Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 11001 - 11050 OF 15583 RESULTS

February 20, 2004

Tumor Necrosis Factor: An Apoptosis JuNKie?

Cell, ISSN: 00928674

Eugene Varfolomeev; Avi Ashkenazi

February 15, 2004

Combining Liquid Chromatography with MALDI Mass Spectrometry Using a Heated Droplet Interface

Analytical Chemistry, ISSN: 00032700

Boyan Zhang; Chris McDonald; Liang Li

February 10, 2004

Similar Molecular Interactions of Factor VII and Factor VIIa with the Tissue Factor Region that Allosterically Regulates Enzyme Activity

Biochemistry, ISSN: 00062960

Robert F. Kelley; Yang; Eigenbrot; Paul Moran; Peek; Michael T. Lipari; Daniel Kirchhofer

February 9, 2004

Vancomycin disulfide derivatives as antibacterial agents

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

YongQi Mu; Matthew B. Nodwell; John Pace; Jeng-Pyng Shaw; J. Kevin Judice

February 1, 2004

Kinase RIP3 Is Dispensable for Normal NF-κBs, Signaling by the B-Cell and T-Cell Receptors, Tumor Necrosis Factor Receptor 1, and Toll-Like Receptors 2 and 4

Molecular and Cellular Biology, ISSN: 02707306

Kim Newton; Xiaoqing Sun; Vishva M. Dixit

February 1, 2004

APRIL-Deficient Mice Have Normal Immune System Development

Molecular and Cellular Biology, ISSN: 02707306

Eugene Varfolomeev; Frank C. Kischkel; Flavius Martin; Dhaya Seshasayee; Hua Wang; David Lawrence; Christine Olsson; Lucrece Tom; Sharon Erickson; French; Peter Schow; Iqbal S. Grewal; Avi Ashkenazi

February 1, 2004

Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice

International Immunology, ISSN: 09538178

Conchi Mora; Iqbal S. Grewal; F. Susan Wong; Richard A. Flavell

February 1, 2004

Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency

Molecular and Cellular Biology, ISSN: 02707306

Kim Newton; French; Minhong Yan; Gretchen D. Frantz; Vishva M. Dixit

February 1, 2004

EphB2 as a Therapeutic Antibody Drug Target for the Treatment of Colorectal Cancer

Cancer Research, ISSN: 00085472

Mao; Luis; Ross; Johnny Silva; Christine Tan; Crowley; Clarissa Chui; Gretchen Franz; Peter Senter; Koeppen; Paul G. Polakis

February 1, 2004

Endocytosed Cation-Independent Mannose 6-Phosphate Receptor Traffics via the Endocytic Recycling Compartment en Route to the trans-Golgi Network and a Subpopulation of Late Endosomes

Molecular Biology of the Cell, ISSN: 10591524

Sharron X. Lin; William Mallet; Amy Y. Huang; Frederick R. Maxfield

January 30, 2004

PEST Domain-Enriched Tyrosine Phosphatase (PEP) Regulation of Effector/Memory T Cells

Science, ISSN: 00368075

Kiminori Hasegawa; Flavius Martin; Guangming Huang; Daniel B. Tumas; Laurie Diehl; Andrew A. Chan

January 29, 2004

Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion

Oncogene, ISSN: 09509232

Beatrix Schäfer; Andreas Gschwind; Axel Ullrich

January 26, 2004

Quinine/Quinidine-Induced Thrombocytopenia: A Great Imitator

Archives of Internal Medicine, ISSN: 00039926

Josina C. Reddy; Shuman; Richard H. Aster

January 23, 2004

Factorial screening of antibody purification processes using three chromatography steps without protein A

Journal of Chromatography A, ISSN: 00219673

Deborah K. Follman; Fahrner

January 22, 2004

Recordings from Single Neocortical Nerve Terminals Reveal a Nonselective Cation Channel Activated by Decreases in Extracellular Calcium

Neuron, ISSN: 08966273

Stephen M. Smith; Jeremy B. Bergsman; Nobutoshi C. Harata; Richard H. Scheller; Richard W. Tsien

January 15, 2004

Alteplase for Treatment of Occluded Peripherally Inserted Central Catheters: Safety and Efficacy in 240 Patients

Journal of Vascular and Interventional Radiology, ISSN: 10510443

Rita Ng; Xin Li; Tri Tu; Charles P. Semba

January 9, 2004

Rip2 Participates in Bcl10 Signaling and T-cell Receptor-mediated NF-κB Activation

