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Publications

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DISPLAYING 4601 - 4650 OF 15805 RESULTS

Design, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugs
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Peter Dragovich; Broccatelli; Jinhua Chen; Peter W. Fan; Hoa Le; Mao; Thomas H. Pillow; Andrew G. Polson; John Wai; Zijin Xu; Hui Yao; Donglu Zhang
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Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Li Di; Christopher Breen; Rob Chambers; Sean T. Eckley; Robert Fricke; Avijit Ghosh; Paul Harradine; Kalvass; Stacy Ho; Caroline A. Lee; Punit H. Marathe; Everett J. Perkins; Mark Qian; Susanna Tse; Zhengyin Yan; Zamek-Gliszczynski
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Baseline asthma burden, comorbidities, and biomarkers in omalizumab-treated patients in PROSPERO
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
Bradley E. Chipps; Robert S. Zeiger; Allan T. Luskin; William W. Busse; Benjamin L. Trzaskoma; Evgeniya Antonova; Hooman Pazwash; Susan L. Limb; Paul G. Solari; Noelle M. Griffin; Thomas B. Casale
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Population pharmacokinetics of trastuzumab emtansine in previously treated patients with HER2-positive advanced gastric cancer (AGC)
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Shang-Chiung Chen; Kagedal; Yuying Gao; Wang; Marie-Laurence Harle-Yge; Sandhya Girish; Jin Y. Jin; Chunze Li
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Exposure–response analyses of trastuzumab emtansine in patients with HER2-positive advanced breast cancer previously treated with trastuzumab and a taxane
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Chunze Li; Wang; Shang-Chiung Chen; Russell D. Wada; Dan Lu; Xin Wang; Daniel Polhamus; Jonathan French; Shweta Vadhavkar; Alexander Strasak; Melanie Smitt; Amita Joshi; Meghna Samant; Angelica Quartino; Jin Y. Jin; Sandhya Girish
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Non-canonical reader modules of BAZ1A promote recovery from DNA damage
Nature Communications, ISSN: 20411723
Mariano Oppikofer; Meredith Sagolla; Benjamin Haley; Hui-Min Zhang; Sarah K. Kummerfeld; Jawahar Sudhamsu; E. Megan Flynn; Tianyi Bai; Jennifer Zhang; Claudio Ciferri; Andrea G Cochran
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Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP)
Scientific Reports, ISSN: 20452322
Travis W. Bainbridge; Diana Ronai Dunshee; Noelyn Kljavin; Nicholas J. Skelton; Junichiro Sonoda; James A. Ernst
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Serum periostin, IgE, and SE-IgE can be used as biomarkers to identify moderate to severe chronic rhinosinusitis with nasal polyps
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Karin Jonstam; Marit Westman; Gabriële Holtappels; Cécile T.J. Holweg; Claus Bachert
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Platform model describing pharmacokinetic properties of vc-MMAE antibody–drug conjugates
Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 15738744 1567567X
Kagedal; Leonid Gibiansky; Jian Xu; Xin Wang; Divya Samineni; Shang-Chiung Chen; Dan Lu; Priya Agarwal; Wang; Ola M. Saad; Neelima Koppada; Bernard M. Fine; Jin Y. Jin; Sandhya Girish; Chunze Li
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Photodegradation Pathways of Protein Disulfides: Human Growth Hormone
Pharmaceutical Research, ISSN: 1573904X 07248741
Daniel Steinmann; Olivier Mozziconacci; Rupesh Bommana; John F. Stobaugh; Y. John Wang; Christian Schöneich
