Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 14151 - 14200 OF 15701 RESULTS

Characterization of neurotrophin receptors by affinity crosslinking
Journal of Neuroscience Research, ISSN: 10974547 03604012
Escandon; Louis E. Burton; Szonyi; Nikolics
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Follistatin modulates activin activity in a cell and tissue-specific manner
Endocrinology, ISSN: 19457170 00137227
Mather; Penelope E. Roberts; Lynne Krummen
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A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor β, or bone morphogenic factor
Journal of Biological Chemistry, ISSN: 00219258
Koichi Matsuzaki; Jian M. Xu; Fen Wang; Wallace L. McKeehan; Lynne Krummen; Mikio Kan
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Mutational analysis of the intracellular domain of the human growth hormone receptor
Journal of Biological Chemistry, ISSN: 00219258
Colosi; Wong; Leong; William I. Wood
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Benzodiazepine peptidomimetics: Potent inhibitors of Ras farnesylation in animal cells
Science, ISSN: 00368075
Guy L. James; Joseph L. Goldstein; Michael S. Brown; Thomas E. Rawson; Todd C. Somers; Robert S. McDowell; Crowley; Brian K. Lucas; Levinson; James C. Marsters Jr.
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Hypothalamic infusion of activin A increases water consumption and urine volume in the rat
Neuroendocrinology, ISSN: 00283835
Ralph H. Schwall; Lyn B. Jakeman; C.Anthony Altar
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Structure and function of human growth hormone: Implications for the hematopoietins
Annual Review of Biophysics and Biomolecular Structure, ISSN: 10568700
James A. Wells; De Vos
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Human recombinant activin-A alters pituitary luteinizing hormone and follicle-stimulating hormone secretion, follicular development, and steroidogenesis, during the menstrual cycle in rhesus monkeys
Journal of Clinical Endocrinology and Metabolism, ISSN: 19457197 0021972X
Richard L. Stouffer; Woodruff; Dahl; David L. Hess; Mather; Theodore A. Molskness
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The Application of size exclusion chromatography and computer simulation to study the thermodynamic and kinetic parameters for short-lived dissociable protein aggregates
Analytical Biochemistry, ISSN: 10960309 00032697
Thomas W. Patapoff; Mrsny; William A. Lee
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Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice
Journal of Clinical Investigation, ISSN: 00219738
Jawaid Quddus; Kent J. Johnson; Jerrie Gavalchin; Edward P. Amento; Clarence E. Chrisp; Raymond L. Yung; Bruce C. Richardson
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Studies on the mechanisms by which transforming growth factor-β (TGF-β) protects against allergic encephalomyelitis: Antagonism between TGF-β and tumor necrosis factor
Journal of Immunology, ISSN: 00221767
Laura Santambrogio; Gerald M. Hochwald; Babita Saxena; Chin-Hung Leu; Joseph E. Martz; Joseph A. Carlino; Nancy Ruddle; Michael A. Palladino; Leslie I. Gold; Thorbecke
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Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis
Endocrinology, ISSN: 19457170 00137227
Lyn B. Jakeman; Armanini; Phillips; Napoleone Ferrara
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Analysis of 24-hour plasma profiles of growth hormone (GH)-binding protein, GH/GH-binding protein-complex, and GH in healthy children
Journal of Clinical Endocrinology and Metabolism, ISSN: 19457197 0021972X
Carlsson; Sten Rosberg; Roderick V. Vitangcol; Wai Lee T. Wong; Kerstin Albertsson-Wikland
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Insulin-like growth factor-1 stimulation of lymphopoiesis
Journal of Clinical Investigation, ISSN: 00219738
Ross Clark; Josef Stresser; McCabe; Kimberly Bobbins; Paula Jardieu
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Activin induces cell death in hepatocytes in vivo and in vitro
Hepatology, ISSN: 15273350 02709139
Ralph H. Schwall; Robbins; Paula Jardieu; Chang; Cora La; Timothy G. Terrel
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A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. I. Serum growth hormone-binding protein
Journal of Clinical Endocrinology and Metabolism, ISSN: 19457197 0021972X
Paul M. Martha Jr.; Alan D. Rogol; Carlsson; Gesundheit; Robert M. Blizzard
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Electrospray ionization mass spectrometry of phosphopeptides isolated by on-line immobilized metal-ion affinity chromatography
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
Lydia M. Nuwaysir; Stults
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Synergistic effect of interleukin‐1β and tumor necrosis factor α on interleukin‐8 gene expression in synovial fibroblasts. evidence that interleukin‐8 is the major neutrophil‐activating chemokine released in response to monokine activation
Arthritis and Rheumatism, ISSN: 15290131 00043591
Palaniswami Rathanaswami; Mohamed Hachicha; Wai Lee T. Wong; Thomas J. Schall; Shaun R. McColl
