Scientists / Publications

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Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 251 - 300 OF 11626 RESULTS

Comments on assays used to measure VEGF in the presence of anti-VEGF therapeutics
Investigative Ophthalmology and Visual Science, ISSN: 15525783 01460404
Eric Wakshull; Robert L. Avery; Mauricio Maia
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Considerations for the Use of Polysorbates in Biopharmaceuticals
Pharmaceutical Research, ISSN: 1573904X 07248741
Michael T. Jones; Hanns-Christian Mahler; Sandeep Yadav; Dilbir Bindra; Vincent Corvari; R. Matthew Fesinmeyer; Kapil Gupta; Alexander M. Harmon; Kenneth D. Hinds; Atanas Koulov; Wei Liu; Kevin Maloney; John Wang; Ping Y. Yeh; Satish K. Singh
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In vitro assessment of chemotherapy-induced neuronal toxicity
Toxicology in Vitro, ISSN: 18793177 08872333
Chelsea Snyder; Lanlan Yu; Tin Ngo; Daniel Sheinson; Yuda Zhu; Min Tseng; Misner; Karin Staflin
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Prevention of Fatal C3 Glomerulopathy by Recombinant Complement Receptor of the Ig Superfamily
Journal of the American Society of Nephrology, ISSN: 15333450 10466673
Xiaoxu Wang; Menno van Lookeren Campagne; Ken Katschke; Damodar Gullipalli; Takashi Miwa; Yoshiyasu Ueda; Yuan Wang; Matthew Palmer; Guolan Xing; Wen-Chao Song
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Sustained Response Following Discontinuation of Methotrexate in Patients With Rheumatoid Arthritis Treated With Subcutaneous Tocilizumab: Results From a Randomized, Controlled Trial
Arthritis and Rheumatology, ISSN: 23265205 23265191
Joel M. Kremer; William F. Rigby; Nora G. Singer; Christine Birchwood; Darcy Gill; Bill Reiss; Jinglan Pei; Margaret Michalska
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Updated Efficacy Analysis Including Secondary Population Results for OAK: A Randomized Phase III Study of Atezolizumab versus Docetaxel in Patients with Previously Treated Advanced Non–Small Cell Lung Cancer
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Louis Fehrenbacher; Joachim Von Pawel; Keunchil Park; Achim Rittmeyer; David R. Gandara; Santiago Ponce Aix; Ji-Youn Han; Shirish M. Gadgeel; Toyoaki Hida; Diego L Cortinovis; Manuel Cobo; Dariusz M Kowalski; Filippo De Marinis; Mayank Gandhi; Bradford Danner; Christina Matheny; Marcin Kowanetz; Pei He; Federico Felizzi; Hina Patel; Alan Sandler; Marcus Ballinger; Fabrice Barlesi
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Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Navpreet Kaur; Ajit Narang; Arvind Kumar Bansal
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Validation of a plasma-based comprehensive cancer genotyping assay utilizing orthogonal tissue- and plasma-based methodologies
Clinical Cancer Research, ISSN: 15573265 10780432
Justin I. Odegaard; John J. Vincent; Stefanie Mortimer; James V. Vowles; Bryan C. Ulrich; Kimberly C. Banks; Stephen R. Fairclough; Oliver Zill; Marcin Sikora; Reza Mokhtari; Diana Abdueva; Rebecca J. Nagy; Christine E. Lee; Lesli A. Kiedrowski; Cloud P. Paweletz; Helmy Eltoukhy; Richard Lanman; Darya I. Chudova; Talasaz
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Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress
Cell Death and Differentiation, ISSN: 14765403 13509047
Mable Lam; David Lawrence; Avi Ashkenazi; Peter Walter
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Phase I study of the anti-α5β1 monoclonal antibody MINT1526A with or without bevacizumab in patients with advanced solid tumors
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Colin D. Weekes; Lee Rosen; Anna Capasso; Kit Man Wong; Weilan Ye; Maria Anderson; Bruce McCall; Jill Fredrickson; Eric Wakshull; Stephen Eppler; Quyen Shon-Nguyen; Rupal Desai; Mahrukh Huseni; Priti Hegde; Tony Pourmohamad; Ina Rhee; Alberto Bessudo
