Scientists / Publications

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Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 201 - 250 OF 11912 RESULTS

Macrolactamization Approaches to Arylomycin Antibiotics Core
Organic Letters, ISSN: 15237060
Ngiap-Kie Lim; Xin Linghu; Nicholas Wong; Haiming Zhang; C. Gregory Sowell; Francis Gosselin
Cellular Plasticity in Intestinal Homeostasis and Disease
Cell Stem Cell, ISSN: 19345909
Felipe de Sousa e Melo; Frederic De Sauvage
Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer
Structure,
Ping Wu; Christopher J. Sneeringer; Keith E. Pitts; Eric S. Day; Bryan Chan; Binqing Wei; Isabelle Lehoux; Kyle Mortara; Hong Li; Jiansheng Wu; Yvonne Franke; John Moffat; Jane Grogan; Tim Heffron; Weiru Wang
Quantitative Determination of Protein-Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry
Analytical Chemistry, ISSN: 00032700
Chengfeng Ren; Aaron O. Bailey; Erica VanderPorten; Angela Oh; Wilson Phung; Melinda M. Mulvihill; Seth Harris; Yichin Liu; Guanghui Han; Wendy Sandoval
Strategies for modifying drug residence time and ocular bioavailability to decrease treatment frequency for back of the eye diseases
Expert Opinion on Drug Delivery, ISSN: 17447593 17425247
Whitney Shatz; Jeffrey Aaronson; Stefan Yohe; Robert F. Kelley; Yogeshvar N. Kalia
View on Scopus
Rapid Identification of Disulfide Bonds and Cysteine-Related Variants in an IgG1 Knob-into-Hole Bispecific Antibody Enhanced by Machine Learning
Analytical Chemistry, ISSN: 15206882 00032700
Jordan Baker; Dana McDaniel; David Cain; Paula Lee Tao; Charlene Li; Yuting Huang; Hongbin Liu; Judy Shimoni; Milady Ninonuevo
View on Scopus
Genomic alterations associated with recurrence and TNBC subtype in high-risk early breast cancers
Molecular Cancer Research, ISSN: 15417786
Tim Wilson; Akshata R. Udyavar; Ching-Wei Chang; Jill Spoerke; Junko Aimi; Heidi Savage; Anneleen Daemen; O'Shaughnessy; Richard Bourgon; Mark Lackner
LACC1 regulates TNF and IL-17 in mouse models of arthritis and inflammation
Journal of Immunology, ISSN: 15506606 00221767
Cara Skon-Hegg; Juan Zhang; Xiumin Wu; Meredith Sagolla; Neko Ota; Art Wuster; Jennifer A. Tom; Emma Doran; Nandhini Ramamoorthi; Patrick Caplazi; John Monroe; Wyne P. Lee; Tim Behrens
View on Scopus
Long-term survival in patients with advanced non–small-cell lung cancer treated with atezolizumab versus docetaxel: Results from the randomised phase III OAK study
European Journal of Cancer, ISSN: 18790852 09598049
Joachim Von Pawel; Rodolfo Bordoni; Satouchi; Louis Fehrenbacher; Manuel Cobo; Han; Hida; Moro-Sibilot; Paul Conkling; Gandara; Achim Rittmeyer; Mayank Gandhi; Wei Yu; Christina Matheny; Hina Patel; Alan Sandler; Marcus Ballinger; Marcin Kowanetz; Keunchil Park
View on Scopus
Measurement of IL-17AA and IL-17FF as Pharmacodynamic Biomarkers to Demonstrate Target Engagement in the Phase I Study of MCAF5352A
AAPS Journal, ISSN: 15507416
Kate Peng; Yehong Wang; Ketevan Siradze; Rich Erickson; Sally Fischer; Tracy Staton
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Microinjection and oviduct transfer procedures for rat model generation with CRISPR-Cas9 technology
Methods in Molecular Biology, ISSN: 10643745
Tuija Alcantar; Xin Rairdan
View on Scopus
Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade
Cancer Letters, ISSN: 18727980 03043835
