Avi Ashkenazi
Distinguished Fellow, Cancer Immunology
Postdoc Mentor
Fellow
"I believe that the most important purpose of science is to advance knowledge toward practical applications that can transform human life."
34
Years at Genentech
181
Publications at Genentech
2
Awards & Honors
I came to Genentech to pursue postdoctoral training because I valued the company’s scientific excellence and its foundational philosophy of integrating basic research and medical translation. My postdoc studies on neurotransmitter receptors led to papers in Science, Nature and Cell, and earned the 1988 Boeringer Ingelheim Award. I joined the department of Molecular Biology as Scientist in 1989, and my lab helped establish a technology to fuse biologically important proteins to antibody molecules. This approach is now widely implemented in biological research and biotech drugs.
In the 1990’s, the Human Genome Project inspired my team to discover several novel members of the TNF cytokine superfamily, most notably, Apo2L/TRAIL and its "death" and "decoy" receptors. This led us to investigate a cell-suicide process called Apoptosis—which has important roles in normal physiology as well as in disease. Our contributions to elucidating the mechanisms of apoptosis led to clinical investigation of a novel class of molecules called Pro-Apoptotic Receptor Agonists, and aided in the advancement of apoptosis-promoting cancer medicines such as venclexta. In separate work, my team identified a set of secreted proteins overexpressed in the tumor microenvironment, and developed antibodies to block their cognate receptors for therapeutic gain.
More recently, we’ve turned our attention to an intracellular signaling network dubbed the unfolded protein response (UPR). The UPR normally helps secretory cells to resolve issues with 3D shaping of newly synthesized proteins. UPR dysregulation can promote diseases such as cancer, autoimmunity and neurodegeneration. We have discovered that the key UPR enzyme IRE1 is hijacked by certain cancer cells to avert apoptosis and resist proteotoxic stress. Our research further revealed that inhibiting IRE1 activity in cancer-surveilling dendritic cells augments anti-tumor immunity. These studies identify IRE1 as a potential therapeutic target for cancer.
Postdoctoral Mentor
To date I have mentored over 30 postdoctoral fellows, who made many key contributions to our lab’s success. Most have gone on to obtain competitive scientific positions in industry or academia. Our postdocs enjoy significant autonomy: They learn how to (1) identify, define and address key biological questions with scientific rigor and elegance; (2) unite intellectual independence with collaborative teamwork; and (3) integrate basic and translational science to discover and develop transformative new medicines.
Featured Publication
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.
Nat Commun 12, 7310 (2021).
Le Thomas, A., et al.
My Focus
We are currently developing strategies that aim to kill cancer cells by directly disrupting their inherent stress-adaptation mechanisms or by augmenting the anti-tumor immune response.
Genentech Publications
Nature Communications, ISSN: 20411723
Fátima Cairrão; Cristiana C. Santos; Adrien Le Thomas; Scot A. Marsters; Avi Ashkenazi; Pedro M. Domingos
Cell Metabolism, ISSN: 19327420 15504131
Ying Xi; Ryan LaCanna; Hsiao-Yen Ma; Elsa N. N'Diaye; Sarah Gierke; Patrick Caplazi; Meredith Sagolla; Zhiyu Huang; Laura Lucio; Alexander Arlantico; Surinc Er Jeet; Hans D. Brightbill; Claire Emson; Aaron Wong; Katrina B. Morshead; Daryle J. DePianto; Merone Roose-Girma; Charles Yu; Lucinda Tam; Guiquan Jia; Thirumalai R. Ramalingam; Scot A. Marsters; Avi Ashkenazi; Si Hyun Kim; Ryan Kelly; Shuang Wu; Paul J. Wolters; Ariel E. Feldstein; Jason A. Vander Heiden; Ning Ding
Cell Metabolism,
Ying Xi; Ryan LaCanna; Hsiao-Yen Ma; Elsa N. N'Diaye; Sarah Gierke; Patrick Caplazi; Meredith Sagolla; Zhiyu Huang; Laura Lucio; Alexander Arlantico; Surinc Er Jeet; Hans D. Brightbill; Claire Emson; Aaron Wong; Katrina B. Morshead; Daryle J. DePianto; Merone Roose-Girma; Charles Yu; Lucinda Tam; Guiquan Jia; Thirumalai R. Ramalingam; Scot A. Marsters; Avi Ashkenazi; Si Hyun Kim; Ryan Kelly; Shuang Wu; Paul J. Wolters; Ariel E. Feldstein; Jason A. Vander Heiden; Ning Ding
eLife, ISSN: 2050084X
Vladislav Belyy; Iratxe Zuazo-Gaztelu; Andrew Alamban; Avi Ashkenazi; Peter Walter
