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Publications

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DISPLAYING 3151 - 3200 OF 15782 RESULTS

Individual therapeutic DAS28-dcrit responses differentiate between effectiveness of rheumatoid arthritis therapies and reflect patient-reported outcomes: retrospective analysis of DAS28 responses in comparative tocilizumab studies
Rheumatology International, ISSN: 1437160X 01728172
Michaela Koehm; Matthew J. McIntosh; Michael W. Hofmann; Varghese Abraham; Cem Gabay; Ernest Choy; Arthur Kavanaugh; Harald Burkhardt; Frank Behrens
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Patient-reported outcomes from the phase III IMpassion130 trial of atezolizumab plus nab-paclitaxel in metastatic triple-negative breast cancer
Annals of Oncology, ISSN: 15698041 09237534
Sylvia Adams; Diéras; Carlos H. Barrios; Eric P. Winer; Andreas Schneeweiss; Iwata; Sherene Loi; Shilpen Patel; Henschel; Chui; Hope S. Rugo; Leisha A. Emens; Schmid
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Reproducible quantification of IgG uptake at endogenous and overexpressed FcRn levels at pH 7.4: Comparison of a wild type IgG and a stronger FcRn binding variant
Journal of Immunological Methods, ISSN: 18727905 00221759
Jianhuan Zhang; Jean-Michel Vernes; Xiaohui Wen; Ernest Oh; Suzie J. Scales; Y. Gloria Meng
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Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors
Annals of Oncology, ISSN: 15698041 09237534
Isakoff; Tabernero; Molife; Jean-Charles Soria; Andrés Cervantes; Nicholas J. Vogelzang; Manish R. Patel; Hussain; Ari Baron; Guillem Argiles; Paul Conkling; Deepak Sampath; Daniel Maslyar; Premal Patel; Wai Y. Chan; Steven Gendreau; Luna Musib; Xu; Han Ma; Kui Lin; Bendell
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Paradise revealed III: why so many ways to die? Apoptosis, necroptosis, pyroptosis, and beyond
Cell Death and Differentiation, ISSN: 14765403 13509047
Marcelo Pires Amaral; Laura Migliari Branco; Andreas Strasser; Vishva M. Dixit; Karina R. Bortoluci
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Pharmacokinetics of polatuzumab vedotin in combination with R/G-CHP in patients with B-cell non-Hodgkin lymphoma
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Colby S. Shemesh; Priya Agarwal; Tong Lu; Calvin Lee; Randall Dere; Xiaobin Li; Chunze Li; Jin Yan Jin; Sandhya Girish; Dale Miles; Dan Lu
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Anti-vimentin antibodies: a unique antibody class associated with therapy-resistant lupus nephritis
Lupus, ISSN: 14770962 09612033
Andrew J Kinloch; Matthew Cascino; Jian Dai; Rene S Bermea; Kichul Ko; Margaret Vesselits; Leonard Dragone; Nirit Mor Vaknin; Maureen Legendre; David M Markovitz; Michael K. Okoreeh; Michael J. Townsend; Marcus R. Clark
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Impact of delaying initiation of anaplastic lymphoma kinase inhibitor treatment on survival in patients with advanced non-small-cell lung cancer
Lung Cancer, ISSN: 18728332 01695002
Daniel Sheinson; Wong; Ning Wu; Mansfield
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Safety and efficacy of satralizumab monotherapy in neuromyelitis optica spectrum disorder: a randomised, double-blind, multicentre, placebo-controlled phase 3 trial
Lancet Neurology, ISSN: 14744465 14744422
Traboulsee; Benjamin M Greenberg; Jeffrey L Bennett; Lech Szczechowski; Edward J Fox; Svitlana Shkrobot; Takashi Yamamura; Yusuke Terada; Yuichi Kawata; Padraig Wright; Athos Gianella-Borradori; Hideki Garren; Brian G Weinshenker
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Protein Stability and Photostability under In Vitro Vitreal Conditions – Implications for Long Acting Delivery of Protein Therapeutics for Ocular Disease
Pharmaceutical Research, ISSN: 1573904X 07248741
