Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4851 - 4900 OF 15805 RESULTS

Employment and absenteeism in working-age persons with multiple sclerosis
Journal of Medical Economics, ISSN: 1941837X 13696998
Amber Salter; Nina Parikh Thomas; Tuula Tyry; Cutter; Ruth Ann Marrie
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Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin
Structure, ISSN: 18784186 09692126
Justin T. Biel; Michael C. Thompson; Christian N. Cunningham; Jacob E. Corn; James S. Fraser
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αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis
Journal of Crohn's and Colitis, ISSN: 18764479
Christopher A. Lamb; John C Mansfield; Tew; Don L. Gibbons; Anna K. Long; Peter M. Irving; Laurie Diehl; Jeffrey Eastham-Anderson; Maria B. Price; Graeme O'Boyle; David E J Jones; Sharon O'Byrne; Adrian C. Hayday; Mary E. Keir; Jackson G. Egen; John A. Kirby
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Incidence, course, and management of toxicities associated with cobimetinib in combination with vemurafenib in the coBRIM study
Annals of Oncology, ISSN: 15698041
Brigitte Dréno; Antoni Ribas; James Larkin; Paolo A. Ascierto; Axel Hauschild; Luc Thomas; Jean-Jacques Grob; Daniel Koralek; Isabelle Rooney; Jessie Hsu; Edward McKenna; McArthur
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Vascular safety of ranibizumab in patients with diabetic macular edema: A pooled analysis of patient-level data from randomized clinical trials
JAMA Ophthalmology, ISSN: 21686165
Marco A. Zarbin; Cornelia Dunger-Baldauf; Zdenka Haskova; Prashil Koovejee; Marie-Catherine Mousseau; Philippe Margaron; Howard Snow; Paul E. Beaumont; Giovanni Staurenghi; Steve Francom
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Peptidoglycan association of murein lipoprotein is required for KpsD-dependent group 2 capsular polysaccharide expression and serum resistance in a uropathogenic escherichia coli isolate
mBio, ISSN: 21507511 21612129
Jingyu Diao; Catrien Bouwman; Donghong Yan; Jing Kang; Anand K. Katakam; Peter S. Liu; Homer Pantua; Abbas Alexander; Nicholas N. Nickerson; Cary D. Austin; Mike Reichelt; Wendy N. Sandoval; Min Xu; Chris Whitfield; Sharookh B. Kapadia
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Modulating therapeutic activity and toxicity of pyrrolobenzodiazepine antibody-drug conjugates with self-immolative disulfide linkers
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Thomas H. Pillow; Melissa Schutten; Shang-Fan Yu; Rachana Ohri; Jack D. Sadowsky; Kirsten Achilles Poon; Willy A. Solis; Fiona Zhong; Geoffrey Del Rosario; MaryAnn Go; Jeffrey Lau; Sharon Fong Yee; Jintang He; Luna Liu; Carl Ng; Keyang Xu; Douglas Leipold; Amrita Kamath; Donglu Zhang; Luke Masterson; Stephen J. Gregson; Philip W. Howard; Fan Fang; Jinhua Chen; Janet Gunzner; Katherine R. Kozak; Spencer; Paul G. Polakis; Andrew G. Polson; Flygare; Jagath R. Junutula
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Effect of fluorouracil, leucovorin, and oxaliplatin with or without onartuzumab in HER2-negative, MET-positive gastroesophageal adenocarcinoma: The METGastric randomized clinical trial
JAMA Oncology, ISSN: 23742445 23742437
Manish A. Shah; Bang; Florian Lordick; Maria Alsina; Meng Chen; Stephen P. Hack; Jean-Marie Bruey; Dustin Smith; Ian McCaffery; David S. Shames; See Phan; David Cunningham
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Processing impact on monoclonal antibody drug products: Protein subvisible particulate formation induced by grinding stress
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Benson Gikanga; Devon Roshan Eisner; Robert Ovadia; Eric S. Day; Oliver B. Stauch; Maa
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Next-Generation Sequencing Reveals Novel Mutations in X-linked Intellectual Disability
OMICS A Journal of Integrative Biology, ISSN: 15578100 15362310
