Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 11251 - 11300 OF 16291 RESULTS

January 1, 2006

Mayo Clinic consensus statement for the use of bisphosphonates in multiple myeloma

Mayo Clinic Proceedings, ISSN: 00256196

Martha Lacy; Angela Dispenzieri; Morie A. Gertz; Philip R. Greipp; Kimberly L. Gollbach; Suzanne R. Hayman; Shaji Kumar; John A. Lust; S. Vincent Rajkumar; Stephen J. Russell; Witzig; Steven R. Zeldenrust; David Dingli; P. Lief Bergsagel; Rafael Fonseca; Craig B. Reeder; A. Keith Stewart; Vivek Roy; Robert J. Dalton; Alan B. Carr; Deepak Kademani; Eugene E. Keller; Christopher F. Viozzi; Robert A. Kyle

January 1, 2006

Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Thomas B. Casale; William W. Busse; Joel N. Kline; Zuhair K. Ballas; Mark H. Moss; Robert G. Townley; Masoud Mokhtarani; Vicki Seyfert-Margolis; Adam Asare; Kirk Bateman; Yamo Deniz

January 1, 2006

Pharmacokinetics/pharmacodynamics of nondepleting anti-CD4 monoclonal antibody (TRX1) in healthy human volunteers

Pharmaceutical Research, ISSN: 07248741

Chee Ng; Stefanich; Banmeet S. Anand; Fielder; Louis Vaickus

January 1, 2006

Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei

International Journal of Infectious Diseases, ISSN: 12019712

Steven P. LaRosa; Steven M. Opal; Barbara Utterback; Sau Chi Betty Yan; Jeffrey D. Helterbrand; Andrew J.H. Simpson; Wipada Chaowagul; Nicholas J. White; Charles J. Fisher Jr.

January 1, 2006

Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma

AIDS Research and Human Retroviruses, ISSN: 08892229

Seth Rakoff-Nahoum; Peter Kuebler; Jonas J. Heymann; Megan E. Sheehy; Gabriel M. Ortiz; Graham S. Ogg; Jason D. Barbour; Jack Lenz; Alan D. Steinfeld; Douglas F. Nixon

January 1, 2006

Proteomic studies support the use of multi-product immunoassays to monitor host cell protein impurities

Proteomics, ISSN: 16159853 16159861

Denise C. Krawitz; William F. Forrest; G. Tony Moreno; Joshua Kittleson; Kathleen M. Champion

January 1, 2006

The crystal structure of murine coronin-1: A regulator of actin cytoskeletal dynamics in lymphocytes

Structure, ISSN: 09692126

Brent A. Appleton; Ping Wu; Wiesmann

January 1, 2006

Cytokines, NF-kappaB, microenvironment, intestinal inflammation and cancer.

Cancer treatment and research, ISSN: 09273042

Arndt J Schottelius; Harald Dinter

January 1, 2006

IL-27 limits IL-2 production during Th1 differentiation

Journal of Immunology, ISSN: 00221767

Alejandro V. Villarino; Jason S. Stumhofer; Christiaan J. M. Saris; Robert A. Kastelein; Frederic J. De Sauvage; Christopher A. Hunter

January 1, 2006

Discovery of thrombin activatable fibrinolysis inhibitor (TAFI)

Journal of Thrombosis and Haemostasis, ISSN: 15387836 15387933

Bertina; Van Tilburg; Haverkate; Bouma; Von Dem Borne; Meijers; William Campbell; Dan L. Eaton; Dirk F. Hendriks; Willemse

January 1, 2006

Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to Leishmania donovani infection but develop severe liver immunopathology

American Journal of Pathology, ISSN: 00029440

Lucia E. Rosas; Anjali A. Satoskar; Kimberly M. Roth; Tracy L. Keiser; Joseph Barbi; Christopher A. Hunter; Frederic J. De Sauvage; Abhay R. Satoskar

January 1, 2006

Nontraditional roles for certified pharmacy technicians in a pharmaceutical company

Journal of the American Pharmacists Association, ISSN: 15443450 15443191

Stacey M. Fung; Christine Gilmour; David McCracken; Korban Shane; Gary Matsuura

January 1, 2006

Synthetic therapeutic antibodies

Nature Chemical Biology, ISSN: 15524469 15524450

Sachdev S. Sidhu; Frederic A. Fellouse

January 1, 2006

Clinical and psychosocial characteristics of men with erectile dysfunction: Baseline data from ExCEED™

Journal of Sexual Medicine, ISSN: 17436109 17436095

David M. Latini; David F. Penson; Katrine L. Wallace; Deborah Lubeck; Tom F. Lue

January 1, 2006

Longitudinal differences in psychological outcomes for Men with erectile dysfunction: Results from ExCEED™