Neelima Mantha; Shalini Burra; Karthikan Rajagopal; Alavattam Sreedhara
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Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure
Journal of Clinical Investigation, ISSN: 15588238 00219738
Wei Zou; Nidhi Rohatgi; Jonathan R. Brestoff; John R. Moley; Yongjia Li; Jesse W. Williams; Yael Alippe; Hua Pan; Terri A. Pietka; Gabriel Mbalaviele; Elizabeth P. Newberry; Nicholas O. Davidson; Anwesha Dey; Kooresh I. Shoghi; Richard D. Head; Samuel A. Wickline; Gwendalyn J. Randolph; Nada A. Abumrad; Steven L. Teitelbaum
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A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys
Toxicological Sciences, ISSN: 10960929 10966080
Mayur S. Mitra; Karla Lancaster; Adedeji; Gopinath S. Palanisamy; Rutwij A. Dave; Fiona Zhong; Matthew S. Holdren; Shannon J. Turley; Wei-Ching Liang; Yan Wu; Y. Gloria Meng; Jean-Michel Vernes; Melissa Schutten
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Absolute Bioavailability of Vemurafenib in Patients With BRAFV600 Mutation–Positive Malignancies
Clinical Pharmacology in Drug Development, ISSN: 21607648 2160763X
Weijiang Zhang; Dawn Colburn; Brian Simmons; Zsuzsanna Papai; Enric Bertran; Simone Schadt; Christophe Husser; Harper Forbes; Dieter Roethlisberger; Thomas Hartung
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Characterization of antineovascularization activity and ocular pharmacokinetics of phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor GNE-947
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Xingrong Liu; Xiaorong Liang; Jennifer Lecouter; Savita Ubhayakar; Jacob Z. Chen; Jay Cheng; Tom Lee; Joseph W. Lubach; Jim Nonomiya; Sheerin Shahidi-Latham; Cristine Quiason; Eric G. Solon; Matthew Wright; Cornelis E. Hop; Timothy P. Heffron
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IMbrave 050: A Phase III trial of atezolizumab plus bevacizumab in high-risk hepatocellular carcinoma after curative resection or ablation
Future Oncology, ISSN: 17448301 14796694
Stephen P. Hack; Spahn; Minshan Chen; Ann-Lii Cheng; Ahmed Kaseb; Masatoshi Kudo; Han Chu Lee; Adam Yopp; Pierce Chow; Shukui Qin
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High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade
Nature Medicine, ISSN: 1546170X 10788956
Kobe Yuen; L-F Liu; Vinita Gupta; Shravan Madireddi; Shilpa Keerthivasan; Congfen Li; Deepali Rishipathak; P. Mickey Williams; Edward E. Kadel III; Koeppen; Ying-Jiun Chen; Zora Modrusan; Jane L. Grogan; Romain Banchereau; Ning Leng; AnnChristine Thåström; Xiaodong Shen; Kenji Hashimoto; Darren Tayama; Michiel S Van Der Heijden; Jonathan E. Rosenberg; David McDermott; Thomas Powles; Priti Hegde; Mahrukh Huseni; Sanjeev Mariathasan
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The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors
PLoS ONE, ISSN: 19326203
Jacob Rinaldi; Ethan S. Sokol; Ryan J. Hartmaier; Sally E. Trabucco; Garrett M Frampton; Michael E. Goldberg; Lee A. Albacker; Anneleen Daemen; Gerard Manning
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Reconstitution reveals two paths of force transmission through the kinetochore
eLife, ISSN: 2050084X
Grace Hamilton; Luke A. Helgeson; Cameron Noland; Charles L. Asbury; Yoana Dimitrova; Trisha N. Davis
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Dose modification of subcutaneous tocilizumab in patients with rheumatoid arthritis
American Health and Drug Benefits, ISSN: 19422970 19422962
Jennie Best; Ibrahim Abbass; Lenore Tominna; William Reiss
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Interleukin-17: A Social Cytokine
Cell, ISSN: 10974172 00928674
Casper C Hoogenraad; Lorena Riol-Blanco
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30 Years of Biotherapeutics Development-What Have We Learned?
