Scientists / Publications

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Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 151 - 200 OF 11542 RESULTS

MicroRNA–mRNA regulatory networks underlying chronic mucus hypersecretion in COPD
European Respiratory Journal, ISSN: 13993003 09031936
Hataitip Tasena; Alen Faiz; Timens; Jacobien Noordhoek; Machteld N. Hylkema; Reinoud Gosens; Pieter S. Hiemstra; Avrum Spira; Dirkje S. Postma; Wei Tew; Michele A. Grimbaldeston; van den Berge; Irene H. Heijink; Brandsma
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Progress in understanding slow inactivation speeds up
Journal of General Physiology, ISSN: 00221295
Jian Payandeh
Analytical Validation of a Hybrid Capture–Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA
Journal of Molecular Diagnostics, ISSN: 19437811 15251578
Travis Clark; Jon H. Chung; Mark Kennedy; Jason D. Hughes; Niru Chennagiri; Daniel S. Lieber; Bernard Fendler; Lauren Young; Mandy Zhao; Michael Coyne; Virginia Breese; Geneva Young; Amy Donahue; Dean Pavlick; Alyssa Tsiros; Timothy Brennan; Shan Zhong; Tariq Mughal; Mark Bailey; Jie He; Steven Roels; Garrett M Frampton; Jill Spoerke; Steven Gendreau; Mark Lackner; Erica Schleifman; Peters; Jeffrey S. Ross; Siraj M. Ali; Vincent A. Miller; Jeffrey P. Gregg; Phillip J. Stephens; Allison Welsh; Geoff A. Otto; Doron Lipson
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Considerations from the innovation and quality induction working group in response to drug-drug interaction guidances from regulatory agencies: Focus on CYP3A4 mRNA in vitro response thresholds, variability, and clinical relevances
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Jane Kenny; Diane Ramsden; David Buckley; Shannon Dallas; Conrad Fung; Michael A. Mohutsky; Heidi J. Einolf; Liangfu Chen; Joshua G. DeKeyser; Maria Fitzgerald; Theunis C Goosen; Amy Siu; Robert L. Walsky; George Zhang; Donald J. Tweedie; Niresh Hariparsad
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Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species
Analytical Biochemistry, ISSN: 10960309 00032697
Jing Wang; Ryan Takahashi; Kevin DeMent; Amy Gustafson; Jane Kenny; Simon G. Wong; Zhengyin Yan
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Long-term survival follow-up of atezolizumab in combination with platinum-based doublet chemotherapy in patients with advanced non–small-cell lung cancer
European Journal of Cancer, ISSN: 18790852 09598049
Stephen V. Liu; D. Ross Camidge; Scott Gettinger; Giuseppe Giaccone; Rebecca S. Heist; F. Stephen Hodi; Neal E. Ready; Wei Zhang; Jeffrey Wallin; Roel Funke; Waterkamp; Paul Foster; Koho Iizuka; John D. Powderly
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Safety and clinical activity of atezolizumab monotherapy in metastatic non-small-cell lung cancer: final results from a phase I study
European Journal of Cancer, ISSN: 18790852 09598049
Leora Horn; Scott Gettinger; Michael S. Gordon; Roy S. Herbst; Leena Gandhi; Enriqueta Felip; Lecia V. Sequist; David Spigel; Scott J. Antonia; Ani Balmanoukian; Philippe A. Cassier; Bo Liu; Marcin Kowanetz; Carol E. O'Hear; Marcella Fasso; William Grossman; Alan Sandler; Jean-Charles Soria
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Zinc finger protein 521 regulates early hematopoiesis through cell-extrinsic mechanisms in the bone marrow microenvironment
Molecular and Cellular Biology, ISSN: 02707306
Courtney J. Fleenor; Tessa Arends; Hong Lei; Josefine Ahsberg; Kazuki Okuyama; Jacob Kuruvilla; Susana Cristobal; Jennifer L. Rabe; Ahwan Pandey; Thomas Danhorn; Desiree Straign; Joaquin M. Espinosa; Soren Warming; Eric Pietras; Mikael Sigvardsson; James R. Hagman
Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: Insights from the faSScinate clinical trial in systemic sclerosis
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Christopher P. Denton; Voon H Ong; Shiwen Xu; Haiyin Chen; Zora Modrusan; Robert Lafyatis; Dinesh Khanna; Angelika Jahreis; Jeffrey Siegel; Thierry Sornasse
