Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 12701 - 12750 OF 15701 RESULTS

January 1, 1998

Detection of mycoplasmas in cell cultures by cultural methods.

Methods in Molecular Biology, ISSN: 10643745

Masover; Becker

January 1, 1998

The efficacy of recombinant thrombopoietin in murine and nonhuman primate models for radiation-induced myelosuppression and stem cell transplantation

Stem Cells, ISSN: 10665099

Gerard Wagemaker; Karen J. Neelis; Simone C. C. Hartong; Albertus W. Wognum; G. Roger Thomas; Fielder; Dan L. Eaton

January 1, 1998

Crystallization of ovine placental lactogen in a 1:2 complex with the extracellular domain of the rat prolactin receptor

Acta Crystallographica Section D: Biological Crystallography, ISSN: 09074449

Hans W. Christinger; Patricia A. Elkins; Yael Sandowski; Edna Sakal; Arieh Gertler; Anthony A. Kossiakoff; De Vos

January 1, 1998

Adjuvants and delivery issues related to immunization: A survey of the recent patent literature

Journal of Drug Targeting, ISSN: 1061186X

Mrsny

January 1, 1998

Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor

Experimental Neurology, ISSN: 00144886

Choi-Lundberg; Qing Lin; Tim Schallert; Donita Crippens; Beverly L. Davidson; Yung-Nien Chang; Yawen L. Chiang; Jiang Qian; Leena Bardwaj; Martha C. Bohn

January 1, 1998

rtPA is a well-characterized protein.

Developments in biological standardization, ISSN: 03015149

O'Connor

January 1, 1998

The human growth hormone saga.

Developments in biological standardization, ISSN: 03015149

Eleanor Canova-Davis

January 1, 1998

Laboratory scaleup of cell cultures (0.5-50 liters)

Methods in Cell Biology, ISSN: 0091679X

Mather

January 1, 1998

Statistical methods for dna sequence segmentation

Statistical Science, ISSN: 08834237

Jerome V. Braun; Hans-Georg Müller

January 1, 1998

Simultaneous measurement of cell cycle and apoptotic cell death

Methods in Cell Biology, ISSN: 0091679X

Alison Moore; Christopher J. Donahue; Kenneth D. Bauer; Mather

January 1, 1998

Genentech and breast cancer advocacy

Breast Disease, ISSN: 08886008

Steven Shak; Bales; Sharon A. Baughman; John G. Curd; Henry J. Fuchs; Perry; Teeter; Leber

January 1, 1998

Recombinant human thrombopoietin clinical development.

Stem Cells, ISSN: 10665099

Jones Jr.; Ashby; Saroj Vadhan-Raj; Somlo; Richard Champlin; Gajewski; Hellmann; Gwendolyn Fyfe

January 1, 1998

Deterioration of lyophilized pharmaceutical proteins

Biochemistry (Moscow), ISSN: 00062979

Henry R. Costantino; Schwendeman; Langer; Klibanov

January 1, 1998

Effect of mannitol crystallization on the stability and aerosol performance of a spray-dried pharmaceutical protein, recombinant humanized anti-lge monoclonal antibody

Journal of Pharmaceutical Sciences, ISSN: 00223549

Henry R. Costantino; Andya; Phuong-Anh Nguyen; Nancy Dasovich; Sweeney; Steven J. Shire; Chung C. Hsu; Maa

January 1, 1998

Expression of active human tissue-type plasminogen activator in Escherichia coli

Applied and Environmental Microbiology, ISSN: 00992240

Ji Qiu; James R. Swartz; George Georgiou

January 1, 1998

Dosing, monitoring, and safety of growth hormone-replacement therapy in adults with growth hormone deficiency

Endocrinologist, ISSN: 10512144

Sandra L. Blethen

January 1, 1998

IL-3 does not contribute to platelet production in c-Mpl-deficient mice.

Stem Cells, ISSN: 10665099

Qi Chen; Gregg Solar; Dan L. Eaton; Frederic J. De Sauvage

January 1, 1998

Periodontal repair in dogs: Effect of recombinant human transforming growth factor-β1 on guided tissue regeneration

Journal of Clinical Periodontology, ISSN: 03036979

Ulf M. E. Wikesjö; Saghi S. Razi; Thorarinn J. Sigurdsson; Dimitris N. Tatakis; Michael B. Lee; Ongpipattanakul; Tue H. Nguyen; Ross Hardwick

January 1, 1998

Evaluation of product comparability.

