Scientists / Publications

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Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 251 - 300 OF 10749 RESULTS

Elements of cancer immunity and the cancer-immune set point
Nature, ISSN: 14764687
Daniel Chen; Ira Mellman
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Expression of MET in circulating tumor cells correlates with expression in tumor tissue from advanced-stage lung cancer patients
Oncotarget, ISSN: 19492553
Marius Ilie; Edith Szafer-Glusman; Véronique Hofman; Elodie Long-Mira; Becky Suttmann; Walter Darbonne; Catherine Butori; Salomé Lalvée; Julien Fayada; Eric Selva; Wei Yu; Charles-Hugo Marquette; David Shames; Elizabeth Punnoose; Paul Hofman
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TREM2, Microglia, and Neurodegenerative Diseases
Trends in Molecular Medicine, ISSN: 14714914
Felix Yeh; David Hansen; Morgan Sheng
TREM2, Microglia, and Neurodegenerative Diseases
Trends in Molecular Medicine, ISSN: 1471499X
Felix Yeh; David Hansen; Morgan Sheng
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The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target
Retina, ISSN: 15392864
David S. Boyer; Ursula Schmidt-Erfurth; Menno van Lookeren Campagne; Erin Henry; Christopher Brittain
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An Investigation of Oral Exposure Variability and Formulation Strategy: A Case Study of PI3Kδ Inhibitor and Physiologically Based Pharmacokinetic Modeling in Beagle Dogs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Po-Chang Chiang; Jodie Pang; Jia Liu; Laurent Salphati
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Anaphylaxis associated with omalizumab administration: Risk factors and patient characteristics
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Phillip Lieberman; Ilisten Jones; Richa Rajwanshi; Karin Rosen; Dale Umetsu
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Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research
Advances in Anatomic Pathology, ISSN: 15334031 10724109
Shona Hendry; Roberto Salgado; Thomas Gevaert; Prudence A. Russell; Tom John; Bibhusal Thapa; Michael Christie; Koen Van De Vijver; Mónica V. Estrada; Paula I. Gonzalez-Ericsson; Melinda E. Sanders; Benjamin Solomon; Cinzia Solinas; Gert G.G.M. Van Den Eynden; Yves Allory; Matthias Preusser; Johannes Hainfellner; Giancarlo Pruneri; Andrea Vingiani; Sandra Demaria; Fraser Symmans; Nuciforo; Laura Comerma; Thompson; Sunil Lakhani; Seong-Rim Kim; Stuart J. Schnitt; Cecile Colpaert; Christos Sotiriou; Stefan J. Scherer; Michail Ignatiadis; Sunil Badve; Robert H. Pierce; Giuseppe Viale; Nicolas Sirtaine; Frederique Penault-Llorca; Tomohagu Sugie; Susan Fineberg; Soonmyung Paik; Ashok Srinivasan; Andrea Richardson; Yihong Wang; Ewa Chmielik; Jane Brock; Douglas B. Johnson; Justin M. Balko; Stephan Wienert; Veerle Bossuyt; Stefan Michiels; Nils Ternes; Nicole Burchardi; Stephen J Luen; Peter Savas; Frederick Klauschen; Peter H. Watson; Brad H. Nelson; Carmen Criscitiello; Sandra O'Toole; Denis Larsimont; Roland D
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Asthma Exacerbations and Triggers in Children in TENOR: Impact on Quality of Life
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
Bradley E. Chipps; Tmirah Haselkorn; Karin Rosen; David R. Mink; Ben Trzaskoma; Allan T. Luskin
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Current state of bow tie risk assessment method
Global Congress on Process Safety 2017 - Topical Conference at the 2017 AIChE Spring Meeting and 13th Global Congress on Process Safety,
