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Publications

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DISPLAYING 4551 - 4600 OF 15805 RESULTS

Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition
Toxicology and Applied Pharmacology, ISSN: 10960333 0041008X
Steven Cepa; David M. Potter; Lisa Wong; Leah Schutt; Jacqueline M. Tarrant; Jodie Pang; Xiaolin Zhang; Roxanne Andaya; Laurent Salphati; Yingqing Ran; Le An; Ryan Morgan; Jonathan M. Maher
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Efficacy and safety of lebrikizumab in adult patients with mild-to-moderate asthma not receiving inhaled corticosteroids
Respiratory Medicine, ISSN: 15323064 09546111
Phillip Korenblat; Edwin Kerwin; Igor Leshchenko; Karl Yen; Cécile T.J. Holweg; Judith Anzures-Cabrera; Carmen Martin; Wendy Putnam; Laura Governale; Julie Olsson; Matthews
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A View on the Importance of “Multi-Attribute Method” for Measuring Purity of Biopharmaceuticals and Improving Overall Control Strategy
AAPS Journal, ISSN: 15507416
Richard S. Rogers; Michael Abernathy; Douglas D. Richardson; Jason C. Rouse; Justin B. Sperry; Patrick Swann; Jette Wypych; X. Christopher Yu; Li Zang; Rohini Deshpande
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A Multi-site In-depth Evaluation of the Quanterix Simoa from a User’s Perspective
AAPS Journal, ISSN: 15507416
Allison Given Chunyk; Alison Joyce; Saloumeh Kadkhodayan Fischer; Mark Dysinger; Alvydas Mikulskis; Andreas Jeromin; Rosemary Lawrence-Henderson; Baker; David Yeung
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Solubilization of a Poorly Soluble B-Raf (Rapidly Accelerated Fibrosarcoma) Inhibitor: From Theory to Application
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Linda Bao; Le An; Yingqing Ran
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Computational support of medicinal chemistry in industrial settings
Methods in Molecular Biology, ISSN: 10643745
Daniel F. Ortwine
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Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Kwong Wah Lai; F. Anthony Romero; Vickie Tsui; Beresini; Gladys De Leon Boenig; Sarah M. Bronner; Kevin Chen; Zhongguo Chen; Edna F. Choo; Terry Crawford; Patrick Cyr; Susan Kaufman; Yingjie Li; Jiangpeng Liao; Wenfeng Liu; Justin Ly; Jeremy Murray; Weichao Shen; John Wai; Fei Wang; Caicai Zhu; Xiaoyu Zhu; Steven Magnuson
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An impedance-based cell contraction assay using human primary smooth muscle cells and fibroblasts
Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719
Daniel D. Bravo; Tania Chernov-Rogan; Jun Chen; Jianyong Wang
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IgG Fc engineering to modulate antibody effector functions
Protein and Cell, ISSN: 16748018 1674800X
Xinhua Wang; Mary Mathieu; Randall J. Brezski
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Asthma Exacerbations and Triggers in Children in TENOR: Impact on Quality of Life
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
Bradley E. Chipps; Tmirah Haselkorn; Karin Rosén; David R. Mink; Benjamin L. Trzaskoma; Allan T. Luskin
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Supplementation of Nucleosides During Selection can Reduce Sequence Variant Levels in CHO Cells Using GS/MSX Selection System
Biotechnology Journal, ISSN: 18607314 18606768
Danming Tang; Cynthia Lam; Salina Louie; Kam Hon Hoi; David Shaw; Mandy Yim; Snedecor; Shahram Misaghi
