Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 12601 - 12650 OF 15583 RESULTS

January 1, 1998

Evaluation of product comparability.

Developments in biological standardization, ISSN: 03015149

Stuart E. Builder

January 1, 1998

Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists

Bioorganic and Medicinal Chemistry, ISSN: 09680896

Kirk D. Robarge; Dina; Todd C. Somers; Arthur Lee; Thomas E. Rawson; Alan G. Olivero; Maureen Tischler; Robert R. Webb II; Kenneth J Weese; Ignacio Aliagas; Brent Blackburn

January 1, 1998

Making informed choices: Medium, serum, and serum-free medium how to choose the appropriate medium and culture system for the model you wish to create

Methods in Cell Biology, ISSN: 0091679X

Mather

January 1, 1998

Purification and Physical Characterization of Cloned Human cAMP Phosphodiesterases PDE-4D and -4C

Cell Biochemistry and Biophysics, ISSN: 10859195

Natalie Saldou; Preston A. Baecker; Bin Li; Zhengyu Yuan; Rena Obernolte; James Ratzliff; Eric Osen; Kurt Jarnagin; Earl R. Shelton

January 1, 1998

Real-time measurement of lysis of mural platelet deposits by fibrinolytic agents under arterial flow

Annals of Biomedical Engineering, ISSN: 00906964

Dionne A. Graham; Trevor C. Huang; Keyt; B. Rita Alevriadou

January 1, 1998

The dormant in vivo phenotype of early stage primary human melanoma: Termination by overexpression of vascular endothelial growth factor

Angiogenesis, ISSN: 09696970

Liisa Bayko; Janusz Rak; Shan Man; Roy Bicknell; Napoleone Ferrara; Robert S. Kerbel

January 1, 1998

Therapeutic potential of neurotrophins for treatment of hearing loss

Molecular Neurobiology, ISSN: 08937648

Gao

January 1, 1998

Biological response to ErbB ligands in nontransformed cell lines correlates with a specific pattern of receptor expression

Endocrinology, ISSN: 00137227

Sundaresan; Penelope E. Roberts; King; Mark X. Sliwkowski; Mather

January 1, 1998

Raw materials as a source of contamination in large-scale cell culture.

Developments in biological standardization, ISSN: 03015149

Robert L. Garnick

January 1, 1998

Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice

Diabetes, ISSN: 00121797

Seamus K. Sreenan; Brian N. Cockburn; Aaron C. Baldwin; Diane M. Ostrega; Matteo Levisetti; Andrew Grupe; Graeme I. Bell; Stewart; Michael W. Roe; Kenneth S. Polonsky

January 1, 1998

Development of a single-shot subunit vaccine for HIV-1. 5. Programmable in vivo autoboost and long lasting neutralizing response

Journal of Pharmaceutical Sciences, ISSN: 00223549

Cleland; Lim; Daugherty; Barron; Noelyn Desardin; Duenas; Eastman; Vennari; Wrin; Berman; Michael Powel

January 1, 1998

Distinct molecular phenotypes in murine cardiac muscle development, growth, and hypertrophy

Journal of Molecular and Cellular Cardiology, ISSN: 00222828

Schoenfeld; Vasser; Jhurani; Ng; John J. Hunter; John Ross Jr.; Kenneth R. Chien; David G Lowe

January 1, 1998

Fast Edman cycles with accelerated PTH analysis

Protein Journal, ISSN: 18758355 15723887

William J. Henzel; Jake Tropea; Kishiyama; Wendy Shillinglaw; David Dupont; Steve O'Neil

December 19, 1997

Determination of Ro 48-3656 in rat plasma by reversed-phase high-performance liquid chromatography. Comparison of 1.5-μm nonporous silica to 3.5-μm porous silica analytical columns

Journal of Chromatography B: Biomedical Applications, ISSN: 15726495

Paasch; Yvonne S. Lin; Seth Porter; Modi; Timothy J. Barder

December 15, 1997

Recombinant human growth hormone poly(lactic-co-glycolic acid) (PLGA) microspheres provide a long lasting effect

Journal of Controlled Release, ISSN: 01683659

Cleland; Duenas; Daugherty; Marian; Yang; Wilson; Abbie Celniker; Shahzamani; Quarmby; Chu; Mukku; Mac; Roussakis; Nancy Gillette; Brooks Boyd; Yeung; Brooks; Maa; Chung C. Hsu; Andrew J.S. Jones