Robin Pitblado; Tim McGrath; Mark Manton; Charles Ian Cowley; Kiran Krishna; Martin Johnson; Ron McLeod; Paul Haydock; Tatiana Norman
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Effectiveness of biologic and non-biologic antirheumatic drugs on anaemia markers in 153,788 patients with rheumatoid arthritis: New evidence from real-world data
Seminars in Arthritis and Rheumatism, ISSN: 00490172
Sanjoy Ketan Paul; Olga Montvida; Jennie Best; Sara Gale; Attila Pethoe-Schramm; Khaled Sarsour
FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes
Molecular Metabolism,
Mark Chen; Joshua C. Chang; Jose Zavala-Solorio; Lance Kates; Minh Thai; Annie Ogasawara; Xiaobo Bai; Sean Flanagan; Victor Nunez; Khanhky Phamluong; James Ziai; Robert J (Research) Newman; Soren Warming; Ganesh Kolumam; Jun Sonoda
High-resolution 2D-LC analysis of key linker drug intermediate used in antibody drug conjugates (ADCs)
Journal of Chromatography A, ISSN: 00219673
C.J. Venkatramani; Shu Rong Huang; Mohammad Al-Sayah; Ila Patel; Larry Wigman
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Jun Liang; Anne Van Abbema; Mercedesz Balazs; Kathy Barrett; Leo Berezhkovsky; Wade Blair; Christine Chang; Donnie Delarosa; Jason DeVoss; James Driscoll; Charles Eigenbrot; Simon Goodacre; Nico Ghilardi; Calum Macleod; Adam Johnson; Pawan Bir Kohli; Yingjie Lai; Zhonghua Lin; Priscilla Mantik; Kapil Menghrajani; Hieu Nguyen; Ivan Peng; Amy Sambrone; Steven Shia; Jan Smith; Sue Sohn; Vickie Tsui; Mark Ultsch; Karen Williams; Lawren Wu; Wenqian Yang; Birong Zhang; Steven Magnuson
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Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): A multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
The Lancet Oncology, ISSN: 14745488 14702045
Sung-Bae Kim; Rebecca Dent; Seock-Ah Im; Marc Espié; Sibel Blau; Antoinette R. Tan; Isakoff; Oliveira; Saura; Matthew Wongchenko; Amy Kapp; Wai Chan; Stina Singel; Daniel Maslyar; Baselga
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Population pharmacokinetics and exposure-response of trastuzumab emtansine in advanced breast cancer previously treated with ≥2 HER2-targeted regimens
British Journal of Clinical Pharmacology, ISSN: 13652125 03065251
Shang-Chiung Chen; Angelica Quartino; Daniel Polhamus; Matthew Riggs; Jonathan French; Xin Wang; Shweta Vadhavkar; Melanie Smitt; Silke Hoersch; Alexander Strasak; Jin; Sandhya Girish; Chunze Li
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Preferences for multiple sclerosis treatments: Using a discrete-choice experiment to examine differences across subgroups of US patients
International Journal of MS Care, ISSN: 15372073
Carol Mansfield; Nina Thomas; David Gebben; Maria Lucas; Brett Hauber
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Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation
Journal of Experimental Medicine, ISSN: 15409538 00221007
Michael Chang; Karpagam Srinivasan; Brad Friedman; Eric Suto; Zora Modrusan; Wyne Lee; Josh Kaminker; David Hansen; Morgan Sheng
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Risk-based predictive stability-an industry perspective
Pharmaceutical Technology, ISSN: 21507376 15432521
Helen Williams; Dennis Stephens; Megan McMahon; Elke Debie; Fenghe Qiu; Cherokee Hoaglund Hyzer; Lois Sechler; Rachel Orr; Debra Webb; Yan Wu; David Hahn
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Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Taner Dogan; Florian Gnad; Jocelyn Chan; Lilian Phu; Amy Young; Mark Chen; Sophia Doll; Matthew P. Stokes; Marcia Belvin; Lori Friedman; Don Kirkpatrick; Klaus Hoeflich; Georgia Hatzivassiliou
