Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 1451 - 1500 OF 16443 RESULTS

Development of a novel, highly sensitive assay for quantification of minimal residual B cells in autoimmune disease and comparison to traditional methods across B-cell–depleting agents
Clinical Immunology, ISSN: 15217035 15216616
Cary M. Looney; Nicolas B. Strauli; Matthew Cascino; Hailey Garma; Aaron Schroeder; Chikara Takahashi; William E. O'Gorman; Cherie Green; Ann E. Herman
View on Scopus
Bioprocess Development and Characterization of a 13C-Labeled Hybrid Bispecific Antibody Produced in Escherichia coli
Antibodies, ISSN: 20734468
Aaron T. Wecksler; Victor Lundin; Ambrose Jon Williams; Karthik Veeravalli; Dorothea Reilly; Sung-Hye Grieco
View on Scopus
The convergence of pharmacometrics and quantitative systems pharmacology in pharmaceutical research and development
European Journal of Pharmaceutical Sciences, ISSN: 18790720 09280987
Amita Joshi; Ramanujan; Jin Y. Jin
View on Scopus
A Robust Purity Method for Biotherapeutics Using New Peak Detection in an LC-MS-Based Multi-Attribute Method
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
Monica Sadek; Benjamin Moore; Christopher Yu; Nicholas Ruppe; Austin Abdun-Nabi; Zhiqi Hao; Melissa Alvarez; Sanket Dahotre; Galahad Deperalta
View on Scopus
Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors
eLife, ISSN: 2050084X
Marc Kschonsak; Christine C. Jao; Christopher P. Arthur; Alexis Rohou; Philippe Bergeron; Daniel F. Ortwine; Steven J. McKerrall; David Hackos; Lunbin Deng; Jun Chen; Tianbo Li; Peter Dragovich; Matthew Volgraf; Matthew Wright; Jian Payandeh; Claudio Ciferri; John C. Tellis
View on Scopus
Considerations for Embedding Inclusive Research Principles in the Design and Execution of Clinical Trials
Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790
Peters; Brenna Turner; Daniel Alvarez; Makaelah Murray; Aruna Sharma; Shalini V. Mohan; Sharmi Patel
View on Scopus
Exploring the potential of dried plasma collection cards for liquid chromatography coupled with tandem mass spectrometry quantitation of giredestrant in human plasma
Biomedical chromatography : BMC, ISSN: 10990801 02693879
Yang Tang; Liuxi Chen; Xiaorong Liang; Brian J. Dean; Jianshuang Wang
View on Scopus
Costs associated with the use of multigene panel tests in three solid tumor types and the impact on insurance premiums
Future Oncology,
Wong; Daniel Sheinson; Yutong Liu; Tu My To
View on Scopus
Assimilating ecological theory with empiricism: Using constrained generalized additive models to enhance survival analyses
Methods in Ecology and Evolution, ISSN: 2041210X
Alison C. Ketz; Daniel J. Storm; Rachel E. Barker; Anthony D. Apa; Cristian Oliva-Aviles; Daniel P. Walsh
View on Scopus
Surgical results of the Lung Cancer Mutation Consortium 3 trial: A phase II multicenter single-arm study to investigate the efficacy and safety of atezolizumab as neoadjuvant therapy in patients with stages IB-select IIIB resectable non–small cell lung cancer
Journal of Thoracic and Cardiovascular Surgery, ISSN: 1097685X 00225223
Valerie W. Rusch; Alan Nicholas; G. Alexander Patterson; Saiama N. Waqar; Eric Toloza; Eric B. Haura; Dan J. Raz; Karen L. Reckamp; Robert E. Merritt; Dwight H. Owen; David J. Finley; Ciaran J. McNamee; Justin D. Blasberg; Edward B. Garon; John D. Mitchell; Robert C Doebele; Frank Baciewicz; Misako Nagasaka; Pass; Katja Schulze; Ann Johnson; Paul A. Bunn Jr.; Bruce E. Johnson; Mark G. Kris; David J. Kwiatkowski; Ignacio I. Wistuba; Jamie E. Chaft; David Carbone; Jay M. Lee
View on Scopus
A Review of the Evolving Landscape of Inclusive Research and Improved Clinical Trial Access
