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Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

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Journal of Colloid and Interface Science, ISSN: 10957103 00219797
Aadithya Kannan; Ian Shieh; Gerald G. Fuller
Frontiers in Cell and Developmental Biology, ISSN: 2296634X
Satoko Kakiuchi-Kiyota; Melissa Schutten; Yu Zhong Yao; James Crawford; Anwesha Dey
Disruption of IRE1α through its kinase domain attenuates multiple myeloma
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Jonathan Harnoss; Adrien Le Thomas; Anna Shemorry; Scot Marsters; David Lawrence; Min Lu; Yung-Chia Ariel Chen; Jing Qing; Klara Totpal; David Kan; Ehud Segal; Mark Merchant; Mike Reichelt; Heidi Ackerly Wallweber; Weiru Wang; Kevin Clark; Susan Kaufman; Maureen Beresini; Steven T. Laing; Wendy Sandoval; Maria Lorenzo; Jiansheng Wu; Justin Ly; Tom De Bruyn; Amy Heidersbach; Benjamin Haley; Alvin Gogineni; Robby Weimer; Dong Lee; Marie-Gabrielle Braun; Joachim Rudolph; Michael J. VanWyngarden; Daniel W. Sherbenou; Patricia Gomez-Bougie; Amiot; Diego Acosta-Alvear; Peter Walter; Avi Ashkenazi
Cell, ISSN: 10974172
Jane Guan; Wei Zhou; Marc Hafner; Robert Blake; Cecile Chalouni; Irene P. Chen; Tom De Bruyn; Jennifer Giltnane; Steven J. Hartman; Amy Heidersbach; Rene Houtman; Ellen Ingalla; Kategaya; Tracy Kleinheinz; Jun Li; Scott E. Martin; Zora Modrusan; Michelle Nannini; Jason Oeh; Savita Ubhayakar; Xiaojing Wang; Ingrid Wertz; Amy Young; Mamie Yu; Deepak Sampath; Jeffrey H. Hager; Lori Friedman; Anneleen Daemen; Ciara Metcalfe
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Changchun Du; Jack Bevers; Ryan Cook; Twyla Lombana; Kamalakannan Rajasekaran; Marissa Matsumoto; Christoph Spiess; Jeong Kim; Zhengmao Ye
Carfilzomib Is Not an Appropriate Payload of Antibody-Drug Conjugates Due to Rapid Inactivation by Lysosomal Enzymes
Drug Metabolism and Disposition,
Yong Ma; Josefa Dela Cruz Chuh; S Cyrus Khojasteh; Peter Dragovich; Thomas Pillow; Donglu Zhang
Seminars in Immunology, ISSN: 10963618 10445323
Christian Neumann; Alexander Scheffold; Sascha Rutz
Annals of Oncology, ISSN: 15698041 09237534
Oliveira; Saura; Nuciforo; Calvo; Andersen; Passos-Coelho; Gil Gil; Bermejo; Debra Patt; Eva Ciruelos; Lorena de la Peña; Xu; Matthew Wongchenko; Shi; Stina Singel; Isakoff
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Heinz-Josef Lenz; Fang-Shu Ou; Alan P. Venook; Hochster; Donna Niedzwiecki; Richard M. Goldberg; Robert J. Mayer; Monica M. Bertagnolli; Charles D. Blanke; Tyler J. Zemla; Xueping Qu; Pratyaksha Wirapati; Sabine Tejpar; Federico Innocenti; Omar Kabbarah
CBP/p300 drives the differentiation of regulatory T cells through transcriptional and non-transcriptional mechanisms
Cancer Research, ISSN: 00085472
Joseph Castillo; Esther Wu; Christopher Lowe; Shrividhya Srinivasan; Mccord; Marie-Claire Wagle; Sangeeta Jayakar; Melissa Gonzalez Edick; Jeff Eastham; Bonnie Liu; Katherine E. Hutchinson; Wendell Jones; Matthew P. Stokes; Somayeh S. Tarighat; Tom Holcomb; Andrew Glibicky; Anthony Romero; Steven Magnuson; Shih-Min A. Huang; Vicki Plaks; Jennifer Giltnane; Mark Lackner; Zineb Mounir
Prognostic impact of natural killer cell count in follicular lymphoma and diffuse large b-cell lymphoma patients treated with immunochemotherapy
Clinical Cancer Research, ISSN: 10780432
