Genentech: Publications

November 1, 2018

Type 2 Biomarkers and Prediction of Future Exacerbations and Lung Function Decline in Adult Asthma

Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198

Ruth Semprini; Mathew Williams; Alex Semprini; Alice McDouall; James Fingleton; Cécile T.J. Holweg; Mark Weatherall; Beasley; Irene Braithwaite

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November 1, 2018

A pharmacology guided approach for setting limits on product-related impurities for bispecific antibody manufacturing

Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719

Sharmila Rajan; Junichiro Sonoda; Timothy Tully; Ambrose Jon Williams; Feng Yang; Frank D. Macchi; Terry Hudson; Mark Chen; Shannon Liu; Nicole R. Valle; Kyra J. Cowan; Thomas R. Gelzleichter

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November 1, 2018

Airway pathological heterogeneity in asthma: Visualization of disease microclusters using topological data analysis

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Salman Siddiqui; Aarti Shikotra; Matthew Richardson; Emma Doran; David F. Choy; Alex Bell; Cary D. Austin; Jeffrey Eastham-Anderson; Beverley Hargadon; Joseph R. Arron; Andrew J. Wardlaw; Chris E. Brightling; Liam G. Heaney; Peter Bradding

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November 1, 2018

CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts

Alzheimer's and Dementia, ISSN: 15525279 15525260

Oskar Hansson; John P. Seibyl; Erik Stomrud; Henrik Zetterberg; John Q. Trojanowski; Tobias Bittner; Valeria Lifke; Veronika Corradini; Udo Eichenlaub; Richard Batrla; Katharina Buck; Katharina Zink; Christina Rabe; Kaj Blennow; Leslie Shaw

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November 1, 2018

Mitigation of Oxidation in Therapeutic Antibody Formulations: a Biochemical Efficacy and Safety Evaluation of N-Acetyl-Tryptophan and L-Methionine

Pharmaceutical Research, ISSN: 1573904X 07248741

Michelle Z. Dion; Danielle L. Leiske; Vikas Sharma; Christina L. Zuch de Zafra; Cleo M. Salisbury

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November 1, 2018

Lymphocytes are a major source of circulating soluble dipeptidyl peptidase 4

Clinical and Experimental Immunology, ISSN: 13652249 00099104

Armanda Casrouge; Sauer; Rosa Barreira da Silva; Tejera-Alhambra; Sánchez-Ramón; Cancrini; Molly A. Ingersoll; Aiuti; Matthew L. Albert

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November 1, 2018

A method for manual and automated multiplex RNAscope in situ hybridization and immunocytochemistry on cytospin samples

PLoS ONE, ISSN: 19326203

Sara M. Chan; Audrey Filézac de L’Etang; Linda Rangell; Patrick Caplazi; John Lowe; Valentina Romeo

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October 30, 2018

Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Kim Newton; Dugger; Arundhati Sengupta Ghosh; Ron Ferrando; Felix Chu; Janet Tao; Wendy Lam; Susan Haller; Sara M. Chan; Susan Sa; Debra Dunlap; Jeffrey Eastham-Anderson; Hai Ngu; Jeffrey Hung; French; Webster; Brad Bolon; Jinfeng Liu; Rohit Reja; Sarah K. Kummerfeld; Ying-Jiun Chen; Zora Modrusan; Joe Lewcock; Vishva M. Dixit

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October 25, 2018

Kinase Inhibitors for the Treatment of Immunological Disorders: Recent Advances

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Marian C. Bryan; Naomi S. Rajapaksa

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October 25, 2018

GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Shumei Wang; Vickie Tsui; Terry Crawford; James E. Audia; Burdick; Beresini; Alexandre Côté; Richard T Cummings; Martin Duplessis; E. Megan Flynn; Michael C. Hewitt; Hon-Ren Huang; Hariharan Jayaram; Ying Jiang; Shivangi Joshi; Jeremy Murray; Christopher G. Nasveschuk; Eneida Pardo; Florence Poy; F. Anthony Romero; Yong Tang; Alexander M. Taylor; Jian Wang; Zhaowu Xu; Laura E. Zawadzke; Xiaoyu Zhu; Brian K Albrecht; Steven Magnuson; Steve Bellon; Andrea G Cochran

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October 23, 2018

Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1)

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Marcin Kowanetz; Wei Zou; Scott Gettinger; Koeppen; Mark Kockx; Schmid; Edward E. Kadel III; Ignacio I. Wistuba; Jamie E. Chaft; Naiyer A. Rizvi; David Spigel; Alexander Spira; Fred R. Hirsch; Victor Cohen; Dustin Smith; Zachary Boyd; Natasha Miley; Susan Flynn; Vincent Leveque; David S. Shames; Ballinger; Mocci; Geetha Shankar; Roel Funke; Garret M. Hampton; Alan Sandler; Lukas Amler; Ira Mellman; Daniel S. Chen; Priti Hegde

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October 19, 2018

Evaluating the Impact of a Decade of Funding from the Green Chemistry Institute Pharmaceutical Roundtable

Organic Process Research and Development, ISSN: 1520586X 10836160

Stefan G. Koenig; David Leahy; Andrew S. Wells

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October 18, 2018

A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition

Nature, ISSN: 14764687 00280836

Brian Biehs; Gerrit J. P. Dijkgraaf; Robert Piskol; Bruno Alicke; Soufiane Boumahdi; Franklin V. Peale Jr.; Stephen Gould; Frederic J. De Sauvage

