Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

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January 1, 2004

EG-VEGF: A novel mediator of endocrine-specific angiogenesis, endothelial phenotype, and function

Annals of the New York Academy of Sciences, ISSN: 00778923

Jennifer Lecouter; Rui Lin; Napoleone Ferrara

January 1, 2004

Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products

Journal of Immunological Methods, ISSN: 00221759

Mire-Sluis; Yu Chen Barrett; Viswanath Devanarayan; Koren; Hank Liu; Mauricio Maia; Thomas Parish; George Scott; Gopi Shankar; Elizabeth Shores; Steven J. Swanson; Gary Taniguchi; Daniel Wierda; Linda A. Zuckerman

January 1, 2004

Benzyl alcohol-induced destabilization of interferon-γ: A study by hydrogen-deuterium isotope exchange

Journal of Pharmaceutical Sciences, ISSN: 00223549

Scott A. Tobler; Bryan W. Holmes; Cromwell; Erik J. Fernandez

January 1, 2004

Challenges in the development of high protein concentration formulations

Journal of Pharmaceutical Sciences, ISSN: 00223549

Steven J. Shire; Shahrokh; Jun Liu

January 1, 2004

Thrombolysis for lower extremity deep venous thrombosis

Techniques in Vascular and Interventional Radiology, ISSN: 10892516

Charles P. Semba; Mahmood K Razavi; Stephen T. Kee; Daniel Y. Sze; Michael D. Dake

January 1, 2004

Phage display-derived ligands provide structural insight into insulin-like growth factor I function

Spectroscopy, ISSN: 07124813

Nicholas J. Skelton; Schaffer; Deshayes; Tamas Blandl; Steven T. Runyon; Nakamura; Sachdev S. Sidhu

January 1, 2004

The Sema domain of Met is necessary for receptor dimerization and activation

Cancer Cell, ISSN: 15356108

Monica Kong-Beltran; Jennifer Stamos; Dineli Wickramasinghe

January 1, 2004

Neonatal hypoglycemia in a growth hormone registry: Incidence and pathogenesis

Journal of Pediatric Endocrinology and Metabolism, ISSN: 0334018X

Jennifer J. Bell; Gilbert P. August; Sandra L. Blethen; Joyce Baptista

January 1, 2004

Targeting death receptors in cancer with Apo2L/TRAIL

Current Opinion in Pharmacology, ISSN: 14714892

Kelley; Avi Ashkenazi

January 1, 2004

Structure-based models of cadherin-mediated cell adhesion: The evolution continues

Cellular and Molecular Life Sciences, ISSN: 1420682X

Alexander W. Koch; Manzur; Shan

January 1, 2004

Bioprocess equipment: Characterization of energy dissipation rate and its potential to damage cells

Biotechnology Progress, ISSN: 87567938

Mike Mollet; Ningning Ma; Yang Zhao; Robert Brodkey; Ron Taticek; Jeffrey J. Chalmers

January 1, 2004

WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair

American Journal of Pathology, ISSN: 00029440

French; Raji J. Kaul; Aloma L. D'Souza; Crowley; Bao; Gretchen D. Frantz; Ellen H. Filvaroff; Luc Desnoyers

January 1, 2004

Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesis

Annals of Allergy, Asthma and Immunology, ISSN: 10811206

Jonathan Corren; David Diaz-Sanchez; Andrew Saxon; Yamo Deniz; Reimann; Sinclair; Teresa Davancaze; Daniel C. Adelman

January 1, 2004

Inhibitors of tissue factor•factor VIIa for anticoagulant therapy

Current Medicinal Chemistry, ISSN: 09298673

Lazarus; Alan G. Olivero; Eigenbrot; Daniel Kirchhofer

January 1, 2004

Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal

Cytotherapy, ISSN: 14653249

Judy C. Young; Wu; Hansteen; Du; Sambucetti; Remiszewski; O'Farrell; Hill; Lavau; Lesley J. Murray

January 1, 2004

Quantitative structure-pharmacokinetic parameters relationships (QSPKR) analysis of antimicrobial agents in humans using simulated annealing k-nearest-neighbor and partial least-square analysis methods

Journal of Pharmaceutical Sciences, ISSN: 00223549

Chee Ng; Yun-De Xiao; Wendy Putnam; Bert L. Lum; Alexander Tropsha

January 1, 2004

Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis

Cancer Cell, ISSN: 15356108

Nan Tang; Lianchun Wang; Jeffrey Esko; Frank J. Giordano; Yan Huang; Hans-Peter Gerber; Napoleone Ferrara; Randall S. Johnson