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Serum periostin, IgE, and SE-IgE can be used as biomarkers to identify moderate to severe chronic rhinosinusitis with nasal polyps
Journal of Allergy and Clinical Immunology, ISSN: 00916749
Karin Jonstam; Marit Westman; Gabriële Holtappels; Cecile Holweg; Claus Bachert
Supplementation of Nucleosides During Selection can Reduce Sequence Variant Levels in CHO Cells Using GS/MSX Selection System
Biotechnology Journal, ISSN: 18607314 18606768
Danming Tang; Cynthia Lam; Salina Louie; Kam Hon Hoi; David (ESCC) Shaw; Mandy Yim; Brad Snedecor; Shahram Misaghi
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Ultrasensitive HIV-1 p24 assay detects single infected cells and differences in reservoir induction by latency reversal agents
Journal of Virology, ISSN: 10985514 0022538X
Caroline Pereira Bittencourt Passaes; Timothée Bruel; Jeremie Decalf; Annie David; Mathieu Angin; Valerie Monceaux; Michaela Muller-Trutwin; Nicolas Noel; Katia Bourdic; Olivier Lambotte; Matthew Albert; Darragh Duffy; Olivier Schwartz; Asier Sáez-Cirión; Christine Rouzioux; Brigitte Autran; Monsef Benkirane; Jeremie Guedj; Laurent Hocqueloux; Christine Katlama; Roger Legrand; Laurence Meyer; Hugo Mouquet; Michaela Müller-Trutwin; Anne- Marie Taburet; Carine Van Lint
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A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains
Journal of Alzheimer's Disease, ISSN: 18758908
Patrick Haddick; Jessica L. Larson; Nisha Rathore; Tushar Bhangale; Qui T. Phung; Karpagam Srinivasan; David Hansen; Jennie Lill; Margaret A. Pericak-Vance; Jonathan Haines; Lindsay A. Farrer; John S.K. Kauwe; Gerard D. Schellenberg; Carlos Cruchaga; Alison Goate; Tim Behrens; Ryan Watts; Robert R. Graham; Josh Kaminker; Marcel van der Brug
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A first-in-human phase I study of the ATP-competitive AKT inhibitor Ipatasertib demonstrates Robust and safe targeting of AKT in patients with solid tumors
Cancer Discovery, ISSN: 21598290
Saura; Desamparados Roda; Susana Roselló; Oliveira; Teresa Macarulla; José Alejandro Pérez-Fidalgo; Rafael Morales-Barrera; Juan Manuel Sanchis-García; Luna Musib; Nageshwar Budha; Jin Zhu; Michelle Nannini; Wai Chan; Sandra Sanabria; Raymond D. Meng; Kui Lin; Yibing Yan; Premal Patel; José Baselga; Tabernero; Andrés Cervantes
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A protective role for interleukin-1 signaling during mouse adenovirus type 1-induced encephalitis
Journal of Virology, ISSN: 10985514
Luiza A. Castro-Jorge; Carla D. Pretto; Asa B. Smith; Oded Foreman; Kelly E. Carnahan; Katherine R. Spindler
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Activity-based probes for the multicatalytic proteasome
FEBS Journal, ISSN: 17424658
David S. Hewings; John A. Flygare; Ingrid Wertz; Matthew Bogyo
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Bruton's tyrosine kinase small molecule inhibitors induce a distinct pancreatic toxicity in rats
Journal of Pharmacology and Experimental Therapeutics, ISSN: 15210103
Rebecca Erickson; Leah Schutt; Jacqueline Tarrant; Michelle McDowell; Lichuan Liu; Adam Johnson; Sock-Cheng Lewin-Koh; Maj Hedehus; Jed Ross; Rick Carano; Karin Staflin; Fiona Zhong; James Crawford; Shelly Zhong; Karin Reif; Arna Katewa; Harvey Wong; Wendy Young; Donna Dambach; Misner
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Building proteomic tool boxes to monitor MHC class I and class II peptides
Proteomics, ISSN: 16159861
Frances-Rose Schumacher; Lelia Delamarre; Suchit Jhunjhunwala; Zora Modrusan; Qui Phung; Joshua E. Elias; Jennie Lill