Journal of Biological Chemistry, ISSN: 00219258

Astrid A. Ruefli-Brasse; Wyne P. Lee; Stephen D. Hurst; Vishva M. Dixit

January 8, 2004

Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

Nature, ISSN: 00280836

Honglin Zhou; Ingrid E. Wertz; Karen M. O'Rourke; Ultsch; Somasekar Seshagiri; Mike Eby; Wei Xiao; Vishva M. Dixit

January 2, 2004

Structure-activity relationships by mass spectrometry: Identification of novel MMP-3 inhibitors

Bioorganic and Medicinal Chemistry, ISSN: 09680896

Denise A. Ockey; Jennafer Dotson; Martin Struble; Stults; James H. Bourell; Clark; Thomas Gadek

January 1, 2004

A Substrate-phage approach for investigating caspase specificity

Protein Journal, ISSN: 18758355 15723887

Samantha Lien; Richard Pastor; Daniel P. Sutherlin; Henry B. Lowman

January 1, 2004

Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal

Cytotherapy, ISSN: 14653249

Judy Young; Wu; Hansteen; Du; Sambucetti; Remiszewski; O'Farrell; Hill; Lavau; Lesley J. Murray

January 1, 2004

Mycobacterium marinum: The generalization and specialization of a pathogenic mycobacterium

Microbes and Infection, ISSN: 1769714X 12864579

Luisa M. Stamm; Eric J. Brown

January 1, 2004

Quality Assurance Practices for Pharmaceutical Industry-Based Drug Information Departments: A Review and Case Study

Therapeutic Innovation and Regulatory Science, ISSN: 21684790

Stacey M. Fung; Joyce Serrano Martin

January 1, 2004

Bevacizumab (Avastin).

Clinical journal of oncology nursing, ISSN: 10921095

Gena Middleton; Denise V Lapka

January 1, 2004

Re: Catheter-directed Thrombolytic Therapy for Limb Ischemia: Current Status and Controversies [1]

Journal of Vascular and Interventional Radiology, ISSN: 10510443

Charles P. Semba; Iris Tam; Martha Blaney

January 1, 2004

Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells

American Journal of Pathology, ISSN: 00029440

Robert D. Galiano; Oren M. Tepper; Catherine R. Pelo; Kirit A. Bhatt; Matthew Callaghan; Nicholas Bastidas; Bunting; Hope Steinmetz; Geoffrey C. Gurtner

January 1, 2004

From functional genomics to target validation: The quest for better drugs

Drug Discovery Today: TARGETS, ISSN: 17418372

Jean-Philippe Stephan

January 1, 2004

A blockade in Wnt signaling is activated following the differentiation of F9 teratocarcinoma cells

Experimental Cell Research, ISSN: 00144827

Sayumi Shibamoto; Jane Winer; Mickey P. Williams; Paul G. Polakis

January 1, 2004

Discovery of novel PTP1b inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Denise A. Ockey; Thomas Gadek

January 1, 2004

Bivalent antibody phage display mimics natural immunoglobulin

Journal of Immunological Methods, ISSN: 00221759

Chingwei V. Lee; Sachdev S. Sidhu; Fuh

January 1, 2004

Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis

Nature Medicine, ISSN: 10788956

Scott T. Avecilla; Koichi Hattori; Beate Heissig; Rafael Tejada; Fang Liao; Koji Shido; David K. Jin; Sergio Dias; Fan Zhang; Travis E. Hartman; Neil R. Hackett; Crystal; Larry Witte; Daniel J. Hicklin; Peter Bohlen; Dan L. Eaton; David Lyden; Frederic J. De Sauvage; Shahin Rafii

January 1, 2004

Neutralizing VEGF Bioactivity with a Soluble Chimeric VEGF-Receptor Protein flt(I-3) IgG Inhibits Testosterone-Stimulated Prostate Growth in Castrated Mice

Prostate, ISSN: 02704137

Ingela Franck Lissbrant; Peter Hammarsten; Erik Lissbrant; Napoleone Ferrara; Stina Häggström Rudolfsson; Anders Bergh

January 1, 2004

Ureagenesis: Evidence for a lack of hepatic regulation of acid-base equilibrium in humans

American Journal of Physiology - Renal Physiology, ISSN: 03636127

Markus Hosch; Juergen Muser; Henry N. Hulter; Reto Krapf

January 1, 2004

Maintaining change control in part 11 - Compliant systems - A quality systems approach

American Pharmaceutical Review, ISSN: 10998012

Peter Bland

January 1, 2004

APC-Independent Activation of NK Cells by the Toll-Like Receptor 3 Agonist Double-Stranded RNA