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An Investigation of Oral Exposure Variability and Formulation Strategy: A Case Study of PI3Kδ Inhibitor and Physiologically Based Pharmacokinetic Modeling in Beagle Dogs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Po-Chang Chiang; Jodie Pang; Jia Liu; Laurent Salphati
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Mechanistic overview of immune checkpoints to support the rational design of their combinations in cancer immunotherapy
Annals of Oncology, ISSN: 15698041 09237534
Rotte; Jin Y. Jin; Vincent Lemaire
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Intracellular regulation of TNF activity in health and disease
Cytokine, ISSN: 10960023 10434666
Eugene Varfolomeev; Domagoj Vucic
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Immune Signaling in Carcinogenesis
Predictive Biomarkers in Oncology: Applications in Precision Medicine,
Mahesh Yadav; Marcin Kowanetz; Koeppen
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Predictive Biomarkers and Targeted Therapies in Immuno-oncology
Predictive Biomarkers in Oncology: Applications in Precision Medicine,
Koeppen; Mark L. McCleland; Marcin Kowanetz
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Inflammation and Hepatotoxicity
Comprehensive Toxicology, Third Edition: Volume 1-15,
James P. Luyendyk; Ganey; Aaron Fullerton; Robert Roth
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No evidence of disease activity (NEDA) analysis by epochs in patients with relapsing multiple sclerosis treated with ocrelizumab vs interferon beta-1a
Multiple Sclerosis Journal - Experimental, Translational and Clinical, ISSN: 20552173
Eva Havrdová; Douglas L. Arnold; Amit Bar-Or; Comi; Hartung; Ludwig Kappos; Lublin; Selmaj; Traboulsee; Belachew; Iain Bennett; Regine Buffels; Hideki Garren; Jian Han; Laura Julian; Julie Napieralski; Stephen L. Hauser; Giovannoni
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Understanding heterogeneity in the host response to Staphylococcus aureus infection for prognostic biomarker discovery
Critical Care, ISSN: 1466609X 13648535
Dinoso; Johnny Gutierrez; David F. Choy; Sarah K. Kummerfeld; Amos Baruch; Chambers; Carrie M. Rosenberger
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Cytokines: Role in Homeostasis and Disease States
Comprehensive Toxicology, Third Edition: Volume 1-15,
Prell; Jacqueline M. Tarrant
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Application of CRISPR for Pooled, Vector-based Functional Genomic Screening in Mammalian Cell Lines
Genome Editing and Engineering: From TALENs, ZFNs and CRISPRs to Molecular Surgery,
Trinna L. Cuellar; Marinella G. Callow; Ted Lau; Colin Watanabe; Russell Bainer; Michael Costa; Benjamin Haley
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No evidence of disease activity (NEDA) analysis by epochs in patients with relapsing multiple sclerosis treated with ocrelizumab vs interferon beta-1a
Multiple Sclerosis Journal - Experimental, Translational and Clinical,
Eva Havrdová; Douglas L. Arnold; Amit Bar-Or; Comi; Hartung; Ludwig Kappos; Lublin; Selmaj; Traboulsee; Belachew; Iain Bennett; Regine Buffels; Hideki Garren; Jian Han; Laura Julian; Julie Napieralski; Stephen L. Hauser; Giovannoni
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Sample Size, Power, and Data Simulation
Genetic Analysis of Complex Diseases: Third Edition,
Sarah A. Pendergrass; Marylyn Ritchie
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CXCR3/CXCL10 axis shapes tissue distribution of memory phenotype CD8+ T Cells in nonimmunized mice
Journal of Immunology, ISSN: 15506606 00221767