Journal of Sexual Medicine, ISSN: 17436109 17436095

David M. Latini; David F. Penson; Katrine L. Wallace; Deborah Lubeck; Tom F. Lue

January 1, 2006

Paracrine VEGF/VE-cadherin action on ovarian cancer permeability

Experimental Biology and Medicine, ISSN: 15353699 15353702

Limin Hu; Napoleone Ferrara; Robert B. Jaffe

January 1, 2006

Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Aditya A. Wakankar; Ronald T. Borchardt

January 1, 2006

Targeted therapies in solid tumors: Monoclonal antibodies and small molecules

Human Antibodies, ISSN: 10932607

Louis M. Weiner; Hossein Borghaei

January 1, 2006

Regulation of ERK3/MAPK6 expression by BRAF

International Journal of Oncology, ISSN: 17912423 10196439

Klaus P. Hoeflich; Mike Eby; William F. Forrest; Daniel C. Gray; Janet Y. Tien; Howard M. Stern; Lesley J. Murray; David P. Davis; Zora Modrusan; Somasekar Seshagiri

January 1, 2006

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

ACS Chemical Biology, ISSN: 15548937

Zobel; Lan Wang; Eugene Varfolomeev; Matthew C Franklin; Linda O. Elliott; Heidi J. A. Wallweber; David C Okawa; Flygare; Domagoj Vucic; Wayne J. Fairbrother; Deshayes

January 1, 2006

Is tobacco use a problem among deaf college students?

American Annals of the Deaf, ISSN: 0002726X

Barbara A. Berman; Coen A. Bernaards; Elizabeth A. Eckhardt; Heidi B. Kleiger; Lauren Maucere; Leanne Streja; Glenn Wong; Shari Barkin; Roshan Bastani

January 1, 2006

Evaluation of erlotinib in advanced non-small cell lung cancer: Impact on the budget of a U.S. health insurance plan

Journal of Managed Care Pharmacy, ISSN: 10834087

Scott D. Ramsey; Lauren Clarke; Tripthi V. Kamath; Deborah Lubeck

January 1, 2006

The application of mechanism-based PK/PD modeling in pharmacodynamic-based dose selection of muM17, a surrogate monoclonal antibody for efalizumab

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Benjamin Wu; Amita Joshi; Song Ren; Chee Ng

January 1, 2006

Apples and oranges: Comparing computer systems audits

Drug Information Journal, ISSN: 00928615

Jacques Mourrain

January 1, 2006

Counterpoint: Why biogenerics are a strawman

Nature Biotechnology, ISSN: 15461696 10870156

Robert L. Garnick

January 1, 2006

Large-scale trends in the evolution of gene structures within 11 animal genomes

PLoS Computational Biology, ISSN: 15537358 1553734X

Mark Yandell; Chris J. Mungall; Chris Smith; Simon Prochnik; Joshua S. Kaminker; George Hartzell; Suzanna E. Lewis; Gerald M. Rubin

December 27, 2005

Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Michelle A. Lowes; Francesca Chamian; Maria V. Abello; Judilyn Fuentes-Duculan; Shao-Lee Lin; Rachel Nussbaum; Inna Novitskaya; Henrietta Carbonaro; Irma Cardinale; Toyoko Kikuchi; Patricia Gilleaudeau; Mary Sullivan-Whalen; Knut Wittkowski; Kim Papp; Marvin Garovoy; Wolfgang Dummer; Ralph M. Steinman; James G. Krueger

December 27, 2005

TGF-β regulates the mechanical properties and composition of bone matrix

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Guive Balooch; Mehdi Balooch; Ravi K. Nalla; Stephen Schilling; Ellen H. Filvaroff; Grayson W. Marshall; Sally J. Marshall; Robert O. Ritchie; Rik Derynck; Tamara Alliston

December 24, 2005

Identification of the minimal protein domain required for priming activity of munc13-1

Current Biology, ISSN: 09609822

David R. Stevens; Zheng-Xing Wu; Ulf Matti; Harald Junge; Claudia Schirra; Ute Becherer; Sonja M. Wojcik; Nils Brose; Jens Rettig

December 15, 2005

Angiogenesis as a therapeutic target

Nature, ISSN: 00280836 14764679

Napoleone Ferrara; Robert S. Kerbel

December 15, 2005

Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients

Clinical Cancer Research, ISSN: 10780432

Robert Yauch; Thomas Januario; Eberhard; Guy Cavet; Wenjing Zhu; Ling Fu; Thinh Q. Pham; Robert Soriano; Stinson; Somasekar Seshagiri; Zora Modrusan; Chin-Yu Lin; Vincent O'Neill; Lukas Amler

December 14, 2005

MORT1/FADD is involved in liver regeneration

World Journal of Gastroenterology, ISSN: 10079327

Marcus Schuchmann; Felix Rückert; Jose F. Garcia-Lazaro; Andrea Karg; Jürgen Burg; Natalia Knorr; Jürgen Siebler; Eugene Varfolomeev; David Wallach; Wolfgang Schreiber; Ansgar W. Lohse; Peter R. Galle