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Shalini V. Mohan; Jamie Freedman
View on Scopus
Obligate role for Rock1 and Rock2 in adult stem cell viability and function
Heliyon, ISSN: 24058440
Arivazhagan Sambandam; Elaine E. Storm; Helen Tauc; Jason A. Hackney; David Garfield; Patrick Caplazi; John Liu; Juan Zhang; Hua Zhang; Jeff Duggan; Surinc Er Jeet; Sarah Gierke; Patrick Chang; Xiumin Wu; Robert J. Newman; Lucinda Tam; Tuija M. Alcantar; Lifen Wang; Meron Roose-Girma; Zora Modrusan; Wyne P. Lee; Heinrich Jasper; Frederic J. De Sauvage; Rajita Pappu
View on Scopus
Single-cell proteomics enabled by next-generation sequencing or mass spectrometry
Nature Methods, ISSN: 15487105 15487091
Hayley M. Bennett; William Stephenson; Christopher M. Rose; Spyros Darmanis
View on Scopus
Phase I Study of Safety and Pharmacokinetics of RO7297089, an Anti-BCMA/CD16a Bispecific Antibody, in Patients with Relapsed, Refractory Multiple Myeloma
Clinical Hematology International, ISSN: 25900048
Torben Plesner; Simon J. Harrison; Hang Quach; Cindy Lee; Adam Bryant; Annette Vangsted; Jane Estell; Michel Delforge; Fritz C. Offner; Patrick S. Twomey; Voleak Choeurng; Junyi Li; Robert Hendricks; Shannon M. Ruppert; Teiko Sumiyoshi; Karen Miller; Eunpi Cho; Fredrik H. Schjesvold
View on Scopus
Evaluation of Novel Urinary Biomarkers in Beagle Dogs With Amphotericin B-Induced Kidney Injury
International Journal of Toxicology, ISSN: 1092874X 10915818
Adedeji; Manisha Sonee; Yafei Chen; Karen Lynch; Katrina Peron; Nicholas King; James E. McDuffie; Petra Vinken
View on Scopus
Targeting MCL-1 and BCL-2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non-Hodgkin lymphoma: Results from preclinical models and a Phase Ib study
American Journal of Hematology, ISSN: 10968652 03618609
Elisabeth A. Lasater; Dhara Amin; Rajat Bannerji; Raghuveer Singh Mali; Kathy Barrett; Ryan N. Rys; Jason Oeh; Eva Lin; Tim Sterne-Weiler; Ellen Ingalla; MaryAnn Go; Shang-Fan Yu; Maxwell M. Krem; Chris Arthur; Uwe Hahn; Anna Johnston; Vinit Karur; Nadia Khan; Paula Marlton; Tycel Phillips; Giuseppe Gritti; John F. Seymour; Monica Tani; Sam L.S. Yuen; Scott Martin; Matthew T. Chang; Christopher M. Rose; Victoria Pham; Andrew G. Polson; Yi Meng Chang; Claudia Wever; Nathalie A. Johnson; Yanwen Jiang; Jamie Hirata; Deepak Sampath; Lisa Musick; Christopher R. Flowers; Ingrid E. Wertz
View on Scopus
Emicizumab in people with moderate or mild haemophilia A (HAVEN 6): a multicentre, open-label, single-arm, phase 3 study
The Lancet Haematology, ISSN: 23523026
Claude Negrier; Johnny N. Mahlangu; Michaela Lehle; Pratima Chowdary; Olivier Catalani; Ronald J Bernardi; Jiménez-Yuste; Benjamin M Beckermann; Christophe Schmitt; Giuliana Ventriglia; Jerzy Windyga; Roseline d'Oiron; Paul Moorehead; Sunita Koparkar; Vanda Teodoro; Amy Shapiro; Johannes Oldenburg; Cedric Hermans
View on Scopus
In silico tissue generation and power analysis for spatial omics
Nature Methods, ISSN: 15487105 15487091
Ethan A. G. Baker; Denis Schapiro; Bianca Dumitrascu; Sanja Vickovic; Aviv Regev
View on Scopus
Emil Raphael Unanue 1934-2022
Nature Immunology, ISSN: 15292916
Schreiber; Andrey S. Shaw
View on Scopus
The Value of New: Consideration of Product Novelty in Health Technology Assessments of Pharmaceuticals
Applied Health Economics and Health Policy, ISSN: 11791896 11755652
Patricia G. Synnott; Dominic Voehler; Daniel E. Enright; Stacey L. Kowal; Daniel A. Ollendorf
View on Scopus
Copay assistance use and prescription abandonment across race, ethnicity, or household income levels for select rheumatoid arthritis and oral oncolytic medicines
Journal of Managed Care and Specialty Pharmacy, ISSN: 23761032 23760540