eLife,
Vladislav Belyy; Iratxe Zuazo-Gaztelu; Andrew Alamban; Avi Ashkenazi; Peter Walter
Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Journal of Cell Biology, ISSN: 15408140 00219525
Ofer Guttman; Adrien Le Thomas; Scot A. Marsters; David Lawrence; Lauren Gutgesell; Iratxe Zuazo-Gaztelu; Jonathan M. Harnoss; Simone M. Haag; Aditya Murthy; Geraldine Strasser; Zora Modrusan; Thomas D Wu; Ira Mellman; Avi Ashkenazi
Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Journal of Cell Biology,
Ofer Guttman; Adrien Le Thomas; Scot A. Marsters; David Lawrence; Lauren Gutgesell; Iratxe Zuazo-Gaztelu; Jonathan M. Harnoss; Simone M. Haag; Aditya Murthy; Geraldine Strasser; Zora Modrusan; Thomas Wu; Ira Mellman; Avi Ashkenazi
Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Journal of Cell Biology, ISSN: 15408140
Ofer Guttman; Adrien Le Thomas; Scot A. Marsters; David Lawrence; Lauren Gutgesell; Iratxe Zuazo-Gaztelu; Jonathan M. Harnoss; Simone M. Haag; Aditya Murthy; Geraldine Strasser; Zora Modrusan; Thomas D Wu; Ira Mellman; Avi Ashkenazi
Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Journal of Cell Biology, ISSN: 15408140
Ofer Guttman; Adrien Le Thomas; Scot A. Marsters; David Lawrence; Lauren Gutgesell; Iratxe Zuazo-Gaztelu; Jonathan M. Harnoss; Simone M. Haag; Aditya Murthy; Geraldine Strasser; Zora Modrusan; Thomas Wu; Ira Mellman; Avi Ashkenazi
eLife, ISSN: 2050084X
Vladislav Belyy; Iratxe Zuazo-Gaztelu; Andrew Alamban; Avi Ashkenazi; Peter Walter
Science Translational Medicine, ISSN: 19466242 19466234
Riccardo Guidi; Daqi Xu; David F. Choy; Thirumalai R. Ramalingam; Wyne P. Lee; Zora Modrusan; Yuxin Liang; Scot A. Marsters; Avi Ashkenazi; Alison Huynh; Jessica Mills; Sean Flanagan; Shannon Hambro; Victor Nunez; Laurie Leong; Ashley Cook; Tiffany Hao Tran; Cary D. Austin; Yi Cao; Christine Clarke; Reynold A. Panettieri; Cynthia Koziol-White; William F. Jester; Fen Wang; Mark S. Wilson
Science Translational Medicine,
Riccardo Guidi; Daqi Xu; David F. Choy; Thirumalai R. Ramalingam; Wyne P. Lee; Zora Modrusan; Yuxin Liang; Scot A. Marsters; Avi Ashkenazi; Alison Huynh; Jessica Mills; Sean Flanagan; Shannon Hambro; Victor Nunez; Laurie Leong; Ashley Cook; Tiffany Hao Tran; Cary D. Austin; Yi Cao; Christine Clarke; Reynold A. Panettieri; Cynthia Koziol-White; William F. Jester; Fen Wang; Mark S. Wilson
Nature Communications, ISSN: 20411723
Adrien Le Thomas; Elena Ferri; Scot A. Marsters; Jonathan M. Harnoss; David Lawrence; Iratxe Zuazo-Gaztelu; Zora Modrusan; Sara M. Chan; Margaret Solon; Cecile Chalouni; Weihan Li; Koeppen; Joachim Rudolph; Weiru Wang; Thomas D Wu; Peter Walter; Avi Ashkenazi
Nature Communications, ISSN: 20411723
Adrien Le Thomas; Elena Ferri; Scot A. Marsters; Jonathan M. Harnoss; David Lawrence; Iratxe Zuazo-Gaztelu; Zora Modrusan; Sara Chan; Margaret Solon; Cecile Chalouni; Weihan Li; Koeppen; Joachim Rudolph; Weiru Wang; Thomas D Wu; Peter Walter; Avi Ashkenazi
Science, ISSN: 10959203 00368075
Ngoc-Han Tran; Stephen D. Carter; Ann De Mazière; Avi Ashkenazi; Judith Klumperman; Peter Walter; Grant J. Jensen
ACS Medicinal Chemistry Letters, ISSN: 19485875
Ramsay E. Beveridge; Heidi J. A. Wallweber; Avi Ashkenazi; Beresini; Clark; Paul Gibbons; Elise Ghiro; Susan Kaufman; Alexandre Larivée; Melissa Leblanc; Jean-Philippe Leclerc; Alexandre Lemire; Cuong Ly; Joachim Rudolph; Jacob B. Schwarz; Sanjay Srivastava; Weiru Wang; Liang Zhao; Marie-Gabrielle Braun
ACS Medicinal Chemistry Letters, ISSN: 19485875
Ramsay E. Beveridge; Heidi J. A. Wallweber; Avi Ashkenazi; Beresini; Clark; Paul Gibbons; Elise Ghiro; Susan Kaufman; Alexandre Larivée; Melissa Leblanc; Jean-Philippe Leclerc; Alexandre Lemire; Cuong Ly; Joachim Rudolph; Jacob B. Schwarz; Sanjay Srivastava; Weiru Wang; Zhao; Marie-Gabrielle Braun
Nature Communications, ISSN: 20411723
Elena Ferri; Adrien Le Thomas; Heidi J. A. Wallweber; Eric S. Day; Benjamin T. Walters; Susan Kaufman; Marie-Gabrielle Braun; Clark; Beresini; Kyle Mortara; Yung-Chia Ariel Chen; Breanna Canter; Wilson Phung; Peter S. Liu; Alfred Lammens; Avi Ashkenazi; Joachim Rudolph; Weiru Wang
Cancer Research, ISSN: 15387445 00085472
Jonathan M. Harnoss; Adrien Le Thomas; Mike Reichelt; Ofer Guttman; Thomas D Wu; Scot A. Marsters; Anna Shemorry; David Lawrence; David Kan; Ehud Segal; Mark Merchant; Klara Totpal; Lisa Crocker; Kathryn Mesh; Monika Dohse; Margaret Solon; Zora Modrusan; Joachim Rudolph; Koeppen; Peter Walter; Avi Ashkenazi