December 13, 2005

Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Cary D. Austin; Xiaohui Wen; Lewis Gazzard; Nelson; Richard H. Scheller; Suzie J. Scales

December 12, 2005

Interspecies exchange mutagenesis of the first epidermal growth factor-like domain of human factor VII

Journal of Thrombosis and Haemostasis, ISSN: 15387933 15387836

Williamson; Pyke; Sampath Sridhara; Robert F. Kelley; Morris A. Blajchman; Bryan J. Clarke

December 9, 2005

Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Eugene Varfolomeev; Heather Maecker; Darcie Sharp; David Lawrence; Renz; Domagoj Vucic; Avi Ashkenazi

December 8, 2005

P63 is an essential proapoptotic protein during neural development

Neuron, ISSN: 08966273

W. Bradley Jacobs; Gregory Govoni; Daniel Ho; Jasvinder K. Atwal; Fanie Barnabe-Heider; William M. Keyes; Alea A. Mills; Freda D. Miller; David R. Kaplan

December 8, 2005

A smooth operator for LPS responses

Nature Immunology, ISSN: 15292908 15292916

Godowski

December 2, 2005

TWEAK attenuates the transition from innate to adaptive immunity

Cell, ISSN: 00928674

Heather Maecker; Eugene Varfolomeev; Frank C. Kischkel; David Lawrence; Heidi LeBlanc; Wyne P. Lee; Stephen D. Hurst; Dimitry Danilenko; Jun Li; Ellen H. Filvaroff; Becky Yang; Dylan Daniel; Avi Ashkenazi

December 1, 2005

Salutary effects of combining early very low-dose systemic estradiol with growth hormone therapy in girls with Turner syndrome

Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X

Rosenfield; Nancy Devine; Joanne Julius Hunold; Nelly Mauras; Thomas Moshang Jr.; Allen W. Root

December 1, 2005

Analysis of protein therapeutics by capillary electrophoresis: Applications and challenges

Developments in Biologicals, ISSN: 14246074

Stacey Ma

December 1, 2005

Quantitative structure-activity relationships of methotrexate and methotrexate analogues transported by the rat multispecific resistance- associated protein 2 (rMrp2)

European Journal of Pharmaceutical Sciences, ISSN: 09280987

Chee Ng; Yun-De Xiao; Bert L. Lum; Yong-Hae Han

December 1, 2005

Expression of HIF-1α in human tumours [5]

Journal of Clinical Pathology, ISSN: 00219746

Adrian M. Jubb; Kenneth J. Hillan

December 1, 2005

Rituximab in combination with fludarabine chemotherapy in low-grade or follicular lymphoma

Journal of Clinical Oncology, ISSN: 0732183X

Myron S. Czuczman; Koryzna; Mohr; Stewart; Donohue; Blumenson; Bernstein; McCarthy; Alam; Hernandez-Ilizaliturri; Skipper; Brown; Chanan-Khan; Klippenstein; Loud; Mike K Rock; Benyunes; Grillo-Lopez; Bernstein

December 1, 2005

Development and the boundaries of the firm: A knowledge-based examination in drug development

Academy of Management 2005 Annual Meeting: A New Vision of Management in the 21st Century, AOM 2005,

Jeffrey T. Macher; Christopher S. Boerner

December 1, 2005

Targeted therapy: Wave of the future

Journal of Clinical Oncology, ISSN: 0732183X

Pegram; Pietras; Alex Bajamonde; Pam Klein; Gwendolyn Fyfe

December 1, 2005

Requirement for the SnoN oncoprotein in transforming growth factor β-induced oncogenic transformation of fibroblast cells

Molecular and Cellular Biology, ISSN: 02707306

Qingwei Zhu; Sonia Pearson-White; Kunxin Luo

December 1, 2005

Class I FIPs, Rab11-binding proteins that regulate endocytic sorting and recycling

Methods in Enzymology, ISSN: 00766879

Elizabeth Tarbutton; Andrew A. Peden; Jagath R. Junutula; Rytis Prekeris

December 1, 2005

Agreement in histologic assessments of the pituitary pars intermedia in aged horses

American Journal of Veterinary Research, ISSN: 00029645

Dianne McFarlane; Lisa M. Miller; Linden E. Craig; Noel Dybdal; Perry L. Habecker; Margaret A. Miller; Jon S. Patterson; Alastair E. Cribb

December 1, 2005

Heterogeneity of recombinant antibodies: Linking structure to function

Developments in Biologicals, ISSN: 14246074

Reed J. Harris

December 1, 2005

Isolation and culture of hair cell progenitors from postnatal rat cochleae

Journal of Neurobiology, ISSN: 00223034

Suo-qiang Zhai; Li Shi; Bu-Er Wang; Gui-liang Zheng; Wei Song; Yin-yan Hu; Gao

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