"My ability to contribute to the discovery of safe and efficacious drugs to treat important unmet medical conditions is what keeps me inspired."
I joined Genentech in 2000 and had the opportunity to contribute in building the state-of-the-art organization that supports small molecule and antibody-drug conjugates in both discovery and development. I work with a very talented team of scientists that are passionate about discovering the next great medicine. This is a great place where great scientists ask fundamental questions and go to the lab to test their hypothesis.
Journal of Computer-Aided Molecular Design 2015, 29(4): 327-38.
My research focus is to figure out the molecular mechanism for metabolism. How and where does a drug candidate is converted to metabolite(s). This is not only focused on cytochrome P450 enzymes, which are very important, but also to all kinds of enzyme systems that are involved in oxidation, reduction, hydrolysis and conjugation. I am also interested in soft spots in the drug candidates and how the molecule could be changed to minimize metabolic rates. I am also interested in the consequence of metabolism, with asking if we are making reactive metabolites that can covalently modify cellular macromolecules.