Lélia Delamarre
Director & Distinguished Scientist, Cancer Immunology, Research Biology
"Genentech provides scientists with the unique opportunity to do ground-breaking science with the goal of developing innovative therapies for patients."
17
Years at Genentech
36
Publications at Genentech
I joined Genentech in 2007 after my postdoctoral training at Yale University where I studied the cellular mechanisms underlying the unique capacity of dendritic cells to capture and present antigens for T cell priming. At Genentech in the Cancer Immunology Department, I have been pursuing my research interests with the goal of developing novel approaches to expand effective T cell responses to cancer through priming. I feel extremely fortunate to be surrounded by colleagues with various scientific background who are highly enthusiastic, engaged, and eager to collaborate. They inspire me to give my best.
Featured Publication
Predicting Immunogenicity of Tumor-specific Mutations by Combining Mass Spectrometry & Exome Sequencing.
Nature. 2014 Nov 27;515(7528):572-6.
Yadav M., Jhunjhunwala S., Phung Q.T., Lupardus P., Tanguay J., Bumbaca S, Franci C. Cheung T.K., Fritsche J., Weinschenk T., Modrusan Z., Mellman I., Lill J.R., Delamarre L.
My Focus
The research projects in my lab have been focused on exploring novel approaches to expand anti-tumor T cell responses through priming. Recently we focused on the identification of the tumor antigens that shape immune responses to cancer. We and others have shown that mutations, also called neo-antigens, that accumulate in cancer are highly immunogenic and can drive protective T cell responses against cancer.
The recent advent of next generation sequencing technologies has enabled rapid and comprehensive discovery of cancer-specific mutations in individual patients and provides the opportunity to develop novel approaches to selectively target neoantigens.
Genentech Publications
Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage
Journal of Experimental Medicine,
Ann-Jay Tong; Rebecca Leylek; Anna-Maria Herzner; Diamanda Rigas; Sara Wichner; Craig D. Blanchette; Siri Tahtinen; Christopher C. Kemball; Ira Mellman; Benjamin Haley; Emily C. Freund; Lélia Delamarre
Seminars in Immunology, ISSN: 10445323
Christine Moussion; Lélia Delamarre
Nature, ISSN: 00280836
Guadalupe Ortiz-Muñoz; Markus Brown; Catherine B. Carbone; Ximo Pechuan-Jorge; Vincent Rouilly; Henrik Lindberg; Alex T. Ritter; Gautham Raghupathi; Qianbo Sun; Tess Nicotra; Shreya R. Mantri; Angela Yang; Jonas Martin Doerr; Deepti R. Nagarkar; Spyros Darmanis; Benjamin Haley; Sanjeev Mariathasan; Wang; Carlos Gomez-Roca; Carlos Eduardo de Andrea; David Spigel; Thomas D Wu; Lélia Delamarre; Johannes Schöneberg; Zora Modrusan; Richard Price; Shannon J. Turley; Ira Mellman; Christine Moussion
Seminars in Immunology, ISSN: 10963618 10445323
Daniel Oreper; Susan Klaeger; Suchit Jhunjhunwala; Lélia Delamarre
Cell Reports Medicine, ISSN: 26663791
Aude-Hélène Capietto; Lélia Delamarre
Cell Reports Medicine,
Aude-Hélène Capietto; Lélia Delamarre
International Journal of Molecular Sciences, ISSN: 14220067
Aude-Hélène Capietto; Reyhane Hoshyar; Lélia Delamarre
International Journal of Molecular Sciences,
Aude-Hélène Capietto; Reyhane Hoshyar; Lélia Delamarre
International Journal of Molecular Sciences, ISSN: 14220067 16616596
Aude-Hélène Capietto; Reyhane Hoshyar; Lélia Delamarre
Nature Immunology, ISSN: 15292916 15292908
Siri Tahtinen; Ann-Jay Tong; Patricia Himmels; Jaehak Oh; Andres Paler Martinez; Leesun Kim; Sara Wichner; Yoko Oei; Mark J. McCarron; Emily C. Freund; Zhainib Adel Amir; Cecile C. de la Cruz; Benjamin Haley; Craig D. Blanchette; Jill Schartner; Weilan Ye; Mahesh Yadav; Ugur Sahin; Lélia Delamarre; Ira Mellman
Nature Reviews Cancer, ISSN: 14741768 1474175X
Suchit Jhunjhunwala; Christian Hammer; Lélia Delamarre
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Samuel B. Pollock; Christopher M. Rose; Martine Darwish; Romain Bouziat; Lélia Delamarre; Craig D. Blanchette; Jennie R. Lill
Journal of Experimental Medicine, ISSN: 15409538 00221007
Emily C. Freund; Jaclyn Y. Lock; Jaehak Oh; Timurs Maculins; Lélia Delamarre; Christopher J. Bohlen; Benjamin Haley; Aditya Murthy