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Human relaxin decreases collagen accumulation in vivo in two rodent models of fibrosis
Journal of Investigative Dermatology, ISSN: 15231747 0022202X
Elaine N. Unemori; Steven Beck; Wyne P. Lee; Yvette Xu; Mark Siegel; Gilbert-Andre Keller; Liggitt; Eugene A. Bauer; Edward P. Amento
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Growth factor modulation of insulin-like growth factor-binding proteins in rat osteoblast-like cells
Endocrinology, ISSN: 19457170 00137227
Theresa L. Chen; Chang; DiGregorio; Andrew J. Perlman; Yung-Fu Huang
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Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk
Journal of Clinical Investigation, ISSN: 00219738
Dowbenko; Kikuta; Christopher Fennie; Nancy Gillett; Lasky
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Partial functional mapping of the human interleukin-8 type A receptor: Identification of a major ligand binding domain
Journal of Biological Chemistry, ISSN: 00219258
Hébert; Anan Chuntharapai; Smith; Timothy J. Colby; Jin Kim; Richard Horuk
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Protein engineering. Editorial overview
Current Opinion in Biotechnology, ISSN: 09581669
Anthony A. Kossiakoff; Michael Smith
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Increased Transforming Growth Factor β Expression Inhibits Cell Proliferation in Vitro, yet Increases Tumorigenicity and Tumor Growth of Meth A Sarcoma Cells
Cancer Research, ISSN: 15387445 00085472
Hsun-Lang Chang; Nancy Gillett; Figari; Alfredo R. Lopez; Michael A. Palladino; Rik Derynck
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Characterization of radioiodinated recombinant human TGF‐β1 binding to bone matrix within rabbit skull defects
Journal of Bone and Mineral Research, ISSN: 15234681 08840431
Richardson; Zioncheck; Edward P. Amentoè; Leo Deguzmanè; Wyne P. Leeè; Yvette Xuè; L. Steven Beckè
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Expression of insulin-like growth factor-I (IGF-I) in the rat fallopian tube: Possible autocrine and paracrine action of fallopian tube-derived IGF-I on the fallopian tube and on the preimplantation embryo
Endocrinology, ISSN: 19457170 00137227
Carlsson; Hillensjo; Anders Nilsson; Tornell; Billig
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Activated eosinophils evoke chloride secretion in model intestinal epithelia primarily via regulated release of 5'-AMP
Journal of Immunology, ISSN: 00221767
Murray B. Resnick; Sean P. Colgan; Thomas W. Patapoff; Mrsny; Christopher S. Awtrey; Charlene Delp-Archer; Peter F. Weller; James L. Madara
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Stability and characterization of human growth hormone.
Chinese Journal of Pharmaceutical Biotechnology, ISSN: 10780467
Rodney Pearlman; Bewley
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Intravenous and endobronchial administration of G4120, a cyclic Arg-Gly-Asp-containing platelet GPIIb/IIIa receptor-blocking pentapeptide, enhances and sustains coronary arterial thrombolysis with rt-PA in a canine preparation
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN: 10795642
Tsunehiro Yasuda; Herman K. Gold; Chikashi Kohmura; Luis Guerrero; Hiroyuki Yaoita; John T. Fallon; Bunting; Desire Collen
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Assessing genetic heterogeneity in production cell lines: Detection by peptide mapping of a low level tyr to gln sequence variant in a recombinant antibody
Nature Biotechnology, ISSN: 10870156
Reed J. Harris; Amy Murnane; Utter; Karen L. Wagner; Edward T. Cox; Gian D. Polastri; Helder; Mary B. Sliwkowski
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The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
Molecular Biology of the Cell, ISSN: 10591524
John E. Park; Gilbert-Andre Keller; Napoleone Ferrara
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Protective effects of selectin chimeras in neutrophil-mediated lung injury
Journal of Immunology, ISSN: 00221767
Michael S. Mulligan; Susan R. Watson; Christopher Fennie; Peter A. Ward
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In situ ligand binding of recombinant human [125I] activin-A and recombinant human [125I]inhibin-A to the adult rat ovary
Endocrinology, ISSN: 19457170 00137227
Woodruff; Lynne Krummen; Glynis McCray; Mather
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Preparation of Radiolabeled Materials for Studies of Deposition of Fibers in the Human Respiratory Tract
Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung, ISSN: 15579026 08942684
Chan; Gonda
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Humanization of an antibody directed against IgE
Journal of Immunology, ISSN: 00221767
Presta; Steven Lahr; Robert L. Shields; James P. Porter; Cornelia M. Gorman; Brian M. Fendly; Paula Jardieu
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Binding of L-selectin to the vascular sialomucin CD34
Science, ISSN: 00368075
Baumhueter; Mark S. Singer; William J. Henzel; Stefan Hemmerich; Renz; Steven D. Rosen; Lasky
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Stability characterization and formulation development of alteplase, a recombinant tissue plasminogen activator.
