Lauren Sirois - Senior Principal Scientist and Director, Process Chemistry

Lauren Sirois

Senior Principal Scientist and Director, Process Chemistry

Years at Genentech
Publications at Genentech

I remain inspired by organic chemistry’s potential to impact the frontiers of drug development, whether that includes “traditional” small molecules, antibody-drug conjugates, novel peptides, or other emerging treatment modalities in Genentech’s pipeline. As a Senior Scientist in Small Molecule Process Chemistry, I have the opportunity to lead teams in developing innovative chemical syntheses and supplying the drug substance for clinical trials of our therapeutic candidates. Prior to joining Genentech in 2014, I began my industrial career as a Research Scientist at Lexicon Pharmaceuticals, where I supported synthesis and manufacturing activities for small molecule active pharmaceutical ingredients. My Ph.D. dissertation as a National Science Foundation Predoctoral Fellow with Prof. Paul Wender at Stanford University focused on the development of new transition metal-catalyzed cycloaddition reactions and their applications.

Featured Publication

Process Development Overcomes a Challenging Pd-Catalyzed C-N Coupling for the Synthesis of RORc Inhibitor GDC-0022

Org. Process Res. Dev. 2020, 24, 567-578.

Sirois, L. E.; Lao, D.; Xu, J.; Angelaud, R.; Tso, J.; Scott, B.; Chakravarty, P.; Malhotra, S.; Gosselin, F.