January 1, 2004

Quality assurance practices for pharmaceutical industry-based drug information departments: A review and case study

Drug Information Journal, ISSN: 00928615

Stacey M. Fung; Joyce Serrano Martin

January 1, 2004

Effect of cardiac dysfunction of treatment outcomes in women receiving trastuzumab for HER2-overexpressing metastatic breast cancer

Clinical Breast Cancer, ISSN: 15268209

Debasish Tripathy; Andrew Seidman; Deborah Keefe; Clifford Hudis; Virginia Paton; Lieberman

January 1, 2004

Quantification of bone lesions in rheumatoid arthritis by MRI multispectral tissue class transition analysis

Seminars in Musculoskeletal Radiology, ISSN: 1098898X 10897860

Richard A. D. Carano; John A. Lynch

January 1, 2004

Ureagenesis: Evidence for a lack of hepatic regulation of acid-base equilibrium in humans

American Journal of Physiology - Renal Physiology, ISSN: 15221466 1931857X

Markus Hosch; Juergen Muser; Henry N. Hulter; Reto Krapf

December 22, 2003

Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz

Journal of Cell Biology, ISSN: 00219525

James E. Wilhelm; Meredith Hilton; Quinlan Amos; William J. Henzel

December 20, 2003

Application of Multivirus Spike Approach for Viral Clearance Evaluation

Biotechnology and Bioengineering, ISSN: 00063592

Christine Valera; Janice W. Chen; Yuan Xu

December 17, 2003

Efalizumab for Patients with Moderate to Severe Plaque Psoriasis: A Randomized Controlled Trial

JAMA - Journal of the American Medical Association, ISSN: 00987484

Kenneth B. Gordon; Kim Papp; Tiffani K. Hamilton; Patricia Walicke; Wolfgang Dummer; Nicole F. Li; Bresnahan; Alan Menter

December 15, 2003

Activation of Toll-Like Receptor 2 on Human Tracheobronchial Epithelial Cells Induces the Antimicrobial Peptide Human β Defensin-2

Journal of Immunology, ISSN: 00221767

Cheryl J. Hertz; Qi Wu; Edith Martin Porter; Yan J. Zhang; Karl-Heinz Weismüller; Godowski; Tomas Ganz; Scott H. Randell; Robert L. Modlin

December 12, 2003

Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling

Science, ISSN: 00368075

Anna I. Lyuksyutova; Chin-Chun Lu; Nancy Milanesio; Leslie A. King; Nini Guo; Yanshu Wang; Jeremy Nathans; Marc Tessier-Lavigne; Yimin Zou

December 9, 2003

IL-27 regulates IL-12 responsiveness of naïve CD4+ T cells through Stat1-dependent and -independent mechanisms

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Sophie Lucas; Nico Ghilardi; Ji Li; Frederic J. De Sauvage

December 4, 2003

IGF-I Receptor Mutations Resulting in Intrauterine and Postnatal Growth Retardation

New England Journal of Medicine, ISSN: 00284793

M. Jennifer Abuzzahab; Anke Schneider; Goddard; Florin Grigorescu; Corinne Lautier; Eberhard Keller; Wieland Kiess; Jürgen Klammt; Jürgen Kratzsch; Doreen Osgood; Roland Pfäffle; Klemens Raile; Berthold Seidel; Robert J. Smith; Chernausek

December 1, 2003

Angiogenesis: New opportunities and solutions for drug development. Predictive markers for antiangiogenic drugs

Expert Opinion on Investigational Drugs, ISSN: 13543784

Hans-Peter Gerber

December 1, 2003

VEGF and bone

Journal of Musculoskeletal Neuronal Interactions, ISSN: 11087161

Ellen H. Filvaroff

December 1, 2003

Semi-synthetic glycopeptide antibacterials

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

J. Kevin Judice; John Pace

December 1, 2003

Generation of Fine Powders of Recombinant Human Deoxyribonuclease Using the Aerosol Solvent Extraction System

Pharmaceutical Research, ISSN: 07248741

Rana T. Bustami; Chan; Sweeney; Fariba Dehghani; Neil R. Foster

December 1, 2003

Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543

Xenobiotica, ISSN: 00498254

S. Cyrus Khojasteh; Rossulek; Fouda; Chandra Prakash

December 1, 2003

B cell defects in SLP65/BLNK-deficient mice can be partially corrected by the absence of CD22, an inhibitory coreceptor for BCR signaling

