Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4901 - 4950 OF 16681 RESULTS

Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development
Clinical and Translational Science, ISSN: 17528062 17528054
Meric A. Ovacik; Kedan Lin
View on Scopus
Crystal anisotropy explains structure-mechanics impact on tableting performance of flufenamic acid polymorphs
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Abhay Jain; Harsh S. Shah; Paul R. Johnson; Ajit S. Narang; Ken R. Morris; Rahul V. Haware
View on Scopus
NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis
Nature Immunology, ISSN: 15292916 15292908
Zuliang Jie; Jin-Young Yang; Meidi Gu; Hui Wang; Xiaoping Xie; Yanchuan Li; Ting Liu; Lele Zhu; Jianhong Shi; Lingyun Zhang; Xiaofei Zhou; Donghyun Joo; Hans D. Brightbill; Yingzi Cong; Daniel Lin; Xuhong Cheng; Shao-Cong Sun
View on Scopus
Lymphocytes are a major source of circulating soluble dipeptidyl peptidase 4
Clinical and Experimental Immunology, ISSN: 13652249 00099104
Armanda Casrouge; Sauer; Barreira da Silva; Tejera-Alhambra; Sánchez-Ramón; Cancrini; Molly A. Ingersoll; Aiuti; Matthew L. Albert
View on Scopus
Mitigation of Oxidation in Therapeutic Antibody Formulations: a Biochemical Efficacy and Safety Evaluation of N-Acetyl-Tryptophan and L-Methionine
Pharmaceutical Research, ISSN: 1573904X 07248741
Michelle Z. Dion; Danielle L. Leiske; Vikas K. Sharma; Christina L. Zuch de Zafra; Cleo M. Salisbury
View on Scopus
Achieving greater efficiency and higher confidence in single-cell cloning by combining cell printing and plate imaging technologies
Biotechnology Progress, ISSN: 15206033 87567938
Mandy Yim; David Shaw
View on Scopus
Development and clinical validation of the Genedrive point-of-care test for qualitative detection of hepatitis C virus
Gut, ISSN: 14683288 00175749
Alba Llibre; Yusuke Shimakawa; Estelle Mottez; Shaun Ainsworth; Tan-Phuc Buivan; Rick Firth; Elliott Harrison; Arielle R Rosenberg; Jean-François Meritet; Arnaud Fontanet; Pablo Castan; Antonio Madejón; Mark Laverick; Allison Glass; Raquel Viana; Stanislas Pol; C Patrick McClure; William Lucien Irving; Gino Miele; Matthew L. Albert; Darragh Duffy
View on Scopus
Tissue Physiology of Cynomolgus Monkeys: Cross-Species Comparison and Implications for Translational Pharmacology
AAPS Journal, ISSN: 15507416
Danielle Mandikian; Isabel Figueroa; Amy Oldendorp; Hanine Rafidi; Sheila Ulufatu; Michelle G. Schweiger; Jessica A. Couch; Noel Dybdal; Sean B. Joseph; Saileta Prabhu; Gregory Z. Ferl; C. Andrew Boswell
View on Scopus
Bleeding events and safety outcomes in persons with haemophilia A with inhibitors: A prospective, multi-centre, non-interventional study
Haemophilia, ISSN: 13652516 13518216
Johnny N. Mahlangu; Johannes Oldenburg; Michael U. Callaghan; Midori Shima; Elena Santagostino; Maggie Moore; Michael Recht; Claudia Garcia; Renchi Yang; Michaela Lehle; Harrison Macharia; Elina Asikanius; Gallia Levy; Kruse-Jarres
View on Scopus
FIR: Efficacy, Safety, and Biomarker Analysis of a Phase II Open-Label Study of Atezolizumab in PD-L1–Selected Patients With NSCLC
Journal of Thoracic Oncology, ISSN: 15561380 15560864
David Spigel; Jamie E. Chaft; Scott Gettinger; Bo H. Chao; Luc Dirix; Schmid; Laura Q.M. Chow; Rodney Hicks; Larry Leon; Jill Fredrickson; Marcin Kowanetz; Alan Sandler; Roel Funke; Naiyer A. Rizvi
View on Scopus
