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Publications

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DISPLAYING 301 - 350 OF 15583 RESULTS

Exploring How Antibody Format Drives Clearance from the Brain
Molecular Pharmaceutics, ISSN: 15438384
Kelly Schwinghamer; Brian M. Kopec; Ebehiremen Ayewoh; Xun Tao; Shraddha Sadekar; Alavattam Sreedhara; Robert F. Kelley; Devin B. Tesar; Teruna J. Siahaan
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Care partner-informed meaningful change thresholds for the Clinical Dementia Rating-Sum of Boxes for trials of early Alzheimer's disease
Alzheimer's and Dementia, ISSN: 15525260
Lansdall; Edmond Teng; Jerome Chague; Rohan Palanganda; Paul Delmar; Janice Smith; Jeffrey L. Cummings; Fiona McDougall
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Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model
Alzheimer's and Dementia, ISSN: 15525260
Antoine Leuzy; Lars Lau Raket; Victor L Villemagne; Gregory Klein; Matteo Tonietto; Emily Olafson; Suzanne Baker; Ziad Saad; Santiago Bullich; Brian J Lopresti; Sandra Sanabria Bohorquez; Mercè Boada; Tobey J. Betthauser; Arnaud Charil; Emily Collins; Jessica A. Collins; Nicholas C. Cullen; Roger N Gunn; Makoto Higuchi; Eric Hostetler; R. Matthew Hutchison; Leonardo Iaccarino; Philip S. Insel; Michael C. Irizarry; Clifford R. Jack; William J. Jagust; Keith Johnson; Sterling C. Johnson; Yashmin Karten; Marta Marquié; Sulantha Mathotaarachchi; Mark A. Mintun; Rik Ossenkoppele; Ioannis Pappas; Ronald C. Petersen; Gil D. Rabinovici; Pedro Rosa-Neto; Christopher G. Schwarz; Ruben Smith; Andrew W Stephens; Alex Whittington; Maria C. Carrillo; Michael J. Pontecorvo; Samantha Budd Haeberlein; Billy Dunn; Hartmuth Kolb; Sudhir Sivakumaran; Christopher Rowe; Oskar Hansson; Vincent Dore
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Long-term Treatment Patterns for Diabetic Macular Edema: Up to 6-Year Follow-up in the IRIS® Registry
Ophthalmology Retina,
Blanche L. Kuo; David Tabano; Vincent Garmo; Eunice Kim; Theodore Leng; Meghan Hatfield; Andrew LaPrise; Rishi Singh
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Systematic Literature Reviews Comparing the Long-Term Safety Outcomes for the Port Delivery System with Ranibizumab (PDS) Versus Other Ocular Implants
Ophthalmology and Therapy, ISSN: 21938245
Nancy M. Holekamp; Manejeh Yaqub; Shrirang Ranade; Ronald A. Cantrell; Sheena Singh; Gus Gazzard
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Supplemental Intravitreal Ranibizumab Injections in Eyes Treated with the Port Delivery System with Ranibizumab in the Archway Trial
Ophthalmology Retina,
Jared Nielsen; Andrew Chang; Nancy M. Holekamp; Melina Cavichini-Cordeiro; Stephanie L. Lin; Dominic Heinrich; Katie F. Maass; Alicia R. Menezes; Natasha Singh; Dante Joseph Pieramici
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High Resolution Ion Mobility Enables the Structural Characterization of Atropisomers of GDC-6036, a KRAS G12C Covalent Inhibitor
Journal of the American Society for Mass Spectrometry, ISSN: 10440305
Marcelino Varona; Daniel P. Dobson; José G. Napolitano; Rekha Thomas; Jessica L. Ochoa; David J. Russell; Christopher M. Crittenden
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Cost-effectiveness analysis of mosunetuzumab for treatment of relapsed or refractory follicular lymphoma after two or more lines of systemic therapy in the United States
Journal of Medical Economics, ISSN: 13696998
Matthew Matasar; Javier Sanchez Alvarez; Hélène Parisé; Eric Zuk; Danilo Di Maio; Sheila Shapouri; Eunice Kim; Shih Wen Lin
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Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions
