Cyrus Khojasteh
Associate Director / Principal Scientist, Drug Metabolism & Pharmacokinetics
"My ability to contribute to the discovery of safe and efficacious drugs to treat important unmet medical conditions is what keeps me inspired."
21
Years at Genentech
70
Publications
8
Awards & Honors
I joined Genentech in 2000 and had the opportunity to contribute in building the state-of-the-art organization that supports small molecule and antibody-drug conjugates in both discovery and development. I work with a very talented team of scientists that are passionate about discovering the next great medicine. This is a great place where great scientists ask fundamental questions and go to the lab to test their hypothesis.
Featured Publication
A probabilistic method to report predictions from a human liver microsomes stability QSAR model: a practical tool for drug discovery.
Journal of Computer-Aided Molecular Design 2015, 29(4): 327-38.
Aliagas I, Gobbi A, Heffron T, Lee ML, Ortwine DF, Zak M, Khojasteh SC.
My Focus
My research focus is to figure out the molecular mechanism for metabolism. How and where does a drug candidate is converted to metabolite(s). This is not only focused on cytochrome P450 enzymes, which are very important, but also to all kinds of enzyme systems that are involved in oxidation, reduction, hydrolysis and conjugation. I am also interested in soft spots in the drug candidates and how the molecule could be changed to minimize metabolic rates. I am also interested in the consequence of metabolism, with asking if we are making reactive metabolites that can covalently modify cellular macromolecules.
Publications
Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti-Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats
Drug Metabolism and Disposition,
Hao Cai; Victor Yip; Violet Lee; Sylvia Wong; Ola Saad; Shuguang Ma; Nina Ljumanovic; S Cyrus Khojasteh; Amrita Kamath; Ben-Quan Shen
Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates
Journal of Medicinal Chemistry,
Leanna Staben; Jinhua Chen; Josefa Dela Cruz-Chuh; Geoff Del Rosario; Mary Ann Go; Jun Guo; S Cyrus Khojasteh; Kathy Kozak; Ginny Li; Carl Ng; Gail D. Lewis Phillips; Thomas Pillow; Rebecca K. Rowntree; John Wai; Binqing Wei; Keyang Xu; Zijin Xu; Shang-Fan Yu; Donglu Zhang; Peter Dragovich
Chemical Research in Toxicology, ISSN: 15205010
Chenghong Zhang; James Crawford; Matthew L. Landry; Huifen Chen; Jane Kenny; S Cyrus Khojasteh; Wendy Lee; Shuguang Ma; Wendy B. Young
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Haeyoung Zhang; Chris Wolford; Abdul Basit; Albert P. Li; Peter Fan; Bernard P. Murray; Ryan Takahashi; Cyrus Khojasteh; Bill J. Smith; Kenneth E. Thummel; Bhagwat Prasad
Xenobiotica, ISSN: 13665928 00498254
Wei Wang; Mulder Teresa; Jingwei Cai; Chenghong Zhang; Susan Wong; Zhengyin Yan; S Cyrus Khojasteh; Donglu Zhang
Carfilzomib Is Not an Appropriate Payload of Antibody-Drug Conjugates Due to Rapid Inactivation by Lysosomal Enzymes
Drug Metabolism and Disposition,
Yong Ma; Josefa Dela Cruz Chuh; S Cyrus Khojasteh; Peter Dragovich; Thomas Pillow; Donglu Zhang
Molecular Pharmaceutics, ISSN: 15438392 15438384