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Anaphylaxis associated with omalizumab administration: Risk factors and patient characteristics
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Phillip Lieberman; Ilisten Jones; Richa Rajwanshi; Karin Rosén; Dale T. Umetsu
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Population pharmacokinetics and exposure–response of trastuzumab emtansine in advanced breast cancer previously treated with ≥2 HER2-targeted regimens
British Journal of Clinical Pharmacology, ISSN: 13652125 03065251
Shang-Chiung Chen; Angelica Quartino; Daniel Polhamus; Matthew Riggs; Jonathan French; Xin Wang; Shweta Vadhavkar; Melanie Smitt; Silke Hoersch; Alexander Strasak; Jin Y. Jin; Sandhya Girish; Chunze Li
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Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes
Nature Communications, ISSN: 20411723
Vagheesh M. Narasimhan; Raheleh Rahbari; Aylwyn Scally; Arthur Wuster; Dan Mason; Yali Xue; John Wright; Richard C. Trembath; Eamonn R Maher; David A. van Heel; Adam Auton; Matthew E. Hurles; Chris Tyler-Smith; Richard Durbin
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Real-world Direct Health Care Costs for Metastatic Colorectal Cancer Patients Treated With Cetuximab or Bevacizumab-containing Regimens in First-line or First-line Through Second-line Therapy
Clinical Colorectal Cancer, ISSN: 19380674 15330028
Stephen S. Johnston; Kathleen Wilson; Helen Varker; Elisabetta Malangone-Monaco; Paul Juneau; Ellen Riehle; Sacha Satram-Hoang; Nicolas Sommer; Sarika Ogale
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Discrepancies between patient-reported outcomes, and endoscopic and histological appearance in UC
Gut, ISSN: 14683288 00175749
Jean-Frédéric Colombel; Mary E. Keir; Alexis Scherl; Rui Zhao; Gert De Hertogh; William A. Faubion Jr.; Timothy T. Lu
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A Diagnostic Approach for Rodent Progressive Cardiomyopathy and Like Lesions in Toxicology Studies up to 28 Days in the Sprague Dawley Rat (Part 2 of 2)
Toxicologic Pathology, ISSN: 15331601 01926233
James R. Hailey; Beverly E. Maleeff; Heath C. Thomas; Gail Pearse; Jan C. Klapwijk; Patrizia G. Cristofori; Brian R. Berridge; Carie L. Kimbrough; George A. Parker; Daniel Morton; Susan A. Elmore; Jerry F. Hardisty; Noel Dybdal; David A. Rehagen; James D. Fikes; Martin Lamb; Kathleen Biddle; Bernard S. Buetow; Vinicius Carreira; Abraham Nyska; Niraj K. Tripathi; Heather C. Workman; Jean-Guy Bienvenu; Ingrid Brees; James R. Turk; Rick R. Adler
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A Diagnostic Approach for Rodent Progressive Cardiomyopathy and Like Lesions in Toxicology Studies up to 28 Days in the Sprague Dawley Rat (Part 1 of 2)
Toxicologic Pathology, ISSN: 15331601 01926233
James R. Hailey; Beverly E. Maleeff; Heath C. Thomas; Gail Pearse; Jan C. Klapwijk; Patrizia G. Cristofori; Brian R. Berridge; Carie L. Kimbrough; George A. Parker; Daniel Morton; Susan A. Elmore; Jerry F. Hardisty; Noel Dybdal; David A. Rehagen; James D. Fikes; Martin Lamb; Kathleen Biddle; Bernard S. Buetow; Vinicius Carreira; Abraham Nyska; Niraj K. Tripathi; Heather C. Workman; Jean-Guy Bienvenu; Ingrid Brees; James R. Turk; Rick R. Adler
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Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis: Experience from 92 Sites in an Open-Label US Expanded Access Program
Pulmonary Therapy, ISSN: 23641746 23641754
Lisa H Lancaster; Lake Morrison; Alexander Auais; Beiying Ding; Ahmar Iqbal; Boris Polman; Kevin R. Flaherty
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What evidence do we need for biomarker qualification?