Developments in biological standardization, ISSN: 03015149

Stuart E. Builder

January 1, 1998

Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists

Bioorganic and Medicinal Chemistry, ISSN: 09680896

Kirk D. Robarge; Dina; Todd C. Somers; Arthur Lee; Thomas E. Rawson; Alan G. Olivero; Maureen Tischler; Robert R. Webb II; Kenneth J Weese; Ignacio Aliagas; Brent Blackburn

January 1, 1998

Making informed choices: Medium, serum, and serum-free medium how to choose the appropriate medium and culture system for the model you wish to create

Methods in Cell Biology, ISSN: 0091679X

Mather

January 1, 1998

Purification and Physical Characterization of Cloned Human cAMP Phosphodiesterases PDE-4D and -4C

Cell Biochemistry and Biophysics, ISSN: 10859195

Natalie Saldou; Preston A. Baecker; Bin Li; Zhengyu Yuan; Rena Obernolte; James Ratzliff; Eric Osen; Kurt Jarnagin; Earl R. Shelton

January 1, 1998

Real-time measurement of lysis of mural platelet deposits by fibrinolytic agents under arterial flow

Annals of Biomedical Engineering, ISSN: 00906964

Dionne A. Graham; Trevor C. Huang; Keyt; B. Rita Alevriadou

January 1, 1998

The dormant in vivo phenotype of early stage primary human melanoma: Termination by overexpression of vascular endothelial growth factor

Angiogenesis, ISSN: 09696970

Liisa Bayko; Janusz Rak; Shan Man; Roy Bicknell; Napoleone Ferrara; Robert S. Kerbel

January 1, 1998

Therapeutic potential of neurotrophins for treatment of hearing loss

Molecular Neurobiology, ISSN: 08937648

Gao

January 1, 1998

Biological response to ErbB ligands in nontransformed cell lines correlates with a specific pattern of receptor expression

Endocrinology, ISSN: 00137227

Sundaresan; Penelope E. Roberts; King; Mark X. Sliwkowski; Mather

January 1, 1998

Raw materials as a source of contamination in large-scale cell culture.

Developments in biological standardization, ISSN: 03015149

Robert L. Garnick

January 1, 1998

Adaptation to hyperglycemia enhances insulin secretion in glucokinase mutant mice

Diabetes, ISSN: 00121797

Seamus K. Sreenan; Brian N. Cockburn; Aaron C. Baldwin; Diane M. Ostrega; Matteo Levisetti; Andrew Grupe; Graeme I. Bell; Stewart; Michael W. Roe; Kenneth S. Polonsky

January 1, 1998

Development of a single-shot subunit vaccine for HIV-1. 5. Programmable in vivo autoboost and long lasting neutralizing response

Journal of Pharmaceutical Sciences, ISSN: 00223549

Cleland; Lim; Daugherty; Barron; Noelyn Desardin; Duenas; Eastman; Vennari; Wrin; Berman; Michael Powel

January 1, 1998

Distinct molecular phenotypes in murine cardiac muscle development, growth, and hypertrophy

Journal of Molecular and Cellular Cardiology, ISSN: 00222828

Schoenfeld; Vasser; Jhurani; Ng; John J. Hunter; John Ross Jr.; Kenneth R. Chien; David G Lowe

January 1, 1998

Fast Edman cycles with accelerated PTH analysis

Protein Journal, ISSN: 18758355 15723887

William J. Henzel; Jake Tropea; Kishiyama; Wendy Shillinglaw; David Dupont; Steve O'Neil

December 19, 1997

Determination of Ro 48-3656 in rat plasma by reversed-phase high-performance liquid chromatography. Comparison of 1.5-μm nonporous silica to 3.5-μm porous silica analytical columns

Journal of Chromatography B: Biomedical Applications, ISSN: 15726495

Paasch; Yvonne S. Lin; Seth Porter; Modi; Timothy J. Barder

December 15, 1997

Recombinant human growth hormone poly(lactic-co-glycolic acid) (PLGA) microspheres provide a long lasting effect

Journal of Controlled Release, ISSN: 01683659

Cleland; Duenas; Daugherty; Marian; Yang; Wilson; Abbie Celniker; Shahzamani; Quarmby; Chu; Mukku; Mac; Roussakis; Nancy Gillette; Brooks Boyd; Yeung; Brooks; Maa; Chung C. Hsu; Andrew J.S. Jones