Jing Zheng; Yonggang Sha; Logan Roof; Oded Foreman; John Lazarchick; Jagadish Kummetha Venkta; Cleopatra Kozlowski; Cristina Gasparetto; Nelson Chao; Allen Ebens; Jianda Hu; Yubin Kang
View on Scopus
Computational pathology definitions, best practices, and recommendations for regulatory guidance: a white paper from the Digital Pathology Association
Journal of Pathology, ISSN: 00223417
Esther Abels; Liron Pantanowitz; Famke Aeffner; Mark D Zarella; Jeroen van der Laak; Marilyn M Bui; Venkata NP Vemuri; Anil V Parwani; Jeff Gibbs; Emmanuel Agosto-Arroyo; Andrew H Beck; Cleopatra Kozlowski
Corrigendum to “Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS” (Neurobiology of Disease (2019) 124 (340–352)(S0969996118303978)(10.1016/j.nbd.2018.12.002)
Neurobiology of Disease, ISSN: 1095953X 09699961
Arundhati Sengupta Ghosh; Sara Dominguez; Luke Xie; Kai Barck; Zhiyu Jiang; Timothy K. Earr; Jose Imperio; Lilian Phu; Hanna G. Budayeva; Don Kirkpatrick; Hao Cai; Dongping He; Jeff Eastham; Hai Ngu; Oded Foreman; Maj Hedehus; Mike Reichelt; Isidro Hotzel; Yonglei Shang; Rick Carano; Gai Ayalon; Amy Easton
View on Scopus
Data-Driven Development of Predictive Models for Sustained Drug Release
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Stijn H.S. Koshari; Debby Chang; Nathan B. Wang; Isidro (Dan) Zarraga; Karthikan Rajagopal; Abraham M. Lenhoff; Norman J. Wagner
View on Scopus
Evaluation and use of an anti-cynomolgus monkey CD79b surrogate antibody–drug conjugate to enable clinical development of polatuzumab vedotin
British Journal of Pharmacology, ISSN: 14765381 00071188
Dongwei Li; Donna Lee; Randy Dere; Bing Zheng; Shang-Fan Yu; Franklin Fuh; Kathy Kozak; Shan Chung; Daniela Bumbaca Yadav; Denise Nazzal; Dimitry Danilenko; MaryAnn Go; Marna Williams; Andy Polson; Kirsten Achilles Poon; Saileta Prabhu
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GDC-0810 pharmacokinetics and transporter-mediated drug interaction evaluation with an endogenous biomarker in the first-in-human, dose escalation study
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Kit Wun Kathy Cheung; Kenta Yoshida; Sravanthi Cheeti; Buyun Chen; Roland Morley; Iris Chan; Srikumar Sahasranaman; Lichuan Liu
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Improved Synthesis of the Nav1.7 Inhibitor GDC-0276 via a Highly Regioselective SNAr Reaction
Organic Process Research and Development, ISSN: 1520586X 10836160
Andy Stumpf; Zhigang Ken Cheng; Danial Beaudry; Remy Angelaud; Francis Gosselin
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The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs
Life Science Alliance, ISSN: 25751077
Mattias Rydenfelt; Matthew Wongchenko; Bertram Klinger; Yibing Yan; Nils Blüthgen
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Unobstructed Multiscale Imaging of Tissue Sections for Ultrastructural Pathology Analysis by Backscattered Electron Scanning Microscopy
Journal of Histochemistry and Cytochemistry, ISSN: 15515044 00221554
Mike Reichelt; Meredith Sagolla; Anand Kumar Katakam; Webster
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A clinically applicable gene-expression classifier reveals intrinsic and extrinsic contributions to consensus molecular subtypes in primary and metastatic colon cancer
Clinical Cancer Research, ISSN: 15573265 10780432