Developmental Cell, ISSN: 15345807
Max Koppers; Nazmiye Özkan; Ha H. Nguyen; Daphne Jurriens; Janine McCaughey; Dan T.M. Nguyen; Chun Hei Li; Riccardo Stucchi; Maarten Altelaar; Harold MacGillavry; Lukas C. Kapitein; Casper C Hoogenraad; Ginny G. Farías
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Meta-Analysis of 49 Roche Oncology Trials Comparing Blinded Independent Central Review (BICR) and Local Evaluation to Assess the Value of BICR
Oncologist, ISSN: 10837159
Qinshu Lian; Jill Fredrickson; Kamila Boudier; Christiane Rothkegel; Magalie Hilton; Alexander Hillebrecht; Andrew McDonald; Xu
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Quantitative characterization of the effects of fulvestrant alone or in combination with taselisib (PI3Kinase inhibitor) on longitudinal tumor growth in patients with estrogen receptor-positive, HER2-negative, PIK3CA-mutant, advanced or metastatic breast cancer
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Anita Moein; Jin Yan Jin; Matthew Wright; Harvey Wong
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Semorinemab Pharmacokinetics and The Effect on Plasma Total Tau Pharmacodynamics in Clinical Studies
Journal of Prevention of Alzheimer's Disease, ISSN: 22745807
Vidya Ramakrishnan; Brendan C. Bender; Jurgen Langenhorst; Mats O. Magnusson; Michael J. Dolton; Shim; Reina N. Fuji; Cecilia Monteiro; Edmond Teng; Nastya Kassir; Jin Yan Jin
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Characteristics of patients with chronic spontaneous urticaria who are late-responders to omalizumab
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
Giselle Mosnaim; Thomas B. Casale; Michael Holden; Benjamin L. Trzaskoma; Jonathan A. Bernstein
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Microfluidic Sample Preparation for Multiplexed Single-Cell Proteomics Using a Nested Nanowell Chip
Methods in Molecular Biology,
Junho Park; Tommy K. Cheung; Ying Zhu
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The receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumour suppression
Journal of Cell Science, ISSN: 00219533
Katherine A. Young; Katarzyna Wojdyla; Tiffany Lai; Katie E. Mulholland; Silvia Aldaz Casanova; Robin Antrobus; Simon Andrews; Laura Biggins; Betania Mahler-Araujo; Philippa R. Barton; Keith R. Anderson; Gareth W. Fearnley; Hayley J. Sharpe
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Investigation of the state of hydration of a non-stoichiometric hydrate in a low dose formulation using 19F solid-state NMR
Journal of Pharmaceutical Sciences, ISSN: 00223549
Jonathan Hau; Antonio G. DiPasquale; Joseph W. Lubach; Paroma Chakravarty
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Exploring the Impact of In Vitro-Transcribed mRNA Impurities on Cellular Responses
Analytical Chemistry, ISSN: 00032700
Julien Camperi; Brian Roper; Emily C. Freund; Rebecca Leylek; Ariane Nissenbaum; Carolina Galan; Roger Caothien; Zhilan Hu; Peggy Ko; Allison Lee; Kamalakar Chatla; Luladey Ayalew; Feng Yang; Steffen Lippold; Axel Guilbaud
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RIP1 inhibition protects retinal ganglion cells in glaucoma models of ocular injury
Cell Death and Differentiation, ISSN: 13509047
Bo Kyoung Kim; Tatiana Goncharov; Sébastien A. Archaimbault; Filip Roudnicky; Webster; Peter D. Westenskow; Domagoj Vucic
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Immunogenicity risk assessment and mitigation for engineered antibody and protein therapeutics
Nature Reviews Drug Discovery, ISSN: 14741776
Paul J. Carter; Quarmby
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Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification
Nature Genetics, ISSN: 10614036