Zhonghua Pei; Chunjiao Chen; Jinhua Chen; Josefa Dela Cruz-Chuh; Reginald Delarosa; Yuzhong Deng; Aimee Fourie-O'Donohue; Isabel Figueroa; Jun Guo; Weiwei Jin; Cyrus Khojasteh; Kathy Kozak; Brandon Latifi; James Lee; Ginny Li; Eva Lin; Liling Liu; Jiawei Lu; Scott Martin; Carl Ng; Trung Nguyen; Rachana Ohri; Gail Phillips; Thomas Pillow; Rebecca K. Rowntree; Nicola Stagg; David Stokoe; Sheila Ulufatu; Vishal Verma; John Wai; Jing Wang; Keyang Xu; Zijin Xu; Hui Yao; Shang-Fan Yu; Donglu Zhang; Peter Dragovich
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Simone Schadt; Bojan Bister; Swapan K. Chowdhury; Christoph Funk; Marcel Hop; W. Griffith Humphreys; Fumihiko Igarashi; D James Alexander; Mark Kagan; Cyrus Khojasteh; Angus N. R Nedderman; Chandra Prakash; Frank Runge; Holger Scheible; Douglas K Spracklin; Piet Swart; Susanna Tse; Josh Yuan; R. Scott Obach
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Donglu Zhang; Shang-Fan Yu; Cyrus Khojasteh; Yong Ma; Thomas Pillow; Jack D. Sadowsky; Dian Su; Kathy Kozak; Keyang Xu; Andy Polson; Peter Dragovich; Marcel Hop
Bioconjugate Chemistry, ISSN: 15204812 10431802
Donglu Zhang; Hoa Le; Josefa Dela Cruz-Chuh; Sudheer Bobba; Jun Guo; Leanna Staben; Chenghong Zhang; Yong Ma; Kathy Kozak; Gail Phillips; Breanna S. Vollmar; Jack D. Sadowsky; Dick Vandlen; Binqing Wei; Dian Su; Peter Fan; Peter Dragovich; Cyrus Khojasteh; Marcel Hop; Thomas Pillow
British Journal of Clinical Pharmacology, ISSN: 13652125 03065251
Tore Bjerregaard Stage; Magnus Graff; Susan Wong; Louise Ladebo Rasmussen; Flemming Nielsen; Anton Pottegård; Kim Brøsen; Deanna L. Kroetz; Cyrus Khojasteh; Per Damkier
Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model
mAbs, ISSN: 19420862
Shun xin Wang-Lin; Chenguang Zhou; Amrita Kamath; Kyu Hong; Neelima Koppada; Ola Saad; Montse Carrasco-Triguero; Cyrus Khojasteh; Rong Deng
Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8)
Journal of Medicinal Chemistry, ISSN: 00222623
Yong Ma; Yue Fu; Cyrus Khojasteh; Deepak Dalvie; Donglu Zhang
CYP1A1-mediated intramolecular rearrangement of aminoazepane in GDC-0339
Drug Metabolism and Disposition, ISSN: 00909556
Ryan Takahashi; Gina Wang; Nathaniel Segraves; Jing Wang; Jae Chang; Cyrus Khojasteh; Shuguang Ma
Inhibitory effects of trapping agents of sulfur drug reactive intermediates against major human cytochrome P450 isoforms
International Journal of Molecular Sciences, ISSN: 16616596
Jasleen K. Sodhi; Erlie Delarosa; Jason Halladay; James Driscoll; Teresa Mulder; Patrick M. Dansette; Cyrus Khojasteh
Biotransformation and bioactivation reactions–2016 literature highlights
Drug Metabolism Reviews, ISSN: 03602532
Cyrus Khojasteh; Ivonne M. C. M. Rietjens; Deepak Dalvie; Grover Miller
Drug Metabolism and Disposition, ISSN: 1521009X
Ryan Takahashi; Jason Halladay; Mike Siu; Yuan Chen; Marcel Hop; Cyrus Khojasteh; Shuguang Ma
Drug Metabolism Letters, ISSN: 18723128
Ryan Takahashi; Cyrus Khojasteh; Matthew Wright; Marcel Hop; Shuguang Ma
Xenobiotica, ISSN: 13665928
Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Justin Ly; Jason Boggs; Alec Fettes; Andrew McClory; Yuzhong Deng; Marcel Hop; Cyrus Khojasteh; Edna Choo
Drug Metabolism and Disposition, ISSN: 1521009X
Yong Ma; Cyrus Khojasteh; Marcel Hop; Hans Erickson; Andy Polson; Thomas Pillow; Shang-Fan Yu; Hong Wang; Peter Dragovich; Donglu Zhang
ACS Medicinal Chemistry Letters, ISSN: 19485875
Donglu Zhang; Thomas Pillow; Yong Ma; Josefa Dela Cruz-Chuh; Kathy Kozak; Jack Sadowsky; Gail Phillips; Jun Guo; Martine Darwish; Peter Fan; Jingtian Chen; Changrong He; Tao Wang; Hui Yao; Zijin Xu; Jinhua Chen; John Wai; Zhonghua Pei; Marcel Hop; Cyrus Khojasteh; Peter Dragovich