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October 17, 2018

Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3

Science Translational Medicine, ISSN: 19466242 19466234

Dionysos S. Slaga; Diego Ellerman; T. Noelle Lombana; Rajesh Vij; Ji Li; Maria Hristopoulos; Robyn Clark; Jennifer A. Johnston; Amy Shelton; Elaine Mai; Kapil Gadkar; Amy Lo; James T. Koerber; Klara Totpal; Prell; Genee Y. Lee; Christoph Spiess; Teemu T. Junttila

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October 15, 2018

Chemotherapy combines effectively with Anti-PD-L1 treatment and can augment antitumor responses

Journal of Immunology, ISSN: 15506606 00221767

Rafael Cubas; Marina Moskalenko; Jeanne Cheung; Michelle Yang; Erin McNamara; Huizhong Xiong; Sabine Hoves; Carola H. Ries; Kim; Stephen Gould

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October 15, 2018

Conventional wastewater treatment and reuse site practices modify bacterial community structure but do not eliminate some opportunistic pathogens in reclaimed water

Science of the Total Environment, ISSN: 18791026 00489697

Prachi Kulkarni; Nathan D. Olson; Joseph N. Paulson; Mihai Pop; Cynthia Maddox; Emma Claye; Rachel E. Rosenberg Goldstein; Manan Sharma; Shawn G. Gibbs; Emmanuel F. Mongodin; Amy R. Sapkota

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October 8, 2018

Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors

Cancer Cell, ISSN: 18783686 15356108

Ivana Yen; Frances Shanahan; Mark Merchant; Christine Orr; Thomas Hunsaker; Matthew Durk; Hank La; Xiaolin Zhang; Scott E. Martin; Eva Lin; John Chan; Yihong Yu; Dhara Amin; Richard M. Neve; Amy Gustafson; Avinashnarayan Venkatanarayan; Scott A. Foster; Joachim Rudolph; Christiaan N. Klijn; Shiva Malek

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October 6, 2018

Quality assessment and interference detection in targeted mass spectrometry data using machine learning 03 Chemical Sciences 0301 Analytical Chemistry

Clinical Proteomics, ISSN: 15590275 15426416

Shadi Toghi Eshghi; Paul Auger; W Rodney Mathews

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October 5, 2018

Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin

Journal of Organic Chemistry, ISSN: 15206904 00223263

Scott Savage; Andrew McClory; Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Colin Masui; Sarah J. Robinson; Chong Han; Christoph Ochs; Pankaj D. Rege; Francis Gosselin

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October 3, 2018

High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants

mAbs, ISSN: 19420870 19420862

Danielle DiCara; Nisana Andersen; Ruby Chan; James A. Ernst; Gai Ayalon; Greg A. Lazar; Nick Agard; Amy Hilderbrand; Isidro Hötzel

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October 3, 2018

Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid

mAbs, ISSN: 19420870 19420862

Rina Fong; Kimberly K. Kajihara; Matthew Chen; Isidro Hötzel; Sanjeev Mariathasan; Wouter L. W. Hazenbos; Patrick J. Lupardus

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October 3, 2018

Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model

mAbs, ISSN: 19420870 19420862

Shun xin Wang-Lin; Chenguang Zhou; Amrita Kamath; Kyu Hong; Neelima Koppada; Ola M. Saad; Montserrat Carrasco-Triguero; S. Cyrus Khojasteh; Rong Deng

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October 3, 2018

Characterization of in vivo biotransformations for trastuzumab emtansine by high-resolution accurate-mass mass spectrometry

mAbs, ISSN: 19420870 19420862

Jintang He; Shang-Fan Yu; Sharon Fong Yee; Surinder Kaur; Keyang Xu

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October 3, 2018

Cost-effectiveness of obinutuzumab plus bendamustine followed by obinutuzumab monotherapy for the treatment of follicular lymphoma patients who relapse after or are refractory to a rituximab-containing regimen in the US

Journal of Medical Economics, ISSN: 1941837X 13696998

Gregory F. Guzauskas; Anthony Masaquel; Carolina Reyes; Coen A. Bernaards; Tania Krivasi; David L. Veenstra

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October 3, 2018

Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole

Xenobiotica, ISSN: 13665928 00498254

Molly Lin; Justin Ly; Ryan Takahashi; John Chen; Alan Deese; Sarah J. Robinson; Aleksandr Kolesnikov; Susan C. Wong; Xiaojing Wang; Jae H. Chang

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October 2, 2018

The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function

Cell Reports, ISSN: 22111247

Sairy Hernandez; Jing Qing; Rebecca Hong Thibodeau; Xiangnan Du; Summer Park; Hyang-Mi Lee; Min Xu; Soyoung Oh; Armando Navarro; Merone Roose-Girma; Robert J. Newman; Søren Warming; Michelle Nannini; Deepak Sampath; Kim; Jane L. Grogan; Ira Mellman

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October 1, 2018

Long-term safety of pirfenidone: Results of the prospective, observational PASSPORT study

ERJ Open Research, ISSN: 23120541

Vincent Cottin; Dirk Koschel; Andreas Günther; Carlo Albera; Arata Azuma; C Magnus Sköld; Sara Tomassetti; Philip Hormel; John L. Stauffer; Indiana Strombom; Klaus-Uwe Kirchgaessler; Toby M. Maher

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October 1, 2018

Primary efficacy results from B-F1RST, a prospective phase II trial evaluating blood-based tumour mutational burden (bTMB) as a predictive biomarker for atezolizumab (atezo) in 1L non-small cell lung cancer (NSCLC)