Babylakshmi Muthusamy; Lakshmi Dhevi N. Selvan; Thong T Nguyen; Jesna Manoj; Eric Stawiski; Bijay S. Jaiswal; Weiru Wang; Remya Raja; Vedam Laxmi Ramprasad; Ravi Gupta; Sakthivel Murugan; Jayarama S. Kadandale; Keshava Prasad; Kavita Reddy; Andrew S. Peterson; Akhilesh Pandey; Somasekar Seshagiri; Satish Chandra Girimaji; Harsha Gowda
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The future of asthma research and development: A roadmap from the European Asthma Research and Innovation Partnership (EARIP)
European Respiratory Journal, ISSN: 13993003 09031936
Sarah Masefield; Jessica Edwards; Kjeld Hansen; Dominique Hamerlijnck; Karin Lisspers; Marc Van Der Schee; Liliana Silva; Matthews; Mina Gaga; Ian Adcock; Stephen Holgate; Samantha Walker; Pippa Powell
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Cost and health care utilization in patients with asthma and high oral corticosteroid use
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
Michael S. Broder; Karina Raimundo; Ka Ming Ngai; Eunice Chang; Noelle M. Griffin; Liam G. Heaney
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Omalizumab in children with uncontrolled allergic asthma: Review of clinical trial and real-world experience
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Bradley E. Chipps; Bob Lanier; Henry Milgrom; Antoine Deschildre; Gunilla Hedlin; Stanley J. Szefler; Meyer Kattan; Farid Kianifard; Benjamin Ortiz; Tmirah Haselkorn; Ahmar Iqbal; Karin Rosén; Benjamin L. Trzaskoma; William W. Busse
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Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions
Molecular Pharmaceutics, ISSN: 15438392 15438384
Justin Ly; Kirsten Messick; Ann R. Qin; Ryan Takahashi; Edna F. Choo
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Routine Assessment of Patient Index Data 3 and the American College of Rheumatology/European League Against Rheumatism Provisional Remission Definitions as Predictors of Radiographic Outcome in a Rheumatoid Arthritis Clinical Trial With Tocilizumab
Arthritis Care and Research, ISSN: 21514658 2151464X
Muznay N. Khawaja; Martin J. Bergman; Jeffrey Yourish; Jinglan Pei; William Reiss; Edward Keystone
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Mapping the Binding Interface of VEGF and a Monoclonal Antibody Fab-1 Fragment with Fast Photochemical Oxidation of Proteins (FPOP) and Mass Spectrometry
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
Ying Zhang; Aaron T. Wecksler; Patricia Molina; Galahad Deperalta; Michael L. Gross
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Erlotinib and bevacizumab in patients with advanced non-small-cell lung cancer and activating EGFR mutations (BELIEF): an international, multicentre, single-arm, phase 2 trial
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Rafael Rosell; Urania Dafni; Enriqueta Felip; Alessandra Curioni-Fontecedro; Oliver Gautschi; Solange Peters; Bartomeu Massutí; Ramon Palmero; Santiago Ponce Aix; Enric Carcereny; Martin Früh; Miklos Pless; Sanjay Popat; Athanasios Kotsakis; Sinead Cuffe; Paolo Bidoli; Adolfo Favaretto; Patrizia Froesch; Noemí Reguart; Javier Puente; Linda Coate; Fabrice Barlesi; Daniel Rauch; Michael Thomas; Carlos Camps; Jose Gómez-Codina; Margarita Majem; Rut Porta; Riyaz Shah; Emer Hanrahan; Roswitha Kammler; Barbara Ruepp; Manuela Rabaglio; Marie Kassapian; Niki Karachaliou; Rachel Tam; David S. Shames; Molina; Rolf A Stahel
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Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GATSBY): an international randomised, open-label, adaptive, phase 2/3 study
The Lancet Oncology, ISSN: 14745488 14702045
Peter C Thuss-Patience; Manish A. Shah; Atsushi Ohtsu; Eric Van Cutsem; Jaffer A. Ajani; Hugo Castro; Wasat Mansoor; Hyun Cheol Chung; Gyorgy Bodoky; Kohei Shitara; Gail L. Phillips; Tina van der Horst; Marie-Laurence Harle-Yge; Betsy Althaus; Yoon-Koo Kang