Simone M. Haag; Shiqi Xie; Celine Eidenschenk; Jean-Philippe Fortin; Marinella G. Callow; Michael Costa; Aaron T. L. Lun; Christian Cox; Sunny Z. Wu; Rachana Pradhan; Jaclyn Y. Lock; Julia A. Kuhn; Loryn Holokai; Minh Thai; Emily C. Freund; Ariane Nissenbaum; Mary E. Keir; Christopher J. Bohlen; Scott E. Martin; Kathryn R. Geiger-Schuller; Hussein A. Hejase; Brian L. Yaspan; Sandra Melo Carlos; Shannon J. Turley; Aditya Murthy
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Development of a Robust Pd-Catalyzed C-S Coupling for the Synthesis of Janus Kinase Inhibitor GDC-9918
Organic Process Research and Development, ISSN: 10836160
Derek M. Dalton; Juno Castillo Siu; Marcelino Varona-Ortiz; C. Gregory Sowell; Francis Gosselin
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A comparison of data visualization tools: A case study in health-related research
Information Visualization, ISSN: 14738716
Hongtai Huang; Sreedevi Ravi; Timothy Warrington; Howe Cui; Carlson Wang; Mark McCreary; Benjamin E. Lauffer; Christina Lu
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Considerations for Industry—Preparing for the FDA Model-Informed Drug Development (MIDD) Paired Meeting Program
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Gerald R. Galluppi; Malidi Ahamadi; Souvik Bhattacharya; Nageshwar Budha; Ferdous Gheyas; Chi-Chung Li; Yuan Chen; Anne-Gaëlle Dosne; Niels Rode Kristensen; Mindy Magee; Mahesh N. Samtani; Vikram Sinha; Kunal S. Taskar; Vijay V. Upreti; Jianning Yang; Jack Cook
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Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development
Xenobiotica, ISSN: 00498254
Michael Z. Liao; Douglas Leipold; Shang-Chiung Chen; Zao Li; Amrita Kamath; Chunze Li
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Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species
Xenobiotica, ISSN: 00498254
Victor Yip; Ola M. Saad; Douglas Leipold; Chunze Li; Amrita Kamath; Shen
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A Novel Step-Up Dosage Regimen for Enhancing the Benefit-to-Risk Ratio of Mosunetuzumab in Relapsed or Refractory Follicular Lymphoma
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Chi-Chung Li; Brendan C. Bender; Justin Wilkins; Feifei Li; Turner; Wang; Rong Deng; Shweta Vadhavkar; Zao Li; Antonia Kwan; Huang Huang; Kun Peng; Elicia M. Penuel; Huw; Pascal Chanu; Chunze Li; Shen Yin; Michael C. Wei
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Interim Results of the Phase III Portal Extension Trial of the Port Delivery System with Ranibizumab in Neovascular Age-Related Macular Degeneration
Ophthalmology Retina,
Peter A. Campochiaro; David Eichenbaum; Margaret A. Chang; W. Lloyd Clark; Jordan M. Graff; Sophie Le Pogam; Melina Cavichini-Cordeiro; Shamika Gune; Melvin D. Rabena; Natasha Singh; Stephanie L. Lin; Natalia F. Callaway
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A Refined Thin-Film Model for Drug Dissolution Considering Radial Diffusion – Simulating Powder Dissolution
Pharmaceutical Research, ISSN: 07248741
Karthik Salish; Chi So; Seong Hoon Jeong; Hao Helen Hou; Chen Mao
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Automated tumor immunophenotyping predicts clinical benefit from anti-PD-L1 immunotherapy
Journal of Pathology, ISSN: 00223417
Xiao Li; Jeffrey Eastham; Jennifer M. Giltnane; Wei Zou; Andries Zijlstra; Evgeniy Tabatsky; Romain Banchereau; Ching-Wei Chang; Barzin Y. Nabet; Namrata S. Patil; Luciana L. Molinero; Steve Chui; Maureen Harryman; Shari Lau; Linda Rangell; Yannick Waumans; Mark Kockx; Darya Y. Orlova; Koeppen
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Analysis of kallikrein-related peptidase 7 (KLK7) autolysis reveals novel protease and cytokine substrates