Magdalena Klanova; Mikkel Z. Oestergaard; Marek Trneny; Wolfgang Hiddemann; Robert Marcus; Laurie H. Sehn; Umberto Vitolo; Alexandra Bazeos; Valentin Goede; Harald Zeuner; Andrea Knapp; Deniz Sahin; Nathalie Spielewoy; Chris Bolen; Andres Cardona; Christian Klein; Jeffrey M. Venstrom; Tina Nielsen; Guenter Fingerle-Rowson
Industrial and Engineering Chemistry Research, ISSN: 15205045 08885885
Yuan Jin; S. Joe Qin; Qiang Huang; Victor Saucedo; Zheng Li; Angela Meier; Siddhartha Kundu; Bri Lehr; Salim Charaniya
Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2
Proceedings of the National Academy of Sciences of the United States of America,
Laurel M. Pegram; Jennifer C. Liddle; Yao Xiao; Maria Hoh; Johannes Rudolph; Dylan B. Iverson; Guy Vigers; Darin Smith; Hailong Zhang; Weiru Wang; John Moffat; Natalie G. Ahn
The Importance of Molecular Immune Investigation in Therapeutic Clinical Development for Biomarker Assessment
Journal of Crohn's and Colitis,
Christopher A. Lamb; John C Mansfield; John A. Kirby; Mary Keir
TAZ is required for lung alveolar epithelial cell differentiation after injury
JCI insight,
Tianhe Sun; Zhiyu Huang; Hua Zhang; Clara Posner; Guiquan Jia; Thiru Ramalingam; Min Xu; Hans Brightbill; Jackson Egen; Anwesha Dey; Joe Arron
Discovery of clinical candidate (1 R,4 r)-4-((R)-2-((S)-6-Fluoro-5 H-imidazo[5,1-A[isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a potent and selective inhibitor of indoleamine 2,3-dioxygenase 1
Journal of Medicinal Chemistry, ISSN: 00222623
Sanjeev Kumar; Jesse P. Waldo; Firoz A. Jaipuri; Agnieszka Marcinowicz; Clarissa Van Allen; James Adams; Tanay Kesharwani; Xiaoxia Zhang; Richard Metz; Angela Oh; Seth Harris; Mario R. Mautino
A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages
Immunity, ISSN: 10747613
Matthew B. Buechler; Ki-Wook Kim; Emily J. Onufer; Jesse W. Williams; Christine C. Little; Claudia Dominguez; Qingling Li; Wendy Sandoval; Jon Cooper; Charles Harris; Melissa Junttila; Gwendalyn J. Randolph; Shannon Turley
IL-17A is associated with the breakdown of the blood-brain barrier in relapsing-remitting multiple sclerosis
Journal of Neuroimmunology, ISSN: 01655728
Francesca Setiadi; Alexander Abbas; Surinder Jeet; Kit Wong; Antje Bischof; Ivan Peng; James Lee; Meire Bremer; Erica L. Eggers; Jason DeVoss; Tracy Staton; Ann Herman; H. -Christian von Büdingen; Michael Townsend
Robust network inference using response logic
Bioinformatics, ISSN: 13674803
Torsten Gross; Matthew Wongchenko; Yibing Yan; Nils Blüthgen
eLife, ISSN: 2050084X
Junghyun Lim; Hyunjoo Park; Jason Heisler; Timurs Maculins; Meron Roose-Girma; Min Xu; Brent McKenzie; Menno van Lookeren Campagne; Kim Newton; Aditya Murthy
Effect of concomitant dosing with acid-reducing agents and vemurafenib dose on survival in patients with BRAFV600 mutation–positive metastatic melanoma treated with vemurafenib ± cobimetinib
European Journal of Cancer, ISSN: 09598049
Karl Lewis; Axel Hauschild; James Larkin; Antoni Ribas; Keith Flaherty; Grant A. McArthur; Brigitte Dréno; Edward McKenna; Qian Zhu; Yong Mun; Paolo A. Ascierto
Effects of PI3K Inhibition on Afucosylated Antibody-Driven FcγRIIIa Events and Phospho-S6 Activity in NK Cells
Journal of Immunology,
Valentina Romeo; Sarah Gierke; Kyle A. Edgar; Scot D. Liu
The Lancet Oncology, ISSN: 14745488 14702045