Annual Review of Immunology, ISSN: 15453278 07320582
Nico Ghilardi; Rajita Pappu; Joseph R. Arron; Andrew A. Chan
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LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits
Science Translational Medicine, ISSN: 19466242 19466234
Marco A. S Baptista; Kalpan Merchant; Ted Barrett; Sakshi Bhargava; Dianne K. Bryce; Michael Ellis; Anthony A. Estrada; Matthew J. Fell; Brian K. Fiske; Reina N. Fuji; Paul Galatsis; Anastasia G. Henry; Sue Hill; Warren D. Hirst; Christopher Houle; Matthew E. Kennedy; Xingrong Liu; Matthew L. Maddess; Carrie Markgraf; Hong Mei; William A. Meier; Elie Needle; Stephen Ploch; Christopher Royer; Karin Rudolph; Alok K. Sharma; Antonia Stepan; Stefan J. Steyn; Craig Trost; Zhizhang Yin; Hongshi Yu; Xiang Wang; Todd Sherer
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Characterization of Antisense Oligonucleotide Impurities by Ion-Pairing Reversed-Phase and Anion Exchange Chromatography Coupled to Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry Using a Versatile Two-Dimensional Liquid Chromatography Setup
Analytical Chemistry, ISSN: 15206882 00032700
Alexandre Goyon; Kelly Zhang
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Bioinformatics driven high-quality genome assembly and annotation of venomous animals for effective anti-venom development
Toxicon, ISSN: 18793150
Kushal Suryamohan
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Process Development Overcomes a Challenging Pd-Catalyzed C-N Coupling for the Synthesis of RORc Inhibitor GDC-0022
Organic Process Research and Development, ISSN: 1520586X 10836160
Lauren E. Sirois; David Lao; Jie Xu; Remy Angelaud; Jerry Tso; Brandon Scott; Paroma Chakravarty; Sushant Malhotra; Francis Gosselin
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A reference map of the human binary protein interactome
Nature, ISSN: 14764687 00280836
Katja Luck; Dae-Kyum Kim; Luke Lambourne; Kerstin Spirohn; Bridget E. Begg; Wenting Bian; Ruth Brignall; Tiziana Cafarelli; Francisco J. Campos-Laborie; Benoit Charloteaux; Dongsic Choi; Atina G. Coté; Meaghan Daley; Steven Deimling; Alice Desbuleux; Amélie Dricot; Marinella Gebbia; Madeleine F. Hardy; Nishka Kishore; Jennifer J. Knapp; István A. Kovács; Irma Lemmens; Miles W. Mee; Joseph C. Mellor; Carl Pollis; Carles Pons; Aaron D. Richardson; Sadie Schlabach; Bridget Teeking; Anupama Yadav; Mariana Babor; Dawit Balcha; Omer Basha; Christian Bowman-Colin; Suet-Feung Chin; Soon Gang Choi; Claudia Colabella; Georges Coppin; Cassandra D’Amata; David De Ridder; Steffi De Rouck; Miquel Duran-Frigola; Hanane Ennajdaoui; Florian Goebels; Liana Goehring; Anjali Gopal; Ghazal Haddad; Elodie Hatchi; Mohamed Helmy; Yves Jacob; Yoseph Kassa; Serena Landini; Roujia Li; Natascha van Lieshout; Andrew MacWilliams; Dylan Markey; Joseph N. Paulson; Sudharshan Rangarajan; John Rasla; Ashyad Rayhan; Thomas Rolland; Adriana San-Miguel; Yun Shen; Dayag Sheykhkarimli; Gloria M. Sheynkman; Eyal Simonovsky; Murat Taşan; Alexander Tejeda; Vincent Tropepe; Jean-Claude Twizere; Yang Wang; Robert J. Weatheritt; Jochen Weile; Yu Xia; Xinping Yang; Esti Yeger-Lotem; Quan Zhong; Patrick Aloy; Gary D. Bader; Javier De Las Rivas; Suzanne Gaudet; Tong Hao; Janusz Rak; Jan Tavernier; David E. Hill; Marc Vidal; Frederick P. Roth; Michael A. Calderwood
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Characterization of therapeutic oligonucleotides by liquid chromatography
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Alexandre Goyon; Peter M. Yehl; Kelly Zhang
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Automated middle-up approach for the characterization of biotherapeutic products by combining on-line hinge-specific digestion with RPLC-HRMS analysis
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Julien Camperi; Davy Guillarme; Ming Lei; Cinzia Stella
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The tumor suppressor BAP1 regulates the hippo pathway in pancreatic ductal adenocarcinoma
Cancer Research, ISSN: 15387445 00085472
Ho-June Lee; Trang Pham; Matthew T. Chang; Dwight Barnes; Allen G. Cai; Rajkumar Noubade; Klara Totpal; Xu Chen; Christopher Tran; Thijs Hagenbeek; Xiumin Wu; Jeffrey Eastham-Anderson; Janet Tao; Wyne P. Lee; Boris C. Bastian; Carbone; Webster; Anwesha Dey