eLife, ISSN: 2050084X
Mable Lam; Scot A. Marsters; Avi Ashkenazi; Peter Walter
mAbs, ISSN: 19420870 19420862
Yanli Yang; Sherry Yeh; Shravan Madireddi; Wadim L. Matochko; Chen Gu; Patricia Pacheco-Sanchez; Ultsch; Gladys De Leon Boenig; Seth F. Harris; Brandon Leonard; Suzie J. Scales; Jing W. Zhu; Erin Christensen; Julie Qi Hang; Randall J. Brezski; Scot A. Marsters; Avi Ashkenazi; Siddharth Sukumaran; Chiu; Rafael Cubas; Kim; Greg A. Lazar
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Jonathan M. Harnoss; Adrien Le Thomas; Anna Shemorry; Scot A. Marsters; David Lawrence; Min Lu; Yung-Chia Ariel Chen; Jing Qing; Klara Totpal; David Kan; Ehud Segal; Mark Merchant; Mike Reichelt; Heidi J. A. Wallweber; Weiru Wang; Clark; Susan Kaufman; Beresini; Steven T. Laing; Wendy N. Sandoval; Maria N. Lorenzo; Jiansheng Wu; Justin Ly; Tom De Bruyn; Amy Heidersbach; Benjamin Haley; Alvin Gogineni; Robby M. Weimer; Dong Lee; Marie-Gabrielle Braun; Joachim Rudolph; Michael J. VanWyngarden; Daniel W. Sherbenou; Patricia Gomez-Bougie; Amiot; Diego Acosta-Alvear; Peter Walter; Avi Ashkenazi
eLife, ISSN: 2050084X
Anna Shemorry; Jonathan M. Harnoss; Ofer Guttman; Scot A. Marsters; László Kömüves; David Lawrence; Avi Ashkenazi
Molecular Cell, ISSN: 10974164 10972765
Tsun-Kai Chang; David Lawrence; Min Lu; Jenille Tan; Jonathan M. Harnoss; Scot A. Marsters; Peter S. Liu; Wendy N. Sandoval; Scott E. Martin; Avi Ashkenazi
Cell Death and Differentiation, ISSN: 14765403 13509047
Mable Lam; David Lawrence; Avi Ashkenazi; Peter Walter
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Avi Ashkenazi; Wayne J. Fairbrother; Joel D. Leverson; Andrew J. Souers
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Veronica G. Anania; Kebing Yu; Florian Gnad; Rebecca R. Pferdehirt; Han Li; Taylur P. Ma; Diana Jeon; Nikolaus Fortelny; William F. Forrest; Avi Ashkenazi; Christopher Overall; Jennie R. Lill
Cell Death and Disease, ISSN: 20414889
Christina de Zafra; Avi Ashkenazi; Darbonne; Melissa Cheu; Klara Totpal; Shirley Ortega; Heather Flores; Mark D. Walker; Bruce Kabakoff; Bert L. Lum; Barbara J. Mounho-Zamora; Scot A. Marsters; Noel Dybdal
Cell Death and Differentiation, ISSN: 14765403 13509047
Sean Petersen; Tom T. Chen; David Lawrence; Scot A. Marsters; François Gonzalvez; Avi Ashkenazi
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Yiyuan Yin; Stevan N. Djakovic; Scot A. Marsters; Janet Y. Tien; Jing Peng; Jarrod Tremayne; Genee Y. Lee; Richard M. Neve; Yan Wu; Mark Merchant; Avi Ashkenazi; Paul J. Carter
BioTechniques, ISSN: 19409818 07366205
Pradeep Nair; Hai Ngu; Eric Torres; Scot A. Marsters; David Lawrence; Jean-Philippe Stephan; László Kömüves; Avi Ashkenazi
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Pradeep Nair; Heather Flores; Alvin Gogineni; Scot A. Marsters; David Lawrence; Robert F. Kelley; Hai Ngu; Meredith Sagolla; László Kömüves; Richard Bourgon; Jeffrey Settleman; Avi Ashkenazi
EBioMedicine, ISSN: 23523964
Tom T. Chen; Ellen H. Filvaroff; Jing Peng; Scot A. Marsters; Adrian M. Jubb; Koeppen; Mark Merchant; Avi Ashkenazi
The Lancet Haematology, ISSN: 23523026
Chan Yoon Cheah; David Belada; Michelle A. Fanale; Andrea Janikova; Myron S. Czucman; Ian Flinn; Amy V. Kapp; Avi Ashkenazi; Kelley; Gordon L. Bray; Scott N. Holden; John F. Seymour
Journal of Clinical Investigation, ISSN: 15588238 00219738
Avi Ashkenazi
Clinical Cancer Research, ISSN: 15573265 10780432
Xiangnan Du; Benjamin C. Lin; Qian-Rena Wang; Hao Li; Ellen Ingalla; Janet Y. Tien; Isabelle Rooney; Avi Ashkenazi; Elicia M. Penuel; Jing Qing
Cancer Research, ISSN: 15387445 00085472
Catherine Wilson; Ye; Thinh Q. Pham; Eva Lin; Sara M. Chan; Eric Cheng; Richard M. Neve; Lisa D. Belmont; Koeppen; Robert Yauch; Avi Ashkenazi; Jeffrey Settleman
Molecular Cell, ISSN: 10974164 10972765
Min Lu; Scot A. Marsters; Ye; Luis; Lino C. Gonzalez Jr.; Avi Ashkenazi
Cell, ISSN: 10974172 00928674
Wayne J. Fairbrother; Avi Ashkenazi
Journal of Immunology, ISSN: 15506606 00221767
Nicholas S. Wilson; Peter Duewell; Becky Yang; Yun Li; Scot A. Marsters; Sandra Koernig; Eicke Latz; Eugene Maraskovsky; Adriana Baz Morelli; Max Schnurr; Avi Ashkenazi
Nature, ISSN: 00280836 14764687
Kim Newton; Joanne M. Hildebrand; Zhirong Shen; Diego Rodriguez; Silvia Alvarez-Diaz; Sean Petersen; Saumil Shah; Dugger; Chunzi Huang; Johan Auwerx; Vandenabeele; Douglas R. Green; Avi Ashkenazi; Vishva M. Dixit; William J. Kaiser; Andreas Strasser; Alexei Degterev; John Silke