William B. Wong; Ashley Donahue; Jeff Thiesen; Jason M. Yeaw
View on Scopus
Estimating recurrences prevented and costs avoided with atezolizumab in early non-small cell lung cancer in the United States
Cancer Medicine, ISSN: 20457634
Rishika Sharma; Sarika Ogale; Nathaniel J. Smith; Janet Shin Lee
View on Scopus
Initial recommendations for performing, benchmarking and reporting single-cell proteomics experiments
Nature Methods, ISSN: 15487105 15487091
Laurent Gatto; Ruedi H. Aebersold; Jürgen Cox; Vadim P. Demichev; Jason Derks; Edward P. Emmott; Alexander M. Franks; Alexander R. Ivanov; Ryan T. Kelly; Luke Khoury; Andrew D. Leduc; Michael J. MacCoss; Peter Nemes; David H. Perlman; Aleksandra A. Petelski; Christopher M. Rose; Erwin Marten Schoof; Jennifer E. van Eyk; Christophe Vanderaa; John R. Yates; Nikolai Slavov
View on Scopus
Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis
Blood advances, ISSN: 24739537 24739529
Antonina V. Kurtova; Melanie Heinlein; Simon Haas; Lars Velten; Gerrit J. P. Dijkgraaf; Elaine E. Storm; Noelyn Kljavin; Soufiane Boumahdi; Patricia Himmels; Aurelie Herault; Andrew G. Mancini; Koeppen; Monique Dail; Qingxiang Yan; Jianhuan Zhang; Ute Koch; Freddy Radtke; Zora Modrusan; Ciara Metcalfe; Robert Piskol; Frederic J. De Sauvage
View on Scopus
New Methodology for Determining Plasma Protein Binding Kinetics Using an Enzyme Reporter Assay Coupling with High-Resolution Mass Spectrometry
Analytical Chemistry, ISSN: 15206882 00032700
Zhengyin Yan; Li Ma; Julie Huang; Pasquale Carione; Jane R. Kenny; Cornelis E. Hop; Matthew Wright
View on Scopus
Enrichment of oral-derived bacteria in inflamed colorectal tumors and distinct associations of Fusobacterium in the mesenchymal subtype
Cell Reports Medicine, ISSN: 26663791
Brett S. Younginger; Oleg Mayba; Jens Reeder; Deepti R. Nagarkar; Zora Modrusan; Matthew L. Albert; Allyson L. Byrd
View on Scopus
Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation
Cell Chemical Biology, ISSN: 24519448 24519456
Scott C. Rosenberg; Frances Shanahan; Sayumi Yamazoe; Marc Kschonsak; Yi J. Zeng; James Lee; Emile G. Plise; Ivana Yen; Christopher M. Rose; John Quinn; Lewis Gazzard; Benjamin T. Walters; Donald S. Kirkpatrick; Steven T. Staben; Scott A. Foster; Shiva Malek
View on Scopus
Top-Down Mass Spectrometry of Synthetic Single Guide Ribonucleic Acids Enabled by Facile Sample Clean-Up
Analytical Chemistry, ISSN: 15206882 00032700
Christopher M. Crittenden; Michael B. Lanzillotti; Bifan Chen
View on Scopus
Population Pharmacokinetics of Tenecteplase in Patients With Acute Myocardial Infarction and Application to Patients With Acute Ischemic Stroke
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Fei Tang; Jurgen B. Langenhorst; Steve Dang; Nastya Kassir; Ryan P. Owen; Barbara Purdon; Mats O. Magnusson; Rong Deng
View on Scopus
Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Hsiaotzu Chien; Helen Prior; Laura Andrews; Leon van Aerts; Annick Cauvin; David Clarke; Kaushik Datta; Maggie Dempster; Noel Dybdal; Wendy Freebern; Lolke de Haan; Danuta Herzyk; Adam Hey; Thomas Kissner; Sven Kronenberg; Michael W. Leach; Donna W. Lee; Katrin Schutte; Fiona Sewell; Kevin Trouba; Peter Ulrich; Lucinda Weir; Peter van Meer
View on Scopus
Longitudinal Exposure—Response Modeling of Multiple Indicators of Alzheimer’s Disease Progression
Journal of Prevention of Alzheimer's Disease, ISSN: 24260266 22745807
Daniel Polhamus; Michael J. Dolton; Rogers; Lee Honigberg; Jin Y. Jin; Angelica Quartino
View on Scopus
Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease
Neurobiology of Disease, ISSN: 1095953X 09699961