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First-in-human phase i study to evaluate the brain-penetrant PI3K/mTOR inhibitor GDC-0084 in patients with progressive or recurrent high-grade glioma
Clinical Cancer Research, ISSN: 15573265 10780432
Patrick Y. Wen; Timothy F. Cloughesy; Alan G. Olivero; Kari M. Morrissey; Wilson; Xuyang Lu; Lars Mueller; Alexandre Coimbra; Benjamin M. Ellingson; Elizabeth Gerstner; Eudocia Q. Lee; Jordi Rodon
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First-in-human phase i study to evaluate the brain-penetrant PI3K/mTOR inhibitor GDC-0084 in patients with progressive or recurrent high-grade glioma
Clinical Cancer Research, ISSN: 15573265 10780432
Patrick Y. Wen; Timothy Cloughesy; Alan G. Olivero; Kari M. Morrissey; Wilson; Xuyang Lu; Lars Mueller; Alexandre Coimbra; Benjamin M. Ellingson; Elizabeth Gerstner; Eudocia Q. Lee; Jordi Rodon
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High-Throughput Platform to Identify Antibody Conjugation Sites from Antibody-Drug Conjugate Libraries
Bioconjugate Chemistry, ISSN: 15204812 10431802
Sayumi Yamazoe; Jason M. Hogan; Sean M. West; Xiaodi A. Deng; Srikanth Kotapati; Xiang Shao; Patrick Holder; Vandana Lamba; Mary Huber; Cong Qiang; Sanjeev Gangwar; Chetana Rao; Gavin Dollinger; Arvind Rajpal; Pavel Strop
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Neutrophils Follow Stromal Omens to Limit Peritoneal Inflammation
Immunity, ISSN: 10974180 10747613
Matthew B. Buechler; Shannon J. Turley
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Complete genome sequences of the human pathogen paenibacillus thiaminolyticus mbale and type Strain P. Thiaminolyticus NRRL B-4156
Microbiology Resource Announcements, ISSN: 2576098X
Christine Hehnly; Lijun Zhang; Joseph N. Paulson; Mathieu Almeida; Benjamin von Bredow; Dona S.S. Wijetunge; Michael Y. Galperin; Kathryn Sheldon; Steven J. Schiff; James R. Broacha
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Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors
ACS Medicinal Chemistry Letters, ISSN: 19485875
Brendan T. Parr; Richard Pastor; Benjamin D. Sellers; Zhonghua Pei; Firoz A. Jaipuri; Georgette M. Castanedo; Lewis Gazzard; Sanjeev Kumar; Xiaokai Li; Wen Liu; Rohan Mendonca; Roheeth K. Pavana; Hima Potturi; Cheng Shao; Venkata Velvadapu; Jesse P. Waldo; Guosheng Wu; Po-Wai Yuen; Zuhui Zhang; Yamin Zhang; Seth F. Harris; Angela Oh; Antonio G. DiPasquale; Kevin Dement; Hank La; Leanne Goon; Amy Gustafson; Erica Vanderporten; Mario R. Mautino; Yichin Liu
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Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody
JCI insight, ISSN: 23793708
Karin Staflin; Christina L. Zuch de Zafra; Leah Schutt; Vanessa Clark; Fiona Zhong; Maria Hristopoulos; Robyn Clark; Ji Li; Mary Mathieu; Xiaocheng Chen; Jennifer A. Johnston; Justin Low; Ryan Ybarra; Dionysos S. Slaga; Yang; Meric A. Ovacik; Noel Dybdal; Klara Totpal; Melissa Junttila; Diego Ellerman; Genee Y. Lee; Dennis; Prell; Teemu T. Junttila
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Mutation position is an important determinant for predicting cancer neoantigens
Journal of Experimental Medicine, ISSN: 15409538 00221007
Aude-Hélène Capietto; Suchit Jhunjhunwala; Samuel B. Pollock; Patrick J. Lupardus; Jim Wong; Lena Hänsch; James Cevallos; Yajun Chestnut; Ajay Fernandez; Nicolas Lounsbury; Tamaki Nozawa; Manmeet Singh; Zhiyuan Fan; Cecile C. de la Cruz; Qui Phung; Lucia Taraborrelli; Benjamin Haley; Jennie R. Lill; Ira Mellman; Richard Bourgon; Lélia Delamarre
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Proteomic Analyses Identify a Novel Role for EZH2 in the Initiation of Cancer Cell Drug Tolerance
Journal of Proteome Research, ISSN: 15353907 15353893
Victoria Pham; Pitti; Charles Tindell; Tommy K. Cheung; Alexandre Masselot; Jean-Philippe Stephan; Gulfem D. Guler; Catherine Wilson; Jennie R. Lill; David Arnott; Marie Classon
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Entering the era of computationally driven drug development
Drug Metabolism Reviews, ISSN: 10979883 03602532
Neha Maharao; Victor Antontsev; Matthew Wright; Jyotika Varshney
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Spectral-Domain OCT–Based Prevalence and Progression of Macular Atrophy in the HARBOR Study for Neovascular Age-Related Macular Degeneration
Ophthalmology, ISSN: 15494713 01616420