Cécile Alanio; Rosa Barreira da Silva; David Michonneau; Philippe Bousso; Molly A. Ingersoll; Matthew L. Albert
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Histology of geographic atrophy secondary to age-related macular degeneration a multilayer approach
Retina, ISSN: 15392864 0275004X
Miaoling Li; Carrie Huisingh; Jeffrey D. Messinger; Rosa Dolz-Marco; Daniela Ferrara; K. Bailey Freund; Christine A. Curcio
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Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Paola Di Lello; Richard Pastor; Jeremy Murray; Robert A. Blake; Frederick Cohen; Terry Crawford; Joy Drobnick; Jason H. Drummond; Kategaya; Tracy L. Kleinheinz; Till Maurer; Lionel Rouge; Xianrui Zhao; Ingrid E. Wertz; Chudi O. Ndubaku; Vickie Tsui
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A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Sarah M. Bronner; Jeremy Murray; F. Anthony Romero; Kwong Wah Lai; Vickie Tsui; Patrick Cyr; Beresini; Gladys De Leon Boenig; Zhongguo Chen; Edna F. Choo; Clark; Terry Crawford; Hariharan Jayaram; Susan Kaufman; Ruina Li; Yingjie Li; Jiangpeng Liao; Xiaorong Liang; Wenfeng Liu; Justin Ly; Jonathan M. Maher; John Wai; Fei Wang; Aijun Zheng; Xiaoyu Zhu; Steven Magnuson
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Tumour lymph vessels boost immunotherapy
Nature, ISSN: 14764687 00280836
Christine Moussion; Shannon J. Turley
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Structural and Functional Characterization of a Hole-Hole Homodimer Variant in a "knob-Into-Hole" Bispecific Antibody
Analytical Chemistry, ISSN: 15206882 00032700
Hui-Min Zhang; Charlene Li; Ming Lei; Victor Lundin; Ho Young Lee; Milady Ninonuevo; Kevin Lin; Guanghui Han; Wendy N. Sandoval; Dongsheng Lei; Gang Ren; Jennifer Zhang; Hongbin Liu
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Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Wei-Jen Chung; Anneleen Daemen; Jason H. Cheng; Jason E. Long; Jonathan Cooper; Bu-Er Wang; Christopher Tran; Mallika Singh; Florian Gnad; Zora Modrusan; Oded Foreman; Melissa Junttila; Anton Berns
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Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Stephen J. Gregson; Luke Masterson; Binqing Wei; Thomas H. Pillow; Spencer; Gyoung-Dong Kang; Shang-Fan Yu; Helga Raab; Jeffrey Lau; Guangmin Li; Gail L. Phillips; Janet Gunzner; Brian S. Safina; Rachana Ohri; Martine Darwish; Katherine R. Kozak; Josefa Dela Cruz Chuh; Andrew G. Polson; Flygare; Philip W. Howard
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TRP’ing up chronic kidney disease
Science, ISSN: 10959203 00368075
Jun-Jae Chung; Andrey S. Shaw
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mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance
Cell Stem Cell, ISSN: 18759777 19345909
Samantha Haller; Subir Kapuria; Rebeccah Riley; Monique N. O'Leary; Katherine H. Schreiber; Julie K. Andersen; Simon Melov; Jianwen Que; Thomas A. Rando; Jason Rock; Brian K. Kennedy; Joseph T. Rodgers; Heinrich Jasper
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T Lymphocytes Expressing AlphaE Beta7 Integrin in Ulcerative Colitis: Associations With Cellular Lineage and Phenotype
Journal of Crohn's and Colitis, ISSN: 18764479
Christopher A. Lamb; John A. Kirby; Mary E. Keir; John C. Mansfield
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Impact of Tocilizumab Monotherapy on Clinical and Patient-Reported Quality-of-Life Outcomes in Patients with Rheumatoid Arthritis
Rheumatology and Therapy, ISSN: 21986584 21986576