Robert Piskol; Ling-Yuh Huw; Ismail Sergin; Christiaan Kljin; Zora Modrusan; Doris Kim; Noelyn Kljavin; Nga Wan Rachel Tam; Rajesh Patel; Jeremy Burton; Elicia Penuel; Xueping Qu; Hartmut Koeppen; Teiko Sumiyoshi; Frederic De Sauvage; Mark Lackner; Felipe de Sousa e Melo; Omar Kabbarah
View on Scopus
An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice
Journal of Cellular Physiology, ISSN: 10974652 00219541
Jungeun Yu; Chris Siebel; Lauren Schilling; Ernesto Canalis
View on Scopus
Comparative Efficacy of Second- and Subsequent-line Treatments for Metastatic NSCLC: A Fractional Polynomials Network Meta-analysis of Cancer Immunotherapies
Clinical Lung Cancer, ISSN: 19380690 15257304
Christian Schulz; David R. Gandara; Carmen Berardo; Rachel Rosenthal; Jason Foo; Chaienna Morel; Marcus Ballinger; Claire Watkins; Paula Chu
View on Scopus
Correction to: Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers (Clinical Drug Investigation, (2019), 10.1007/s40261-019-00807-3)
Clinical Drug Investigation, ISSN: 11791918 11732563
Michael E. Rothenberg; Tagen; Jae H. Chang; Janel Boyce-Rustay; Michel Friesenhahn; David Hackos; Avis Hains; Dan Sutherlin; Michael Ward; William Cho
View on Scopus
Early notch signals induce a pathogenic molecular signature during priming of alloantigen-specific conventional CD4+ T cells in graft-versus-host disease
Journal of Immunology, ISSN: 15506606 00221767
Jooho Chung; Vedran Radojcic; Eric Perkey; Timothy J. Parnell; Yashar Niknafs; Xi Jin; Ann Friedman; Nathalie Labrecque; Bruce R. Blazar; Todd V. Brennan; Chris Siebel; Ivan Maillard
View on Scopus
Nasal gene expression changes with inhaled corticosteroid treatment in asthma
Allergy: European Journal of Allergy and Clinical Immunology, ISSN: 13989995 01054538
Ilse M. Boudewijn; Andy Lan; Alen Faiz; Claire A. Cox; Sharon Brouwer; Siebrig Schokker; Sebastiaan J. Vroegop; Nawijn; Prescott G. Woodruff; Stephanie Christenson; Paul Hagedoorn; Henderik W. Frijlink; David Choy; Uilke Brouwer; Marissa Wisman; Dirkje S. Postma; James Fingleton; Richard Beasley; van den Berge; Victor Guryev
View on Scopus
Positron Emission Tomography Imaging of [11C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Sarah Billington; Steven Shoner; Scott Lee; Kindra Clark-Snustad; Matthew Pennington; David Lewis; Mark Muzi; Shirley Rene; Jean Lee; Tot Bui Nguyen; Vineet Kumar; Kazuya Ishida; Laigo Chen; Xiaoyan Chu; Yurong Lai; Laurent Salphati; Marcel Hop; Guangqing Xiao; Mingxiang Liao; Jashvant D. Unadkat
View on Scopus
Safety, pharmacokinetics, and pharmacodynamic activity of obinutuzumab, a type 2 anti-CD20 monoclonal antibody for the desensitization of candidates for renal transplant
American Journal of Transplantation, ISSN: 16006143 16006135
Robert R. Redfield; Stanley C. Jordan; Stephan Busque; Vincenti; E. Steve Woodle; Niraj Desai; Elaine Reed; Simon Tremblay; Andrea A. Zachary; Ashley A. Vo; Richard Formica; Thomas Schindler; Ha Tran; Carrie Looney; Candice Jamois; Cherie Green; Alyssa Morimoto; Richa Rajwanshi; Aaron Schroeder; Matthew Cascino; Paul Brunetta; Dominic Borie
View on Scopus
Trastuzumab emtansine with or without pertuzumab versus trastuzumab with taxane for human epidermal growth factor receptor 2–positive advanced breast cancer: Final results from MARIANNE