Methods in Enzymology, ISSN: 15577988 00766879
Pradeep Nair; Min Lu; Sean Petersen; Avi Ashkenazi
Science, ISSN: 10959203 00368075
Min Lu; David Lawrence; Scot A. Marsters; Diego Acosta-Alvear; Philipp Kimmig; Aaron S. Mendez; Adrienne W. Paton; James C. Paton; Peter Walter; Avi Ashkenazi
Annual review of cell and developmental biology, ISSN: 15308995
Avi Ashkenazi; Guy S. Salvesen
Clinical Colorectal Cancer, ISSN: 15330028 19380674
Zev A. Wainberg; Wells A. Messersmith; Parvin F. Peddi; Amy V. Kapp; Avi Ashkenazi; Stephanie Royer-Joo; Chia C. Portera; Kozloff
Journal of Experimental Medicine, ISSN: 00221007 15409538
Kim; Avi Ashkenazi
Cancer Biology and Therapy, ISSN: 15384047 15558576
Bora Lim; Angelique Scicchitano; Cheryl Beachler; Niraj Gusani; Nabeel Sarwani; Zhaohai Yang; Kevin Staveley-O'Carroll; Avi Ashkenazi; Chia C. Portera; Wafik S. El-Deiry
Immunology and Cell Biology, ISSN: 08189641 14401711
Amitabha Chaudhuri; Nicholas S. Wilson; Becky Yang; Andres Paler Martinez; Jinfeng Liu; Catherine Zhu; Nicole Bricker; Suzana Couto; Zora Modrusan; French; James Cupp; Avi Ashkenazi
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Kilian M. Gust; David J. McConkey; Shannon Awrey; Paul K. Hegarty; Jing Qing; Jolanta Bondaruk; Avi Ashkenazi; Bogdan Czerniak; Colin P. Dinney; Peter C. Black
eLife, ISSN: 2050084X
Carmela Sidrauski; Diego Acosta-Alvear; Arkady Khoutorsky; Punitha Vedantham; Brian R. Hearn; Han Li; Karine Gamache; Ciara M. Gallagher; Kenny K.-H. Ang; Chris Wilson; Voytek Okreglak; Avi Ashkenazi; Byron Hann; Karim Nader; Michelle R. Arkin; Adam R. Renslo; Nahum Sonenberg; Peter Walter
Nuclear Medicine and Biology, ISSN: 09698051 18729614
Annie Ogasawara; Jeff N. Tinianow; Alexander N. Vanderbilt; Herman S. Gill; Sharon Fong Yee; Judith E. Flores; Simon P. Williams; Avi Ashkenazi; Jan Marik
Molecular Cell, ISSN: 10972765 10974164
François Gonzalvez; David Lawrence; Becky Yang; Sharon Fong Yee; Pitti; Scot A. Marsters; Victoria Pham; Jean-Philippe Stephan; Jennie R. Lill; Avi Ashkenazi
Cancer Research, ISSN: 00085472 15387445
Xiangnan Du; Qian-Rena Wang; Emily Chan; Mark Merchant; Jinfeng Liu; French; Avi Ashkenazi; Jing Qing
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Vivek Subbiah; Robert E. Brown; Jamie Buryanek; Jonathan Trent; Avi Ashkenazi; Roy S. Herbst; Razelle Kurzrock
Cancer Cell, ISSN: 18783686 15356108
Nicholas S. Wilson; Annie Yang; Becky Yang; Suzana Couto; Howard M. Stern; Alvin Gogineni; Pitti; Scot A. Marsters; Robby M. Weimer; Mallika Singh; Avi Ashkenazi
Journal of Proteome Research, ISSN: 15353893 15353907
Victoria Pham; Pitti; Veronica G. Anania; Corey Bakalarski; Daisy J. Bustos; Suchit Jhunjhunwala; Qui Phung; Kebing Yu; William F. Forrest; Donald S. Kirkpatrick; Avi Ashkenazi; Jennie R. Lill
Immunology and Cell Biology, ISSN: 08189641 14401711
Nicholas S. Wilson; Becky Yang; Adriana Baz Morelli; Sandra Koernig; Annie Yang; Stefanie Loeser; Denise Airey; Larissa Provan; Hass; Hal Braley; Suzana Couto; Debbie Drane; Jeff Boyle; Gabrielle T Belz; Avi Ashkenazi; Eugene Maraskovsky
PLoS ONE, ISSN: 19326203
French; Benjamin C. Lin; Manping Wang; Adams; Theresa Shek; Kathy Hötzel; Brad Bolon; Ron Ferrando; Craig Blackmore; Kurt A. Schroeder; Luis A Rodriguez; Maria Hristopoulos; Rayna Venook; Avi Ashkenazi; Luc Desnoyers
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Jean-Charles Soria; Zsuzsanna Márk; Petr Zatloukal; Barna Szima; István Albert; Erzsébet Juhász; Jean-Louis Pujol; Jerzy Kozielski; Nigel Baker; Dominic Smethurst; Yong-Jiang Hei; Avi Ashkenazi; Howard M. Stern; Lukas Amler; Pan; Fiona Blackhall
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Amitabha Chaudhuri; Xie; Becky Yang; Kaushiki Mahapatra; Jinfeng Liu; Scot A. Marsters; Sweta Bodepudi; Avi Ashkenazi
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Aminah Ikner; Avi Ashkenazi
Cell, ISSN: 00928674
Sharon Biton; Avi Ashkenazi
Cancer Cell, ISSN: 18783686 15356108
Nicholas S. Wilson; Becky Yang; Annie Yang; Stefanie Loeser; Scot A. Marsters; David Lawrence; Yun Li; Pitti; Klara Totpal; Sharon Fong Yee; Ross; Jean-Michel Vernes; Yanmei Lu; Cam Adams; Rienk Offringa; Bob Kelley; Sarah G. Hymowitz; Dylan Daniel; Meng; Avi Ashkenazi
Molecular Cell, ISSN: 10972765 10974164
Anil Bagri; Avi Ashkenazi