Leslie R. Harrold; Ani John; Reed; Tmirah Haselkorn; Chitra Karki; Youfu Li; Jennie Best; Steve Zlotnick; Joel M. Kremer; Jeffrey D. Greenberg
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Primary PFS and safety analyses of a randomized phase III study of carboplatin + paclitaxel +/− bevacizumab, with or without atezolizumab in 1L non-squamous metastatic nsclc (IMPOWER150)
Annals of Oncology, ISSN: 15698041 09237534
Martin Reck; Mark A. Socinski; Federico Cappuzzo; Orlandi; Stroyakovskii; Nogami; Rodriguez-Abreu; Moro-Sibilot; Thomas; Fabrice Barlesi; Finley; Kelsch; Lee; Coleman; Shen; Marcin Kowanetz; Ariel Lopez-Chavez; Alan Sandler; Jotte
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TGF-β signalling attenuates tumour response to PD-L1 checkpoint blockade by contributing to retention of T cells in the peritumoural stroma
Annals of Oncology, ISSN: 15698041 09237534
Sanjeev Mariathasan; Shannon J. Turley; Dorothee Nickles; Alessandra Castiglioni; Kobe Yuen; Wang; Edward E; Koeppen; Jillian L. Astarita; Rafael Cubas; Suchit Jhunjhunwala; Yagai Yang; Yasin Senbabaoglu; Michiel S Van Der Heijden; Yohann Loriot; Ira Mellman; Daniel S. Chen; Priti Hegde; Richard Bourgon; Thomas Powles
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Primary PFS and safety analyses of a randomized phase III study of carboplatin + paclitaxel +/− bevacizumab, with or without atezolizumab in 1L non-squamous metastatic nsclc (IMPOWER150)
Annals of Oncology, ISSN: 15698041 09237534
Martin Reck; Mark A. Socinski; Federico Cappuzzo; Orlandi; Stroyakovskii; Nogami; Rodriguez-Abreu; Moro-Sibilot; Thomas; Fabrice Barlesi; Finley; Kelsch; Lee; Coleman; Shen; Marcin Kowanetz; Ariel Lopez-Chavez; Alan Sandler; Jotte
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TGF-β signalling attenuates tumour response to PD-L1 checkpoint blockade by contributing to retention of T cells in the peritumoural stroma
Annals of Oncology, ISSN: 15698041 09237534
Sanjeev Mariathasan; Shannon J. Turley; Dorothee Nickles; Alessandra Castiglioni; Yuen; Wang; Edward E; Koeppen; Jillian L. Astarita; Rafael Cubas; Suchit Jhunjhunwala; Yang; Yasin Senbabaoglu; Michiel S Van Der Heijden; Yohann Loriot; Ira Mellman; Daniel S. Chen; Priti Hegde; Richard Bourgon; Thomas Powles
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Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model
npj Systems Biology and Applications, ISSN: 20567189
Kirouac; Gabriele Schaefer; Jocelyn Chan; Mark Merchant; Christine Orr; Shih-Min A. Huang; John Moffat; Lichuan Liu; Kapil Gadkar; Ramanujan
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Erratum to: Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model (npj Systems Biology and Applications, (2017), 3, 1, (14), 10.1038/s41540-017-0016-1)
npj Systems Biology and Applications, ISSN: 20567189
Kirouac; Gabriele Schaefer; Jocelyn Chan; Mark Merchant; Christine Orr; Shih-Min A. Huang; John Moffat; Lichuan Liu; Kapil Gadkar; Ramanujan
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Statistical characterization of therapeutic protein modifications
Scientific Reports, ISSN: 20452322
Tsung-Heng Tsai; Zhiqi Hao; Qiuting Hong; Benjamin Moore; Cinzia Stella; Jeffrey H. Zhang; Yan Chen; Michael Kim; Theo Koulis; Gregory Ryslik; Erik Verschueren; Fred Jacobson; William E. Haskins; Olga Vitek
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Atezolizumab in platinum-treated locally advanced or metastatic urothelial carcinoma: Post-progression outcomes from the phase II IMvigor210 study
Annals of Oncology, ISSN: 15698041 09237534
