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Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

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Cancer Discovery, ISSN: 21598290
Claudia Dominguez; Sören Müller; Shilpa Keerthivasan; Hartmut Koeppen; Jeffrey Hung; Sarah Gierke; Beatrice Breart; Oded Foreman; Travis Bainbridge; Alessandra Castiglioni; Yasin Senbabaoglu; Zora Modrusan; Yuxin Liang; Melissa Junttila; Christiaan Klijn; Richard Bourgon; Shannon Turley
Nature Structural and Molecular Biology, ISSN: 15459985 15459993
Annette M. Vogl; Lilian Phu; Raquel Becerra; Sebastian A. Giusti; Erik Verschueren; Trent Hinkle; Martín D. Bordenave; Max Adrian; Amy Heidersbach; Patricio Yankilevich; Fernando D. Stefani; Wolfgang Wurst; Casper C Hoogenraad; Don Kirkpatrick; Damian Refojo; Morgan Sheng
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Aaron G. Bart; Ryan Takahashi; Gina Wang; Emily E. Scott
Nature Medicine, ISSN: 1546170X 10788956
Katherine S Ruth; Felix R Day; Jessica Tyrrell; Deborah J Thompson; Andrew R Wood; Anubha Mahajan; Robin N Beaumont; Laura Wittemans; Susan Martin; Alexander S. Busch; A. Mesut Erzurumluoglu; Benjamin Hollis; Tracy A. O’Mara; Mark McCarthy; Claudia Langenberg; Douglas F. Easton; Nicholas J Wareham; Stephen Burgess; Anna Murray; Ken K. Ong; Timothy M. Frayling; John R. Perry
Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1–2 trials
The Lancet Oncology, ISSN: 14702045
Robert C Doebele; Alexander Drilon; Luis Paz-Ares; Siena; Alice T. Shaw; Anna F Farago; Collin M Blakely; Takashi Seto; Byung Chul Cho; Diego Tosi; Benjamin Besse; Sant P Chawla; Lyudmila Bazhenova; John C Krauss; Young K Chae; Minal Barve; Ignacio Garrido-Laguna; Stephen V. Liu; Paul Conkling; Thomas John; Marwan Fakih; Darren Sigal; Herbert H Loong; Gary L Buchschacher; Pilar Garrido; Jorge Nieva; Conor Steuer; Tobias R Overbeck; Daniel W. Bowles; Elizabeth Fox; Todd Riehl; Edna Chow-Maneval; Brian Simmons; Na Cui; Ann Johnson; Susan Eng; Tim Wilson; George Demetri
Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1–2 trials
The Lancet Oncology, ISSN: 14702045
Alexander Drilon; Siena; Rafal Dziadziuszko; Fabrice Barlesi; Matthew G Krebs; Alice T. Shaw; Filippo de Braud; Christian Rolfo; Myung-Ju Ahn; Jurgen Wolf; Takashi Seto; Byoung Chul Cho; Manish R. Patel; Chao-Hua Chiu; Tom John; Koichi Goto; Karapetis; Hendrick-Tobias Arkenau; Sang-We Kim; Yuichiro Ohe; Yu-Chung Li; Young K Chae; Christine H Chung; Gregory A Otterson; Haruyasu Murakami; Chia-Chi Lin; Daniel S W Tan; Hans Prenen; Todd Riehl; Edna Chow-Maneval; Brian Simmons; Na Cui; Ann Johnson; Susan Eng; Tim Wilson; Robert C Doebele
International standards for the analysis of quality-of-life and patient-reported outcome endpoints in cancer randomised controlled trials: recommendations of the SISAQOL Consortium
The Lancet Oncology, ISSN: 14702045