Howard West; Michael McCleod; Maen Hussein; Alessandro Morabito; Achim Rittmeyer; Henry J Conter; Hans-Georg Kopp; Davey B Daniel; Steven McCune; Tarek Mekhail; Alona Zer; Niels Reinmuth; Ahad Sadiq; Alan Sandler; Wei Lin; Tania Ochi Lohmann; Venice Archer; Lijia Wang; Marcin Kowanetz; Federico Cappuzzo
AAPS PharmSciTech, ISSN: 15309932
Samarth D. Thakore; Poonam Singh Thakur; Ganesh Shete; Rahul Gangwal; Ajit Narang; Abhay T. Sangamwar; Arvind Kumar Bansal
Annals of Oncology, ISSN: 15698041 09237534
Matthew D. Hellmann; Kim; Lee; Goh; Miller; Do-Youn Oh; Rahima Jamal; Chee; Laura Q.M. Chow; Gainor; Jayesh Desai; Benjamin Solomon; Meghna Das Thakur; Bethany Pitcher; Paul Foster; Genevive Hernandez; Matthew Wongchenko; Edward Cha; Bang; Siu; Bendell
Genes, ISSN: 20734425
Ze Zhang; Danni Luo; Xue Zhong; Jin Huk Choi; Yuanqing Ma; Stacy Wang; Elena Mahrt; Wei Guo; Eric Stawiski; Zora Modrusan; Somasekar Seshagiri; Payal Kapur; Gary C. Hon; James Brugarolas; Tao Wang
The Lancet Oncology, ISSN: 14745488 14702045
Herve Tilly; Morschhauser; Nancy L. Bartlett; Amitkumar Mehta; Gilles Salles; Corinne Haioun; Javier Munoz; Andy I Chen; Kathryn S. Kolibaba; Dan Lu; Mark Yan; Elicia Penuel; Jamie Hirata; Calvin Lee; Jeff P. Sharman
Nature Methods, ISSN: 15487105 15487091
Glenn R. Masson; John E. Burke; Natalie G. Ahn; Ganesh Srinivasan Anand; Christoph H. Borchers; Sébastien Brier; George M. Bou-Assaf; John R. Engen; S. Walter Englander; Johan Faber; Rachel Garlish; Patrick Griffin; Michael L. Gross; Miklos Guttman; Yoshitomo Hamuro; Albert J.R. Heck; Damian Houde; Roxana E. Iacob; Thomas J. D. Jørgensen; Igor A. Kaltashov; Judith P. Klinman; Lars Konermann; Petr Man; Leland Mayne; Bruce D. Pascal; Dana Reichmann; Mark Skehel; Joost Snijder; Timothy S. Strutzenberg; Eric S. Underbakke; Cornelia Wagner; Thomas E. Wales; Ben Walters; David D. Weis; Derek J. Wilson; Patrick L. Wintrode; Zhongqi Zhang; Jie Zheng; David C. Schriemer; Kasper D. Rand
Molecular Pharmaceutics, ISSN: 15438392
David A. Hirsh; Anuradha V. Wijesekara; Scott L. Carnahan; Ivan Hung; Joe Lubach; Karthik Nagapudi; Aaron J. Rossini
Prognostic risk score for patients with relapsed or refractory chronic lymphocytic leukaemia treated with targeted therapies or chemoimmunotherapy: a retrospective, pooled cohort study with external validations
The Lancet Haematology,
Jacob D Soumerai; Ai Ni; Mohamed Darif; Anil Londhe; Guan Xing; Yong Mun; Neil E Kay; Tait D Shanafelt; Kari G Rabe; John C. Byrd; Chanan-Khan; Richard Furman; Hillmen; Jeffrey Jones; John F. Seymour; Jeff P. Sharman; Lucille Ferrante; Mehrdad Mobasher; Thomas Stark; Vijay Reddy; Lyndah K Dreiling; Pankaj Bhargava; Angela Howes; Danelle F James; Zelenetz
Molecular Pharmaceutics, ISSN: 15438392
Joseph A. O'Donoghue; Daniel C. Danila; Neeta Pandit-Taskar; Volkan Beylergil; Sarah M. Cheal; Stephen E. Fleming; Josef J. Fox; Shutian Ruan; Pat B. Zanzonico; Govind Ragupathi; Serge K. Lyashchenko; Simon P. Williams; Scher; Bernard Fine; John L. Humm; Steven M. Larson; Michael J. Morris; Jorge A. Carrasquillo
Cell Reports, ISSN: 22111247
Hsu; Sébastien Tabariès; Radia Johnson; Sylvia Andrzejewski; Julien Senecal; Camille Lehuédé; Matthew G. Annis; Ma; Sandra Völs; LeeAnn Ramsay; Remi Froment; Anie Monast; Ian R. Watson; Zvi Granot; Jones; Julie St-Pierre; Siegel
Massive antibody discovery used to probe structure-function relationships of the essential outer membrane protein LptD
eLife,