Drug Metabolism and Disposition, ISSN: 1521009X
Donglu Zhang; Shang-Fan Yu; Yong Ma; Keyang Xu; Peter Dragovich; Thomas Pillow; Luna Liu; Geoff Del Rosario; Jintang He; Zhonghua Pei; Jack Sadowsky; Hans Erickson; Marcel Hop; Cyrus Khojasteh
Drug Metabolism and Disposition, ISSN: 1521009X
Peter Fan; Donglu Zhang; Jason Halladay; James Driscoll; Cyrus Khojasteh
Drug Metabolism Letters, ISSN: 18723128
Hoa Le; Peter Fan; Susan Wong; Shuguang Ma; James Driscoll; Marcel Hop; Cyrus Khojasteh
Drug Metabolism Letters, ISSN: 18723128
Peter Fan; Jacob Chen; Allan Jaochico; Hank La; Ning Liu; Teresa Mulder; Robert T. Cass; Matthew Durk; Kirsten Messick; Nicole Valle; Shannon Liu; Wendy Lee; James Crawford; Joachim Rudolph; Lesley Murray; Cyrus Khojasteh; Matthew Wright
Pharmaceutical Research, ISSN: 1573904X
Jialin Mao; Suzanne Brown; Cyrus Khojasteh; Yuan Chen; Marcel Hop; Jane Kenny
Drug Metabolism and Disposition, ISSN: 1521009X
Ryan Takahashi; Edna Choo; Shuguang Ma; Susan Wong; Jason Halladay; Yuzhong Deng; Isabelle Rooney; Mary Gates; Marcel Hop; Cyrus Khojasteh; Mark Dresser; Luna Musib
Drug Metabolism and Disposition, ISSN: 1521009X
Ryan Takahashi; Shuguang Ma; Sarah Robinson; Qin Yue; Edna Choo; Cyrus Khojasteh
Drug Metabolism and Disposition, ISSN: 1521009X
Jasleen K. Sodhi; Susan Wong; Don Kirkpatrick; Lichuan Liu; Cyrus Khojasteh; Marcel Hop; John T. Barr; Jeffrey P. Jones; Jason Halladay
European Journal of Drug Metabolism and Pharmacokinetics, ISSN: 21070180
Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Joe Lyssikatos; Kelly Regal; Kevin W. Hunt; Nicholas C. Kallan; Mike Siu; Marcel Hop; Xingrong Liu; Cyrus Khojasteh
Journal of Computer-Aided Molecular Design, ISSN: 15734951
Ignacio Aliagas; Alberto Gobbi; Tim Heffron; Man Ling Lee; Dan Ortwine; Mark Zak; Cyrus Khojasteh
Drug Metabolism Reviews, ISSN: 10979883
Perry Gordon; Cyrus Khojasteh
Bioanalysis, ISSN: 17576199
Ola Saad; Ben-Quan Shen; Keyang Xu; Cyrus Khojasteh; Sandhya Girish; Surinder Kaur
Drug Metabolism Letters, ISSN: 18723128
Ben-Quan Shen; Daniela Yadav; Qin Yue; Ola Saad; Jack (Jay) Tibbitts; Cyrus Khojasteh; Sandhya Girish
Drug Metabolism and Disposition, ISSN: 00909556
Cyrus Khojasteh; Qin Yue; Shuguang Ma; Georgette Castanedo; Jacob Chen; Joe Lyssikatos; Teresa Mulder; Ryan Takahashi; Justin Ly; Kirsten Messick; Wei Jia; Lichuan Liu; Marcel Hop; Harvey Wong
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Shuguang Ma; Alan Deese; Qin Yue; Heasook Kim-Kang; Yijun Yi; Mike Siu; Kevin W. Hunt; Nicholas C. Kallan; Marcel Hop; Xingrong Liu; Cyrus Khojasteh
Toxicology Research, ISSN: 20454538
Chenghong Zhang; Shuguang Ma; Erlie Delarosa; Suzanne Brown; Jasleen K. Sodhi; Vivek Musinipally; Patricia Chang; Rama Pai; Jason Halladay; Misner; Jane Kenny; Marcel Hop; Cyrus Khojasteh
Drug Metabolism and Disposition, ISSN: 1521009X
Suzanne Tay; Hoa Le; Kevin Ford; Sidney D. Nelson; Cyrus Khojasteh; Peter M. Rademacher
Future Medicinal Chemistry, ISSN: 17568927
Peter Fan; Yang Song; Leo Berezhkovskiy; Jonathan Cheong; Emile Plise; Cyrus Khojasteh
Drug Metabolism and Disposition, ISSN: 1521009X
Jasleen K. Sodhi; Kevin Ford; Sophie Aurangabadwala; Susan Wong; Marcel Hop; Cyrus Khojasteh; Jason Halladay
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Markova; Teresa De Marco; Bendjilali; Kobashigawa; Mefford; Jasleen K. Sodhi; Le; Zhang; Jason Halladay; Rettie; Cyrus Khojasteh; McGlothlin; Wu; Hsueh; Witte; Schwartz; Deanna L. Kroetz