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Novel mechanism of decyanation of GDC-0425 by cytochrome P450
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Jason S Halladay; Michael Siu; Yuan Chen; Cornelis E. Hop; S. Cyrus Khojasteh; Shuguang Ma
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Evaluation of heavy chain C-terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells
Biotechnology Progress, ISSN: 15206033 87567938
Zhilan Hu; Danming Tang; Shahram Misaghi; Guoying Jiang; X. Christopher Yu; Mandy Yim; David Shaw; Snedecor; Mike Laird; Amy Shen
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The Clinical Importance of Changes in Diabetic Retinopathy Severity Score
Ophthalmology, ISSN: 15494713 01616420
Michael S. Ip; Jiameng Zhang; Jason S. Ehrlich
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Seasonal variability of severe asthma exacerbations and clinical benefit from lebrikizumab
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Tracy Staton; Joseph R. Arron; Julie Olsson; Cécile T.J. Holweg; Matthews; David F. Choy
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Impact of physiologically based pharmacokinetic models on regulatory reviews and product labels: Frequent utilization in the field of oncology
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Yoshida; Nageshwar Budha; Jin Y. Jin
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Activity-based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights
FEBS Journal, ISSN: 17424658 1742464X
David S. Hewings; Flygare; Matthew Bogyo; Ingrid E. Wertz
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Melt extrusion vs. spray drying: The effect of processing methods on crystalline content of naproxen-povidone formulations
European Journal of Pharmaceutical Sciences, ISSN: 18790720 09280987
Abbe Haser; Tu Cao; Joseph W. Lubach; Tony Listro; Larry Acquarulo; Feng Zhang
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Reply
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Phillip Lieberman; Dale T. Umetsu; Gillis Carrigan; Abdelkader Rahmaoui
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Assessment of Correlation Between Early and Late Efficacy Endpoints to Identify Potential Surrogacy Relationships in Non-Hodgkin Lymphoma: a Literature-Based Meta-analysis of 108 Phase II and Phase III Studies
AAPS Journal, ISSN: 15507416
Rui Zhu; Dan Lu; Yu-Waye Chu; Akiko Chai; Michelle Green; Nancy Zhang; Jin Y. Jin
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Activity-based probes for the multicatalytic proteasome
FEBS Journal, ISSN: 17424658 1742464X
David S. Hewings; Flygare; Ingrid E. Wertz; Matthew Bogyo
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Longitudinal variation of serum periostin levels in adults with stable asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Ruth Semprini; Caswell-Smith; James Fingleton; Cécile T.J. Holweg; Matthews; Mark Weatherall; Beasley; Irene Braithwaite
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Cardiovascular and cerebrovascular events among patients receiving omalizumab: Pooled analysis of patient-level data from 25 randomized, double-blind, placebo-controlled clinical trials
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Carlos Iribarren; Kenneth J. Rothman; Mary S. Bradley; Gillis Carrigan; Mark D. Eisner; Hubert Chen
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Cardiovascular and cerebrovascular events among patients receiving omalizumab: Results from EXCELS, a prospective cohort study in moderate to severe asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Carlos Iribarren; Abdelkader Rahmaoui; Aidan Long; Stanley J. Szefler; Mary S. Bradley; Gillis Carrigan; Mark D. Eisner; Hubert Chen; Theodore A. Omachi; Michael E. Farkouh; Kenneth J. Rothman
