Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 12101 - 12150 OF 16477 RESULTS

March 1, 2003

A randomized controlled trial evaluating the efficacy and safety of intermittent 3-, 4-, and 5-day cycles of intravenous recombinant human interleukin-2 combined with antiretroviral therapy (ART) versus ART alone in HIV-seropositive patients with 100-300 CD4+ T cells

Clinical Immunology, ISSN: 15216616

Alberdina W. De Boer; Norman Markowitz; H.Clifford Lane; Louis D. Saravolatz; Susan L. Koletar; Haig Donabedian; Carl Yoshizawa; A-M. Duliege; Gwendolyn Fyfe; Ronald T. Mitsuyasu

March 1, 2003

Intravenous mouse infection model for studying the pathology of Enterococcus faecalis infections

Infection and Immunity, ISSN: 00199567

Claudia Gentry-Weeks; Monica Estay; Cindy Loui; Dale Baker

March 1, 2003

α-1-acid glycoprotein as an independent predictor for treatment effects and a prognostic factor of survival in patients with non-small cell lung cancer treated with docetaxel

Clinical Cancer Research, ISSN: 10780432

Rene Bruno; Robert Olivares; Jocelyne Berille; Philip Chaikin; Nicole Vivier; Luz Hammershaimb; Gerald R. Rhodes; James R. Rigas

March 1, 2003

Selective cyclin-dependent kinase 2/cyclin A antagonists that differ from ATP site inhibitors block tumor growth

Cancer Research, ISSN: 00085472

Nerissa Mendoza; Fong; James C. Marsters Jr.; Koeppen; Ralph H. Schwall; Dineli Wickramasinghe

February 28, 2003

Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the erbin PDZ domain

Journal of Biological Chemistry, ISSN: 00219258

Nicholas J. Skelton; Michael F. T. Koehler; Zobel; Wai Lee T. Wong; Sherry Yeh; Pisabarro; Jianping Yin; Lasky; Sachdev S. Sidhu

February 15, 2003

High-throughput protein sequencing

Analytical Chemistry, ISSN: 00032700

Victoria Pham; Jake Tropea; Suzy Wong; James Quach; William J. Henzel

February 15, 2003

Inhibition of human papilloma virus E2 DNA binding protein by covalently linked polyamides

Nucleic Acids Research, ISSN: 03051048

Thomas D. Schaal; William Mallet; Dustin McMinn; Nam V. Nguyen; Michelle M. Sopko; Sam John; Bhavin S. Parekh

February 7, 2003

Angiogenesis-independent endothelial protection of liver: Role of VEGFR-1

Science, ISSN: 00368075

Jennifer Lecouter; Dirk R. Moritz; Bing Li; Gail L. Phillips; Xiao Huan Liang; Hans-Peter Gerber; Kenneth J. Hillan; Napoleone Ferrara

February 6, 2003

Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists

Neuron, ISSN: 08966273

Mala Murthy; Dan Garza; Richard H. Scheller; Thomas L. Schwarz

February 1, 2003

A profile hidden Markov model for signal peptides generated by HMMER

Bioinformatics, ISSN: 13674803

Zemin Zhang; William I. Wood

February 1, 2003

Differential scanning calorimetric, circular dichroism, and Fourier transform infrared spectroscopic characterization of the thermal unfolding of xylanase A from Streptomyces lividans

Proteins: Structure, Function and Bioinformatics, ISSN: 08873585

Roberge; Ruthven N.A.H. Lewis; François Shareck; Rolf Morosoli; Dieter Kluepfel; Claude Dupont; Ronald N. McElhaney

February 1, 2003

Adhesion molecules as therapeutic targets for autoimmune diseases and transplant rejection

Expert Opinion on Biological Therapy, ISSN: 14712598

Russell L Dedrick; Bodary; Marvin Garovoy

February 1, 2003

A unified model for apical caspase activation

Molecular Cell, ISSN: 10972765

Kelly M. Boatright; Martin Renatus; Fiona L. Scott; Sabina Sperandio; Hwain Shin; Irene M. Pedersen; Jean-Ehrland Ricci; Wade A. Edris; Daniel P. Sutherlin; Douglas R. Green; Guy S. Salvesen

February 1, 2003

Impairment of myocardial perfusion in both culprit and nonculprit arteries in acute myocardial infarction: A LIMIT AMI substudy

American Journal of Cardiology, ISSN: 00029149

Sabina A. Murphy; Christopher Chen; Steven G. Gourlay; Raymond J. Gibbons; Hal V. Barron; C.Michael Gibson

February 1, 2003

Do growth hormone (GH) serial sampling, insulin-like growth factor-I (IGF-I) or auxological measurements have an advantage over GH stimulation testing in predicting the linear growth response to GH therapy?