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Characterization and survival of patients with metastatic basal cell carcinoma in the Department of Veterans Affairs: a retrospective electronic health record review
Archives of Dermatological Research, ISSN: 1432069X 03403696
Vanessa W. Stevens; David D. Stenehjem; Olga V. Patterson; Kamauu; Yeun Mi Yim; Robert Morlock; Scott L. Duvall
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Alteplase for the treatment of acute ischemic stroke in patients with low National Institutes of Health Stroke Scale and not clearly disabling deficits (Potential of rtPA for Ischemic Strokes with Mild Symptoms PRISMS): Rationale and design
International Journal of Stroke, ISSN: 17474949 17474930
Sharon D. Yeatts; Broderick; Anjan Chatterjee; Edward C Jauch; Steven R. Levine; Jose G Romano; Jeffrey L. Saver; Achala Vagal; Barbara Purdon; Jenny Devenport; Pooja Khatri
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Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Digoxin in Patients With BRAFV600 Mutation–Positive Metastatic Malignancy
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Weijiang Zhang; Christine McIntyre; Melissa Kuhn; Harper Forbes; Tae Min Kim; Jeeyun Lee; Lev Demidov; Dawn Colburn
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Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines
Genome Medicine, ISSN: 1756994X
Petar Scepanovic; Cécile Alanio; Christian Hammer; Flavia Hodel; Jacob Bergstedt; Etienne Patin; Christian W. Thorball; Nimisha Chaturvedi; Bruno Charbit; Laurent Abel; Lluis Quintana-Murci; Darragh Duffy; Matthew Albert; Jacques Fellay; Andres Alcover; Hugues Aschard; Philippe Bousso; Pierre Bruhns; Ana Cumano; Caroline Demangel; Ludovic Deriano; James P. Di Santo; Françoise Dromer; Gérard Eberl; Jost Enninga; Odile Gelpi; Ivo Gomperts-Boneca; Milena Hasan; Claude Leclerc; Hugo Mouquet; Sandra Pellegrini; Lars Rogge; Anavaj Sakuntabhai; Olivier Schwartz; Benno Schwikowski; Spencer Shorte; Frédéric Tangy; Marie-Noëlle Ungeheuer; Kalla Astrom; Serge Hercberg; Mathilde Touvier; Olivier Lantz; Vassili Soumelis; Stanislas Pol; Antonio Rausell; Eric Tartour; Antoine Toubert
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Serum periostin levels following small bone fractures, long bone fractures and joint replacements: An observational study
Allergy, Asthma and Clinical Immunology, ISSN: 17101492 17101484
Rachel Varughese; Ruth Semprini; Claire Munro; James Fingleton; Cecile Holweg; Mark Weatherall; Richard Beasley; Irene Braithwaite
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Hydroamination versus Allylic Amination in Iridium-Catalyzed Reactions of Allylic Acetates with Amines: 1,3-Aminoalcohols via Ester-Directed Regioselectivity
Journal of the American Chemical Society, ISSN: 15205126 00027863
Seung Wook Kim; Thomas Wurm; Gilmar A. Brito; Woo-Ok Jung; Jason R. Zbieg; Craig Stivala; Michael J. Krische
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Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation
eLife,
Ryan Ferrao; Heidi Ackerly Wallweber; Patrick Lupardus
Change in biomarkers of type-2 inflammation following severe exacerbations of asthma
Thorax, ISSN: 14683296 00406376
Ruth Semprini; Nick Shortt; Stefan Ebmeier; Alex Semprini; Rachel Varughese; Cecile Holweg; John Matthews; James Fingleton; Mark Weatherall; Richard Beasley; Irene Braithwaite
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FRET Reagent Reveals the Intracellular Processing of Peptide-Linked Antibody-Drug Conjugates
Bioconjugate Chemistry, ISSN: 15204812 10431802
Byoung Chul Lee; Cecile Chalouni; Sophia Doll; Sam C. Nalle; Martine Darwish; Siao Ping Tsai; Kathy Kozak; Geoff Del Rosario; Shang-Fan Yu; Hans Erickson; Dick Vandlen
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A model of overall survival predicts treatment outcomes with atezolizumab versus chemotherapy in non–small cell lung cancer based on early tumor kinetics
Clinical Cancer Research, ISSN: 15573265 10780432
Laurent Claret; Jin Y. Jin; Charles Ferte; Helen Winter; Sandhya Girish; Mark Stroh; Pei He; Marcus Ballinger; Alan Sandler; Amita Joshi; Achim Rittmeyer; David Gandara; Jean-Charles Soria; Rene A. Bruno