December 15, 1997

The effect of size, charge and cyclization of model peptides on their in vitro release from DL-PLGA microspheres

Journal of Controlled Release, ISSN: 01683659

Okumu; Cleland; Ronald T. Borchardt

December 12, 1997

Heregulins and the ErbB-2/3/4 receptors in gliomas

Journal of Neuro-Oncology, ISSN: 0167594X

Manfred Westphal; Leonie Meima; Szonyi; Julie A. Lofgren; Meissner; Wolfgang Hamel; Nikolics; Mark X. Sliwkowski

December 9, 1997

A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

James Verna; Adriana Lodder; Kyunghee Lee; Alicia Vagts; Roymarie Ballester

December 9, 1997

Inhibition of HIV type 1 infectivity by constrained α-helical peptides: Implications for the viral fusion mechanism

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

J. Kevin Judice; Jeffrey Tom; Wei Huang; Wrin; Vennari; Christos J. Petropoulos; Robert S. McDowell

December 1, 1997

Solution structure of the EGF-1 domain from blood coagulation factor VII by NMR spectroscopy: The effect of O-fucosylation

FASEB Journal, ISSN: 08926638

Kao; Geoffrey F. Lee; Yang Wanga; Robert F. Kelley; Spellman; Laura Lerner

December 1, 1997

Validation of an HPLC method for the analysis of the charge heterogeneity of the recombinant monoclonal antibody IDEC-C2B8 after papain digestion

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Kathy Moorhouse; Wassim Nashabeh; James Deveney; Nancy Bjork; Michael G. Mulkerrin; Thomas C. Ryskamp

December 1, 1997

Data handling issues in a gmp environment

FASEB Journal, ISSN: 08926638

Nolan

December 1, 1997

Rapid analytical tryptic mapping of a recominant chimeric monoclonal antibody and method validation challenges

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Kannan; Michael G. Mulkerrin; Zhang; Gray; Steinharter; Sewerin; Baffi; Reed J. Harris; Karunatilake

December 1, 1997

Engineering hyperactive human dnase i with over 4000-fold higher activity in human serum by altering its functional mechan1sm

FASEB Journal, ISSN: 08926638

Clark Q. Pan; Tony H. Dodge; Baker; Sinicropi; Lazarus

December 1, 1997

Solution structure of the EGF-1 domain from blood coagulation factor VII by NMR spectroscopy: The effect of O-fucosylation

FASEB Journal, ISSN: 08926638

Yung-Hsiang Kao; Geoffrey F. Lee; Yang Wanga; Robert F. Kelley; Spellman; Laura Lerner

December 1, 1997

Fourier-transform infrared spectroscopic analysis of the secondary structure of recombinant humanized immunoglobulin G

Pharmaceutical Sciences, ISSN: 13566881

Henry R. Costantino; Andya; Steven J. Shire; Chung C. Hsu

December 1, 1997

The resurgence of analytical ultracentrifugation: An old technique applied to a new technology

Proceedings of SPIE - The International Society for Optical Engineering, ISSN: 0277786X

Steven J. Shire; Jun Liu

December 1, 1997

High-dose aldesleukin in renal cell carcinoma: Long-term survival update

Cancer Journal from Scientific American, ISSN: 10814442

Richard I. Fisher; Steven A. Rosenberg; Mario Sznol; David R. Parkinson; Gwendolyn Fyfe

December 1, 1997

Mannose phosphorylat10n on secretory glycoproteins

FASEB Journal, ISSN: 08926638

Nase; Nishikawa; Walter Gregory; Akash Nanda; John Frenz; Stuart Kornfeld

December 1, 1997

Minimization of a protein binding domain

FASEB Journal, ISSN: 08926638

Andrew Braisted

December 1, 1997

Primary B cell development is impaired in mice with defects of the pituitary/thyroid axis

Journal of Immunology, ISSN: 00221767

Encarnacion Montecino-Rodriguez; Ross Clark; Powell-Braxton; Kenneth Dorshkind

December 1, 1997

Downregulation of natriuretic peptide C-receptor protein in the hypertrophied ventricle of the aortovenocaval fistula rat

Cardiovascular Research, ISSN: 00086363

Lesley A. Brown; Richard A.D. Rutherford; Derek J.R. Nunez; John Wharton; David G Lowe; Martin R. Wilkins

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