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Mike Siu; Rich Pastor; Wendy Liu; Kathy Barrett; Megan Berry Swadell; Wade Blair; Christine Chang; Jacob Chen; Charles Eigenbrot; Nico Ghilardi; Paul Gibbons; Haiying He; Christopher A. Hurley; Jane Kenny; Cyrus Khojasteh; Hoa Le; Leslie Lee; Joe Lyssikatos; Steven Magnuson; Rebecca Pulk; Vickie Tsui; Mark Ultsch; Yisong Xiao; Bing-Yan Zhu; Deepak Sampath
Elucidation of the mechanism of ribose conjugation in a pyrazole-containing compound in rodent liver
Xenobiotica, ISSN: 00498254
Hoa Le; Kevin Ford; Cyrus Khojasteh; Peter Fan
Drug Metabolism and Disposition, ISSN: 00909556
Qin Yue; Teresa Mulder; Patrick Rudewicz; Eric G. Solon; Nageshwar Budha; Joseph Ware; Joe Lyssikatos; Marcel Hop; Harvey Wong; Cyrus Khojasteh
Drug Metabolism Letters, ISSN: 18723128
Sophie Aurangabadwala; Suzanne Brown; Daniel Tran; Leslie Wang; Erlie Delarosa; Cyrus Khojasteh; Jason Halladay; Jane Kenny
Chemical Research in Toxicology, ISSN: 0893228X
Cyrus Khojasteh; Dylan Hartley; Kevin Ford; Hirdesh Uppal; Shimako Oishi; Sidney D. Nelson
Current Drug Metabolism, ISSN: 13892002
Ben-Quan Shen; Daniela Yadav; Ola Saad; Qin Yue; Cinthia Pastuskovas; Cyrus Khojasteh; Jack (Jay) Tibbitts; Surinder Kaur; Bei Wang; Wayne Chu; Patricia M. LoRusso; Sandhya Girish
Journal of Pharmacological and Toxicological Methods, ISSN: 10568719
Jason Halladay; Susan Wong; Cyrus Khojasteh; Susan Grepper
Pharmaceutical Research, ISSN: 07248741
Jane Kenny; Sophie Aurangabadwala; Chenghong Zhang; Suzanne Brown; Carol Collins; Aleksandra Galetin; Cyrus Khojasteh
Combinatorial Chemistry and High Throughput Screening, ISSN: 13862073
Young Shin; Hoa Le; Cyrus Khojasteh; Marcel Hop
Chemical Research in Toxicology, ISSN: 0893228X
Chenghong Zhang; Jane Kenny; Hoa Le; Alan Deese; Kevin Ford; Luke K. Lightning; Peter Fan; James Driscoll; Jason Halladay; Marcel Hop; Cyrus Khojasteh
Drug Metabolism and Disposition, ISSN: 00909556
Lichuan Liu; Jason Halladay; Young Shin; Susan Wong; Melis Coraggio; Hank La; Matt Baumgardner; Hoa Le; Sashi Gopaul; Jason Boggs; Peter Kuebler; John Davis; Charlene Liao; Joe Lubach; Alan Deese; Greg Sowell; Kevin S. Currie; Wendy Young; Cyrus Khojasteh; Marcel Hop; Harvey Wong
Drug Metabolism Letters, ISSN: 18723128
Jason Halladay; Erlie Delarosa; Daniel Tran; Leslie Wang; Susan Wong; Cyrus Khojasteh
Drug Metabolism and Disposition, ISSN: 00909556
Qin Yue; John Chen; Teresa Mulder; Alan Deese; Ryan Takahashi; Patrick Rudewicz; Mark Reynolds; Eric G. Solon; Marcel Hop; Harvey Wong; Cyrus Khojasteh
European Journal of Drug Metabolism and Pharmacokinetics, ISSN: 03787966
Cyrus Khojasteh; Saileta Prabhu; Jane Kenny; Jason Halladay; Anthony Y. H. Lu
Chemical Research in Toxicology, ISSN: 0893228X
Cyrus Khojasteh; Shimako Oishi; Sidney D. Nelson
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Georgette Castanedo; Shumei Wang; Kirk Robarge; Beth Blackwood; Dan Burdick; Christine Chang; Peter Dijkgraaf; Stephen Gould; Janet Gunzner-Toste; Oivin Guichert; Jason Halladay; Cyrus Khojasteh; Leslie Lee; James Marsters; Lesley Murray; David Peterson; Emile Plise; Laurent Salphati; Frederic De Sauvage; Susan Wong; Dan Sutherlin
Chemical Research in Toxicology, ISSN: 0893228X