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Comparative effectiveness of tocilizumab versus TNF inhibitors as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis after the use of at least one biologic disease-modifying antirheumatic drug: Analyses from the pan-European TOCERRA register collaboration
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Kim Lauper; Dan C. Nordström; Karel Pavelka; Maria Victoria Hernández; Tore K. Kvien; Eirik Klami Kristianslund; Maria Jose Santos; Žiga Rotar; Florenzo Iannone; Catalin Codreanu; Galina Lukina; Sara Gale; Khaled Sarsour; Yves Luder; Delphine Sophie Courvoisier; Cem Gabay
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Erratum to: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells (Nature Chemical Biology, (2018), 14, 6, (582-590), 10.1038/s41589-018-0035-2)
Nature Chemical Biology, ISSN: 15524469 15524450
Aaron Nile; Felipe de Sousa e Melo; Susmith Mukund; Robert Piskol; Simon Hansen; Lijuan Zhou; Yingnan Zhang; Yue Fu; Emily Gogol; László Kömüves; Zora Modrusan; Stephane Angers; Yvonne Franke; Chris Koth; Wayne Fairbrother; Weiru Wang; Frederic De Sauvage; Rami Hannoush
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Patient-Reported Outcomes in OAK: A Phase III Study of Atezolizumab Versus Docetaxel in Advanced Non–Small-cell Lung Cancer
Clinical Lung Cancer, ISSN: 19380690 15257304
Rodolfo Bordoni; Fortunato Ciardiello; Joachim Von Pawel; Diego L Cortinovis; Thomas Karagiannis; Marcus Ballinger; Alan Sandler; Wei Yu; Pei He; Christina Matheny; Federico Felizzi; Achim Rittmeyer
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The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation
PLoS Biology, ISSN: 15457885 15449173
Konstantin Knoblich; Sara Cruz Migoni; Susan M. Siew; Elizabeth Jinks; Baksho Kaul; Hannah C. Jeffery; Alfie T. Baker; Muath Suliman; Katerina Vrzalikova; Hisham Mehenna; Paul G. Murray; Francesca Barone; Ye H. Oo; Philip N. Newsome; Gideon Hirschfield; Deirdre Kelly; Steven P. Lee; Biju Parekkadan; Shannon Turley; Anne L. Fletcher
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Gut-selective integrin-targeted therapies for inflammatory bowel disease
Journal of Crohn's and Colitis, ISSN: 18764479 18739946
Christopher A. Lamb; Sharon O'Byrne; Mary Keir; Eugene C. Butcher
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Kinase domain dimerization drives RIPK3-dependent necroptosis
Science Signaling, ISSN: 19450877
Saravanan Raju; Dan Whalen; Meron Mengistu; Carter J. Swanson; John G. Quinn; Susan Taylor; Webster; Kim Newton; Andrey Shaw
Development of an Efficient Manufacturing Process for Reversible Bruton's Tyrosine Kinase Inhibitor GDC-0853
Organic Process Research and Development, ISSN: 10836160
Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Qingping Tian; Danial Beaudry; Jessica L. Defreese; Alec Fettes; Philippe James; David Linder; Sushant Malhotra; Chong Han; Remy Angelaud; Francis Gosselin
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate
Molecular Cell, ISSN: 10974164 10972765
Tsun-Kai Chang; David Lawrence; Min Lu; Jenille Tan; Jonathan M. Harnoss; Scot Marsters; Peter Liu; Wendy Sandoval; Scott Martin; Avi Ashkenazi
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ERK Mutations and amplification confer resistance to ERK-inhibitor therapy
Clinical Cancer Research, ISSN: 15573265 10780432
Bijay Jaiswal; Steffen Durinck; Eric Stawiski; Peter Yin; Weiru Wang; Eva Lin; John Moffat; Scott Martin; Zora Modrusan; Somasekar Seshagiri
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Facile quantitation of free thiols in a recombinant monoclonal antibody by reversed-phase high performance liquid chromatography with hydrophobicity-tailored thiol derivatization
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Leslie Welch; Xiao Dong; Dan Hewitt; Michelle Irwin; Luke McCarty; Christina Tsai; Tomasz Baginski
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Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation
Cell Reports, ISSN: 22111247
Ryan Raisner; Samir Kharbanda; Lingyan Jin; Edwin Jeng; Emily Chan; Mark Merchant; Matthias Peter; Russell Bainer; Tommy K Cheung; David Arnott; Megan Flynn; Anthony Romero; Steven Magnuson; Karen Gascoigne
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Reply to J.J. Tao et al
Journal of Clinical Oncology, ISSN: 0732183X
John Hainsworth; Funda Meric-Bernstam; Charles Swanton; Herbert Hurwitz; David Spigel; Christopher J. Sweeney; Howard A. Burris; Ron Bose; Bongin Yoo; Alisha Stein; Beattie; Razelle Kurzrock
Scaffold-Hopping Approach to Discover Potent, Selective, and Efficacious Inhibitors of NF-ΰB Inducing Kinase
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Nicole Blaquiere; Georgette Castanedo; Jason Burch; Leo Berezhkovskiy; Hans Brightbill; Suzanne Brown; Connie Chan; Po-Chang Chiang; James J. Crawford; Teresa Dong; Peter Fan; Jianwen Feng; Nico Ghilardi; Robert Godemann; Emily Gogol; Alice Grabbe; Alison J. Hole; Baihua Hu; Sarah Hymowitz; Moulay Hicham Alaoui Ismaili; Hoa Le; Patrick Lee; Wyne Lee; Xingyu Lin; Ning Liu; Paul A. McEwan; Brent McKenzie; Hernani L. Silvestre; Eric Suto; Swathi Sujatha-Bhaskar; Guosheng Wu; Lawren Wu; Yamin Zhang; Zoe Zhong; Steven Staben
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The Effect of Low Ionic Strength on Diffusion and Viscosity of Monoclonal Antibodies
Molecular Pharmaceutics, ISSN: 15438392 15438384
Masha Pindrus; Steve Shire; Sandeep Yadav; Devendra S. Kalonia
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Novel markers to track oxidative polysorbate degradation in pharmaceutical formulations
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Sanket Dahotre; Anthony Tomlinson; Baiwei Lin; Sandeep Yadav
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Adsorption of polysorbate 20 and proteins on hydrophobic polystyrene surfaces studied by neutron reflectometry
Colloids and Surfaces B: Biointerfaces, ISSN: 18734367 09277765
Zhenhuan Zhang; Sara Orski; Ann Marie Woys; Guangcui Yuan; Isidro (Dan) Zarraga; Norman J. Wagner; Yun Liu
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Comments on assays used to measure VEGF in the presence of anti-VEGF therapeutics
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Eric Wakshull; Robert L. Avery; Mauricio Maia
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Considerations for the Use of Polysorbates in Biopharmaceuticals
Pharmaceutical Research, ISSN: 1573904X 07248741
Michael T. Jones; Hanns-Christian Mahler; Sandeep Yadav; Dilbir Bindra; Vincent Corvari; R. Matthew Fesinmeyer; Kapil Gupta; Alexander M. Harmon; Kenneth D. Hinds; Atanas Koulov; Wei Liu; Kevin Maloney; John Wang; Ping Y. Yeh; Satish K. Singh
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In vitro assessment of chemotherapy-induced neuronal toxicity
Toxicology in Vitro, ISSN: 18793177 08872333
Chelsea Snyder; Lanlan Yu; Tin Ngo; Daniel Sheinson; Yuda Zhu; Min Tseng; Misner; Karin Staflin
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Prevention of Fatal C3 Glomerulopathy by Recombinant Complement Receptor of the Ig Superfamily
Journal of the American Society of Nephrology, ISSN: 15333450 10466673
Xiaoxu Wang; Menno van Lookeren Campagne; Ken Katschke; Damodar Gullipalli; Takashi Miwa; Yoshiyasu Ueda; Yuan Wang; Matthew Palmer; Guolan Xing; Wen-Chao Song
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Sustained Response Following Discontinuation of Methotrexate in Patients With Rheumatoid Arthritis Treated With Subcutaneous Tocilizumab: Results From a Randomized, Controlled Trial
Arthritis and Rheumatology, ISSN: 23265205 23265191
Joel M. Kremer; William F. Rigby; Nora G. Singer; Christine Birchwood; Darcy Gill; Bill Reiss; Jinglan Pei; Margaret Michalska