Kelly Storek; Joyce Chan; Rajesh Vij; Nancy Chiang; Zhonghua Lin; Jack Bevers; Chris Koth; Jean-Michel Vernes; Gloria Meng; Peter Yin; Heidi Ackerly Wallweber; Olivier Dalmas; Stephanie Shriver; Christine Tam; Kellen Schneider; Dhaya Seshasayee; Gerry Nakamura; Peter Smith; Jian Payandeh; JT Koerber; Laetitia Comps-Agrar; Steven Rutherford
Mechanisms of immune-related adverse events associated with immune checkpoint blockade: Using germline genetics to develop a personalized approach
Genome Medicine,
Zia Khan; Christian Hammer; Ellie Guardino; G. Scott Chandler; Matthew Albert
Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial
The Lancet, ISSN: 01406736
Brian I. Rini; Thomas Powles; Michael B. Atkins; Bernard Escudier; David McDermott; Cristina Suárez; Sergio Bracarda; Walter M. Stadler; Frede Donskov; Jae-Lyun Lee; Robert E. Hawkins; Alain Ravaud; Boris Alekseev; Michael D. Staehler; Motohide Uemura; Ugo De Giorgi; Begoña Mellado; Camillo Porta; Melichar; Howard Gurney; Jens Bedke; Toni K. Choueiri; Francis Parnis; Tarik Khaznadar; Alpa Thobhani; Shi Li; Elisabeth Piault-Louis; Gretchen Frantz; Mahrukh Huseni; Christina Schiff; Marjorie Green; Robert J. Motzer
Journal of Neuroscience, ISSN: 15292401
Daniel Fleck; Lilian Phu; Erik Verschueren; Trent Hinkle; Mike Reichelt; Tushar Bhangale; Benjamin Haley; Yuanyuan Wang; Rob Graham; Don Kirkpatrick; Morgan Sheng; Baris Bingol
BMC Cancer, ISSN: 14712407
Sumanta Kumar Pal; Jun Gong; Shivani K. Mhatre; Wenny Lin; Andy Surinach; Sarika Ogale; Rini Vohra; Herschel Wallen; Daniel George
Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb
Analytical Chemistry, ISSN: 00032700
Jeffrey W. Hudgens; Elyssia S. Gallagher; Ioannis Karageorgos; Kyle W. Anderson; James J. Filliben; Richard Y.-C. Huang; Guodong Chen; George M. Bou-Assaf; Alfonso Espada; Michael J. Chalmers; Eduardo Harguindey; Hui-Min Zhang; Ben Walters; Jennifer Zhang; John Venable; Caitlin Steckler; Inhee Park; Ansgar Brock; Xiaojun Lu; Ratnesh Pandey; Arun Chandramohan; Ganesh Srinivasan Anand; Sasidhar N. Nirudodhi; Justin B. Sperry; Jason C. Rouse; James A. Carroll; Kasper D. Rand; Ulrike Leurs; David D. Weis; Mohammed A. Al-Naqshabandi; Tyler S. Hageman; Daniel Deredge; Patrick L. Wintrode; Malvina Papanastasiou; John D. Lambris; Sheng Li; Sarah Urata
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Whitney P. Kirschbrown; Kagedal; Wang; Lars Lindbom; Adam Knott; Rachelle Mack; Sharareh Monemi; Ihsan Nijem; Sandhya Girish; Christie Freeman; Fumagalli; Robin McConnell; Guy Jerusalem; Chris Twelves; Baselga; Gunter Von Minckwitz; José Bines; Amit Garg
In Vivo Assessment of Antibody-Dependent Enhancement of Influenza B Infection
Toxicological Sciences,
Gautham K. Rao; Rodney Prell; Steven Laing; Stefanie C M Burleson; Allen Nguyen; Jacqueline McBride; Crystal Zhang; Daniel Sheinson; Wendy Halpern
Genomic features of exceptional response in vemurafenib cobimetinib–treated patients with BRAFV600-mutated metastatic melanoma
Clinical Cancer Research, ISSN: 10780432
Yibing Yan; Matthew Wongchenko; Caroline Robert; James Larkin; Paolo A. Ascierto; Brigitte Dréno; Michele Maio; Claus Garbe; Paul B. Chapman; Jeffrey A. Sosman; Zhen Shi; Hartmut Koeppen; Jessie Hsu; Ilsung Chang; Ivor Caro; Isabelle Rooney; Grant A. McArthur; Antoni Ribas
Effects of concomitant glucocorticoids in TOZURA, a common-framework study programme of subcutaneous tocilizumab in rheumatoid arthritis