Robert Brendza; Xiaoying Gao; Kimberly L. Stark; Han Lin; Seung-Hye Lee; Changyun Hu; Hao Cai; Danielle DiCara; Yi-Chun Hsiao; Hai Ngu; Oded Foreman; Miriam Baca; Monika Dohse; Jean-Philippe Fortin; Corpuz; Dhaya Seshasayee; Amy Easton; Gai Ayalon; Isidro Hötzel; Ben Chih
View on Scopus
Development of a Near-Infrared Spectroscopy (NIRS)–Based Characterization Approach for Inherent Powder Blend Heterogeneity in Direct Compression Formulations
AAPS Journal, ISSN: 15507416
Zhenqi Shi; Kallakuri Suparna Rao; Prajwal Thool; Robert Kuhn; Rekha Thomas; Sharyl Rich; Chen Mao
View on Scopus
Development of an 18F-labeled anti-human CD8 VHH for same-day immunoPET imaging
European Journal of Nuclear Medicine and Molecular Imaging, ISSN: 16197089 16197070
Shravan Sriraman; Christopher W. Davies; Herman S. Gill; James R. Kiefer; Jianping Yin; Annie Ogasawara; Alejandra Urrutia; Vincent Javinal; Zhonghua Lin; Dhaya Seshasayee; Ryan Abraham; Phil Haas; Christopher M. Koth; Jan Marik; James T. Koerber; Simon P. Williams
View on Scopus
The Development and Characterization of a Highly Sensitive Mature TGFβ3 Assay to Evaluate Anti-TGFβ3 Target Engagement
AAPS Journal, ISSN: 15507416
A F. Setiadi; Gizette Sperinde; Melissa Cheu; Wei-Ching Liang; WeiYu Lin; Connie Mahood; Saloumeh Kadkhodayan Fischer
View on Scopus
Injectable Polymer-Nanoparticle Hydrogel for the Sustained Intravitreal Delivery of Bimatoprost
Advanced Therapeutics, ISSN: 23663987
Emily L. Meany; Roxanne Andaya; Shijia Tang; Catherine M. Kasse; Reina N. Fuji; Abigail K. Grosskopf; Andrea L. d'Aquino; Joshua T. Bartoe; Ryan Ybarra; Amy Shelton; Zachary Pederson; Chloe Hu; Dennis Leung; Karthik Nagapudi; Savita Ubhayakar; Matthew Wright; Chun-Wan Yen; Eric A. Appel
View on Scopus
Predicting the immediate impact of national lockdown on neovascular age-related macular degeneration and associated visual morbidity: an INSIGHT Health Data Research Hub for Eye Health report
British Journal of Ophthalmology, ISSN: 14682079
Susan P. Mollan; Dun Jack Fu; Ching-Yi Chuo; Jacqueline Gannon; Wen Hwa Lee; J. Jill Hopkins; Cian Hughes; Alastair K. Denniston; Pearse A. Keane; Ronald A. Cantrell
View on Scopus
TEAD Proteins Associate With DNA Repair Proteins to Facilitate Cellular Recovery From DNA Damage
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Philamer C. Calses; Victoria Pham; Alissa D. Guarnaccia; Meena Choi; Erik Verschueren; Sietske T. Bakker; Trang Pham; Trent Hinkle; Chad Liu; Matthew T. Chang; Noelyn Kljavin; Corey Bakalarski; Benjamin Haley; Jianing Zou; Cuicui Yan; Xia Song; Xiaoyan Lin; Rebecca Rowntree; Alan Ashworth; Anwesha Dey; Jennie R. Lill
View on Scopus
Current nonclinical approaches for immune assessments of immuno-oncology biotherapeutics
Drug Discovery Today, ISSN: 18785832 13596446
Grimaldi; Ibraghimov; Kiessling; Benno Rattel; Changhua Ji; Claudette L. Fuller; Frank R. Brennan; Franziska Regenass-Lechner; Jacintha Shenton; Karen Price; Marie-Soleil Piché; Meredith A. Steeves; Prell; Sherri Dudal; Sven Kronenberg; Wendy Freebern; Diann Blanset
View on Scopus
Correction: End-to-End Approach to Surfactant Selection, Risk Mitigation, and Control Strategies for Protein-Based Therapeutics (The AAPS Journal, (2022), 25, 1, (6), 10.1208/s12248-022-00773-3)
AAPS Journal, ISSN: 15507416
Annette Medina Morales; Alavattam Sreedhara; Jakob Buecheler; Sebastian Brosig; Danny Chou; Twinkle R. Christian; Tapan Das; Isabella de Jong; Jonas Fast; Bharat Jagannathan; Ehab Moussa; M. Reza Nejadnik; Indira Prajapati; Allison Radwick; Yusra Rahman; Shubhadra N. Singh
View on Scopus
End-to-End Approach to Surfactant Selection, Risk Mitigation, and Control Strategies for Protein-Based Therapeutics