December 15, 1997

The effect of size, charge and cyclization of model peptides on their in vitro release from DL-PLGA microspheres

Journal of Controlled Release, ISSN: 01683659

Okumu; Cleland; Ronald T. Borchardt

December 12, 1997

Heregulins and the ErbB-2/3/4 receptors in gliomas

Journal of Neuro-Oncology, ISSN: 0167594X

Manfred Westphal; Leonie Meima; Szonyi; Julie A. Lofgren; Meissner; Wolfgang Hamel; Nikolics; Mark X. Sliwkowski

December 9, 1997

A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

James Verna; Adriana Lodder; Kyunghee Lee; Alicia Vagts; Roymarie Ballester

December 9, 1997

Inhibition of HIV type 1 infectivity by constrained α-helical peptides: Implications for the viral fusion mechanism

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

J. Kevin Judice; Jeffrey Tom; Wei Huang; Wrin; Vennari; Christos J. Petropoulos; Robert S. McDowell

December 1, 1997

Solution structure of the EGF-1 domain from blood coagulation factor VII by NMR spectroscopy: The effect of O-fucosylation

FASEB Journal, ISSN: 08926638

Kao; Geoffrey F. Lee; Yang Wanga; Robert F. Kelley; Spellman; Laura Lerner

December 1, 1997

Validation of an HPLC method for the analysis of the charge heterogeneity of the recombinant monoclonal antibody IDEC-C2B8 after papain digestion

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Kathy Moorhouse; Wassim Nashabeh; James Deveney; Nancy Bjork; Michael G. Mulkerrin; Thomas C. Ryskamp

December 1, 1997

Data handling issues in a gmp environment

FASEB Journal, ISSN: 08926638

Nolan

December 1, 1997

Rapid analytical tryptic mapping of a recominant chimeric monoclonal antibody and method validation challenges

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Kannan; Michael G. Mulkerrin; Zhang; Gray; Steinharter; Sewerin; Baffi; Reed J. Harris; Karunatilake

December 1, 1997

Engineering hyperactive human dnase i with over 4000-fold higher activity in human serum by altering its functional mechan1sm

FASEB Journal, ISSN: 08926638

Clark Q. Pan; Tony H. Dodge; Baker; Sinicropi; Lazarus

December 1, 1997

Solution structure of the EGF-1 domain from blood coagulation factor VII by NMR spectroscopy: The effect of O-fucosylation

FASEB Journal, ISSN: 08926638

Yung-Hsiang Kao; Geoffrey F. Lee; Yang Wanga; Robert F. Kelley; Spellman; Laura Lerner

December 1, 1997

Fourier-transform infrared spectroscopic analysis of the secondary structure of recombinant humanized immunoglobulin G

Pharmaceutical Sciences, ISSN: 13566881

Henry R. Costantino; Andya; Steven J. Shire; Chung C. Hsu

December 1, 1997

The resurgence of analytical ultracentrifugation: An old technique applied to a new technology

Proceedings of SPIE - The International Society for Optical Engineering, ISSN: 0277786X

Steven J. Shire; Jun Liu

December 1, 1997

High-dose aldesleukin in renal cell carcinoma: Long-term survival update

Cancer Journal from Scientific American, ISSN: 10814442

Richard I. Fisher; Steven A. Rosenberg; Mario Sznol; David R. Parkinson; Gwendolyn Fyfe

December 1, 1997

Mannose phosphorylat10n on secretory glycoproteins

FASEB Journal, ISSN: 08926638

Nase; Nishikawa; Walter Gregory; Akash Nanda; John Frenz; Stuart Kornfeld

December 1, 1997

Minimization of a protein binding domain

FASEB Journal, ISSN: 08926638

Andrew Braisted

December 1, 1997

Primary B cell development is impaired in mice with defects of the pituitary/thyroid axis

Journal of Immunology, ISSN: 00221767

Encarnacion Montecino-Rodriguez; Ross Clark; Powell-Braxton; Kenneth Dorshkind

December 1, 1997

Downregulation of natriuretic peptide C-receptor protein in the hypertrophied ventricle of the aortovenocaval fistula rat

Cardiovascular Research, ISSN: 00086363

Lesley A. Brown; Richard A.D. Rutherford; Derek J.R. Nunez; John Wharton; David G Lowe; Martin R. Wilkins