Corneel Coens; Madeline Pe; Amylou Dueck; Jeff A. Sloan; Ethan Basch; Melanie Calvert; Alicyn Campbell; Charles S. Cleeland; Kim Cocks; Laurence Collette; Nancy Devlin; Lien Dorme; Hans-Henning Flechtner; Carolyn C. Gotay; Ingolf Griebsch; Mogens Groenvold; Madeleine King; Paul G Kluetz; Michael Koller; Daniel C Malone; Francesca Martinelli; Sandra A Mitchell; Jammbe Musoro; Daniel O'Connor; Kathy Oliver; Elisabeth Piault-Louis; Martine Piccart; Chantal Quinten; Jaap C Reijneveld; Christoph Schürmann; Ashley Wilder Smith; Katherine M Soltys; Martin J. B. Taphoorn; Galina Velikova; Andrew Bottomley
Pharmaceutical Research, ISSN: 1573904X 07248741
Phyllis Chan; Jiajie Yu; Leslie Chinn; Marita Prohn; Jan Huisman; Brett Matzuka; William D. Hanley; Katie Tuckwell; Angelica Quartino
Pharmacology Research and Perspectives, ISSN: 20521707
Khaled Sarsour; Senam Beckley-Kartey; Simone Melega; Adefowope Odueyungbo; Petra Kirchner; Natasha Khalife; Joanne Bangs
Clinical Cancer Research, ISSN: 15573265 10780432
Katherine E. Hutchinson; Susan E. Yost; Ching-Wei Chang; Radia Johnson; Adrian R. Carr; Paul R. McAdam; Daniel L Halligan; Chun-Chieh Chang; Daniel Schmolze; Jackson Liang; Yuan Yuan
Brain, ISSN: 14602156
Kaj Blennow; Chun Chen; Claudia Cicognola; Kristin Wildsmith; Paul T. Manser; Sandra M Sanabria Bohorquez; Zhentao Zhang; Boer Xie; Junmin Peng; Oskar Hansson; Hlin Kvartsberg; Erik Portelius; Henrik Zetterberg; Tammaryn Lashley; Gunnar Brinkmalm; Geoffrey A. Kerchner; Robby Weimer; Keqiang Ye; Kina Höglund
Genome-wide analysis of differential gene expression and splicing in excitatory neurons and interneuron subtypes
Journal of Neuroscience, ISSN: 02706474
Melanie Huntley; Karpagam Srinivasan; Brad Friedman; Tzu-Ming Wang; Ada X. Yee; Yuanyuan Wang; Josh Kaminker; Morgan Sheng; David Hansen; Jesse E. Hanson
Cell Reports, ISSN: 22111247
Luz D. Orozco; Hsu-Hsin Chen; Christian Cox; Ken Katschke; Rommel Arceo; Carmina Espiritu; Patrick Caplazi; Sarajane Saturnio Nghiem; Jasmine Chen; Zora Modrusan; Amy Stockwell; Leonard Goldstein; Christine Clarke; Tushar Bhangale; Brian Yaspan; Marion Jeanne; Michael Townsend; Menno van Lookeren Campagne; Jason Hackney
Alzheimer's Research and Therapy, ISSN: 17589193
Yoshida; Anita Moein; Tobias Bittner; Ostrowitzki; Helen Lin; Lee Honigberg; Jin Y. Jin; Angelica Quartino
Analytical Chemistry, ISSN: 15206882 00032700
Hae-Min Park; Valerie J. Winton; Jared J. Drader; Sheri Manalili Wheeler; Greg Lazar; Neil L Kelleher; Yichin Liu; John C. Tran; Philip D. Compton
Clinical Cancer Research, ISSN: 15573265 10780432
David E. Gerber; Jeffrey R. Infante; Michael S. Gordon; Sarah B. Goldberg; Miguel Martín; Enriqueta Felip; Maria Martinez Garcia; Joan H. Schiller; David Spigel; Julie Cordova; Valerie Westcott; Wang; David Shames; YJ Choi; Robert S. Kahn; Randy Dere; Divya Samineni; Jian Xu; Kedan Lin; Katie Wood; Stephanie Joo; Lemahieu; Schuth; Vaze; Daniel Maslyar; Eric Humke; Howard A. Burris
Cell Reports, ISSN: 22111247