Science Translational Medicine, ISSN: 19466242 19466234
Chris Leptak; Joseph P. Menetski; John A. Wagner; Jiri Aubrecht; Linda Brady; Martha Brumfield; William W. Chin; Steven Hoffmann; Gary J. Kelloff; Gabriela Lavezzari; Rajesh Ranganathan; John-Michael Sauer; Frank D. Sistare; Tanja S. Zabka; David Wholley
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GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
F. Anthony Romero; Jeremy Murray; Kwong Wah Lai; Vickie Tsui; Brian K Albrecht; Le An; Beresini; Gladys De Leon Boenig; Sarah M. Bronner; Emily Chan; Kevin Chen; Zhongguo Chen; Edna F. Choo; Kyle Clagg; Clark; Terry Crawford; Patrick Cyr; Denise De Almeida Nagata; Karen Gascoigne; Jane L. Grogan; Georgia Hatzivassiliou; Wei Huang; Thomas Hunsaker; Susan Kaufman; Stefan G. Koenig; Ruina Li; Yingjie Li; Xiaorong Liang; Jiangpeng Liao; Wenfeng Liu; Justin Ly; Jonathan M. Maher; Colin Masui; Mark Merchant; Yingqing Ran; Alexander M. Taylor; John Wai; Fei Wang; Xiaocang Wei; Dong Yu; Bing-Yan Zhu; Xiaoyu Zhu; Steven Magnuson
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Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach
Organic Letters, ISSN: 15237052 15237060
Ngiap-Kie Lim; Patrick Weiss; Beryl X. Li; Christina H. McCulley; Stephanie R. Hare; Bronwyn L. Bensema; Teresa A. Palazzo; Dean J. Tantillo; Haiming Zhang; Francis Gosselin
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Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye
mAbs, ISSN: 19420870 19420862
Devin B. Tesar; Jacob Luoma; Emily A. Wyatt; Catherine Shi; Whitney Shatz; Hass; Mary Mathieu; Li Yi; Jacob E. Corn; Katie F. Maass; Kathryn Wang; Michelle Z. Dion; Nisana Andersen; Kelly M. Loyet; Menno Van Lookeren Campagne; Karthikan Rajagopal; Leslie Dickmann; Justin M. Scheer; Robert F. Kelley
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Preclinical pharmacokinetic characterization of an adipose tissue-targeting monoclonal antibody in obese and non-obese animals
mAbs, ISSN: 19420870 19420862
Sharmila Rajan; Danielle Mandikian; Amos Baruch; Thomas R. Gelzleichter; Dale Stevens; Junichiro Sonoda; Kyra J. Cowan; C. Andrew Boswell; Stefanich
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Patients' priorities in selecting chronic lymphocytic leukemia treatments
Blood advances, ISSN: 24739537 24739529
Carol Mansfield; Anthony Masaquel; Jessie Sutphin; Elisa Weiss; Meghan Gutierrez; Jennifer Wilson; Marco Boeri; Jia Li; Carolina Reyes
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PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Thomas Januario; Ye; Russell Bainer; Bruno Alicke; Tunde Smith; Benjamin Haley; Zora Modrusan; Stephen Gould; Robert Yauch
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An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD
Blood, ISSN: 15280020 00064971
Jonathan C. Poe; Wei Jia; Hsuan Su; Sarah Anand; Jeremy J. Rose; Prasanthi V. Tata; Amy N. Suthers; Corbin D. Jones; Pei Fen Kuan; Benjamin G. Vincent; Jonathan S. Serody; Mitchell E. Horwitz; Vincent T. Ho; Steve Pavletic; Fran Hakim; Kouros Owzar; Dadong Zhang; Bruce R. Blazar; Christian W. Siebel; Nelson J. Chao; Ivan Maillard; Stefanie Sarantopoulos
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Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Yong Ma; Yue Fu; S. Cyrus Khojasteh; Deepak Dalvie; Donglu Zhang
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FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia
Cell Metabolism, ISSN: 19327420 15504131
Tian Lan; Donald A. Morgan; Kamal Rahmouni; Junichiro Sonoda; Xiaorong Fu; Shawn C. Burgess; William L. Holland; Steven A. Kliewer; David J. Mangelsdorf
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B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement
JCI insight, ISSN: 23793708
Alfred H.J. Kim; Jun-Jae Chung; Shreeram Akilesh; Ania Koziell; Sanjay Jain; Jeffrey B. Hodgin; Mark J. Miller; Thaddeus S. Stappenbeck; Jeffrey H. Miner; Andrey S. Shaw
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Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control
Cell, ISSN: 10974172 00928674
Richard G. Yau; Kerstin Doerner; Erick R. Castellanos; Diane L. Haakonsen; Achim Werner; Nan Wang; X. William Yang; Nadia Martinez-Martin; Marissa L. Matsumoto; Vishva M. Dixit; Michael Rape