Andrea Necchi; Richard W. Joseph; Yohann Loriot; Jean Hoffman-Censits; Jose Luis Perez-Gracia; Petrylak; Christina L. Derleth; Darren Tayama; Qian Zhu; Beiying Ding; Constanze Kaiser; Jonathan E. Rosenberg
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Reversed-phase chromatography with large pore superficially porous particles for high throughput immunoglobulin G2 disulfide isoform separation
Journal of Chromatography A, ISSN: 18733778 00219673
Bingchuan Wei; Bing Zhang; Barry E. Boyes; Taylor Zhang
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2017 White Paper on recent issues in bioanalysis: A global perspective on immunogenicity guidelines & biomarker assay performance (Part 3-LBA: Immunogenicity, biomarkers and PK assays)
Bioanalysis, ISSN: 17576199 17576180
Shalini Gupta; Richards; Lakshmi Amaravadi; Steven Piccoli; Binodh DeSilva; Renuka Pillutla; Lauren Stevenson; Devangi Mehta; Montserrat Carrasco-Triguero; Robert J. Neely; Michael A. Partridge; Roland F Staack; Xuemei Zhao; Boris Gorovits; Gerry Kolaitis; Giane Sumner; Kay Stubenrauch; Zou; Shashi Amur; Chris Beaver; Isabella Berger; Flora Berisha; Herbert Birnboeck; Joe Bower; Seongeun Julia Cho; Isabelle Cludts; Cocea; Lorella Di Donato; Saloumeh Kadkhodayan Fischer; Stephanie Fraser; Fabio Garofolo; Sam Haidar; Jonathan Haulenbeek; Charles Hottenstein; Jenny Hu; Akiko Ishii-Watabe; Rafiqul Islam; Darshana Jani; John Kadavil; John Kamerud; Daniel Kramer; Pekka Kurki; Stephen MacMannis; Jim McNally; Ashley Mullan; Apollon Papadimitriou; Joao Pedras-Vasconcelos; Soma Ray; Afshin Safavi; Yoshiro Saito; Natasha Savoie; Marianne Scheel Fjording; Kara Scheibner; John Smeraglia; An Song; Bruce C. Stouffer; Nilufer Tampal; Barry Van Der Strate; Thorsten Verch; Jan Welink; Yuanxin Xu; Tong-Yuan Yang; Lilian Yengi; Jianing Zeng; Yan Zhang; Yanhua Zhang; Stephen Zoog
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A phase i dose-escalation study of the safety and pharmacokinetics of pictilisib in combination with erlotinib in patients with advanced solid tumors
Oncologist, ISSN: 1549490X 10837159
Stephen Leong; Rebecca A. Moss; Daniel W. Bowles; Joseph A. Ware; Jing Zhou; Jill M. Spoerke; Lackner; Geetha Shankar; Jennifer L. Schutzman; Ruud van der Noll; Emile E. Voest; Jan H. M. Schellens
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Found in translation: How preclinical research is guiding the clinical development of the BCL2-selective inhibitor venetoclax
Cancer Discovery, ISSN: 21598290 21598274
Joel D. Leverson; Deepak Sampath; Andrew J. Souers; Saul H. Rosenberg; Wayne J. Fairbrother; Amiot; Marina Konopleva; Anthony Letai
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Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity
Scientific Reports, ISSN: 20452322
Simon Hansen; Jakob C. Stüber; Patrick Ernst; Alexander Koch; Daniel Bojar; Alexander Batyuk; Pluckthun
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Tissue Localization of Glycosphingolipid Accumulation in a Gaucher Disease Mouse Brain by LC-ESI-MS/MS and High-Resolution MALDI Imaging Mass Spectrometry
SALAS Discovery, ISSN: 24725560 24725552
E. Ellen Jones; Wujuan Zhang; Xueheng Zhao; Cristine Quiason; Stephanie Dale; Sheerin Shahidi-Latham; Gregory A. Grabowski; Kenneth D.R. Setchell; Richard R. Drake; Ying Sun
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Identification of Small-Molecule Noncovalent Binders Utilizing SAMDI Technology
SALAS Discovery, ISSN: 24725560 24725552
Erica Vanderporten; Michael D. Scholle; John Sherrill; John C. Tran; Yichin Liu
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