Disrupting Gram-negative bacterial outer membrane biosynthesis through inhibition of the lipopolysaccharide transporter MsbA
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Mary Kate Alexander; Anh Miu; Angela Oh; Mike Reichelt; Hoangdung Ho; Cecile Chalouni; Sharada Labadie; Lan Wang; Jun Liang; Nicholas N. Nickerson; Huiyong Hu; Lan Yu; Miaofen Du; Donghong Yan; Summer Park; Janice Kim; Min Xu; Benjamin D. Sellers; Hans E. Purkey; Nicholas J. Skelton; Michael F. T. Koehler; Jian Payandeh; Vishal A. Verma; Yiming Xu; Christopher M. Koth; Mireille Nishiyama
View on Scopus
Resolution of unexpected pregnancy-related findings in a rat embryofetal development and toxicokinetic study of monoclonal antibodies specific for hCMV
Birth Defects Research, ISSN: 24721727
Paula Katavolos; Prell; Doris Zane; Rong Deng; Wendy Halpern
View on Scopus
Draft genome sequence of an erwinia tracheiphila isolate from an infected muskmelon (Cucumis melo)
Microbiology Resource Announcements, ISSN: 2576098X
Lori R. Shapiro; Andres Andrade; Erin D. Scully; Jorge Rocha; Joseph N. Paulson; Roberto Kolter
View on Scopus
A20-binding inhibitor of NF-κB (ABIN) 2 negatively regulates allergic airway inflammation
Journal of Experimental Medicine, ISSN: 15409538 00221007
Sonia Ventura; Florencia Cano; Yashaswini Kannan; Felix Breyer; Michael J. Pattison; Mark S. Wilson; Steven C. Ley
View on Scopus
Targeting the MAPK Pathway in RAS Mutant Cancers
Cold Spring Harbor Perspectives in Medicine, ISSN: 21571422
Sarah G. Hymowitz; Shiva Malek
View on Scopus
Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease
PLoS Genetics, ISSN: 15537404 15537390
Nisha Rathore; Sree R. Ramani; Homer Pantua; Jian Payandeh; Tushar Bhangale; Arthur Wuster; Manav Kapoor; Yonglian Sun; Sharookh B. Kapadia; Lino C. Gonzalez Jr.; Ali A. Zarrin; Alison M. Goate; David V. Hansen; Timothy W. Behrens; Robert R. Graham
View on Scopus
Assessment of OATP transporter-mediated drug–drug interaction using physiologically-based pharmacokinetic (PBPK) modeling – a case example
Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782
Yuan Chen; Rui Zhu; Fang Ma; Jialin Mao; Eugene C. Chen; Edna F. Choo; Srikumar Sahasranaman; Lichuan Liu
View on Scopus
A method for manual and automated multiplex RNAscope in situ hybridization and immunocytochemistry on cytospin samples
PLoS ONE, ISSN: 19326203
Sara Chan; Audrey Filézac de L’Etang; Linda Rangell; Patrick Caplazi; John Lowe; Valentina Romeo
View on Scopus
Multiproduct resin reuse for clinical and commercial manufacturing - Methodology and acceptance criteria
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Rizwan Sharnez; Steve Doares; Shane Manning; Krunal Mehta; Ekta Mahajan; Angela To; William Daniels; Judy Glynn; Sagar Dhamane; Xiaona Wen; Yunjuan Wang; Pankaj Gour; Constanze Guenther; Derek Foley; Ronan Hayes; Adam Mott; Sunil Prabhu; Dawn Tavalsky; Michael Hendershot; David Haas; Ashley Hesslein; Norbert Schuelke; Hendri Tjandra
View on Scopus
Safety and clinical activity of atezolizumab in head and neck cancer: Results from a phase I trial
Annals of Oncology, ISSN: 15698041 09237534
A. Dimitrios Colevas; Rastilav Bahleda; Fadi S. Braiteh; Ani Balmanoukian; Brana; Chau; Indrani Sarkar; Luciana L. Molinero; William Grossman; Fairooz F. Kabbinavar; Marcella Fassò; Carol O’Hear; John D. Powderly
View on Scopus