James Driscoll; Ignacio Aliagas; Jennifer Harris; Jason Halladay; Sheerin Latham; Alan Deese; Nathaniel Segraves; Cyrus Khojasteh
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Kirk Robarge; Shirley A. Brunton; Georgette Castanedo; Yong Cui; Michael Dina; Rich Goldsmith; Stephen Gould; Oivin Guichert; Janet Gunzner-Toste; Jason Halladay; Wei Jia; Cyrus Khojasteh; Michael Koehler; Karen Kotkow; Hank La; Rebecca Lyn K. LaLonde; Kevin Lau; Leslie Lee; Derek Marshall; James Marsters; Lesley Murray; Changgeng Qian; Lee L. Rubin; Laurent Salphati; Mark Stanley; John H.A. Stibbard; Dan Sutherlin; Savita Ubhayakar; Shumei Wang; Susan Wong; Minli Xie
Drug Metabolism and Disposition, ISSN: 1521009X
Harvey Wong; Peter Theil; Yong Cui; James Marsters; Cyrus Khojasteh; Laurent Vernillet; Hank La; Xiling Song; Hong Wang; Eric Morinello; Yuzhong Deng; Marcel Hop
Xenobiotica, ISSN: 00498254
Harvey Wong; Jian Chen; Bilin Chou; Jason Halladay; Jane Kenny; Hank La; James Marsters; Emile Plise; Patrick Rudewicz; Kirk Robarge; Young Shin; Susan Wong; Chenghong Zhang; Cyrus Khojasteh
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Kirk Robarge; Shirley A. Brunton; Georgette Castanedo; Yong Cui; Michael Dina; Rich Goldsmith; Stephen Gould; Oivin Guichert; Janet Gunzner-Toste; Jason Halladay; Wei Jia; Cyrus Khojasteh; Michael Koehler; Karen Kotkow; Hank La; Rebecca Lyn K. LaLonde; Kevin Lau; Leslie Lee; Derek Marshall; James Marsters; Lesley Murray; Changgeng Qian; Lee L. Rubin; Laurent Salphati; Mark Stanley; John H.A. Stibbard; Dan Sutherlin; Savita Ubhayakar; Shumei Wang; Susan Wong; Minli Xie
Journal of Pharmaceutical Sciences, ISSN: 00223549
Leo Berezhkovskiy; Cyrus Khojasteh; Jason Halladay; Marcel Hop
Drug Metabolism Letters, ISSN: 18723128
Chenghong Zhang; Susan Wong; Erlie Delarosa; Jane Kenny; Jason S. Hallday; Marcel Hop; Cyrus Khojasteh
Xenobiotica, ISSN: 00498254
Cyrus Khojasteh; Douglas Leipold; Lai; Hank La; Matt Baumgardner; Desino; Olafur S. Gudmundsson; Duane Bloedow; Sarah C. Bodary; Mark Reynolds; Thomas R. Gadek; Sara Kenkare-Mitra
Drug Metabolism and Disposition, ISSN: 00909556
Chandra Prakash; John O'Donnell; Cyrus Khojasteh
Drug Metabolism Letters, ISSN: 18723128
Jason Halladay; Susan Wong; Sharmin M Jaffer; Achintya Sinhababu; Cyrus Khojasteh
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232
Frances Y. Lai; Cyrus Khojasteh
Xenobiotica, ISSN: 00498254
Cyrus Khojasteh; Rossulek; Fouda; Chandra Prakash
Chemical Research in Toxicology, ISSN: 0893228X
Deepak Dalvie; Amit S. Kalgutkar; Cyrus Khojasteh; R. Scott Obach; John O'Donnell
Education
- University of Washington, Medicinal Chemistry, Ph.D. – 1998
- California State University, Sacramento, Organic Chemistry, M.S. – 1991
- University of California, Berkeley, Chemistry, B.A. – 1988
Awards & Honors
- Special Advisors to Pharmaceutical and BioScience Society – 2017
- President-elect of APA Boston Society – 2017
- Associate Editor for Journal of Drug Metabolism Reviews – 2016, 2017
- UW Distinguished Alumni Award for Excellence in Pharmaceutical Sciences and Research – 2016-2017
- Member of the International Society for Studying Xenobiotics Abstract Review Committee – 2009
- Member of the International Society for Studying Xenobiotics Exhibitors Committee – 2008-2011
- Predoctoral National Institutes of Health Grant Awardee, University of Washington – 1998
- Travel Award from American Society for Pharmacology and Experimental Therapeutics – 1998