; Jennifer Burwick; Ling Fu; Gretchen D. Frantz; Koeppen
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Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A
Journal of Cell Biology, ISSN: 00219525
Parker L. Andersen; Honglin Zhou; Landon Pastushok; Trevor Moraes; Sean McKenna; Barry Ziola; Michael J. Ellison; Vishva M. Dixit; Wei Xiao
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Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy
Biochemical and Biophysical Research Communications, ISSN: 0006291X
Napoleone Ferrara; Kenneth J. Hillan; Novotny
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Quality of care by classification of myocardial infarction. Treatment patterns for ST-segment elevation vs non-ST-segment elevation myocardial infarction
Archives of Internal Medicine, ISSN: 00039926
Matthew T. Roe; Lori Parsons; Charles V. Pollack Jr.; John G. Canto; Hal V. Barron; Nathan R. Every; William J. Rogers; Eric D. Peterson
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EphB2 is a prognostic factor in colorectal cancer
Clinical Cancer Research, ISSN: 10780432
Adrian M. Jubb; Fiona Zhong; Sheila Bheddah; Grabsch; Gretchen D. Frantz; Wolfram Mueller; Kavi; Philip Quirke; Paul G. Polakis; Koeppen
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IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-γ responses if IL-12p70 is available
Journal of Immunology, ISSN: 00221767
Shabaana A. Khader; John E. Pearl; Kaori Sakamoto; Leigh Gilmartin; Guy Bell; Dawn M. Jelley-Gibbs; Nico Ghilardi; Frederic J. De Sauvage; Andrea M. Cooper
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