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Concordance between plasma-based and tissue-based next-generation sequencing in LOTUS
The Lancet Oncology, ISSN: 14745488 14702045
Sung-Bae Kim; Rebecca Dent; Matthew Wongchenko; Stina M. Singel; Baselga
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Monitoring and Targeting Anti-VEGF Induced Hypoxia within the Viable Tumor by 19F–MRI and Multispectral Analysis
Neoplasia (United States), ISSN: 14765586 15228002
Yunzhou Shi; Jason Oeh; Anna Hitz; Maj Hedehus; Jeffrey Eastham-Anderson; Franklin V. Peale Jr.; Patricia Hamilton; Thomas O'Brien; Deepak Sampath; Richard A. D. Carano
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An exploratory, open-label, randomized, multicenter study to investigate the pharmacodynamics of a glycoengineered antibody (imgatuzumab) and cetuximab in patients with operable head and neck squamous cell carcinoma
Annals of Oncology, ISSN: 15698041 09237534
Stéphane Temam; Spicer; Farzaneh; Jean-Charles Soria; Oppenheim; McGurk; Antoine Hollebecque; Sarini; Hussain; Soehrman Brossard; Manenti; Stefan Evers; Paul Delmar; Di Scala; Christoph Mancao; Feuerhake; Luc Andries; Ott; Passioukov; Delord
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Effect of docetaxel duration on clinical outcomes: Exploratory analysis of CLEOPATRA, a phase III randomized controlled trial
Annals of Oncology, ISSN: 15698041 09237534
David W. Miles; Im; Fung; Bongin Yoo; Adam Knott; Sarah Heeson; Beattie; Sandra M. Swain
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Combining "bottom-up" and "top-down" approaches to assess the impact of food and gastric pH on pictilisib (GDC-0941) pharmacokinetics
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Tong Lu; Grazyna Fraczkiewicz; Laurent Salphati; Nageshwar Budha; Gena Dalziel; Gillian S. Smelick; Kari M. Morrissey; John Davis; Jin Y. Jin; Joseph A. Ware
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A new lead to NLRP3 inhibition
Journal of Experimental Medicine, ISSN: 15409538 00221007
Lamkanfi; Vishva M. Dixit
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Higher order structure of proteins in biopharmaceutical development
Pharmacopeial Forum, ISSN: 15421945 03634655
Yves Aubin; Michael D. Brenowitz; Edward Chess; Thomas M. Laue; Jasper C. Lin; Donald MacLean; John P. Marino; Linda O. Narhi; William Weiss; Qin Zou
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A blueprint to advance colorectal cancer immunotherapies
Cancer immunology research, ISSN: 23266074 23266066
Dung T. Le; Vanessa M. Hubbard-Lucey; Michael A. Morse; Christopher R. Heery; Andrea Dwyer; Thomas H. Marsilje; Arthur N. Brodsky; Emily Chan; Dustin A. Deming; Luis A. Diaz; Wolf H. Fridman; Richard M. Goldberg; Stanley R. Hamilton; Franck Housseau; Elizabeth M. Jaffee; S. Peter Kang; Smitha S. Krishnamurthi; Christopher H. Lieu; Wells A. Messersmith; Cynthia L. Sears; Neil H. Segal; Arvin Yang; Rebecca A. Moss; Edward Cha; Jill O'Donnell-Tormey; Roach; Anjelica Q. Davis; Keavy McAbee; Sharyn Worrall; Al B. Benson
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Silencing of retrotransposons by SET DB1 inhibits the interferon response in acute myeloid leukemia
Journal of Cell Biology, ISSN: 15408140 00219525
Trinna L. Cuellar; Anna-Maria Herzner; Xiaotian Zhang; Yogesh Goyal; Colin K. Watanabe; Brad A. Friedman; Vasantharajan Janakiraman; Durinck; Stinson; David Arnott; Tommy K. Cheung; Subhra Chaudhuri; Zora Modrusan; Jonas Martin Doerr; Marie Classon; Benjamin Haley
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Phase 2 randomized trial of the safety and efficacy of MHAA4549A, a broadly neutralizing monoclonal antibody, in a human influenza a virus challenge model
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Jacqueline McBride; Jeremy Lim; Tracy Burgess; Rong Deng; Michael A. Derby; Mauricio Maia; Priscilla Horn; Omer Siddiqui; Daniel Sheinson; Haiyin Chen-Harris; Elizabeth Newton; Dimitri Fillos; Denise Nazzal; Carrie M. Rosenberger; Maikke B. Ohlson; Rob Lambkin-Williams; Hosnieh Fathi; Harris; Jorge A. Tavela