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Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing
JCI insight, ISSN: 23793708
Omar H. Maarouf; Mayuko Uehara; Vivek Kasinath; Zhabiz Solhjou; Naima Banouni; Baharak Bahmani; Liwei Jiang; Osman A. Yilmam; Indira Guleria; Scott B. Lovitch; Jane Grogan; Paolo Fiorina; Peter T. Sage; Jonathan S. Bromberg; Martina M. McGrath; Reza Abdi
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Cost-effectiveness of obinutuzumab plus bendamustine followed by obinutuzumab monotherapy for the treatment of follicular lymphoma patients who relapse after or are refractory to a rituximab-containing regimen in the US
Journal of Medical Economics, ISSN: 1941837X 13696998
Gregory F. Guzauskas; Anthony Masaquel; Carolina Reyes; Coen Bernaards; Tania Krivasi; David L. Veenstra
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Palladium-Catalyzed Site-Selective Amidation of Dichloroazines
Organic Letters, ISSN: 15237052 15237060
Ian S. Young; Anna-Lena Glass; Theresa Cravillion; Chong Han; Haiming Zhang; Francis Gosselin
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OTULIN limits cell death and inflammation by deubiquitinating LUBAC
Nature, ISSN: 14764687 00280836
Klaus Heger; Kate Wickliffe; Ada Ndoja; Juan Zhang; Aditya Murthy; Debbie Dugger; Maltzman; Felipe de Sousa e Melo; Jeffrey Hung; Yi Zeng; Erik Verschueren; Don Kirkpatrick; Domagoj Vucic; Wyne Lee; Meron Roose-Girma; Robert J (Research) Newman; Soren Warming; Yi-Chun Hsiao; László Kömüves; Webster; Kim Newton; Vishva Dixit
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Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche
Nature, ISSN: 14764687 00280836
Ysbrand M. Nusse; Adam K. Savage; Pauline Marangoni; Axel K. M. Rosendahl-Huber; Tyler A. Landman; Frederic De Sauvage; Richard M. Locksley; Ophir D. Klein
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Interplay of DDP4 and IP-10 as a potential mechanism for cell recruitment to tuberculosis lesions
Frontiers in Microbiology, ISSN: 1664302X
Thomas Blauenfeldt; Linda Petrone; Franca del Nonno; Andrea Baiocchini; Laura Falasca; Teresa Chiacchio; Vincent Bondet; Valentina Vanini; Fabrizio Palmieri; Gianni Galluccio; Armanda Casrouge; Jesper Eugen-Olsen; Matthew Albert; Delia Goletti; Darragh Duffy; Morten Ruhwald
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Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an anti-CD33 ADC
mAbs, ISSN: 19420870 19420862
Isabel Figueroa; Douglas Leipold; Steve Leong; Bing Zheng; Montserrat Triguero-Carrasco; Aimee Fourie-O'Donohue; Kathy Kozak; Keyang Xu; Melissa Schutten; Hong Wang; Andy Polson; Amrita Kamath
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Abundance of phase 1 and 2 drug-metabolizing enzymes in alcoholic and hepatitis C cirrhotic livers: A quantitative targeted proteomics study
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Bhagwat Prasad; Deepak Kumar Bhatt; Katherine Johnson; Revathi Chapa; Xiaoyan Chu; Laurent Salphati; Guangqing Xiao; Caroline A. Lee; Marcel Hop; Anita Mathias; Yurong Lai; Mingxiang Liao; W. Griffith Humphreys; Sean C. Kumer; Jashvant D. Unadkat
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Association of p27 and cyclin D1 expression and benefit from adjuvant trastuzumab treatment in HER2-positive early breast cancer: A TransHERA study
Clinical Cancer Research, ISSN: 15573265 10780432
Martin Filipits; Urania Dafni; Michael Gnant; Polydoropoulou; Margaret Hills; Astrid Kiermaier; Evandro De Azambuja; Denis Larsimont; Federico Rojo; Viale; Masakazu Toi; Nadia Harbeck; Kathleen I. Prichard; Richard D. Gelber; Phuong Dinh; Zardavas; Brian R. Leyland-Jones; Piccart-Gebhart; Mitch Dowsett
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Association of programmed death ligand-1 (PD-L1) expression with treatment outcomes in patients with BRAF mutation-positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib
Pigment Cell and Melanoma Research, ISSN: 1755148X 17551471
Matthew Wongchenko; Antoni Ribas; Brigitte Dréno; Paolo A. Ascierto; McArthur; Jorge D. Gallo; Isabelle Rooney; Jessie Hsu; Hartmut Koeppen; Yibing Yan; James Larkin
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Automated On-tip Affinity Capture Coupled with Mass Spectrometry to Characterize Intact Antibody-Drug Conjugates from Blood
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
Ke Sherry Li; Phillip Chu; Aimee Fourie-O'Donohue; Neha Srikumar; Kathy Kozak; Yichin Liu; John C. Tran
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Correction to: Strategies of Drug Transporter Quantitation by LC-MS: Importance of Peptide Selection and Digestion Efficiency (The AAPS Journal, (2017), 19, 5, (1469-1478), 10.1208/s12248-017-0106-4)
AAPS Journal, ISSN: 15507416
Buyun Chen; Liling Liu; Hoangdung Ho; Yuan Chen; Ze Yang; Xiaorong Liang; Jian Payandeh; Brian Dean; Marcel Hop; Yuzhong Deng
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Cryo-EM in drug discovery: Achievements, limitations and prospects
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Jean-Paul Renaud; Ashwin Chari; Claudio Ciferri; Wen-Ti Liu; Hervé-William Rémigy; Holger Stark; Christian Wiesmann
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Determination of the acceptable ambient light exposure during drug product manufacturing for long-term stability of monoclonal antibodies
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Lin M. Luis; Yuzhe Hu; Camellia Zamiri; Sreedhara Alavattam
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Implementation of plate imaging for demonstration of monoclonality in biologics manufacturing development
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Kyle Zingaro; David (ESCC) Shaw; Jerry Carson; Anke Mayer-Bartschmid; Christian Bender; Christina Alves; Duncan McVey; Nan-Xin Qian; Qingxiang Wei; Mike Laird; Yuan Zhu; Robyn Emmins; John A. Follit; Alison Porter; Andrew J. Racher; Sarah Milne; Ivan Carubelli; Zhimei; Ankita Khatri; Marilyne Failly; Hervé Broly; Frank Lee; Matthew Reeser; Jared Spidel; Karin Anderson; Christine Demaria; Jennifer Di-Carlo; John Gill; Amie Lundquist; Sampath R. Kumar; Tony Gill
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Mechanisms of acquired resistance to trastuzumab emtansine in breast cancer cells
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Ginny Li; Jun Guo; Ben-Quan Shen; Daniela Yadav; Mark Sliwkowski; Lisa Crocker; Jennifer Lacap; Gail Phillips
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New opportunities with quantification of protein therapeutics by LC-MS
Bioanalysis, ISSN: 17576199 17576180
Hendrik Neubert; Keyang Xu
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Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD)
Journal of Leukocyte Biology, ISSN: 19383673 07415400
Paneez Khoury; Praveen Akuthota; Steven J. Ackerman; Joe Arron; Bruce S. Bochner; Margaret H. Collins; Jean-Emmanuel Kahn; Patricia C. Fulkerson; Gerald J. Gleich; Rashmi Gopal-Srivastava; Elizabeth A. Jacobsen; Kristen M. Leiferman; Levi-Schaffer Francesca; Sameer K. Mathur; Michael Minnicozzi; Calman Prussin; Marc E. Rothenberg; Florence Roufosse; Kathleen Sable; Dagmar Simon; Hans-Uwe Simon; Lisa A. Spencer; Jonathan Steinfeld; Andrew J. Wardlaw; Michael E. Wechsler; Peter F. Weller; Amy D. Klion
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Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage
Journal of the International AIDS Society, ISSN: 17582652
Mickaël J Ploquin; Armanda Casrouge; Yoann Madec; Nicolas Noel; Beatrice Jacquelin; Nicolas Huot; Darragh Duffy; Simon P Jochems; Luca Micci; Camille Lécuroux; Faroudy Boufassa; Thijs Booiman; Thalia Garcia-Tellez; Mathilde Ghislain; Roger Le Grand; Olivier Lambotte; Neeltje Kootstra; Laurence Meyer; Cecile Goujard; Mirko Paiardini; Matthew Albert; Michaela Müller-Trutwin
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Usability of the Ranibizumab 0.5 mg prefilled syringe: Human factors studies to evaluate critical task completion by healthcare professionals