Cancer, ISSN: 10970142 0008543X
Edith Perez; Carlos H. Barrios; Wolfgang Eiermann; Masakazu Toi; Im; Pier Franco Conte; Miguel Martin; Tadeusz Pieńkowski; Pivot; Howard A. Burris; Jenny Petersen; Sanne De Haas; Silke Hoersch; Patre; Paul Ellis
View on Scopus
Variance component analysis of circulating miR-122 in serum from healthy human volunteers
PLoS ONE,
Jennifer Vogt; Daniel Sheinson; Paula Katavolos; Hiroko Irimagawa; Min Tseng; Kathila Alatsis; William R. Proctor
[18F]GTP1 (Genentech Tau Probe 1), a radioligand for detecting neurofibrillary tangle tau pathology in Alzheimer’s disease
European Journal of Nuclear Medicine and Molecular Imaging, ISSN: 16197070
Sandra Sanabria; Jan Marik; Annie Ogasawara; Jeff Tinianow; Herman Gill; Olivier Barret; Gilles D. Tamagnan; David Alagille; Gai Ayalon; Paul T. Manser; Thomas Bengtsson; Michael Ward; Simon P. Williams; Geoffrey A. Kerchner; John P. Seibyl; Ken Marek; Robby Weimer
A prognostic model of persistent bacteremia and mortality in complicated staphylococcus aureus bloodstream infection
Clinical Infectious Diseases, ISSN: 15376591 10584838
Alessander O. Guimaraes; Yi Cao; Kyu Hong; Oleg Mayba; Melicent Peck; Johnny Gutierrez; Felicia Ruffin; Montse Carrasco-Triguero; Dinoso; Angelo Clemenzi-Allen; Catherine A. Koss; Stacey A. Maskarinec; Chambers; Vance G. Fowler; Amos Baruch; Carrie Rosenberger
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Bayesian Population Model of the Pharmacokinetics of Venetoclax in Combination with Rituximab in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia: Results from the Phase III MURANO Study
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Rong Deng; Leonid Gibiansky; Tong Lu; Priya Agarwal; Hao Ding; Xiaobin Li; Smita Kshirsagar; Dan Lu; Chunze Li; Sandhya Girish; Jue Wang; Michelle Boyer; Kathryn Humphrey; Kevin J. Freise; Ahmed Hamed Salem; John F. Seymour; Kater; Dale Miles
View on Scopus
Bioanalytical challenges in development of ultrasensitive Home Brew assays: A case study using IL-13
Bioanalysis, ISSN: 17576199 17576180
Gizette Sperinde; Martha Hokom; Kate Peng; Sally Fischer
View on Scopus
Long-Term Safety of Rituximab in Patients With Rheumatoid Arthritis: Results of a Five-Year Observational Study
Arthritis Care and Research, ISSN: 2151464X
Kevin L. Winthrop; Saag; Matthew Cascino; Jinglan Pei; Ani John; Angelika Jahreis; Tmirah Haselkorn; Daniel E. Furst
Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus
mAbs, ISSN: 19420870 19420862
Rong Deng; Chenguang Zhou; Dongwei Li; Hao Cai; Sid Sukumaran; Montse Carrasco-Triguero; Ola Saad; Denise Nazzal; Christopher Lowe; Saroja Ramanujan; Amrita Kamath
View on Scopus
Quantitative Comparison of Conventional and t-SNE-guided Gating Analyses
Frontiers in Immunology,
Shadi Toghi Eshghi; Amelia Au-Yeung; Chikara Takahashi; Chris Bolen; Maclean N. Nyachienga; Sean P. Lear; Cherie Green; Rod Mathews; William E. O'Gorman
Structural and Functional Variation in Outer Membrane Polysaccharide Export (OPX) Proteins from the Two Major Capsule Assembly Pathways Present in Escherichia coli
Journal of Bacteriology, ISSN: 10985530 00219193
Caitlin Sande; Catrien Bouwman; Elisabeth Kell; Nicholas Nickerson; Sharookh Kapadia; Chris Whitfield
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Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members