Jesse E. Hanson; Keran Ma; Justin Elstrott; Martin Weber; Sandrine Saillet; Abdullah S. Khan; Jeffrey Simms; Benjamin Liu; Thomas A. Kim; Gui-Qiu Yu; Yelin Chen; Tzu-Ming Wang; Zhiyu Jiang; Bianca Liederer; Gauri Deshmukh; Hilda Solanoy; Connie Chan; Ben Sellers; Matthew Volgraf; Jacob Schwarz; David Hackos; Robby Weimer; Morgan Sheng; T. Michael Gill; Kimberly Scearce-Levie; Jorge J. Palop
Nature, ISSN: 14764687 00280836
Melina Claussnitzer; Judy H. Cho; Rory Collins; Nancy J. Cox; Emmanouil T. Dermitzakis; Matthew E. Hurles; Sekar Kathiresan; Eimear E. Kenny; Cecilia M. Lindgren; Daniel G. MacArthur; Kathryn N. North; Sharon E. Plon; Heidi L. Rehm; Neil Risch; Charles Rotimi; Jay Shendure; Nicole Soranzo; Mark McCarthy
ACS Medicinal Chemistry Letters, ISSN: 19485875
Matthew L. Landry; James Crawford
Chemico-Biological Interactions, ISSN: 18727786 00092797
Genualdi; Stuart C. Feinstein; Wilson; Jordan; Nicola Stagg
A randomized, placebo-controlled trial evaluating effects of lebrikizumab on airway eosinophilic inflammation and remodelling in uncontrolled asthma (CLAVIER)
Clinical and Experimental Allergy, ISSN: 09547894
Cary Austin; Melissa Gonzalez Edick; Ronald E. Ferrando; Margaret Solon; Miriam Baca; Kathryn Mesh; Peter Bradding; Gauvreau; Kaharu Sumino; FitzGerald; Elliot Israel; Lief Bjermer; Arnaud Bourdin; Joe Arron; David Choy; Julie Olsson; Francis Abreu; Monet Howard; Kit Wong; Fang Cai; Kun Peng; Wendy Putnam; Cecile Holweg; John Matthews; Monica Kraft; Prescott G. Woodruff
Border Control: Regulating LPS Biogenesis
Trends in Microbiology, ISSN: 0966842X
Randi L. Guest; Steven Rutherford; Thomas J. Silhavy
Development of deep learning models to predict best-corrected visual acuity from optical coherence tomography
Translational Vision Science and Technology,
Michael G. Kawczynski; Thomas Bengtsson; Jian Dai; Jill Hopkins; Simon S. Gao; Jeffrey R. Willis
Multisite supply planning for drug products under uncertainty
AIChE Journal, ISSN: 00011541
Apoorva M. Sampat; Ranjeet Kumar; Remya Pushpangatha Kurup; Kawa Chiu; Victor Saucedo; Victor M. Zavala
Proprotein convertase 7 (PCSK7) reduces apoA-V levels
FEBS Journal, ISSN: 1742464X
Yahya Ashraf; Stéphanie Duval; Vatsal Sachan; Rachid Essalmani; Delia Susan-Resiga; Anna Roubtsova; Josée Hamelin; Gerhardy; Daniel Kirchhofer; Vincent S. Tagliabracci; Annik Prat; Robert Scott Kiss; Nabil G. Seidah
Molecular Subsets in Renal Cancer Determine Outcome to Checkpoint and Angiogenesis Blockade
Cancer Cell, ISSN: 15356108
Robert J. Motzer; Romain Banchereau; Habib Hamidi; Thomas Powles; David McDermott; Michael B. Atkins; Bernard Escudier; L-F Liu; Ning Leng; Alexander Abbas; Jinzhen Fan; Hartmut Koeppen; Jennifer Lin; Susheela Carroll; Kenji Hashimoto; Sanjeev Mariathasan; Marjorie Green; Darren Tayama; Priti Hegde; Christina Schiff; Mahrukh Huseni; Brian I. Rini
A Multicompany Assessment of Submicron Particle Levels by NTA and RMM in a Wide Range of Late-Phase Clinical and Commercial Biotechnology-Derived Protein Products
Journal of Pharmaceutical Sciences, ISSN: 00223549
Mario Hubert; Dennis T. Yang; Stanley C. Kwok; Anacelia Rios; Tapan K. Das; Ankit Patel; Klaus Wuchner; Valentyn Antochshuk; Friederike Junge; George M. Bou-Assaf; Shawn Cao; Miguel Saggu; Luis Montrond; Nataliya Afonina; Parag Kolhe; Vakhtang Loladze; Linda O. Narhi