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Andrew N. Antoszyk; Carl Baker; Jorge Calzada; Howard Cummings; Joanna; Carlos Quezada-Ruiz; Zdenka Haskova
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Use of subcutaneous and intraperitoneal administration methods to facilitate cassette dosing in microdialysis studies in rats
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Matthew Durk; Gauri Deshmukh; Nicole Valle; Xiao Ding; Bianca Liederer; Xingrong Liu
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Vapor phase hydrogen peroxide decontamination or sanitization of an isolator for aseptic filling of monoclonal antibody drug product—hydrogen peroxide uptake and impact on protein quality
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Aaron Hubbard; Thomas Roedl; Ada Hui; Stephanie Knueppel; Kirk Eppler; Siegfried Lehnert; Yuh-Fun Maa
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CRISPR off-target analysis in genetically engineered rats and mice
Nature Methods, ISSN: 15487105 15487091
Keith R. Anderson; Maximilian Haeussler; Colin Watanabe; Vasant Janakiraman; Jessica Lund; Zora Modrusan; Jeremy Stinson; Qixin Bei; Andrew Buechler; Charles Yu; Sobha R. Thamminana; Lucinda Tam; Michael-Anne Sowick; Tuija Alcantar; Natasha O'Neil; Jinjie Li; Linda Ta; Lisa Lima; Meron Roose-Girma; Xin Rairdan; Steffen Durinck; Soren Warming
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Immune Characteristics of Chinese Diffuse Large B-Cell Lymphoma Patients: Implications for Cancer Immunotherapies
EBioMedicine, ISSN: 23523964
Peng-peng Xu; Chun Sun; Xu Cao; Xia Zhao; Hang-jun Dai; Shan Lu; Jian-jun Guo; Shi-jing Fu; Yu-xia Liu; Su-chun Li; Meng Chen; Mccord; Jeffrey M. Venstrom; Edith Szafer-Glusman; Elizabeth Punnoose; Astrid Kiermaier; Gang Cheng; Wei-li Zhao
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Exploring a Kinetic Model Approach in Biopharmaceutics: Estimating the Fraction Absorbed of Orally Administered Drugs in Humans
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Po-Chang Chiang; Jia Liu; Peter Fan; Harvey Wong
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Self-reported healthcare utilization by adults with diabetic retinopathy in the United States
Ophthalmic Epidemiology, ISSN: 17445086 09286586
Jeffrey R. Willis; Quan V. Doan; Michelle Gleeson; Zdenka Haskova; Pradeep Ramulu; Lawrence S. Morse; Ronald Cantrell
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Determination of Affinity and Residence Time of Potent Drug-Target Complexes by Label-free Biosensing
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
John G. Quinn; Keith E. Pitts; Micah Steffek; Melinda M. Mulvihill
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Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Asha Nayak-Kapoor; Zhonglin Hao; Ramses Sadek; Robin Dobbins; Lisa Marshall; Nicholas N. Vahanian; Jay Ramsey; Eugene Kennedy; Mario R. Mautino; Charles J. Link; Ray Lin; Stephanie Royer Joo; Xiaorong Liang; Laurent Salphati; Kari Morrissey; Sami Mahrus; Bruce McCall; Andrea Pirzkall; David H. Munn; John E. Janik; Samir N. Khleif
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Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells
Cell Reports, ISSN: 22111247
Margaret E. Kirkling; Urszula Cytlak; Colleen M. Lau; Kanako L. Lewis; Anastasia Resteu; Alireza Khodadadi-Jamayran; Chris Siebel; Hélène Salmon; Miriam Merad; Aristotelis Tsirigos; Matthew Collin; Venetia Bigley; Boris Reizis
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Plasmacytoid dendritic cells control dengue and chikungunya virus infections via IRF7-regulated interferon responses
eLife,
Brian Webster; Scott Werneke; Biljana Zafirova; Sébastien This; Séverin Coléon; Elodie Décembre; Helena Paidassi; Isabelle Bouvier; Pierre-Emmanuel Joubert; Darragh Duffy; Thierry Walzer; Matthew Albert; Marlène Dreux

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