Biological Chemistry, ISSN: 14374315 14316730
Swapnil V. Ghodge; Lazarus
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Caregiver Global Impression Observations from EMBARK: A Phase 3 Study Evaluating Delandistrogene Moxeparvovec in Ambulatory Patients with Duchenne Muscular Dystrophy
Neurology and Therapy, ISSN: 21936536 21938253
Craig M. McDonald; Jacob S. Elkins; Sai Dharmarajan; Katherine Gooch; Teofil Ciobanu; Lansdall; Alexander P. Murphy; Fiona McDougall; Eugenio Mercuri; Ivana Audhya
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Virtual Control Groups in Non-clinical Toxicity Studies: Impacts on Toxicologic Clinical Pathology Data Interpretation
Toxicologic Pathology, ISSN: 15331601 01926233
Adedeji; Adi Wasserkrug Naor
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The dynamics of hematopoiesis over the human lifespan
Nature Methods, ISSN: 15487105 15487091
Hojun Li; Parker Côté; Michael Kuoch; Jideofor Ezike; Katie Frenis; Anton Afanassiev; Laura Greenstreet; Mayuri Tanaka-Yano; Giuseppe Tarantino; Stephen Zhang; Jennifer Whangbo; Vincent L. Butty; Enrico Moiso; Marcelo Falchetti; Kate Lu; Guinevere G. Connelly; Vivian Morris; Dahai Wang; Antonia F. Chen; Giada Bianchi; George Q. Daley; Salil Garg; David R. Liu; Stella T. Chou; Aviv Regev; Edroaldo Lummertz da Rocha; Geoffrey Schiebinger; R. Grant Rowe
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Preclinical assessment of the PI3Kα selective inhibitor inavolisib and prediction of its pharmacokinetics and efficacious dose in human
Xenobiotica, ISSN: 13665928 00498254
Laurent Salphati; Jodie Pang; Emile G. Plise; Jonathan Cheong; Marie-Gabrielle Braun; Lori S. Friedman; Rebecca Hong Thibodeau; Allan Jaochico; Ryan Johnson; Ning Liu; Michelle Nannini; Deepak Sampath; Kyung Song; Emily J. Hannan; Steven T. Staben
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A workflow for accurate and consistent quantitation of host cell proteins by SWATH LC–MS/MS analysis to support process development
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Jia Guo; Regina Kufer; Midori Greenwood-Goodwin; Stefanie Wohlrab; Fem Woodruff; Delia Li; Katharina Reckermann; Jonghae Youn; Dilip Kumar Reddy Kandula; Lei Xiong; Feng Yang
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Deoxygenative alcohol–nucleophile coupling via carbocations
Chem Catalysis, ISSN: 26671093 26671107
Léa Thai-Savard; Jason R. Zbieg; Jack A. Terrett
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Retinal Fluid and Thickness Fluctuations in Archway Trial for Port Delivery System with Ranibizumab versus Monthly Ranibizumab Injections
Ophthalmology Retina, ISSN: 24686530
Veeral Sheth; Nancy M. Holekamp; Arshad M. Khanani; Aleksandra Rachitskaya; Steven Blotner; Shamika Gune; Dominic Heinrich; Katie F. Maass; Usha Chakravarthy
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Prognostic Significance of Recurrence and Timing of Recurrence on Survival Among Patients with Early-Stage Hepatocellular Carcinoma in U.S. Clinical Practice
Annals of Surgical Oncology, ISSN: 15344681 10689265
Shishir K. Maithel; Rongrong Wang; Joanna Harton; Adam Yopp; Shimul A. Shah; Flavio G. Rocha; Sairy Hernandez; Spencer Cheng; Sarika Ogale; Ruoding Tan
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Long-term 3-year follow-up of mosunetuzumab in relapsed or refractory follicular lymphoma after ≥2 prior therapies
Blood, ISSN: 15280020 00064971
Laurie H. Sehn; Nancy L. Bartlett; Matthew Matasar; Stephen J. Schuster; Sarit E. Assouline; Pratyush Giri; Kuruvilla; Mazyar Shadman; Chan Yoon Cheah; Sascha Dietrich; Keith Fay; Matthew Ku; Loretta J. Nastoupil; Michael C. Wei; Shen Yin; Iris To; Derrick Kaufman; Antonia Kwan; Elicia M. Penuel; Christopher R. Bolen; Lihua E. Budde