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Updated Efficacy Analysis Including Secondary Population Results for OAK: A Randomized Phase III Study of Atezolizumab versus Docetaxel in Patients with Previously Treated Advanced Non–Small Cell Lung Cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Louis Fehrenbacher; Joachim Von Pawel; Keunchil Park; Achim Rittmeyer; David R. Gandara; Santiago Ponce Aix; Ji-Youn Han; Shirish M. Gadgeel; Toyoaki Hida; Diego L Cortinovis; Manuel Cobo; Dariusz M Kowalski; Filippo De Marinis; Mayank Gandhi; Bradford Danner; Christina Matheny; Marcin Kowanetz; Pei He; Federico Felizzi; Hina Patel; Alan Sandler; Marcus Ballinger; Fabrice Barlesi
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Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Navpreet Kaur; Ajit Narang; Arvind Kumar Bansal
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Validation of a plasma-based comprehensive cancer genotyping assay utilizing orthogonal tissue- and plasma-based methodologies
Clinical Cancer Research, ISSN: 15573265 10780432
Justin I. Odegaard; John J. Vincent; Stefanie Mortimer; James V. Vowles; Bryan C. Ulrich; Kimberly C. Banks; Stephen R. Fairclough; Oliver Zill; Marcin Sikora; Reza Mokhtari; Diana Abdueva; Rebecca J. Nagy; Christine E. Lee; Lesli A. Kiedrowski; Cloud P. Paweletz; Helmy Eltoukhy; Richard Lanman; Darya I. Chudova; Talasaz
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Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress
Cell Death and Differentiation, ISSN: 14765403 13509047
Mable Lam; David Lawrence; Avi Ashkenazi; Peter Walter
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Phase I study of the anti-α5β1 monoclonal antibody MINT1526A with or without bevacizumab in patients with advanced solid tumors
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Colin D. Weekes; Lee Rosen; Anna Capasso; Kit Man Wong; Weilan Ye; Maria Anderson; Bruce McCall; Jill Fredrickson; Eric Wakshull; Stephen Eppler; Quyen Shon-Nguyen; Rupal Desai; Mahrukh Huseni; Priti Hegde; Tony Pourmohamad; Ina Rhee; Alberto Bessudo
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Characterization and survival of patients with metastatic basal cell carcinoma in the Department of Veterans Affairs: a retrospective electronic health record review
Archives of Dermatological Research, ISSN: 1432069X 03403696
Vanessa W. Stevens; David D. Stenehjem; Olga V. Patterson; Kamauu; Yeun Mi Yim; Robert Morlock; Scott L. Duvall
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Alteplase for the treatment of acute ischemic stroke in patients with low National Institutes of Health Stroke Scale and not clearly disabling deficits (Potential of rtPA for Ischemic Strokes with Mild Symptoms PRISMS): Rationale and design
International Journal of Stroke, ISSN: 17474949 17474930
Sharon D. Yeatts; Broderick; Anjan Chatterjee; Edward C Jauch; Steven R. Levine; Jose G Romano; Jeffrey L. Saver; Achala Vagal; Barbara Purdon; Jenny Devenport; Pooja Khatri
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Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Digoxin in Patients With BRAFV600 Mutation–Positive Metastatic Malignancy
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Weijiang Zhang; Christine McIntyre; Melissa Kuhn; Harper Forbes; Tae Min Kim; Jeeyun Lee; Lev Demidov; Dawn Colburn
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Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines
Genome Medicine, ISSN: 1756994X
Petar Scepanovic; Cécile Alanio; Christian Hammer; Flavia Hodel; Jacob Bergstedt; Etienne Patin; Christian W. Thorball; Nimisha Chaturvedi; Bruno Charbit; Laurent Abel; Lluis Quintana-Murci; Darragh Duffy; Matthew Albert; Jacques Fellay; Andres Alcover; Hugues Aschard; Philippe Bousso; Pierre Bruhns; Ana Cumano; Caroline Demangel; Ludovic Deriano; James P. Di Santo; Françoise Dromer; Gérard Eberl; Jost Enninga; Odile Gelpi; Ivo Gomperts-Boneca; Milena Hasan; Claude Leclerc; Hugo Mouquet; Sandra Pellegrini; Lars Rogge; Anavaj Sakuntabhai; Olivier Schwartz; Benno Schwikowski; Spencer Shorte; Frédéric Tangy; Marie-Noëlle Ungeheuer; Kalla Astrom; Serge Hercberg; Mathilde Touvier; Olivier Lantz; Vassili Soumelis; Stanislas Pol; Antonio Rausell; Eric Tartour; Antoine Toubert