December 1, 1997

Regulation of tissue inhibitor of metalloproteinase-1 in fibroblasts and acute phase proteins in hepatocytes in vitro by mouse oncostatin M, cardiotrophin-1, and IL-6

Journal of Immunology, ISSN: 00221767

Richards; Christine Kerr; Minoru Tanaka; Takahiko Hara; Atsushi Miyajima; Diane Pennica; Fernando Botelho; Langdon

December 1, 1997

Deep-lung delivery of therapeutic proteins

CHEMTECH, ISSN: 00092703

John R. Patton

December 1, 1997

TNK-tissue plasminogen activator compared with frontloaded tpa in acute myocardial infarction: clinical update

Fibrinolysis and Proteolysis, ISSN: 13690191

Bruce A. Kevt

December 1, 1997

Hepatic clearance and metabolism of tnk-tpa, a long half-life variant of rt-PA

Fibrinolysis and Proteolysis, ISSN: 13690191

Geralyn G. Deguzman; Richardson; Keyt; Zioncheck

December 1, 1997

Redesigning antibodies

FASEB Journal, ISSN: 08926638

Presta

December 1, 1997

Pharmacokinetics and dynamics of longer half-life and pai-1 resistant tissue plasminogen activator mutants: slow clearing molecules are not rapidly inhibited

Fibrinolysis and Proteolysis, ISSN: 13690191

Bruce A. Kevtt; Lea Berleau; Hung V. Nguyen; Stephen Epplerf; Nishit Modif

December 1, 1997

Evaluation of ABRF-96SEQ: A sequence assignment exercise

Techniques in Protein Chemistry, ISSN: 10808914

Joseph Fernandez; Arie Admon; Karen De Jongh; Greg Grant; William J. Henzel; William Lane; Kathryn Stone; Barbara Merrill

December 1, 1997

A novel receptor for Apo2L/TRAIL contains a truncated death domain

Current Biology, ISSN: 09609822

Scot A. Marsters; James P. Sheridan; Pitti; Arthur Huang; Skubatch; Daryl T. Baldwin; Jean Q. Yuan; Austin L. Gurney; Goddard; Godowski; Avi Ashkenazi

December 1, 1997

Metabolic labeling for monitoring sialylation of recombinant proteins in growing chinese hamster ovary cell cultures

FASEB Journal, ISSN: 08926638

Santeli; Ryll Twang; Jane Gunson; Warner

December 1, 1997

Native fluorescence detection of recombinant human growth hormone resolve from E. coli cell paste extract by capillary zone electrophoresls

FASEB Journal, ISSN: 08926638

McNerney; Robert L. Bridenbaugh

December 1, 1997

Identification of components of the cell death pathway

Fibrinolysis and Proteolysis, ISSN: 13690191

Vishva M. Dixit

December 1, 1997

Engineering hyperactive human DNASE I with over 4000-fold higher activity in human serum

Protein Engineering, ISSN: 02692139

Pan; Tony H. Dodge; Baker; Sinicropi; Lazarus

December 1, 1997

RhDNase I is a well characterized protein

Pharmaceutical Sciences, ISSN: 13566881

Quan; Cacia; John Frenz; O'Connor

December 1, 1997

Hemodynamic effects of scatter factor in conscious rats

Journal of Cardiovascular Pharmacology, ISSN: 01602446

Renhui Yang; Bunting; Annie Ko; Ralph H. Schwall; Hongkui Jin

December 1, 1997

Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors

American Journal of Pathology, ISSN: 00029440

Alicia M. Viloria Petit; Janusz Rak; Mien-Chie Hung; Patricia Rockwell; Neil Goldstein; Brian M. Fendly; Robert S. Kerbel

December 1, 1997

Inhibition of angiogenesis by blocking vegf action: mutational analysis of vegf:receptor binding and epitope mapping of neutralizing antibodies

Fibrinolysis and Proteolysis, ISSN: 13690191

Keyt

December 1, 1997

Intravenous infusion of vascular endothelial growth factor (VEGF) substantially attenuates its hemodynamic effects

FASEB Journal, ISSN: 08926638

Renhui Yang; Bunting; Annie Ko; Keyt; Napoleone Ferrara; Hongkui Jin

December 1, 1997

How integrins are activated

Nature, ISSN: 00280836

Lasky

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