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Macular Sensitivity Endpoints in Geographic Atrophy: Exploratory Analysis of Chroma and Spectri Clinical Trials
Ophthalmology Science,
Dolly Chang; Natalia F. Callaway; Verena Steffen; Karl G. Csaky; Robyn H. Guymer; David G. Birch; Praveen J. Patel; Michael S. Ip; Simon S. Gao; Jayla Briggs; Lee Honigberg; Phillip Lai; Daniela Ferrara; Yasir J. Sepah
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Inhibitors targeting BamA in gram-negative bacteria
Biochimica et Biophysica Acta - Molecular Cell Research, ISSN: 01674889
Kelly M. Storek; Dawei Sun; Steven T. Rutherford
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Lymphoid System
Toxicologic Pathology: a Primer,
Steven T. Laing
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Dose Optimization in Oncology Drug Development: An International Consortium for Innovation and Quality in Pharmaceutical Development White Paper
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Divya Samineni; Karthik Venkatakrishnan; Ahmed A. Othman; Yazdi K. Pithavala; Srinivasu Poondru; Chirag Patel; Pavan Vaddady; Wendy Ankrom; Ramanujan; Nageshwar Budha; Michael Wu; Nahor Haddish-Berhane; Holger Fritsch; Azher Hussain; Jitendra Kanodia; Meng Li; Mengyao Li; Murad Melhem; Apurvasena Parikh; Vijay V. Upreti; Neeraj Gupta
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Patient preferences for chronic lymphocytic leukemia treatments: a discrete-choice experiment
Future Oncology, ISSN: 14796694
Arliene Ravelo; Kelley Myers; Robyn Brumble; Cooper Bussberg; Brian Koffman; Beenish S. Manzoor; Juliana M L Biondo; Carol Mansfield
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Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model
Journal of Medicinal Chemistry, ISSN: 00222623
Marie-Gabrielle Braun; Avi Ashkenazi; Ramsay E. Beveridge; Georgette M. Castanedo; Heidi J. A. Wallweber; Beresini; Clark; Tom De Bruyn; Liqiang Fu; Paul Gibbons; Fan Jiang; Susan Kaufman; David Kan; James R. Kiefer; Jean-Philippe Leclerc; Alexandre Lemire; Cuong Q. Ly; Ehud Segal; Jessica Sims; Weiru Wang; Wentao Wei; Zhao; Jacob B. Schwarz; Joachim Rudolph
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A novel biomarker assay qualification strategy for rare human matrices–a case study of biomarkers in aqueous humor
Bioanalysis, ISSN: 17576180
Jennifer A. Getz; Trung Nguy; Randall Dere; Mauricio Maia
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Role of NaV1.7 in postganglionic sympathetic nerve function in human and guinea-pig arteries
Journal of Physiology, ISSN: 00223751
Joyce S. Kim; Sonya Meeker; Fei Ru; Minh Tran; Tanja S. Zabka; David Hackos; Bradley J. Undem
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Online Nucleotide Mapping of mRNAs
Analytical Chemistry, ISSN: 00032700
Alexandre Goyon; Brandon Scott; Peter M. Yehl; Kelly Zhang
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A New Approach for Preparing Stable High-Concentration Peptide Nanoparticle Formulations
Pharmaceuticals,
Chloe Hu; Nanzhi Zang; Yu Tong Tam; Desmond Dizon; Kaylee Lee; Jodie Pang; Elizabeth Torres; Yusi Cui; Chun-Wan Yen; Dennis H. Leung
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Model-based comparisons of post-treatment free IgE and FEV1 between omalizumab asthma dosing tables in the United States and European Union
British Journal of Clinical Pharmacology, ISSN: 03065251
Rui Zhu; Rik Schoemaker; Aurelie Gautier; Xianbin Tian; Cheryl HooiMing Sim; Theodore A. Omachi; Amita Joshi; Jin Jin; Ryan Owen
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