Systemic Safety in Ranibizumab-Treated Patients with Neovascular Age-Related Macular Degeneration: A Patient-Level Pooled Analysis
Kidney International Reports, ISSN: 24686530
Marco A. Zarbin; Steve Francom; Susanna M. Grzeschik; Lisa Tuomi; Zdenka Haskova; Wayne Macfadden; Philippe Margaron; Howard Snow; Alan Cruess; Giovanni Staurenghi; Cornelia Dunger-Baldauf
View on Scopus
IMpower133: Primary efficacy and safety + CNS-related adverse events in a phase I/III study of first-line (1L) atezolizumab + carboplatin + etoposide in extensive-stage SCLC (ES-SCLC)
Annals of Oncology, ISSN: 15698041
Tony SK Mok; Martin Reck; Leora Horn; Lam; David S. Shames; Liu; Fairooz F. Kabbinavar; Lin; Alan Sandler; Stephen V. Liu
View on Scopus
CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts
Alzheimer's and Dementia, ISSN: 15525279 15525260
Oskar Hansson; John P. Seibyl; Erik Stomrud; Henrik Zetterberg; John Q. Trojanowski; Tobias Bittner; Valeria Lifke; Veronika Corradini; Udo Eichenlaub; Richard Batrla; Katharina Buck; Katharina Zink; Christina Rabe; Kaj Blennow; Leslie Shaw
View on Scopus
Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Kim Newton; Dugger; Arundhati Sengupta Ghosh; Ron Ferrando; Felix Chu; Janet Tao; Wendy Lam; Susan Haller; Sara M. Chan; Susan Sa; Debra Dunlap; Jeffrey Eastham-Anderson; Hai Ngu; Jeffrey Hung; French; Webster; Brad Bolon; Jinfeng Liu; Rohit Reja; Sarah K. Kummerfeld; Ying-Jiun Chen; Zora Modrusan; Joe Lewcock; Vishva M. Dixit
View on Scopus
GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Shumei Wang; Vickie Tsui; Terry Crawford; James E. Audia; Burdick; Beresini; Alexandre Côté; Richard T Cummings; Martin Duplessis; E. Megan Flynn; Michael C. Hewitt; Hon-Ren Huang; Hariharan Jayaram; Ying Jiang; Shivangi Joshi; Jeremy Murray; Christopher G. Nasveschuk; Eneida Pardo; Florence Poy; F. Anthony Romero; Yong Tang; Alexander M. Taylor; Jian Wang; Zhaowu Xu; Laura E. Zawadzke; Xiaoyu Zhu; Brian K Albrecht; Steven Magnuson; Steve Bellon; Andrea G Cochran
View on Scopus
Kinase Inhibitors for the Treatment of Immunological Disorders: Recent Advances
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Marian C. Bryan; Naomi S. Rajapaksa
View on Scopus
Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1)
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Marcin Kowanetz; Wei Zou; Scott Gettinger; Koeppen; Mark Kockx; Schmid; Edward E. Kadel III; Ignacio I. Wistuba; Jamie E. Chaft; Naiyer A. Rizvi; David Spigel; Alexander Spira; Fred R. Hirsch; Victor Cohen; Dustin Smith; Zachary Boyd; Natasha Miley; Susan Flynn; Vincent Leveque; David S. Shames; Ballinger; Mocci; Geetha Shankar; Roel Funke; Garret M. Hampton; Alan Sandler; Lukas Amler; Ira Mellman; Daniel S. Chen; Priti Hegde
View on Scopus
Evaluating the Impact of a Decade of Funding from the Green Chemistry Institute Pharmaceutical Roundtable
Organic Process Research and Development, ISSN: 1520586X 10836160
Stefan G. Koenig; David Leahy; Andrew S. Wells
View on Scopus
A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition
Nature, ISSN: 14764687 00280836
Brian Biehs; Gerrit J. P. Dijkgraaf; Robert Piskol; Bruno Alicke; Soufiane Boumahdi; Franklin V. Peale Jr.; Stephen Gould; Frederic J. De Sauvage
View on Scopus
Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3
Science Translational Medicine, ISSN: 19466242 19466234