Current Opinion in Cell Biology, ISSN: 09550674
Annie Yang; Nicholas S. Wilson; Avi Ashkenazi
Oncogene, ISSN: 09509232 14765594
François Gonzalvez; Avi Ashkenazi
Apoptosis, ISSN: 13608185 1573675X
Eimon; Avi Ashkenazi
Clinical Cancer Research, ISSN: 10780432
Howard M. Stern; Mary Padilla; Klaus W. Wagner; Lukas Amler; Avi Ashkenazi
Clinical Cancer Research, ISSN: 10780432
D. Ross Camidge; Roy S. Herbst; Michael S. Gordon; Gail Eckhardt; Razelle Kurzrock; Blythe Durbin; Josephine Ing; Tanyifor M. Tohnya; Jason Sager; Avi Ashkenazi; Gordon L. Bray; David Mendelson
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eugene Varfolomeev; Bruno Alicke; J. Michael Elliott; Zobel; Kristina West; Harvey Wong; Justin M. Scheer; Avi Ashkenazi; Stephen Gould; Wayne J. Fairbrother; Domagoj Vucic
Cell, ISSN: 00928674
Zhaoyu Jin; Yun Li; Pitti; David Lawrence; Victoria Pham; Jennie R. Lill; Avi Ashkenazi
Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice
Journal of Clinical Investigation, ISSN: 00219738 15588238
Jing Qing; Xiangnan Du; Yongmei Chen; Pamela Chan; Hao Li; Ping Wu; Scot A. Marsters; Scott Stawicki; Janet Y. Tien; Klara Totpal; Ross; Susanna Y. Stinson; David Dornan; French; Qian-Rena Wang; Jean-Philippe Stephan; Yan Wu; Wiesmann; Avi Ashkenazi
Nature Immunology, ISSN: 15292908 15292916
Nicholas S. Wilson; Vishva M. Dixit; Avi Ashkenazi
Clinical Cancer Research, ISSN: 10780432
Hongkui Jin; Renhui Yang; Ross; Fong; Richard A. D. Carano; Klara Totpal; David Lawrence; Zhong Zheng; Koeppen; Howard M. Stern; Ralph H. Schwall; Avi Ashkenazi
Nature Reviews Drug Discovery, ISSN: 14741776 14741784
Avi Ashkenazi
Molecular Cancer Therapeutics, ISSN: 15357163
Yonglei Shang; Yifan Mao; Jennifer Batson; Suzie J. Scales; Gail L. Phillips; Lackner; Klara Totpal; Simon P. Williams; Yang; Zhijun Tang; Zora Modrusan; Christine Tan; Wei-Ching Liang; Ping Tsai Siao; Alexander N. Vanderbilt; Kenji Kozuka; Klaus P. Hoeflich; Janet Y. Tien; Ross; Congfen Li; Hoon Lee Sang; An Song; Yan Wu; Jean-Philippe Stephan; Avi Ashkenazi; Jiping Zha
Journal of Clinical Investigation, ISSN: 00219738 15588238
Avi Ashkenazi; Roy S. Herbst
Cytokine and Growth Factor Reviews, ISSN: 13596101
Avi Ashkenazi
Cell Death and Differentiation, ISSN: 13509047 14765403
Cam Adams; Klara Totpal; David Lawrence; Scot A. Marsters; Pitti; Sharon Fong Yee; Ross; Laura DeForge; Koeppen; Meredith Sagolla; Deanne M. Compaan; Henry B. Lowman; Sarah G. Hymowitz; Avi Ashkenazi
Oncogene, ISSN: 09509232 14765594
Luc Desnoyers; Rama Pai; Ron Ferrando; Kathy Hötzel; Tom Le; Ross; Richard A. D. Carano; Aloma L. D'Souza; Jing Qing; Iman Mohtashemi; Avi Ashkenazi; French
Blood, ISSN: 00064971 00064971
Dylan Daniel; Becky Yang; David Lawrence; Klara Totpal; Inessa Balter; Wyne P. Lee; Alvin Gogineni; Mary J. Cole; Sharon Fong Yee; Ross; Avi Ashkenazi
Nature Medicine, ISSN: 10788956 1546170X
Klaus W. Wagner; Elizabeth A. Punnoose; Thomas Januario; David Lawrence; Pitti; Kate Lancaster; Dori Lee; Melissa Von Goetz; Sharon Fong Yee; Klara Totpal; Huw; Viswanatham Katta; Guy Cavet; Sarah G. Hymowitz; Lukas Amler; Avi Ashkenazi
PLoS ONE, ISSN: 19326203
Charles R. Holst; Hani Bou-Reslan; Bryan B. Gore; Karen Wong; Deanna Grant; Sreedevi Chalasani; Richard A. D. Carano; Gretchen D. Frantz; Marc Tessier-Lavigne; Brad Bolon; French; Avi Ashkenazi
Gene Therapy, ISSN: 14765462 09697128
Naumann; Bähr; Wolburg; Altenberend; Wick; Liston; Avi Ashkenazi; Michael Weller
Journal of Molecular Biology, ISSN: 00222836
Bing Li; Russell; Deanne M. Compaan; Klara Totpal; Scot A. Marsters; Avi Ashkenazi; Andrea G Cochran; Sarah G. Hymowitz; Sachdev S. Sidhu
Cell Death and Differentiation, ISSN: 14765403 13509047
Kratz; Eimon; Kiran Mukhyala; Howard M. Stern; Jiping Zha; Andreas Strasser; Reece K. Hart; Avi Ashkenazi
Cell Death and Differentiation, ISSN: 14765403 13509047
Eimon; Kratz; Eugene Varfolomeev; Sarah G. Hymowitz; Howard M. Stern; Jiping Zha; Avi Ashkenazi
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Cary D. Austin; David Lawrence; Andrew A. Peden; Eugene Varfolomeev; Klara Totpal; Ann De Mazière; Judith Klumperman; David Arnott; Victoria Pham; Richard H. Scheller; Avi Ashkenazi
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eugene Varfolomeev; Heather Maecker; Darcie Sharp; David Lawrence; Renz; Domagoj Vucic; Avi Ashkenazi
Cell, ISSN: 00928674