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Cardiovascular and cerebrovascular events among patients receiving omalizumab: Pooled analysis of patient-level data from 25 randomized, double-blind, placebo-controlled clinical trials
Journal of Allergy and Clinical Immunology, ISSN: 10976825
Carlos Iribarren; Kenneth J. Rothman; Shannon Bradley; Gillis Carrigan; Mark Eisner; Hubert Chen
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Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma
Gastroenterology, ISSN: 15280012
Yiwei Wang; Dan Huang; Kai-Yuan Chen; Min Cui; Weihuan Wang; Xiaoran Huang; Amad Awadellah; Qing Li; Ann Friedman; William Xin; Luca Di Martino; Fabio Cominelli; Alex Miron; Ricky Chan; James G. Fox; Yan Xu; Xiling Shen; Mathew F. Kalady; Sanford D. Markowitz; Ivan Maillard; John B. Lowe (Path); Wei Xin; Lan Zhou
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IL-22R ligands IL-20, IL-22, and IL-24 promote wound healing in diabetic db/db mice
PLoS ONE, ISSN: 19326203
Ganesh Kolumam; Xiumin Wu; Wyne Lee; Jason Hackney; Jose Zavala-Solorio; Vineela Gandham; Dimitry Danilenko; Puneet Arora; Xiaoting Wang; Wenjun Ouyang
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Longitudinal variation of serum periostin levels in adults with stable asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825
Ruth Semprini; Caswell-Smith; James Fingleton; Cecile Holweg; John Matthews; Mark Weatherall; Beasley; Irene Braithwaite
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Mass cytometry panel optimization through the designed distribution of signal interference
Cytometry Part A, ISSN: 15524930
Chikara Takahashi; Amelia Au-Yeung; Franklin Fuh; Teresa Ramirez-Montagut; Chris Bolen; William Mathews; William E. O'Gorman
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Preclinical efficacy of an antibody-drug conjugate targeting mesothelin correlates with quantitative89 Zr-ImmunoPET
Molecular Cancer Therapeutics, ISSN: 15388514
Anton G. T. Van Terwisscha Scheltinga; Annie Ogasawara; Glenn Pacheco; Alex Vanderbilt; Jeff Tinianow; Nidhi Gupta; Dongwei Li; Ron Firestein; Jan Marik; Suzie Scales; Simon Williams
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Quantitative proteomics reveals fundamental regulatory differences in oncogenic hras and isocitrate dehydrogenase (IDH1) driven astrocytoma
Molecular and Cellular Proteomics, ISSN: 15359484
Sophia Doll; Anatoly Urisman; Juan A. Oses-Prieto; David Arnott; Alma L. Burlingame
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Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions
Trends in Immunology, ISSN: 14714981
Robin Aglietti; Erin Dueber
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Taming hyperactive hDNase I: Stable inducible expression of a hyperactive salt- and actin-resistant variant of human deoxyribonuclease I in CHO cells
Biotechnology Progress, ISSN: 15206033
Cynthia Lam; Lydia Santell; Blair Wilson; Mandy Yim; Salina Louie; Danming Tang; David (ESCC) Shaw; Pamela Chan; Bob Lazarus; Brad Snedecor; Shahram Misaghi
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Tumour-infiltrating lymphocytes in advanced HER2-positive breast cancer treated with pertuzumab or placebo in addition to trastuzumab and docetaxel: a retrospective analysis of the CLEOPATRA study
The Lancet Oncology, ISSN: 14745488
Stephen J Luen; Roberto Salgado; Stephen Fox; Peter Savas; Jennifer Eng-Wong; Emma Clark; Astrid Kiermaier; Sandra M. Swain; Jose Baselga; Stefan Michiels; Sherene Loi
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What is the value of conducting a trial of r-tPA for the treatment of mild stroke patients?