Journal of Immunology, ISSN: 00221767

Kerstin N. Schmidt; Beatrice Leung; Mandy Kwong; Kol A. Zarember; Sanjeev Satyal; Tony A. Navas; Fay Wang; Godowski

January 1, 2004

Design and baseline characteristics of The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study: A large cohort of patients with severe or difficult-to-treat asthma

Annals of Allergy, Asthma and Immunology, ISSN: 10811206

Chantal M. Dolan; Kyle Fraher; Eugene R. Bleecker; Larry Borish; Bradley E. Chipps; Mary Lou Hayden; Weiss; Zheng; Charles A. Johnson; Sally E. Wenzel

January 1, 2004

Editorial introductions

Current Opinion in Nephrology and Hypertension, ISSN: 10624821

Barry M. Brenner; Marc R. Hammerman; Matthew R. Weir; Ronald C. Blantz; Pierre M. Ronco

January 1, 2004

Single lead ST-segment recovery: A simple, reliable measure of successful fibrinolysis after acute myocardial infarction

American Heart Journal, ISSN: 00028703

Mushabbar A. Syed; Steven Borzak; Abed Asfour; Madhavi Gunda; Omar Obeidat; Sabina A. Murphy; Raymond J. Gibbons; Steven G. Gourlay; Hal V. Barron; W.Douglas Weaver; Michael Hudson

January 1, 2004

Treatment of Pulmonary Arterial Hypertension with Sildenafil

Hospital Pharmacy, ISSN: 00185787

Stacey M. Fung; Mary J. Ferrill

January 1, 2004

Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor

Thrombosis and Haemostasis, ISSN: 03406245

Sabine Raab; Heike Beck; Andreas Gaumann; Ali Yüce; Hans-Peter Gerber; Karl Plate; Hans-Peter Hammes; Napoleone Ferrara; Georg Breier

January 1, 2004

Reflections on Rice's formulae for level crossings - History, extensions and use

Australian and New Zealand Journal of Statistics, ISSN: 13691473

Leadbetter; Spaniolo

January 1, 2004

Evaluation of procedures for amplification of small-size samples for hybridization on microarrays

Genomics, ISSN: 08887543

Sandra Klur; Toy; Mickey P. Williams; Ulrich Certa

January 1, 2004

The HER receptor family: A rich target for therapeutic development

International Journal of Radiation Oncology Biology Physics, ISSN: 03603016

Robert Mass

January 1, 2004

Quantification of Tumor Tissue Populations by Multispectral Analysis

Magnetic Resonance in Medicine, ISSN: 07403194

Richard A. D. Carano; Adrienne L. Ross; Ross; Simon P. Williams; Koeppen; Ralph H. Schwall; Nicholas Van Bruggen

January 1, 2004

Substrate capacity consideration in developing kinase assays

Assay and Drug Development Technologies, ISSN: 1540658X

Laura DeForge; Andrea G. Cochan; Sherry Yeh; Brian S. Robinson; Karen L Billeci; Wai Lee T. Tong

January 1, 2004

Raman Spectroscopic Characterization of Drying-Induced Structural Changes in a Therapeutic Antibody: Correlating Structural Changes with Long-Term Stability

Journal of Pharmaceutical Sciences, ISSN: 00223549

Samir Sane; Wong; Chung C. Hsu

January 1, 2004

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

Cancer Cell, ISSN: 15356108

Matthew C Franklin; Kendall Carey; Vajdos; Daniel J. Leahy; De Vos; Mark X. Sliwkowski

January 1, 2004

The discovery of receptor tyrosine kinases: Targets for cancer therapy

Nature Reviews Cancer, ISSN: 1474175X

Andreas Gschwind; Oliver M. Fischer; Axel Ullrich

January 1, 2004

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

Nature Reviews Drug Discovery, ISSN: 14741776

Napoleone Ferrara; Kenneth J. Hillan; Hans-Peter Gerber; Novotny

January 1, 2004

Hydrophobic vancomycin derivatives with improved ADME properties: Discovery of telavancin (TD-6424)

Journal of Antibiotics, ISSN: 00218820

Michael R. Leadbetter; Stacy M. Adams; Bettina Bazzini; Paul R. Fatheree; Dane E. Karr; Kevin M. Krause; Bernice M.T. Lam; Martin S. Linsell; Matthew B. Nodwell; John Pace; Kelly Quast; Jeng-Pyng Shaw; Elizabeth Soriano; Sean Trapp; Jenny D. Villena; Terry X. Wu; Burton G. Christensen; J. Kevin Judice

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