Bingchuan Wei
Senior Principal Scientist, Synthetic Molecule Analytical Chemistry, Drug Discovery
I have long been attracted by Genentech's commitment to science and innovation, a fascination that began during my school years through reading all the publications. I was thrilled to join Genentech in 2014, and since then, I have had the privilege of collaborating with exceptional colleagues and working on a variety of therapeutic modalities, including synthetic molecules, biologics, and their combinations. The most rewarding aspect of my work is hearing from patients about how the drugs we developed—from discovery to commercialization—have changed their lives.
Postdoctoral Mentor
The postdoctoral program at Genentech provides a unique and balanced experience that bridges academia and industry. As a participant, you will engage in fundamental scientific research while also applying your findings to make impactful changes in patients' lives. Additionally, you will become part of a vibrant community of young scientists, expanding your network within the drug discovery and development field. I am extremely fortunate to serve as a postdoc mentor and looking forward to exploring scientific challenges together with you.
Featured Publication
Probing the Protein-Excipient Interaction in the Orally Delivered Protein by Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry and Molecular Dynamics.
Anal Chem 2024, 96 (2), 802-809
Pan, X.; Lenka, S.; Davis, J.; Nagapudi, K.; Mantik, P.; Saggu, M.; Dai, L.; Cadang, L.; Zhang, H. M.; Zhang, J.; Izadi, S.; Yang, F.; Wei, B.,
Multi-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics.
MAbs 2022, 14 (1), 2007564.
Wei, B.; Woon, N.; Dai, L.; Fish, R.; Tai, M.; Handagama, W.; Yin, A.; Sun, J.; Maier, A.; McDaniel, D.; Kadaub, E.; Yang, J.; Saggu, M.; Woys, A.; Pester, O.; Lambert, D.; Pell, A.; Hao, Z.; Magill, G.; Yim, J.; Chan, J.; Yang, L.; Macchi, F.; Bell, C.; Deperalta, G.; Chen, Y.,
Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation.
MAbs 2021, 13 (1), 1893427
Wei, B.; Gao, X.; Cadang, L.; Izadi, S.; Liu, P.; Zhang, H. M.; Hecht, E.; Shim, J.; Magill, G.; Pabon, J. R.; Dai, L.; Phung, W.; Lin, E.; Wang, C.; Whang, K.; Sanchez, S.; Oropeza, J., Jr.; Camperi, J.; Zhang, J.; Sandoval, W.; Zhang, Y. T.; Jiang, G.,
Native Hydrophobic Interaction Chromatography Hyphenated to Mass Spectrometry for Characterization of Monoclonal Antibody Minor Variants.
Anal Chem 2019, 91 (24), 15360-15364.
Wei, B.; Han, G.; Tang, J.; Sandoval, W.; Zhang, Y. T.,
My research focuses on developing and leveraging advanced analytical technologies in drug development to understand the structural-functional relationship of different therapeutic modalities. I am also interested in foster entrepreneurial spirit in the biopharmaceutical industry.
- Pennsylvania State University, M.B.A. in Business Analysis – 2021
- Purdue University, Ph.D. in Chemistry – 2011
- Peking University, B.S. in Chemistry and Mathematics – 2007