Clinical Endocrinology, ISSN: 03000664

Alan D. Rogol; Sandra L. Blethen; Judy P. Sy; Johannes D. Veldhuis

February 1, 2003

Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor

Immunity, ISSN: 10747613

Dhaya Seshasayee; Patricia A. Valdez; Minhong Yan; Vishva M. Dixit; Daniel B. Tumas; Iqbal S. Grewal

February 1, 2003

Early treatment with hepatocyte growth factor improves cardiac function in experimental heart failure induced by myocardial infarction

Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565

Hongkui Jin; Renhui Yang; Wei Li; Annie Ogasawara; Ralph H. Schwall; Eberhard; Zhong Zheng; David W. Kahn; Nicholas F. Paoni

February 1, 2003

Isolating Substrates for an Engineered α-Lytic Protease by Phage Display

Journal of Protein Chemistry, ISSN: 02778033

Samantha Lien; Geoffrey L. Francis; Lloyd D. Graham; John C. Wallace

February 1, 2003

Turn stability in β-hairpin peptides: Investigation of peptides containing 3:5 type I G1 bulge turns

Protein Science, ISSN: 09618368

Tamas Blandl; Andrea G Cochran; Nicholas J. Skelton

January 29, 2003

UV Raman spectrum of 1,3-dimethylcyclopentenyl cation adsorbed in zeolite H-MFI

Journal of the American Chemical Society, ISSN: 00027863

Yek Tann Chua; Peter C. Stair; John B. Nicholas; Weiguo Song; James F. Haw

January 28, 2003

Distribution of toll-like receptor 1 and toll-like receptor 2 in human lymphoid tissue

Immunology, ISSN: 00192805

Maria Teresa Ochoa; Annaliza Legaspi; Zena Hatziris; Godowski; Robert L. Modlin; Peter A. Sieling

January 23, 2003

Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

Nature, ISSN: 00280836

Claudia Kemper; Andrew A. Chan; Jonathan M. Green; Kelly A. Brett; Kenneth M. Murphy; John P. Atkinson

January 17, 2003

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

Journal of Biological Chemistry, ISSN: 00219258

Aggarwal; Nico Ghilardi; Xie; Frederic J. De Sauvage; Austin L. Gurney

January 15, 2003

Stability of cyclic β-hairpins: Asymmetric contributions from side chains of a hydrogen-bonded cross-strand residue pair

Journal of the American Chemical Society, ISSN: 00027863

Russell; Tamas Blandl; Nicholas J. Skelton; Andrea G Cochran

January 3, 2003

Exploring protein-protein interactions with phage display

ChemBioChem, ISSN: 14394227

Sachdev S. Sidhu; Wayne J. Fairbrother; Deshayes

January 1, 2003

An overview of quantitative PCR assays for biologicals: quality and safety evaluation.

Developments in Biologicals, ISSN: 14246074

Yuan Xu; Kurt Brorson

January 1, 2003

The Crystal Structures of EDA-A1 and EDA-A2: Splice Variants with Distinct Receptor Specificity

Structure, ISSN: 09692126

Sarah G. Hymowitz; Deanne M. Compaan; Minhong Yan; Heidi J. A. Wallweber; Vishva M. Dixit; Melissa A. Starovasnik; De Vos

January 1, 2003

Tissue microarrays in drug discovery

Nature Reviews Drug Discovery, ISSN: 14741776

Guido Sauter; Ronald Simon; Kenneth J. Hillan

January 1, 2003

Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulations

AAPS Journal, ISSN: 15507416

Andya; Chung C. Hsu; Steven J. Shire

January 1, 2003

EGFR signal transactivation in cancer cells

Biochemical Society Transactions, ISSN: 03005127

Oliver M. Fischer; Stefan Hart; Andreas Gschwind; Axel Ullrich

January 1, 2003

EphA/ephrin-A interactions regulate epileptogenesis and activity-dependent axonal sprouting in adult rats

Molecular and Cellular Neuroscience, ISSN: 10447431

Xu; Li; Brown; Gerlai; Fahnestock; Racine

January 1, 2003

Development of a Patient Recruitment Program for Phase 2 Trials in a Biotechnology Company