AAPS Journal, ISSN: 15507416
Alavattam Sreedhara; Jakob Buecheler; Sebastian Brosig; Danny Chou; Twinkle R. Christian; Tapan Das; Isabella de Jong; Jonas Fast; Bharat Jagannathan; Annette Medina Morales; Ehab Moussa; M. Reza Nejadnik; Indira Prajapati; Allison Radwick; Yusra Rahman; Shubhadra N. Singh
View on Scopus
A Review of Protein- and Peptide-Based Chemical Conjugates: Past, Present, and Future
Pharmaceutics, ISSN: 19994923
Emily Holz; Martine Darwish; Devin B. Tesar; Whitney Shatz-Binder
View on Scopus
FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
David Ackley; Joanne Birkebak; Jorg Blumel; Todd Bourcier; Christina de Zafra; Andrew Goodwin; Wendy Halpern; Danuta Herzyk; Sven Kronenberg; Robert Mauthe; Jacintha Shenton; Dana Shuey; Ronald L. Wange
View on Scopus
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
Nature Genetics, ISSN: 15461718 10614036
Emilie Abby; Stefan C. Dentro; Michael W. J. Hall; Joanna C. Fowler; Swee Hoe Ong; Roshan Sood; Albert Herms; Gabriel Piedrafita; Irina Abnizova; Christian W. Siebel; Moritz Gerstung; Benjamin A. Hall; Philip H. Jones
View on Scopus
Real-World Clinical Outcomes Based on Body Mass Index and Annualized Weight Change in Patients with Idiopathic Pulmonary Fibrosis
Advances in Therapy, ISSN: 18658652 0741238X
Joyce S. Lee; Adam Martin-Schwarze; Elizabeth A. Freiheit; Benjamin L. Trzaskoma; Cindy Burg
View on Scopus
Evaluation of bottom-up modeling of the blood–brain barrier to improve brain penetration prediction via physiologically based pharmacokinetic modeling
Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782
Christine M. Bowman; Fang Ma; Jialin Mao; Emile G. Plise; Eugene C. Chen; Liling Liu; Shu Zhang; Yuan Chen
View on Scopus
Efficacy of emicizumab is maintained throughout dosing intervals for bleed prophylaxis
Research and Practice in Thrombosis and Haemostasis, ISSN: 24750379
Steven W Pipe; Benjamin L. Trzaskoma; Miranda Minhas; Michaela Lehle; Richard H. Ko; Ling Gao; Johnny N. Mahlangu; Kempton; Craig Kessler; Kruse-Jarres
View on Scopus
The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Helen Prior; Laura Andrews; Annick Cauvin; Hsiaotzu Chien; David Clarke; Kaushik Datta; Maggie Dempster; Noel Dybdal; Wendy Freebern; Lolke de Haan; Danuta Herzyk; Adam Hey; Thomas Kissner; Sven Kronenberg; Michael W. Leach; Donna W. Lee; Kirsty Reid; Katrin Schutte; Fiona Sewell; Kevin Trouba; Peter Ulrich; Leon van Aerts; Peter van Meer; Lucinda Weir
View on Scopus
Network-based assessment of HDAC6 activity predicts preclinical and clinical responses to the HDAC6 inhibitor ricolinostat in breast cancer
Nature Cancer, ISSN: 26621347
Tizita Zewde Zeleke; Qingfei Pan; Codruta C. Chiuzan; Maika Onishi; Yuxin Li; Haiyan Tan; Mariano Javier Álvarez; Erin Honan; Min Yang; Peiling Chia; Partha Mukhopadhyay; Sean Kelly; Ruby Wu; Kathleen M. Fenn; Meghna S. Trivedi; Melissa Kate Accordino; Katherine D. Crew; Dawn Lauryn Hershman; Matthew A. Maurer; Simon Jones; Anthony A. High; Junmin Peng; Andrea C. Califano; Kevin M. Kalinsky; Jiyang Yu; José Maria Silva
View on Scopus
CD3 Target Affinity Chromatography Mass Spectrometry as a New Tool for Function-Structure Characterization of T-Cell Engaging Bispecific Antibody Proteoforms and Product-Related Variants
Analytical Chemistry, ISSN: 15206882 00032700
Steffen Lippold; Michaela Hook; Christian Spick; Alexander Knaupp; Kevin Whang; Fabian Ruperti; Lance Cadang; Nisana Andersen; Annette Vogt; Michael Grote; Dietmar Reusch; Markus Haberger; Feng Yang; Tilman Schlothauer
View on Scopus
© 2026 Genentech, Inc. All rights reserved. This site is intended for US residents only.