Changes in Organic Anion Transporting Polypeptide Uptake in HEK293 Overexpressing Cells in the Presence and Absence of Human Plasma
Drug Metabolism and Disposition,
Christine M. Bowman; Eugene Chen; Liuxi Chen; Yi-Chen Chen; Xiaorong Liang; Matthew Wright; Yuan Chen; Jialin Mao
Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies
mAbs, ISSN: 19420862
Chunze Li; Cindy Zhang; Zao Li; Divya Samineni; Dan Lu; Wang; Shang-Chiung Chen; Rong Zhang; Priya Agarwal; Bernard Fine; Sandhya Girish
Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies
mAbs, ISSN: 19420862
Cholpon Tilegenova; Saeed Izadi; Peter Yin; Christine Huang; Jiansheng Wu; Diego Ellerman; Sarah Hymowitz; Benjamin Walters; Cleo Salisbury; Paul Carter
Harnessing MerTK agonism for targeted therapeutics
mAbs, ISSN: 19420862
Vivekananda Kedage; Diego Ellerman; Yongmei Chen; Wei-Ching Liang; Joven Borneo; Yan Wu; Minhong Yan
High-Resolution Characterization of ADCs by Orbitrap LCMS
Methods in Molecular Biology, ISSN: 10643745
Jintang He; Surinder Kaur; Keyang Xu
The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti-integrin therapies
Medicinal Research Reviews, ISSN: 01986325
Iris Dotan; Matthieu Allez; Silvio Danese; Mary Keir; Swati Tole; Jacqueline McBride
European Journal of Nuclear Medicine and Molecular Imaging, ISSN: 16197089 16197070
Marion Chomet; Maxime Schreurs; Maria J. Bolijn; Mariska Verlaan; Wissam Beaino; Kari Brown; Alex J. Poot; Albert D. Windhorst; Herman Gill; Jan Marik; Simon P. Williams; Joseph Cowell; Gilles Gasser; Thomas L. Mindt; Guus van Dongen; Daniëlle Vugts
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Sathej Gopalakrishnan; William G. Wierda; Brenda Chyla; Rajeev Menon; Dale Miles; Rod A. Humerickhouse; Walid Awni; Ahmed Hamed Salem; Sven Mensing; Kevin J. Freise
Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial
The Lancet Respiratory Medicine, ISSN: 22132600
Dinesh Khanna; Celia J.F. Lin; Daniel E. Furst; Goldin; Grace Kim; Masataka Kuwana; Yannick Allanore; Marco Matucci-Cerinic; Oliver Distler; Shima; Jacob M van Laar; Helen Spotswood; Bridget Wagner; Jeffrey Siegel; Angelika Jahreis; Christopher P Denton; Eleonora Lucero; Bernardo A. Pons-Estel; Mariano Rivero; Guillermo Tate; Vanessa Smith; Ellen De Langhe; Rasho Rashkov; Anastas Batalov; Ivan Goranov; Rumen Stoilov; James Dunne; Sindhu R. Johnson; Janet E. Pope; Dušanka Martinović Kaliterna; Mette Mogensen; Anne Braae Olesen; Joerg Christoph Henes; Ulf Müller-Ladner; Gabriela Riemekasten; Alla Skapenko; Panayiotis Vlachoyiannopoulos; Emese Kiss; Tünde Minier; Lorenzo Beretta; Elisa Gremese; Gabriele Valentini; Yoshihide Asano; Tatsuya Atsumi; Hironobu Ihn; Tomonori Ishii; Osamu Ishikawa; Hiroki Takahashi; Kazuhiko Takehara; Yoshiya Tanaka; Yoshioki Yamasaki; Loreta Bukauskiene; Irena Butrimiene; Gabriel Medrano Ramirez; Cesar Ramos-Remus; Tatiana Sofia Rodriguez Reyna; Jeska de Vries-Bouwstra; Jacob M.