Chinese Journal of Pharmaceutical Biotechnology, ISSN: 10780467
Tue H. Nguyen; Carole A. Ward
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Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells: Interacting effects involving suppression, synergistic suppression, and blocking of suppression
Journal of Immunology, ISSN: 00221767
Hal E. Broxmeyer; Barbara Sherry; Scott Cooper; Li Lu; Rodney Maze; M. Patricia Beckmann; Cerami; Peter Ralph
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Appearance of additional ouabain binding sites on platelet surfaces following activation
Experimental Cell Research, ISSN: 00144827
Tracie Bork; Mrsny
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Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet α-granules
Journal of Clinical Investigation, ISSN: 00219738
Prem Handagama; Dorothy F. Bainton; Yvonne Jacques; Marion T. Conn; Lazarus; Shuman
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IGF-I is required for normal embryonic growth in mice
Genes and Development, ISSN: 08909369
Powell-Braxton; Hollingshead; Warburton; Mary Dowd; Sharon Pitts-Meek; Dyana K. Dalton; Nancy Gillett; Stewart
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Biosynthesis and function of membrane bound and secreted forms of recombinant CD11b/CD18 (Mac‐1)
Journal of Cellular Biochemistry, ISSN: 10974644 07302312
Berman; Nakamura; Riddle; Chiu; Karen L. Fisher; Mark Champe; Gray; Ward; Fong
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Crystal structure of a sweet tasting protein thaumatin I, at 1·65 Å resolution
Journal of Molecular Biology, ISSN: 00222836
Craig M. Ogata; Paul F. Gordon; De Vos; Sung-Hou Kim
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Identification of a single amino acid residue responsible for the binding of a class of β-adrenergic receptor antagonists to 5-hydroxytryptamine(1A) receptors
Molecular Pharmacology, ISSN: 0026895X
Xiao-Ming Guan; Peroutka; Brian K. Kobilka
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Identification of human milk α-lactalbumin as a cell growth inhibitor
Protoplasma, ISSN: 0033183X 16156102
Thompson; Farrell Jr.; Sanjeeva Mohanam; Sue Liu; Kidwell; Bansal; Cook; Medina; Claire Kotts; Mozeena Bano
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Guidelines for national authorities on quality assurance for biological products
World Health Organization - Technical Report Series, ISSN: 05123054
Ayres; Benmansour; Breschkin; Darodjatun; Drozdov; Esber; Furesz; Homma; Jeffcoate; Kalyanaraman; Langlois; Magrath; Moor; John F. Obijeski; Sizaret; Spieser; Weber; Xiang Jianzhi
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Expression and characterization of hepatocyte growth factor receptor-IgG fusion proteins. Effects of mutations in the potential proteolytic cleavage site on processing and ligand binding
Journal of Biological Chemistry, ISSN: 00219258
Melanie R Mark; Lokker; Zioncheck; Luis; Godowski
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Both intrathymic and peripheral selection modulate the differential expression of Vβ among CD4+ and CD8+ T cells
Journal of Experimental Medicine, ISSN: 15409538 00221007
Pamela J. Fink; Kathryn Swan; Gail Turk; Mark Moore; Francis R. Carbone
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Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
Journal of Biological Chemistry, ISSN: 00219258
Houck; Leung; Rowland; Jane Winer; Napoleone Ferrara
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Basis for the use of rhDNase as a therapy in cystic fibrosis
Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering, ISSN: 07430515
Pearlman; Steven J. Shire; Cipolla; Daugherty; Thomas W. Patapoff; Ross C. Clark; Gilbert-Andre Keller; Mrsny
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