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Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates
British Journal of Pharmacology, ISSN: 14765381 00071188
Daniela Bumbaca; Janice Maloney; Kristin R. Wildsmith; Reina N. Fuji; William J. Meilandt; Hilda Solanoy; Yanmei Lu; Kun Peng; Blair Wilson; Pamela Chan; Kapil Gadkar; Andrew Kosky; Marisa Goo; Daugherty; Jessica A. Couch; Thomas Keene; Karen Hayes; Lisa Jungbauer Nikolas; Deanna Lane; Robert Switzer; Eric L. Adams; Ryan J. Watts; Kimberly Scearce-Levie; Saileta Prabhu; Lisa Shafer; Deepak R Thakker; Keith Hildebrand; Jasvinder K. Atwal
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Obinutuzumab or rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in previously untreated diffuse large b-cell lymphoma
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Umberto Vitolo; Marek Trneny; David Belada; John M. Burke; Angelo Michele Carella; Neil Chua; Pau Abrisqueta; Judit Demeter; Ian Flinn; Xiaonan Hong; Won Seog Kim; Antonio Pinto; Yuan-Kai Shi; Yoichi Tatsumi; Mikkel Z. Oestergaard; Michael Wenger; Guenter Fingerle-Rowson; Olivier Catalani; Tina Nielsen; Maurizio Martelli; Laurie H. Sehn
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High-Throughput and Sensitive Quantification of Circulating Tumor DNA by Microfluidic-Based Multiplex PCR and Next-Generation Sequencing
Journal of Molecular Diagnostics, ISSN: 19437811 15251578
Yinghui Guan; Oleg Mayba; Thomas Sandmann; Shan Lu; Younjeong Choi; Darbonne; Vincent Leveque; Lisa Ryner; Eric W. Humke; Nga W.R. Tam; Sundari Sujathasarma; Anna Cheung; Richard Bourgon; Lackner; Wang
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Drug Target Interference in Immunogenicity Assays: Recommendations and Mitigation Strategies
AAPS Journal, ISSN: 15507416
Zhandong Don Zhong; Adrienne Clements-Egan; Boris Gorovits; Mauricio Maia; Giane Sumner; Valerie Theobald; Yuling Wu; Manoj Rajadhyaksha
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A phase IB dose-escalation study of the safety and pharmacokinetics of pictilisib in combination with either paclitaxel and carboplatin (with or without bevacizumab) or pemetrexed and cisplatin (with or without bevacizumab) in patients with advanced non–small cell lung cancer
European Journal of Cancer, ISSN: 18790852 09598049
Jean-Charles Soria; Alex Adjei; Rastilav Bahleda; Benjamin Besse; Charles Ferte; David Planchard; Jing Zhou; Joseph A. Ware; Kari M. Morrissey; Geetha Shankar; Wei Lin; Jennifer L. Schutzman; Grace Dy; Harry J.M. Groen
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FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes
Molecular Metabolism, ISSN: 22128778
Mark Chen; Joshua C. Chang; Jose Zavala-Solorio; Lance Kates; Minh Thai; Annie Ogasawara; Xiaobo Bai; Sean Flanagan; Victor Nunez; Khanhky Phamluong; James Ziai; Robert J. Newman; Søren Warming; Ganesh Kolumam; Junichiro Sonoda
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Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database
Toxicology and Applied Pharmacology, ISSN: 10960333 0041008X
Thomas M. Monticello; Thomas W. Jones; Donna M. Dambach; David M. Potter; Michael W. Bolt; Maggie Liu; Douglas A. Keller; Timothy K. Hart; Vivek J. Kadambi
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Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound
Pharmaceutical Research, ISSN: 1573904X 07248741
Jialin Mao; Peter W. Fan; Susan C. Wong; Jianshuang Wang; Moulay Hicham Alaoui Ismaili; Brian J. Dean; Cornelis E. Hop; Matthew Wright; Yuan Chen
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Approaches for Establishing Clinically Relevant Dissolution Specifications for Immediate Release Solid Oral Dosage Forms
AAPS Journal, ISSN: 15507416
Andre Hermans; Andreas M. Abend; Filippos Kesisoglou; Talia Flanagan; Michael J. Cohen; Dorys A. Diaz; Mao; Limin Zhang; Gregory K. Webster; Yiqing Lin; David Hahn; Carrie A. Coutant; Haiyan Grady
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Effect of Aggregation on the Hydrodynamic Properties of Bovine Serum Albumin
Pharmaceutical Research, ISSN: 1573904X 07248741
Mariya Pindrus; James L. Cole; Japneet Kaur; Steven J. Shire; Sandeep Yadav; Devendra S. Kalonia
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