Heather Maecker; Eugene Varfolomeev; Frank C. Kischkel; David Lawrence; Heidi LeBlanc; Wyne P. Lee; Stephen D. Hurst; Dimitry Danilenko; Jun Li; Ellen H. Filvaroff; Becky Yang; Dylan Daniel; Avi Ashkenazi
Immunology and Cell Biology, ISSN: 08189641
Erika Cretney; Jonathan L. McQualter; Nobuhiko Kayagaki; Hideo Yagita; Claude C.A. Bernard; Iqbal S. Grewal; Avi Ashkenazi; Mark J. Smyth
Journal of Biological Chemistry, ISSN: 00219258
Darcie Sharp; David Lawrence; Avi Ashkenazi
Journal of Biological Chemistry, ISSN: 00219258
Robert F. Kelley; Klara Totpal; Stephanie H. Lindstrom; Mary Mathieu; Karen L Billeci; Laura DeForge; Roger Pai; Sarah G. Hymowitz; Avi Ashkenazi
Nature Chemical Biology, ISSN: 15524469 15524450
Sarah G. Hymowitz; Avi Ashkenazi
Cancer Research, ISSN: 00085472
Rajani Ravi; Ajay J. Jain; Richard D. Schulick; Vui Pham; Traci S. Prouser; Heather Allen; Elizabeth Garrett Mayer; Hua Yu; Drew M. Pardoll; Avi Ashkenazi; Atul Bedi
Cancer Research, ISSN: 00085472
Hongkui Jin; Renhui Yang; Fong; Klara Totpal; David Lawrence; Zhong Zheng; Ross; Koeppen; Ralph H. Schwall; Avi Ashkenazi
Cell, ISSN: 00928674
Eugene Varfolomeev; Avi Ashkenazi
Molecular and Cellular Biology, ISSN: 02707306
Eugene Varfolomeev; Frank C. Kischkel; Flavius Martin; Dhaya Seshasayee; Hua Wang; David Lawrence; Christine Olsson; Lucrece Tom; Sharon Erickson; French; Peter Schow; Iqbal S. Grewal; Avi Ashkenazi
Current Opinion in Pharmacology, ISSN: 14714892
Kelley; Avi Ashkenazi
Journal of Immunology, ISSN: 00221767
Kathy Miller; Meng; Jun Liu; Amy Hurst; Vanessa Hsei; Wai Lee T. Wong; Rene Ekert; David Lawrence; Steve Sherwood; Laura DeForge; Jacques Gaudreault; Gilbert-Andre Keller; Mark X. Sliwkowski; Avi Ashkenazi; Presta
Cytokine and Growth Factor Reviews, ISSN: 13596101
Alexandru Almasan; Avi Ashkenazi
Cell Death and Differentiation, ISSN: 13509047
Heidi LeBlanc; Avi Ashkenazi
American Journal of Pathology, ISSN: 00029440
Vassiliki Poulaki; Constantine S. Mitsiades; Vassiliki Kotoula; Sophia Tseleni-Balafouta; Avi Ashkenazi; Demetrios A. Koutras; Nicholas Mitsiades
Nature Reviews Cancer, ISSN: 1474175X
Avi Ashkenazi
Nature Medicine, ISSN: 10788956
Heidi LeBlanc; David Lawrence; Eugene Varfolomeev; Klara Totpal; John Morlan; Peter Schow; Fong; Ralph H. Schwall; Sinicropi; Avi Ashkenazi
Journal of Biological Chemistry, ISSN: 00219258
Frank C. Kischkel; David Lawrence; Antoine Tinel; Heidi LeBlanc; Arvind Virmani; Peter Schow; Adi Gazdar; John Blenis; David Arnott; Avi Ashkenazi
Nature Immunology, ISSN: 15292908
Hua Wang; Scot A. Marsters; Thad Baker; Betty Chan; Wyne P. Lee; Ling Fu; Daniel B. Tumas; Minhong Yan; Vishva M. Dixit; Avi Ashkenazi; Iqbal S. Grewal
Nature Medicine, ISSN: 10788956
David Lawrence; Shahrokh; Scot A. Marsters; Kirsten Achilles Poon; Danny Shih; Barbara Mounho; Kenneth J. Hillan; Klara Totpal; Laura DeForge; Peter Schow; Jeff Hooley; Steve Sherwood; Roger Pai; Susan Leung; Lolo Khan; Brian Gliniak; Bussiere; Craig A. Smith; Stephen S. Strom; Kelley; Judy Fox; Deborah Thomas; Avi Ashkenazi
Journal of Immunology, ISSN: 00221767
Anan Chuntharapai; Dodge; Grimmer; Kurt A. Schroeder; Scot A. Marsters; Koeppen; Avi Ashkenazi; K.Jin Kim
Current Biology, ISSN: 09609822
Scot A. Marsters; Minhong Yan; Pitti; Philip E. Haas; Vishva M. Dixit; Avi Ashkenazi
Cancer Research, ISSN: 00085472
Qun Zhou; Paula Fukushima; William DeGraff; James B. Mitchell; Maryalice Stetler-Stevenson; Avi Ashkenazi; Patricia S. Steeg
Immunity, ISSN: 10747613
Frank C. Kischkel; David Lawrence; Anan Chuntharapai; Peter Schow; K.Jin Kim; Avi Ashkenazi
BioTechniques, ISSN: 07366205
Frank C. Kischkel; Avi Ashkenazi
Nature Immunology, ISSN: 15292908
Minhong Yan; Scot A. Marsters; Iqbal S. Grewal; Hua Wang; Avi Ashkenazi; Vishva M. Dixit
Recent Progress in Hormone Research, ISSN: 00799963
Scot A. Marsters; Pitti; James P. Sheridan; Avi Ashkenazi
Biochemical and Biophysical Research Communications, ISSN: 0006291X
Wilfried Roth; Stefan Isenmann; Ulrike Naumann; Sebastian Kügler; Mathias Bähr; Johannes Dichgans; Avi Ashkenazi; Michael Weller
Journal of Immunology, ISSN: 00221767
Anan Chuntharapai; Gibbs; Lu; Ow; Scot A. Marsters; Avi Ashkenazi; De Vos; K.Jin Kim
Journal of Immunology, ISSN: 00221767
Shunsuke Mori; Kaoru Murakami-Mori; Shuji Nakamura; Avi Ashkenazi; Benjamin Bonavida
Current Opinion in Cell Biology, ISSN: 09550674
Avi Ashkenazi; Vishva M. Dixit
Current Biology, ISSN: 09609822