Drug Information Journal, ISSN: 00928615

Stacey M. Fung; Ellen Suen; Herbert B. Lee

January 1, 2003

Is there evidence of implicit exclusion criteria for elderly subjects in randomized trials? Evidence from the GUSTO-1 study

American Heart Journal, ISSN: 00028703

Harlan M. Krumholz; Cary P. Gross; Eric D. Peterson; Hal V. Barron; Martha J. Radford; Lori Parsons; Nathan R. Every

January 1, 2003

B cell therapy for rheumatoid arthritis: The rituximab (anti-CD20) experience

Annals of the Rheumatic Diseases, ISSN: 00034967

Tim Shaw; Joanne M. Quan; Totoritis

January 1, 2003

Hepatocytes Express Nerve Growth Factor during Liver Injury: Evidence for Paracrine Regulation of Hepatic Stellate Cell Apoptosis

American Journal of Pathology, ISSN: 00029440

Fiona Oakley; Nathan Trim; Christothea M. Constandinou; Weilan Ye; Gray; Gretchen D. Frantz; Kenneth J. Hillan; Tim Kendall; R. Christopher Benyon; Derek A. Mann; John P. Iredale

January 1, 2003

Cyclic pressure modulates endothelial barrier function

Endothelium: Journal of Endothelial Cell Research, ISSN: 10623329

Hainsworth Y. Shin; Rena Bizios; Mary E. Gerritsen

January 1, 2003

Differential in vivo effects of rituximab on two B-cell subsets in cynomolgus monkeys

International Immunopharmacology, ISSN: 15675769

Yulia Vugmeyster; Howell; Kathleen McKeever; Dan Combs; Eleanor Canova-Davis

January 1, 2003

Trastuzumab and Cardiac Dysfunction: Update on Preclinical Studies

Seminars in Oncology, ISSN: 00937754

Pam Klein; Noel Dybdal

January 1, 2003

Pharmacodynamics of omalizumab: Implications for optimised dosing strategies and clinical efficacy in the treatment of allergic asthma

Current Medical Research and Opinion, ISSN: 03007995

Guenther Hochhaus; Laurence Brookman; Howard Fox; Charles A. Johnson; Matthews; Song Ren; Yamo Deniz

January 1, 2003

Protein identification: The origins of peptide mass fingerprinting

Journal of the American Society for Mass Spectrometry, ISSN: 10440305

William J. Henzel; Colin K. Watanabe; Stults

January 1, 2003

Characterization of gentamicin-resistant Mycoplasma hyorhinis

Biologicals, ISSN: 10451056

Arit D. Idowu; Michelle C. Celones; Amparo E. Salgado; Kristine M. Marquez; Nancy Pleibel

January 1, 2003

Molecular targets in cancer therapy

Seminars in Oncology Nursing, ISSN: 07492081

Danielle M. Gale

January 1, 2003

Trends in cancer therapy: Role of monoclonal antibodies

Seminars in Oncology Nursing, ISSN: 07492081

Kristi V. Schmidt; Barbara A. Wood

January 1, 2003

Apo2L/TRAIL: Apoptosis signaling, biology, and potential for cancer therapy

Cytokine and Growth Factor Reviews, ISSN: 13596101

Alexandru Almasan; Avi Ashkenazi

January 1, 2003

Preclinical studies with erlotinib (Tarceva)

Seminars in Oncology, ISSN: 00937754

Robert W. Akita; Mark X. Sliwkowski

January 1, 2003

An antibody to VEGF upregulates factor VIII via interleukin-1 in activated adrenal cortex-derived capillary endothelial cells

International Immunopharmacology, ISSN: 15675769

Wenlu Li; Gilbert-Andre Keller

January 1, 2003

Effect of Anti-CD20 Monoclonal Antibody, Rituxan, on Cynomolgus Monkey and Human B Cells in a Whole Blood Matrix

Cytometry Part A, ISSN: 15524922

Yulia Vugmeyster; Howell; Anahid Bakshl; Flores; Eleanor Canova-Davis

January 1, 2003

Regulation of thymocyte development: Only the meek survive

Current Opinion in Immunology, ISSN: 09527915

Paul E. Love; Andrew A. Chan

January 1, 2003

Neutralizing interferon alpha as a therapeutic approach to autoimmune diseases

Cytokine and Growth Factor Reviews, ISSN: 13596101

Stewart

January 1, 2003

Use of process data to assess chromatographic performance in production-scale protein purification columns

Biotechnology Progress, ISSN: 87567938

Tina M. Larson; Jeff Davis; Harry Lam; Cacia

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