International Journal of Stroke, ISSN: 17474949
Gregory F. Guzauskas; Er Chen; Deepa Lalla; Elaine Yu; Darren Tayama; David L. Veenstra
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Photo-oxidation of IgG1 and Model Peptides: Detection and Analysis of Triply Oxidized His and Trp Side Chain Cleavage Products
Pharmaceutical Research, ISSN: 1573904X
Jessica Bane; Olivier Mozziconacci; Li Yi; John Wang; Sreedhara Alavattam; Christian Schöneich
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Degradation Mechanisms of Polysorbate 20 Differentiated by 18O-labeling and Mass Spectrometry
Pharmaceutical Research, ISSN: 1573904X
Lin Zhang; Sandeep Yadav; Barthelemy Demeule; John Wang; Olivier Mozziconacci; Christian Schӧneich
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Specific Immune Response to Phospholipase B-Like 2 Protein, a Host Cell Impurity in Lebrikizumab Clinical Material
AAPS Journal, ISSN: 15507416
Sally Fischer; Melissa Cheu; Kate Peng; John Lowe; James Araujo; Elaine Murray; Mcclintock; John Matthews; Patty Siguenza; An Song
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Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics
AAPS Journal, ISSN: 15507416
Sid Sukumaran; Crystal Zhang; Douglas Leipold; Ola Saad; Keyang Xu; Kapil Gadkar; Divya Samineni; Wang; Marija Milojic Blair; Montse Carrasco-Triguero; Bonnee Rubinfeld; Fielder; Kedan Lin; Saroja Ramanujan
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Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death
Cell Death and Differentiation, ISSN: 14765403
Maria Cristina De Almagro; Tanya Goncharov; Anita Izrael-Tomasevic; Stefanie Duttler; Matthias Kist; Eugene Varfolomeev; Xiumin Wu; Wyne Lee; Jeremy Murray; Joshua Webster; Kebing Yu; Don Kirkpatrick; Kim Newton; Domagoj Vucic
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Bevacizumab plus paclitaxel versus placebo plus paclitaxel as first-line therapy for HER2-negative metastatic breast cancer (MERiDiAN): A double-blind placebo-controlled randomised phase III trial with prospective biomarker evaluation
European Journal of Cancer, ISSN: 18790852
David W. Miles; David Cameron; Igor Bondarenko; Lyudmila Manzyuk; Juan Carlos Alcedo; Roberto Ivan Lopez; Seock-Ah Im; Jean-Luc Canon; Yaroslav Shparyk; Denise A. Yardley; Norikazu Masuda; Jungsil Ro; Neelima Denduluri; Stanislas Hubeaux; Cheng Quah; Carlos Bais; O'Shaughnessy
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Efficacy and Safety of Onartuzumab in Combination With First-Line Bevacizumab- or Pemetrexed-Based Chemotherapy Regimens in Advanced Non-Squamous Non–Small-Cell Lung Cancer
Clinical Lung Cancer, ISSN: 19380690
Heather Wakelee; Zanete Zvirbule; Filippo De Braud; C. Daniel Kingsley; Tarek Mekhail; Thomas Lowe; Wolfgang Schütte; Hervé Lena; William Lawler; Fadi S. Braiteh; Thomas Cosgriff; Diego Kaen; Michelle Boyer; Jessie Hsu; See Phan; Silvia Novello
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TIGIT: A Key Inhibitor of the Cancer Immunity Cycle
Trends in Immunology, ISSN: 14714981
Nicholas A. Manieri; Eugene Chiang; Jane Grogan
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A phase 1 study to evaluate the safety and LDL cholesterol-lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9
Clinical Cardiology, ISSN: 19328737
Amos Baruch; Diana Luca; Robert S. Kahn; Kyra Cowan; Maya Leabman; Nageshwar Budha; Cecilia Chiu; Yan Wu; Daniel Kirchhofer; Andy Peterson; John C. Davis; Whittemore Tingley
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Activity-based probes for the ubiquitin conjugation-deconjugation machinery: New chemistries, new tools, and new insights
FEBS Journal, ISSN: 17424658
David Hewings; John A. Flygare; Matthew Bogyo; Ingrid Wertz
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