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Serum periostin levels following small bone fractures, long bone fractures and joint replacements: An observational study
Allergy, Asthma and Clinical Immunology, ISSN: 17101492 17101484
Rachel Varughese; Ruth Semprini; Claire Munro; James Fingleton; Cecile Holweg; Mark Weatherall; Richard Beasley; Irene Braithwaite
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Hydroamination versus Allylic Amination in Iridium-Catalyzed Reactions of Allylic Acetates with Amines: 1,3-Aminoalcohols via Ester-Directed Regioselectivity
Journal of the American Chemical Society, ISSN: 15205126 00027863
Seung Wook Kim; Thomas Wurm; Gilmar A. Brito; Woo-Ok Jung; Jason R. Zbieg; Craig Stivala; Michael J. Krische
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Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation
eLife,
Ryan Ferrao; Heidi Ackerly Wallweber; Patrick Lupardus
Change in biomarkers of type-2 inflammation following severe exacerbations of asthma
Thorax, ISSN: 14683296 00406376
Ruth Semprini; Nick Shortt; Stefan Ebmeier; Alex Semprini; Rachel Varughese; Cecile Holweg; John Matthews; James Fingleton; Mark Weatherall; Richard Beasley; Irene Braithwaite
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FRET Reagent Reveals the Intracellular Processing of Peptide-Linked Antibody-Drug Conjugates
Bioconjugate Chemistry, ISSN: 15204812 10431802
Byoung Chul Lee; Cecile Chalouni; Sophia Doll; Sam C. Nalle; Martine Darwish; Siao Ping Tsai; Kathy Kozak; Geoff Del Rosario; Shang-Fan Yu; Hans Erickson; Dick Vandlen
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A model of overall survival predicts treatment outcomes with atezolizumab versus chemotherapy in non–small cell lung cancer based on early tumor kinetics
Clinical Cancer Research, ISSN: 15573265 10780432
Laurent Claret; Jin Y. Jin; Charles Ferte; Helen Winter; Sandhya Girish; Mark Stroh; Pei He; Marcus Ballinger; Alan Sandler; Amita Joshi; Achim Rittmeyer; David Gandara; Jean-Charles Soria; Rene A. Bruno
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Cost-effectiveness of obinutuzumab plus bendamustine followed by obinutuzumab monotherapy for the treatment of follicular lymphoma patients who relapse after or are refractory to a rituximab-containing regimen in the US
Journal of Medical Economics, ISSN: 1941837X 13696998
Gregory F. Guzauskas; Anthony Masaquel; Carolina Reyes; Coen Bernaards; Tania Krivasi; David L. Veenstra
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Palladium-Catalyzed Site-Selective Amidation of Dichloroazines
Organic Letters, ISSN: 15237052 15237060
Ian S. Young; Anna-Lena Glass; Theresa Cravillion; Chong Han; Haiming Zhang; Francis Gosselin
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OTULIN limits cell death and inflammation by deubiquitinating LUBAC
Nature, ISSN: 14764687 00280836
Klaus Heger; Kate Wickliffe; Ada Ndoja; Juan Zhang; Aditya Murthy; Debbie Dugger; Maltzman; Felipe de Sousa e Melo; Jeffrey Hung; Yi Zeng; Erik Verschueren; Don Kirkpatrick; Domagoj Vucic; Wyne Lee; Meron Roose-Girma; Robert J (Research) Newman; Soren Warming; Yi-Chun Hsiao; László Kömüves; Webster; Kim Newton; Vishva Dixit
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Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche
Nature, ISSN: 14764687 00280836
Ysbrand M. Nusse; Adam K. Savage; Pauline Marangoni; Axel K. M. Rosendahl-Huber; Tyler A. Landman; Frederic De Sauvage; Richard M. Locksley; Ophir D. Klein
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Interplay of DDP4 and IP-10 as a potential mechanism for cell recruitment to tuberculosis lesions
Frontiers in Microbiology, ISSN: 1664302X
Thomas Blauenfeldt; Linda Petrone; Franca del Nonno; Andrea Baiocchini; Laura Falasca; Teresa Chiacchio; Vincent Bondet; Valentina Vanini; Fabrizio Palmieri; Gianni Galluccio; Armanda Casrouge; Jesper Eugen-Olsen; Matthew Albert; Delia Goletti; Darragh Duffy; Morten Ruhwald
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