Alexis Rohou - Senior Principal Scientist - Technology, Structural Biology, drug discovery

Alexis Rohou

Senior Principal Scientist - Technology, Structural Biology, drug discovery

Years at Genentech
Publications at Genentech

I joined Genentech in late 2016, as the company was setting up its new cryogenic electron microscopy (cryoEM) facility to support drug discovery and basic research. As a postdoc, I had worked for many years on algorithm and methods development for cryoEM image analysis, so I had a pretty narrow, but very deep, specialization and I was excited to see how my skills could be put to use in the service of drug discovery, which I knew almost nothing about.

I had (and still have!) a lot to learn, and that has been my favorite thing about working at Genentech. The experience of learning has been intense, multi-dimensional, and seemingly never ending. The scale and depth of collaboration that occurs every day within Research is staggering, and the experience of working on projects that are much, much larger than anything I could have achieved in a regular academic lab is truly addictive. As a result of this amazing culture of collaboration, I have become familiar with several areas of human disease and biology and got a chance to contribute to several projects by solving structures of protein targets bound by small and large molecules. It has been thrilling to help these projects progress, in some cases successfully nominating molecules into clinic trials.

Featured Publication

Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab

Science, ISSN: 00368075

Lionel Rouge; Nancy Chiang; Micah Steffek; Christine Kugel; Tristan I. Croll; Christine Tam; Alberto Estevez; Chris Arthur; Chris Koth; Claudio Ciferri; Edward Kraft; Jian Payandeh; Gerry Nakamura; JT Koerber; Alexis Rohou