Dionysos S. Slaga; Diego Ellerman; T. Noelle Lombana; Rajesh Vij; Ji Li; Maria Hristopoulos; Robyn Clark; Jennifer A. Johnston; Amy Shelton; Elaine Mai; Kapil Gadkar; Amy Lo; James T. Koerber; Klara Totpal; Prell; Genee Y. Lee; Christoph Spiess; Teemu T. Junttila
View on Scopus
Targeted LC-MS/MS Proteomics-Based Strategy to Characterize in Vitro Models Used in Drug Metabolism and Transport Studies
Analytical Chemistry, ISSN: 15206882 00032700
Meijuan Juang Xu; Neha Saxena; Marc Vrana; Haeyoung Zhang; Vineet Kumar; Sarah Faye Billington; Cyrus Khojasteh; Scott A. Heyward; Jashvant D. Unadkat; Bhagwat Prasad
View on Scopus
Conventional wastewater treatment and reuse site practices modify bacterial community structure but do not eliminate some opportunistic pathogens in reclaimed water
Science of the Total Environment, ISSN: 18791026 00489697
Prachi Kulkarni; Nathan D. Olson; Joseph N. Paulson; Mihai Pop; Cynthia Maddox; Emma Claye; Rachel E. Rosenberg Goldstein; Manan Sharma; Shawn G. Gibbs; Emmanuel F. Mongodin; Amy R. Sapkota
View on Scopus
Chemotherapy combines effectively with Anti-PD-L1 treatment and can augment antitumor responses
Journal of Immunology, ISSN: 15506606 00221767
Rafael Cubas; Marina Moskalenko; Jeanne Cheung; Michelle Yang; Erin McNamara; Huizhong Xiong; Sabine Hoves; Carola H. Ries; Kim; Stephen Gould
View on Scopus
Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
Cancer Cell, ISSN: 18783686 15356108
Ivana Yen; Frances Shanahan; Mark Merchant; Christine Orr; Thomas Hunsaker; Matthew Durk; Hank La; Xiaolin Zhang; Scott E. Martin; Eva Lin; John Chan; Yihong Yu; Dhara Amin; Richard M. Neve; Amy Gustafson; Avinashnarayan Venkatanarayan; Scott A. Foster; Joachim Rudolph; Christiaan N. Klijn; Shiva Malek
View on Scopus
Quality assessment and interference detection in targeted mass spectrometry data using machine learning 03 Chemical Sciences 0301 Analytical Chemistry
Clinical Proteomics, ISSN: 15590275 15426416
Shadi Toghi Eshghi; Paul Auger; W Rodney Mathews
View on Scopus
Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin
Journal of Organic Chemistry, ISSN: 15206904 00223263
Scott Savage; Andrew McClory; Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Colin Masui; Sarah J. Robinson; Chong Han; Christoph Ochs; Pankaj D. Rege; Francis Gosselin
View on Scopus
Characterization of in vivo biotransformations for trastuzumab emtansine by high-resolution accurate-mass mass spectrometry
mAbs, ISSN: 19420870 19420862
Jintang He; Shang-Fan Yu; Sharon Fong Yee; Surinder Kaur; Keyang Xu
View on Scopus
Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model
mAbs, ISSN: 19420870 19420862
Shun xin Wang-Lin; Chenguang Zhou; Amrita Kamath; Kyu Hong; Neelima Koppada; Ola M. Saad; Montserrat Carrasco-Triguero; S. Cyrus Khojasteh; Rong Deng
View on Scopus
Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid
mAbs, ISSN: 19420870 19420862
Rina Fong; Kimberly K. Kajihara; Matthew Chen; Isidro Hötzel; Sanjeev Mariathasan; Wouter L. W. Hazenbos; Patrick J. Lupardus
View on Scopus
High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants
mAbs, ISSN: 19420870 19420862
Danielle DiCara; Nisana Andersen; Ruby Chan; James A. Ernst; Gai Ayalon; Greg A. Lazar; Nick Agard; Amy Hilderbrand; Isidro Hötzel
View on Scopus
Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole
Xenobiotica, ISSN: 13665928 00498254