Shamika Gune; Nizar Saleh Abdelfattah; Ayesha Karamat; Siva Balasubramanian; Kenneth M. Marion; Elizabeth A. Morgenthien; Srinivas Sadda
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Changes in Manufacturing Processes of Biologic Therapies Can Alter the Immunogenicity Profile of the Product
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Vanderlaan; Aristides Maniatis; Robert Olney; Abdelkader Rahmaoui; Linda Yau; Quarmby; Craig Azzolino; Cynthia Woods; Dalia Moawad
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Incidence and Management of Diarrhea With Adjuvant Pertuzumab and Trastuzumab in Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer
Clinical Breast Cancer, ISSN: 19380666 15268209
José Bines; Marion Procter; Eleonora Restuccia; Giuseppe Viale; Zardavas; Suter; Amal Arahmani; Veerle Van Dooren; José Baselga; Emma Clark; Jennifer Eng-Wong; Richard D. Gelber; Martine Piccart; Volker Mobus; Evandro De Azambuja
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The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study
Diabetologia, ISSN: 14320428 0012186X
Robert W. Koivula; Naeimeh Atabaki-Pasdar; Giuseppe N. Giordano; Tom White; Jerzy Adamski; Jimmy D. Bell; Joline Beulens; Søren Brage; Søren Brunak; Federico De Masi; Emmanouil T. Dermitzakis; Ian M. Forgie; Gary Frost; Torben Hansen; Tue H. Hansen; Andrew T. Hattersley; Tarja Kokkola; Azra Kurbasic; Markku Laakso; Andrea Mari; Timothy J. McDonald; Oluf Pedersen; Femke Rutters; Jochen M. Schwenk; Harriet J. A. Teare; E. Louise Thomas; Ana Vinuela; Anubha Mahajan; Mark I. McCarthy; Hartmut Ruetten; Mark Walker; Ewan Pearson; Imre Pavo; Paul W. Franks
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Mitochondrial Functions in Infection and Immunity
Trends in Cell Biology, ISSN: 18793088 09628924
Varnesh Tiku; Man-Wah Tan; Ivan Dikic
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Micellar Morphology of Polysorbate 20 and 80 and Their Ester Fractions in Solution via Small-Angle Neutron Scattering
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Jannatun Nayem; Zhenhuan Zhang; Anthony Tomlinson; Isidro E. Zarraga; Norman J. Wagner; Yun Liu
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Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus
Nature Medicine, ISSN: 1546170X 10788956
Yuri Kotliarov; Rachel Sparks; Andrew J. Martins; Matthew P. Mulè; Yong Lu; Meghali Goswami; Lela Kardava; Romain Banchereau; Virginia Pascual; Angélique Biancotto; Jinguo Chen; Pamela L. Schwartzberg; Neha Bansal; Candace C. Liu; Foo Cheung; Susan Moir; John S. Tsang
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Efficacy of chemotherapy and atezolizumab in patients with non-small-cell lung cancer receiving antibiotics and proton pump inhibitors: pooled post hoc analyses of the OAK and POPLAR trials
Annals of Oncology, ISSN: 15698041 09237534
Chalabi; Andres Cardona; Deepti R. Nagarkar; Dhawahir Scala; David R. Gandara; Achim Rittmeyer; Matthew L. Albert; Thomas Powles; Kok; Herrera
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Publisher Correction: Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics (Nature Structural & Molecular Biology, (2020), 27, 2, (210-220), 10.1038/s41594-019-0370-3)
Nature Structural and Molecular Biology, ISSN: 15459985 15459993
Annette M. Vogl; Lilian Phu; Raquel Becerra; Sebastian A. Giusti; Erik Verschueren; Trent Hinkle; Martín D. Bordenave; Max Adrian; Amy Heidersbach; Patricio Yankilevich; Fernando D. Stefani; Wolfgang Wurst; Casper C Hoogenraad; Donald S. Kirkpatrick; Damian Refojo; Morgan Sheng
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Complex formation of anti-VEGF-C with VEGF-C released during blood coagulation resulted in an artifact in its serum pharmacokinetics
Pharmacology Research and Perspectives, ISSN: 20521707
Daniela Bumbaca Yadav; Arthur Reyes; Priyanka Gupta; Jean-Michel Vernes; Y. Gloria Meng; Michelle G. Schweiger; Shannon Stainton; Fuh; Fielder; Amrita Kamath; Shen
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Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs
Toxicologic Pathology, ISSN: 15331601 01926233
Paula Katavolos; Cain; Cindy A. Farman; F. Anthony Romero; Steven Magnuson; Justin Ly; Edna F. Choo; Anand K. Katakam; Roxanne Andaya; Jonathan M. Maher
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