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Patient and physician preferences for anticancer drugs for the treatment of metastatic colorectal cancer: A discrete-choice experiment
Cancer Management and Research, ISSN: 11791322
Juan Marcos González; Sarika Ogale; Rob Morlock; Joshua Posner; A. Brett Hauber; Nicolas Sommer; Grothey
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NPTX2 and cognitive dysfunction in Alzheimer’s Disease
eLife, ISSN: 2050084X
Mei-Fang Xiao; Desheng Xu; Michael T Craig; Kenneth A Pelkey; Chun-Che Chien; Yang Shi; Juhong Zhang; Susan Resnick; Olga Pletnikova; David Salmon; James Brewer; Steven Edland; Jerzy Wegiel; Benjamin Tycko; Alena Savonenko; Roger H. Reeves; Juan C. Troncoso; Chris J. McBain; Douglas Galasko; Paul F Wegiel
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Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult
eLife, ISSN: 2050084X
Martin Larhammar; Sarah Huntwork-Rodriguez; Zhiyu Jiang; Hilda Solanoy; Arundhati Sengupta Ghosh; Bei Wang; Joshua S. Kaminker; Kevin Huang; Jeffrey Eastham-Anderson; Michael Siu; Zora Modrusan; Madeline M. Farley; Marc Tessier-Lavigne; Joe Lewcock; Trent A. Watkins
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Highly Regioselective and Practical Synthesis of 5-Bromo-4-chloro-3-nitro-7-azaindole
Organic Process Research and Development, ISSN: 1520586X 10836160
Chong Han; Keena L. Green; Eugen Pfeifer; Francis Gosselin
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Highly Regioselective and Practical Synthesis of 5-Bromo-4-chloro-3-nitro-7-azaindole
Organic Process Research and Development, ISSN: 10836160
Chong Han; Keena L. Green; Eugen Pfeifer; Francis Gosselin
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A Novel Cascade Benzyne Nucleophilic Addition/Fries Rearrangement for Entry into 2,3-Disubstituted Phenols
Synlett, ISSN: 14372096 09365214
Sarah M. Bronner; Daniel Lee; Vlad Bacauanu; Patrick Cyr
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The Janus Kinase (JAK) FERM and SH2 domains: Bringing specificity to JAK-receptor interactions
Frontiers in Endocrinology, ISSN: 16642392
Ryan Ferrao; Patrick J. Lupardus
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The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation
Science Signaling, ISSN: 19379145 19450877
Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason A. Hackney; Cesar A. Corzo; Jenna L. Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzhadeh; Patrick Caplazi; Ivan Peng; A F. Setiadi; Ross Francis; Andres Paler Martinez; Youngsu C. Kwon; Vladimir Ramirez-Carrozzi; Yonglian Sun; Patricia W. Grigg; Merone Roose-Girma; Surinc Er Jeet; Kai H. Barck; Anna Pham; Naruhisa Ota; Connie Ha; Stinson; Joseph Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent Mckenzie; Michael J. Townsend; Richard A. D. Carano; Søren Warming; Domagoj Vucic; Jason De Voss; Wyne P. Lee; Jennie R. Lill; Ali A. Zarrin
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The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation
Science Signaling, ISSN: 19450877
Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason A. Hackney; Cesar A. Corzo; Jenna L. Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzhadeh; Patrick Caplazi; Ivan Peng; A F. Setiadi; Ross Francis; Andres Paler Martinez; Youngsu C. Kwon; Vladimir Ramirez-Carrozzi; Yonglian Sun; Patricia W. Grigg; Merone Roose-Girma; Surinc Er Jeet; Kai H. Barck; Anna Pham; Ota; Connie Ha; Stinson; Joseph Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent S. McKenzie; Michael J. Townsend; Richard A. D. Carano; Søren Warming; Domagoj Vucic; Jason De Voss; Wyne P. Lee; Jennie R. Lill; Ali A. Zarrin
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Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Aaron H Nile; Susmith Mukund; Karen Stanger; Weiru Wang; Rami N. Hannoush
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The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation
Science Signaling, ISSN: 19379145 19450877
Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason A. Hackney; Cesar A. Corzo; Jenna L. Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzadeh; Patrick Caplazi; Ivan Peng; A F. Setiadi; Ross Francis; Andres Paler Martinez; Youngsu C. Kwon; Vladimir Ramirez-Carrozzi; Yonglian Sun; Patricia W. Grigg; Merone Roose-Girma; Surinc Er Jeet; Kai H. Barck; Anna Pham; Naruhisa Ota; Connie Ha; Stinson; Joseph Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent Mckenzie; Michael J. Townsend; Richard A. D. Carano; Søren Warming; Domagoj Vucic; Jason De Voss; Wyne P. Lee; Jennie R. Lill; Ali A. Zarrin
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A CEACAM6-high airway neutrophil phenotype and CEACAM6-high epithelial cells are features of severe asthma
Journal of Immunology, ISSN: 15506606 00221767
Aarti Shikotra; David F. Choy; Salman Siddiqui; Greer Arthur; Deepti R. Nagarkar; Guiquan Jia; Adam K. A. Wright; Chandra M. Ohri; Emma Doran; Claire A. Butler; Beverley Hargadon; Abbas Alexander; Janet Jackman; Lawren C. Wu; Liam G. Heaney; Joseph R. Arron; Peter Bradding
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Compatibility study of a parenteral microdose polyethylene glycol formulation in medical devices and identification of degradation impurity by 2D-LC/MS
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Lulu Dai; Geoffrey K. Yeh; Yingqing Ran; Peter M. Yehl; Kelly Zhang
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Transcription factor Etv5 is essential for the maintenance of alveolar type II cells
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Zhen Zhang; Kim Newton; Sarah K. Kummerfeld; Webster; Donald S. Kirkpatrick; Lilian Phu; Jeffrey Eastham-Anderson; Jinfeng Liu; Wyne P. Lee; Jiansheng Wu; Hong Li; Melissa Junttila; Vishva M. Dixit
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Genomics and evolution of protein phosphatases
Science Signaling, ISSN: 19379145 19450877
Mark J. Chen; Jack E. Dixon; Gerard Manning
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Validation of a two-dimensional liquid chromatography method for quality control testing of pharmaceutical materials
Journal of Chromatography A, ISSN: 18733778 00219673
Samuel H. Yang; Jennifer Wang; Kelly Zhang
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Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell–associated damage in IFNα-driven lupus nephritis
JCI insight, ISSN: 23793708
Arna Katewa; Yugang Wang; Jason A. Hackney; Tao Huang; Eric Suto; Nandhini Ramamoorthi; Cary D. Austin; Meire C. Bremer; Jacob Z. Chen; James J. Crawford; Kevin S. Currie; Peter Blomgren; Jason Devoss; Julie Dipaolo; Jonathan Hau; Adam R. Johnson; Justin Lesch; Laura DeForge; Zhonghua Lin; Marya Liimatta; Joseph W. Lubach; Sami McVay; Zora Modrusan; Allen Nguyen; Chungkee Poon; Jianyong Wang; Lichuan Liu; Wyne P. Lee; Harvey Wong; Wendy B. Young; Michael J. Townsend; Karin Reif
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Computationally Discovered Potentiating Role of Glycans on NMDA Receptors
Scientific Reports, ISSN: 20452322
Anton V. Sinitskiy; Nathaniel H. Stanley; David Hackos; Jesse E. Hanson; Benjamin D. Sellers; Vijay S. Pande
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Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands
Journal of Clinical Investigation, ISSN: 15588238 00219738
Jooho Chung; Christen Ebens; Eric Perkey; Vedran Radojcic; Ute Koch; Leonardo Scarpellino; Alexander Tong; Frederick Allen; Sherri Wood; Jiane Feng; Ann Friedman; David Granadier; Ivy T. Tran; Qian Chai; Lucas Onder; Minhong Yan; Pavan Reddy; Bruce R. Blazar; Alex Y. Huang; Todd V. Brennan; D. Keith Bishop; Burkhard Ludewig; Christian W. Siebel; Freddy Radtke; Sanjiv A. Luther; Ivan Maillard
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