Molly Lin; Justin Ly; Ryan Takahashi; John Chen; Alan Deese; Sarah J. Robinson; Aleksandr Kolesnikov; Susan C. Wong; Xiaojing Wang; Jae H. Chang
View on Scopus
Cost-effectiveness of obinutuzumab plus bendamustine followed by obinutuzumab monotherapy for the treatment of follicular lymphoma patients who relapse after or are refractory to a rituximab-containing regimen in the US
Journal of Medical Economics, ISSN: 1941837X 13696998
Gregory F. Guzauskas; Anthony Masaquel; Carolina Reyes; Coen A. Bernaards; Tania Krivasi; David L. Veenstra
View on Scopus
The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function
Cell Reports, ISSN: 22111247
Sairy Hernandez; Jing Qing; Rebecca Hong Thibodeau; Xiangnan Du; Summer Park; Hyang-Mi Lee; Min Xu; Soyoung Oh; Armando Navarro; Merone Roose-Girma; Robert J. Newman; Søren Warming; Michelle Nannini; Deepak Sampath; Kim; Jane L. Grogan; Ira Mellman
View on Scopus
Buffer exchange path influences the stability and viscosity upon storage of a high concentration protein
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Mary E. Krause; Ajit S. Narang; Gregory Barker; Sibylle Herzer; Smeet Deshmukh; Wenkui Lan; Daniel Fichana; John M. Wasylyk; Bahar Demirdirek; Limin Zhang; John Fiske; Matthew McGann; Monica L. Adams; Rajesh B. Gandhi
View on Scopus
Development and validation of a novel semi-homogenous clinical assay for quantitation of Ranibizumab in human serum
Journal of Immunological Methods, ISSN: 18727905 00221759
John Lowe; Eric Wakshull; Theresa Shek; Anan Chuntharapai; Rebecca Elliott; Jeriza Rusit; Mauricio Maia
View on Scopus
Investigation of Metal-Catalyzed Antibody Carbonylation With an Improved Protein Carbonylation Assay
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Yi Yang; Anna Mah; Inn H. Yuk; Parbir Grewal; Abigail F.J. Pynn; Will Cole; Di Gao; Fan Zhang; Jia Chen; Lynn Gennaro; Christian Schöneich
View on Scopus
An automated mapping method for Nissl-stained mouse brain histologic sections
Journal of Neuroscience Methods, ISSN: 1872678X 01650270
Smadar Shiffman; Sayantani Basak; Cleopatra Kozlowski; Reina N. Fuji
View on Scopus
Modeled Prognostic Subgroups for Survival and Treatment Outcomes in BRAF V600-Mutated Metastatic Melanoma: Pooled Analysis of 4 Randomized Clinical Trials
JAMA Oncology, ISSN: 23742445 23742437
Axel Hauschild; James Larkin; Antoni Ribas; Brigitte Dréno; Keith Flaherty; Paolo A. Ascierto; Karl Lewis; Edward McKenna; Qian Zhu; Yong Mun; McArthur
View on Scopus
Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process
Molecular Pharmaceutics, ISSN: 15438392 15438384
Ankai Xu; Hok Seon Kim; Samarkand Estee; Sharon Viajar; William J. Galush; Avinash Gill; Isidro Hötzel; Greg A. Lazar; Paul McDonald; Nisana Andersen; Christoph Spiess
View on Scopus
Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer
Nature Cell Biology, ISSN: 14764679 14657392
Kristiaan J. Lenos; Daniël M. Miedema; Sophie C. Lodestijn; Lisanne E. Nijman; Tom van den Bosch; Xavier Romero Ros; Filipe C. Lourenço; Maria C. Lecca; Maartje van der Heijden; Sanne M. van Neerven; Anita van Oort; Nicolas Leveille; Ronja S. Adam; Felipe de Sousa e Melo; Joy Otten; Patrick Veerman; Guillaume Hypolite; Lianne Koens; Scott K. Lyons; Stassi; Douglas J. Winton; Jan Paul Medema; Edward Morrissey; Maarten F. Bijlsma; Louis Vermeulen
View on Scopus
© 2026 Genentech, Inc. All rights reserved. This site is intended for US residents only.