Austin L. Gurney; Scot A. Marsters; Arthur Huang; Pitti; Melanie R Mark; Daryl T. Baldwin; Gray; Patrick Dowd; Brush; Sherry Heldens; Peter Schow; Goddard; William I. Wood; Kevin Baker; Godowski; Avi Ashkenazi
Journal of Clinical Investigation, ISSN: 00219738
Avi Ashkenazi; Roger Pai; Fong; Susan Leung; David Lawrence; Scot A. Marsters; Christine Blackie; Ling Chang; Amy E. McMurtrey; Andrea Hebert; Laura DeForge; Iphigenia Koumenis; Lewis; Louise A. Harris; Bussiere; Koeppen; Shahrokh; Ralph H. Schwall
Molecular Cell, ISSN: 10972765
Sarah G. Hymowitz; Hans W. Christinger; Fuh; Ultsch; Mark P. O'Connell; Robert F. Kelley; Avi Ashkenazi; De Vos
Cytokine, ISSN: 10434666
Ann-Charlotte Johnsen; Johan Haux; Bjørg Steinkjer; Unni Nonstad; Kjartan Egeberg; Anders Sundan; Avi Ashkenazi; Espevik
Nature, ISSN: 00280836
Pitti; Scot A. Marsters; David Lawrence; Margaret Roy; Frank C. Kischkel; Patrick Dowd; Arthur Huang; Christopher J. Donahue; Steve Sherwood; Daryl T. Baldwin; Godowski; William I. Wood; Austin L. Gurney; Kenneth J. Hillan; Robert L. Cohen; Goddard; David Botstein; Avi Ashkenazi
Science, ISSN: 00368075
Avi Ashkenazi; Vishva M. Dixit
FEBS Letters, ISSN: 00145793
Johannes Rieger; Ulrike Naumann; Tamara Glaser; Avi Ashkenazi; Michael Weller
Current Biology, ISSN: 09609822
Scot A. Marsters; James P. Sheridan; Pitti; Brush; Goddard; Avi Ashkenazi
Journal of Immunology, ISSN: 00221767
Sylvia L. F. Pender; John M. E. Fell; Steven M. Chamow; Avi Ashkenazi; Thomas T. MacDonald
Current Biology, ISSN: 09609822
Scot A. Marsters; James P. Sheridan; Pitti; Arthur Huang; Skubatch; Daryl T. Baldwin; Jean Q. Yuan; Austin L. Gurney; Goddard; Godowski; Avi Ashkenazi
Science, ISSN: 00368075
James P. Sheridan; Scot A. Marsters; Pitti; Austin L. Gurney; Skubatch; Daryl T. Baldwin; Lakshmi Ramakrishnan; Christa Gray; Kevin Baker; William I. Wood; Goddard; Godowski; Avi Ashkenazi
Journal of Biological Chemistry, ISSN: 00219258
Scot A. Marsters; T. Merrill Ayres; Skubatch; Christa Gray; Mike Rothe; Avi Ashkenazi
Current Opinion in Immunology, ISSN: 09527915
Avi Ashkenazi; Steven M. Chamow
Biotechnology Advances, ISSN: 07349750
Avi Ashkenazi; Steven M. Chamow; Timothy P. Kogan
FASEB Journal, ISSN: 08926638
Avi Ashkenazi; Pitti; Scot A. Marsters; Siegfried Ruppert; Christopher J. Donahue; Alison Moore
Journal of Biological Chemistry, ISSN: 00219258
Pitti; Scot A. Marsters; Siegfried Ruppert; Christopher J. Donahue; Alison Moore; Avi Ashkenazi
Journal of Immunology, ISSN: 00221767
Kimberly J. Van Zee; Lyle L. Moldawer; Hester S. A. Oldenburg; William A. Thompson; Sarah A. Stackpole; Walton J. Montegut; Michael A. Rogy; Carol Meschter; Harald Gallati; Claus-Dieter Schiller; Wolfgang F. Richter; Hansruedi Loetscher; Avi Ashkenazi; Steven M. Chamow; Florian M. Wurm; Steve E. Calvano; Stephen F. Lowry; Werner Lesslauer
Trends in Biotechnology, ISSN: 01677799
Steven M. Chamow; Avi Ashkenazi
Current Biology, ISSN: 09609822
Scot A. Marsters; Pitti; Christopher J. Donahue; Siegfried Ruppert; Kenneth D. Bauer; Avi Ashkenazi
Current Biology, ISSN: 09609822
Scot A. Marsters; James P. Sheridan; Christopher J. Donahue; Pitti; Christa Gray; Goddard; Kenneth D. Bauer; Avi Ashkenazi
Molecular and Cellular Biology, ISSN: 02707306
Bach; William Tanner; Scot A. Marsters; Avi Ashkenazi; Michel Aguet; Andrey S. Shaw; Schreiber
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Scot A. Marsters; Diane Pennica; Bach; Schreiber; Avi Ashkenazi
Methods in Enzymology, ISSN: 10462023
Avi Ashkenazi; Steven M. Chamow
Journal of Clinical Investigation, ISSN: 00219738
Hongkui Jin; Renhui Yang; Scot A. Marsters; Avi Ashkenazi; Bunting; Marra; Scott; Baker
Journal of Hematotherapy, ISSN: none 15258165
Steven M. Chamow; Zhang; Xiang Y. Tan; Mhatre; Scot A. Marsters; Peers; Randal A. Byrn; Avi Ashkenazi; Junghans
Journal of Neurochemistry, ISSN: 14714159 00223042
Donna Oksenberg; Sona Havlik; Peroutka; Avi Ashkenazi
Science, ISSN: 00368075
Bach; Susanne J. Szabo; Anand S. Dighe; Avi Ashkenazi; Michel Aguet; Kenneth M. Murphy; Schreiber
Journal of Immunology, ISSN: 00221767
Steven M. Chamow; Zhang; Xiang Y. Tan; Mhatre; Scot A. Marsters; Peers; Randal A. Byrn; Avi Ashkenazi; Junghans
Biochimica et Biophysica Acta - Biomembranes, ISSN: 00052736
Diana Flasher; Krystyna Konopka; Steven M. Chamow; Paul Dazin; Avi Ashkenazi; Elizabeth Pretzer; Nejat Düzgüneş
Bioconjugate Chemistry, ISSN: 15204812 10431802