mAbs, ISSN: 19420870 19420862
Yanli Yang; Sherry H. Yeh; Shravan Madireddi; Wadim Matochko; Chen Gu; Patricia Pacheco-Sanchez; Mark Ultsch; Gladys Boenig; Seth Harris; Brandon Leonard; Suzie Scales; Jing W. Zhu; Erin Christensen; Julie Q. Hang; Randall Brezski; Scot Marsters; Avi Ashkenazi; Sid Sukumaran; Henry Chiu; Rafael Cubas; Kim; Greg Lazar
View on Scopus
Cyclodextrin Reduces Intravenous Toxicity of a Model Compound
Journal of Pharmaceutical Sciences, ISSN: 00223549
Priscilla Mantik; Minli Xie; Harvey Wong; Hank La; Ronald Steigerwalt; Uday Devanaboyina; Geoffrey Ganem; Danny Shih; John Flygare; Wayne Fairbrother; Paroma Chakravarty; David Russell; Gilberto E. Fernandez; Ajit Narang
Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy
Cancer Cell, ISSN: 18783686 15356108
Tuba N. Gide; Camelia Quek; Alexander M. Menzies; Annie T. Tasker; Ping Shang; Jeff Holst; Jason Madore; Su Yin Lim; Rebecca Velickovic; Matthew Wongchenko; Yibing Yan; Serigne Lo; Matteo S. Carlino; Alexander Guminski; Robyn P.M. Saw; Angel Pang; Helen M. McGuire; Umaimainthan Palendira; John F. Thompson; Helen Rizos; Ines Pires da Silva; Marcel Batten; Richard A. Scolyer; Georgina V. Long; James S. Wilmott
View on Scopus
Durability of Diabetic Retinopathy Improvement with As-Needed Ranibizumab: Open-Label Extension of RIDE and RISE Studies
Ophthalmology, ISSN: 01616420
Jennifer K. Sun; Pin-wen Wang; Sarah Taylor; Zdenka Haskova
Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain
Journal of Molecular Biology, ISSN: 10898638 00222836
Mark Ultsch; Wei Li; Charles Eigenbrot; Paola Di Lello; Terry Lipari; Gerhardy; Andrew Ah Young; John Quinn; Yvonne Franke; Chen; Monica Beltran; Andy Peterson; Daniel Kirchhofer
View on Scopus
Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance
Cancer Cell, ISSN: 15356108
Jon Cooper; Filippo G Giancotti
Interaction of cell culture process parameters for modulating mAb afucosylation
Biotechnology and Bioengineering, ISSN: 00063592
Anh Nguyen Dang; Melissa Mun; Christopher M. Rose; Patrick Ahyow; Angela Meier; Wendy Sandoval; Inn Yuk
Quantifying the vial capping process: Residual seal force and container closure integrity
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Robert Ovadia; Alexander Streubel; Yenny Webb-Vargas; Lea Ulland; Joerg Luemkemann; Kamila Rauch; Juergen Eder; Philippe Lam; Vassia Tegoulia; Yuh-Fun Maa
Quantitative X-Ray Microcomputed Tomography Assessment of Internal Tablet Defects
Journal of Pharmaceutical Sciences, ISSN: 00223549
Edward Yost; Pascal Chalus; Shawn Zhang; Stefanie Peter; Ajit Narang
Risk of serious infections in tocilizumab versus other biologic drugs in patients with rheumatoid arthritis: A multidatabase cohort study
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Ajinkya Pawar; Rishi J. Desai; Daniel H. Solomon; Adrian J. Santiago Ortiz; Sara Gale; Min Bao; Khaled Sarsour; Sebastian Schneeweiss; Seoyoung C. Kim
View on Scopus
Simulating an Anti–Vascular Endothelial Growth Factor Switch in Neovascular Age-Related Macular Degeneration: A HARBOR Subanalysis
Ophthalmology, ISSN: 01616420
Marco A. Zarbin; Min Tsuboi; Lauren Hill; Ivo Stoilov
Split-cakes, still delicious
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Philippe Lam; Thomas Patapoff

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