European Journal of Immunology, ISSN: 00142980

Judith Gerlach; Snigdha Ghosch; Hassan Jumaa; Michael Reth; Jürgen Wienands; Andrew A. Chan; Lars Nitschke

December 1, 2003

Hair Cell Development in Higher Vertebrates

Current Topics in Developmental Biology, ISSN: 00702153

Gao

December 1, 2003

The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons

Nature Neuroscience, ISSN: 10976256

John C. Lin; Ho; Austin L. Gurney; Rosenthal

December 1, 2003

Nonlinear models for repeated measurement data: An overview and update

Journal of Agricultural, Biological, and Environmental Statistics, ISSN: 10857117

Davidian; Giltinan

December 1, 2003

Underlying chronic granulomatous disease in a patient with bronchocentric granulomatosis

Thorax, ISSN: 00406376

Moltyaner; Geerts; Chamberlain; Heyworth; Noack; Julie Rae; Doyle; Downey

December 1, 2003

Regulation of interactions of endotoxin with host cells

Journal of Endotoxin Research, ISSN: 09680519

Theresa L. Gioannini; Athmane Teghanemt; Kol A. Zarember; Weiss

November 28, 2003

Regulation of NF-κB-Dependent Lymphocyte Activation and Development by Paracaspase

Science, ISSN: 00368075

Astrid A. Ruefli-Brasse; French; Vishva M. Dixit

November 28, 2003

Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress

Journal of Biological Chemistry, ISSN: 00219258

Laura Leung; Mandy Kwong; Stephen Hou; Candy Lee; Jefferson Y. Chan

November 28, 2003

Stanniocalcin 1 Is an Autocrine Modulator of Endothelial Angiogenic Responses to Hepatocyte Growth Factor

Journal of Biological Chemistry, ISSN: 00219258

Constance Zlot; Gladys S. Ingle; Hongo; Suya Yang; Zhong Sheng; Ralph H. Schwall; Nicholas F. Paoni; Fay Wang; Franklin V. Peale Jr.; Mary E. Gerritsen

November 27, 2003

A New Synthetic Approach to the C Ring of Known as Well as Novel Bryostatin Analogues

Organic Letters, ISSN: 15237060

Paul A. Wender; Michael F. T. Koehler; Martin Sendzik

November 24, 2003

Systematic identification of regulatory proteins critical for T-cell activation

Journal of Biology, ISSN: 14785854 14754924

Peter C. Chu; Jorge Pardo; Haoran Zhao; Connie C. Li; Erlina Pali; Mary M. Shen; Kunbin Qu; Simon X. Yu; Betty Huang; Peiwen Yu; Esteban S. Masuda; Susan M. Molineaux; Frank Kolbinger; Gregorio Aversa; Jan De Vries; Donald G. Payan; X. Charlene Liao

November 20, 2003

A Novel Targeted T-Cell Modulator, Efalizumab, for Plaque Psoriasis

New England Journal of Medicine, ISSN: 00284793

Mark Lebwohl; Stephen K. Tyring; Tiffani K. Hamilton; Darryl P. Toth; Scott Glazer; Naji H. Tawfik; Patricia Walicke; Wolfgang Dummer; Xiaolin Wang; Marvin Garovoy; David M. Pariser

November 13, 2003

A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor

Neuron, ISSN: 08966273

Sonia K. Pollitt; Judit Pallos; Jieya Shao; Urvee A. Desai; Aye Aye K. Ma; Leslie Michels Thompson; J. Lawrence Marsh; Marc I. Diamond

November 13, 2003

Assembling Polycyclic Bisguanidine Motifs Resembling Batzelladine Alkaloids by Double Tethered Biginelli Condensations

Organic Letters, ISSN: 15237060

Frederick Cohen; Shawn K. Collins; Larry E. Overman

November 7, 2003

Signaling from FGF Receptors in Development and Disease

Handbook of Cell Signaling,

Monica Kong-Beltran; Daniel J. Donoghue

November 7, 2003

The Mechanism of NGF Suggested by the NGF-TrkA-D5 Complex

Handbook of Cell Signaling,

De Vos; Wiesmann

November 7, 2003

Mammalian Brain Morphogenesis and Midline Axon Guidance Require Heparan Sulfate

Science, ISSN: 00368075

Masaru Inatani; Fumitoshi Irie; Andrew Plump; Marc Tessier-Lavigne; Yu Yamaguchi

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