Steven M. Chamow; Peers; Timothy P. Kogan; Michael C. Venuti; Thomas Gadek; Reed J. Harris; Joyce Mordenti; Steven Shak; Avi Ashkenazi
Journal of Infectious Diseases, ISSN: 15376613 00221899
Hongkui Jin; Renhui Yang; Scot A. Marsters; Bunting; Florian M. Wurm; Steven M. Chamow; Avi Ashkenazi
Journal of Immunology, ISSN: 00221767
Haak-Frendscho; Scot A. Marsters; Joyce Mordenti; Brady; Nancy Gillett; Chen; Avi Ashkenazi
Molecular Immunology, ISSN: 01615890
Pitti; Scot A. Marsters; Haak-Frendscho; Gary Osaka; Joyce Mordenti; Steven M. Chamow; Avi Ashkenazi
Molecular Immunology, ISSN: 01615890
Joanne T. Beck; Scot A. Marsters; Reed J. Harris; Paul J. Carter; Avi Ashkenazi; Steven M. Chamow
Biochemistry, ISSN: 15204995 00062960
Diane Pennica; Van Lam; Weber; William J. Kohr; Basa; Spellman; Avi Ashkenazi; Steven J. Shire; David V. Goeddel
International Reviews of Immunology, ISSN: 08830185
Avi Ashkenazi; Capon; Ward
Immunology, ISSN: 00192805
Haak-Frendscho; Scot A. Marsters; Steven M. Chamow; Peers; Simpson; Avi Ashkenazi
Journal of Biological Chemistry, ISSN: 00219258
Elisabeth T. Barfod; Yi Zheng; Wun-Jing Kuang; Matthew J. Hart; Tony Evans; Richard A. Cerione; Avi Ashkenazi
Nature, ISSN: 00280836
Donna Oksenberg; Scot A. Marsters; Brian F. O'Dowd; Hui Jin; Sona Havlik; Peroutka; Avi Ashkenazi
Journal of Biological Chemistry, ISSN: 00219258
Hui Jin; Donna Oksenberg; Avi Ashkenazi; Peroutka; Alessandra M. V. Duncan; Richard Rozmahel; Yilli Yang; Mengod; Jose M. Palacios; Brian F. O'Dowd
Journal of Biological Chemistry, ISSN: 00219258
Scot A. Marsters; Frutkin; Simpson; Brian M. Fendly; Avi Ashkenazi
Journal of Biological Chemistry, ISSN: 00219258
Steven M. Chamow; Timothy P. Kogan; Peers; Hastings; Randal A. Byrn; Avi Ashkenazi
International journal of cancer. Supplement = Journal international du cancer. Supplement, ISSN: 00207136
Steven M. Chamow; A-M. Duliege; Arthur J. Ammann; Kahn; Allen; Eichberg; Randal A. Byrn; Capon; Ward; Avi Ashkenazi
Journal of Virology, ISSN: 0022538X
John P. Moore; Jane A. Mckeating; Yaoxing Huang; Avi Ashkenazi; David D. Ho
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Avi Ashkenazi; Smith; Scot A. Marsters; Riddle; Timothy Gregory; David D. Ho; Capon
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Avi Ashkenazi; Scot A. Marsters; Capon; Steven M. Chamow; Figari; Diane Pennica; David V. Goeddel; Michael A. Palladino; Smith
Biochemistry, ISSN: 15204995 00062960
Steven M. Chamow; Peers; Randal A. Byrn; Michael G. Mulkerrin; Reed J. Harris; Wen-Ching Wang; Pamela J. Bjorkman; Capon; Avi Ashkenazi
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Avi Ashkenazi; Presta; Scot A. Marsters; Camerato; Rosenthal; Brian M. Fendly; Capon
Cell, ISSN: 00928674
Avi Ashkenazi; Ernest G. Peralta; Winslow; Ramachandran; Capon
Science, ISSN: 00368075
Daniel Lamarre; Avi Ashkenazi; Sylvain Fleury; Smith; Rafick-P. Sekaly; Capon
Nature, ISSN: 00280836
Avi Ashkenazi; Ramachandran; Capon
Progress in clinical and biological research, ISSN: 03617742
Ramachandran; Ernest G. Peralta; Avi Ashkenazi; Winslow; Smith; Capon
Trends in Pharmacological Sciences, ISSN: 01656147
Avi Ashkenazi; Ernest G. Peralta; Winslow; Ramachandran; Capon
BioEssays, ISSN: 15211878 02659247
Ramachandran; Ernest G. Peralta; Avi Ashkenazi; Winslow; Capon
Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451
Avi Ashkenazi; Ernest G. Peralta; Winslow; Ramachandran; Capon
Nature, ISSN: 00280836
Ernest G. Peralta; Avi Ashkenazi; Winslow; Ramachandran; Capon
EMBO Journal, ISSN: 02614189
Ernest G. Peralta; Avi Ashkenazi; Winslow; Smith; Ramachandran; Capon
Trends in Pharmacological Sciences, ISSN: 0165604X
Ernest G. Peralta; Winslow; Avi Ashkenazi; Smith; Ramachandran; Capon
Science, ISSN: 00368075
Ernest G. Peralta; Winslow; Gary L. Peterson; Smith; Avi Ashkenazi; Ramachandran; Michael I. Schimerlik; Capon
Science, ISSN: 00368075
Avi Ashkenazi; Winslow; Ernest G. Peralta; Gary L. Peterson; Michael I. Schimerlik; Capon; Ramachandran
Education
- Genentech, Inc., Department of Developmental Biology, Postdoctoral Fellow – 1987
- University of California, San Francisco, Department of Hormone Research, Postdoctoral Fellow – 1986
- Hebrew University, Israel, Department of Biochemistry, Ph.D. – 1986
- Hebrew University, Israel, Department of Biochemistry, B.S. – 1983
Awards & Honors
- Adjunct Professor, Department of Biochemistry and Biophysics, UCSF – 2015
- First Prize, Boeringer Ingelheim Award – 1988