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Sreedhara Alavattam; Camellia Zamiri; Sirj Goswami; Sarah Weiser; Michael Cram; Twinkle R. Christian; Bharat Jagannathan
Trends in Neurosciences, ISSN: 1878108X 01662236
Brienne A. McKenzie; Vishva Dixit; Christopher Power
Urologic Oncology: Seminars and Original Investigations, ISSN: 18732496 10781439
Ahmad S. Halwani; Kelli M. Rasmussen; Vikas Patil; Catherine C. Li; Christina M. Yong; Zachary Burningham; Sumati Gupta; Sujata Narayanan; Wenny Lin; Susheela Carroll; Shivani K. Mhatre; Julie N. Graff; Robert Dreicer; Brian C. Sauer
Ophthalmology Retina, ISSN: 24686530
Glenn Yiu; R. Joel Welch; Yinwen Wang; Zhe Wang; Pin-wen Wang; Zdenka Haskova
mAbs, ISSN: 19420870 19420862
Yue Sun; Alberto Estevez; Tilman Schlothauer; Aaron Wecksler
eLife, ISSN: 2050084X
Agata Wesolowska-Andersen; Grace Zhuo Yu; Vibe Nylander; Fernando Abaitua; Matthias Thurner; Jason M. Torres; Anubha Mahajan; Anna L. Gloyn; Mark McCarthy
Genetics meets proteomics: perspectives for large population-based studies
Nature Reviews Genetics, ISSN: 14710056
Karsten Suhre; Mark McCarthy; Jochen M. Schwenk
Maintenance rituximab in Veterans with follicular lymphoma
Cancer Medicine,
Ahmad S. Halwani; Kelli M. Rasmussen; Vikas Patil; Deborah Morreall; Catherine C. Li; Christina M. Yong; Zachary Burningham; Keith Dawson; Anthony Masaquel; Kevin Henderson; Elisha DeLong-Sieg; Brian C. Sauer
Ophthalmology Retina, ISSN: 24686530
Andrew N. Antoszyk; Kathleen Wade Tarnowski; Karen Basu; Jason Ehrlich; Zdenka Haskova
Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy
Toxicologic Pathology, ISSN: 01926233
Edward Dere; Susie Crowell; Mauricio Maia; Chris Schuetz; Phillip Lai; Vladimir Bantseev; Helen Booler
Impact of polymer type, ASD loading and polymer-drug ratio on ASD tablet disintegration and drug release
International Journal of Pharmaceutics, ISSN: 03785173
Wei Zhang; Ryan Noland; Steven Chin; Milan Petkovic; Ruth Zuniga; Bethany Santarra; Breanna Conklin; Hao Helen Hou; Karthik Nagapudi; Jason Gruenhagen; Peter Yehl; Tao Chen
Fab-Nanolipoprotein Conjugate Causes Vitreous Opacity and Cataracts Following a Single Intravitreal Administration in New Zealand White Rabbits
Toxicologic Pathology, ISSN: 01926233
Nardos G. Tassew; Steven T. Laing; Whitney Shatz; Susie Crowell; Kelly Loyet; Chris Schuetz; Craig D. Blanchette
Confounding factors in exposure–response analyses and mitigation strategies for monoclonal antibodies in oncology
British Journal of Clinical Pharmacology, ISSN: 03065251
Sonoko Kawakatsu; Rene A. Bruno; Kagedal; Chunze Li; Sandhya Girish; Amita Joshi; Benjamin Wu
BCL2 Expression in First-Line Diffuse Large B-Cell Lymphoma Identifies a Patient Population With Poor Prognosis
Clinical Lymphoma, Myeloma and Leukemia, ISSN: 21522650
Elizabeth Punnoose; Frank Peale; Edith Szafer-Glusman; Guiyuan Lei; Richard Bourgon; An D. Do; Eugene Kim; Liping Zhang; Pedro Farinha; Randy D. Gascoyne; F. Javier Munoz; Maurizio Martelli; Anja Mottok; Gilles Salles; Laurie H. Sehn; John F. Seymour; Marek Trněný; Mikkel Z. Oestergaard; Kirsten Mundt; Umberto Vitolo