Rheumatology,
Ernest Choy; Roberto Caporali; Ricardo Xavier; Bruno Fautrel; Raimón Sanmarti; Bao; Jenny Devenport; Attila Pethö-Schramm
Coexpression of inhibitory receptors enriches for activated and functional CD8+ T cells in murine syngeneic tumor models
Cancer immunology research, ISSN: 23266066
Huizhong Xiong; Stephanie Mittman; Ryan Rodriguez; Patricia Pacheco-Sanchez; Marina Moskalenko; Yagai Yang; Justin Elstrott; Alex Ritter; Sören Müller; Dorothee Nickles; Teresita L. Arenzana; Aude-Helene Capietto; Lelia Delamarre; Zora Modrusan; Sascha Rutz; Ira Mellman; Rafael Cubas
Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial
The Lancet Oncology, ISSN: 14702045
Cathy Eng; Tae Won Kim; Bendell; Guillem Argiles; Niall C. Tebbutt; Maria Di Bartolomeo; Alfredo Falcone; Marwan Fakih; Kozloff; Neil H. Segal; Alberto Sobrero; Yibing Yan; Ilsung Chang; Anne Uyei; Louise Roberts; Fortunato Ciardiello; Ahn; Jamil Asselah; Badarinath; Baijal; Begbie; Berry; Jean-Luc Canon; Carbone; Andrés Cervantes; Cha; Chang; Chaudhry; Chmielowska; Cho; Chu; Couture; Cultrera; David Cunningham; Eric Van Cutsem; Cuyle; Davies; Dowden; Dvorkin; Vinod Ganju; Garcia; Kerr; Kim; King; Kortmansky; Kozloff; Lam; Lee; Lee; Lesperance; Luppi; Ma; Evaristo Maiello; Mandanas; John Marshall; Marx; Mullamitha; Nechaeva; Park; Pavlakis; Ponce; Potemski; Raouf; James A. Reeves; Segal; Siena; Smolin; Streb; Strickland; Szutowicz-Zielinska; Tabernero; Tan; Valera; Van den Eynde; Vergauwe; Vickers; Womack; Wroblewska; Young
Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients
Nature Medicine, ISSN: 10788956
Ryan J. Sullivan; Omid Hamid; Rene Gonzalez; Jeffery R. Infante; Manish R. Patel; F. Stephen Hodi; Karl Lewis; Hussein Tawbi; Genevive Hernandez; Matthew Wongchenko; YiMeng Chang; Louise Roberts; Marcus Ballinger; Yibing Yan; Edward Cha; Patrick Hwu
A phase 1, randomized, single-ascending-dose study to investigate the safety, tolerability, and pharmacokinetics of DSTA4637S, an anti-staphylococcus aureus thiomab antibody-antibiotic conjugate, in healthy volunteers
Antimicrobial Agents and Chemotherapy, ISSN: 00664804
Melicent Peck; Michael E. Rothenberg; Rong Deng; Nicholas Lewin-Koh; Gaohong She; Amrita Kamath; Montse Carrasco-Triguero; Ola Saad; Aide Castro; Lisa Teufel; Daniel S. Dickerson; Marisa Leonardelli; Jorge Tavel
Aging Cell, ISSN: 14749726 14749718
Lifen Wang; Sonnet S. Davis; Martin Borch Jensen; Imilce A. Rodriguez-Fernandez; Cagsar Apaydin; Gábor Juhász; Bradford W. Gibson; Birgit Schilling; Arvind Ramanathan; Sina Ghaemmaghami; Heinrich Jasper
The Lancet Haematology, ISSN: 23523026
Steven W Pipe; Midori Shima; Michaela Lehle; Amy Shapiro; Sammy Chebon; Katsuyuki Fukutake; Nigel S. Key; Agnès Portron; Christophe Schmitt; Maria Podolak-Dawidziak; Nives Selak Bienz; Cedric Hermans; Avrita Campinha-Bacote; Anna Kiialainen; Kathelijne Peerlinck; Gallia Levy; Jiménez-Yuste
Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103
Harvey Wong; Lichuan Liu; Wenjun Ouyang; Yuzhong Deng; Matthew Wright; Marcel Hop
Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias
PLoS Genetics,
Benjamin J. Huang; Anica M. Wandler; Lauren K. Meyer; Monique Dail; Anneleen Daemen; Deepak Sampath; Qing Li; Xinyue Wang; Jasmine C. Y. Wong; Joy Nakitandwe; James R. Downing; Jinghui Zhang; Barry S. Taylor; Kevin Shannon