OncoImmunology, ISSN: 21624011
Mathias Vormehr; Sophie M. Lehar; Lena M. Kranz; Siri Tahtinen; Yoko Oei; Vincent Javinal; Lélia Delamarre; Kerstin C. Walzer; Mustafa Diken; Sebastian Kreiter; Ira Mellman; Ugur Sahin; Jill Schartner; Özlem Türeci
Molecular and Cellular Oncology, ISSN: 23723556
Aude-Hélène Capietto; Suchit Jhunjhunwala; Lélia Delamarre
Journal of Experimental Medicine, ISSN: 15409538 00221007
Aude-Hélène Capietto; Suchit Jhunjhunwala; Samuel B. Pollock; Patrick J. Lupardus; Jim Wong; Lena Hänsch; James Cevallos; Yajun Chestnut; Ajay Fernandez; Nicolas Lounsbury; Tamaki Nozawa; Manmeet Singh; Zhiyuan Fan; Cecile C. de la Cruz; Qui Phung; Lucia Taraborrelli; Benjamin Haley; Jennie R. Lill; Ira Mellman; Richard Bourgon; Lélia Delamarre
Nature, ISSN: 14764687 00280836
Thomas D Wu; Shravan Madireddi; Patricia De Almeida; Romain Banchereau; Ying-Jiun J. Chen; Avantika S. Chitre; Eugene Y. Chiang; Hina Iftikhar; William E. O’Gorman; Amelia Au-Yeung; Chikara Takahashi; Leonard D. Goldstein; Chungkee Poon; Shilpa Keerthivasan; Denise De Almeida Nagata; Xiangnan Du; Hyang-Mi Lee; Karl L. Banta; Sanjeev Mariathasan; Meghna Das Thakur; Mahrukh Huseni; Ballinger; Ivette Estay; Patrick Caplazi; Zora Modrusan; Lélia Delamarre; Ira Mellman; Richard Bourgon; Jane L. Grogan
Science immunology, ISSN: 24709468
Emel Esen; Ismail Sergin; Rajiv Jesudason; Patricia Himmels; Webster; Hua Zhang; Min Xu; Robert Piskol; Erin McNamara; Stephen Gould; Aude-Hélène Capietto; Lélia Delamarre; Kevin B. Walsh; Weilan Ye
OncoImmunology, ISSN: 2162402X 21624011
Mathias Vormehr; Sophie M. Lehar; Lena M. Kranz; Siri Tahtinen; Yoko Oei; Vincent Javinal; Lélia Delamarre; Kerstin C. Walzer; Mustafa Diken; Sebastian Kreiter; Ira Mellman; Ugur Sahin; Jill Schartner; Özlem Türeci
Nature, ISSN: 14764687 00280836
Jonathan L. Linehan; Lélia Delamarre
Cancer immunology research, ISSN: 23266074 23266066
Huizhong Xiong; Stephanie Mittman; Ryan Rodriguez; Patricia Pacheco-Sanchez; Marina Moskalenko; Yagai Yang; Justin Elstrott; Alex T. Ritter; Sören Müller; Dorothee Nickles; Teresita L. Arenzana; Aude-Hélène Capietto; Lélia Delamarre; Zora Modrusan; Sascha Rutz; Ira Mellman; Rafael Cubas
Current Opinion in Immunology, ISSN: 18790372 09527915
Aude-Hélène Capietto; Suchit Jhunjhunwala; Lélia Delamarre
Proteomics, ISSN: 16159861 16159853
Frances-Rose Schumacher; Lélia Delamarre; Suchit Jhunjhunwala; Zora Modrusan; Qui Phung; Joshua E. Elias; Jennie R. Lill
Science, ISSN: 10959203 00368075
Mahesh Yadav; Lélia Delamarre
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Anand K. Katakam; Hans D. Brightbill; Christian Franci; Chung Kung; Victor Nunez; Charles Jones III; Ivan Peng; Surinc Er Jeet; Lawren C. Wu; Ira Mellman; Lélia Delamarre; Cary D. Austin
Science, ISSN: 10959203 00368075
Lélia Delamarre; Ira Mellman; Mahesh Yadav
Nature, ISSN: 14764687 00280836
Mahesh Yadav; Suchit Jhunjhunwala; Qui Phung; Patrick J. Lupardus; Josh Tanguay; Stephanie M. Bumbaca; Christian Franci; Tommy K. Cheung; Jens Fritsche; Toni Weinschenk; Zora Modrusan; Ira Mellman; Jennie R. Lill; Lélia Delamarre
Frontiers in Immunology, ISSN: 16643224
Lillian Cohn; Lélia Delamarre
Nature, ISSN: 14764687 00280836
Norihiro Nakamura; Jennie R. Lill; Qui Phung; Zhaoshi Jiang; Corey Bakalarski; Ann De Mazière; Judith Klumperman; Megan Schlatter; Lélia Delamarre; Ira Mellman
Journal of Experimental Medicine, ISSN: 15409538 00221007
Lillian Cohn; Bithi Chatterjee; Filipp Esselborn; Anna Smed-Sörensen; Norihiro Nakamura; Cecile Chalouni; Byoung-Chul Lee; Richard L. Vandlen; Tibor Keler; Peter Lauer; Dirk Brockstedt; Ira Mellman; Lélia Delamarre
Blood, ISSN: 15280020 00064971
Bithi Chatterjee; Anna Smed-Sörensen; Lillian Cohn; Cecile Chalouni; Richard L. Vandlen; Byoung-Chul Lee; Jenifer Widger; Tibor Keler; Lélia Delamarre; Ira Mellman
PLoS Pathogens, ISSN: 15537374 15537366
Anna Smed-Sörensen; Cecile Chalouni; Bithi Chatterjee; Lillian Cohn; Peter Blattmann; Norihiro Nakamura; Lélia Delamarre; Ira Mellman
Seminars in Immunology, ISSN: 10445323
Lélia Delamarre; Ira Mellman
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Craig D. Platt; Jessica K. Ma; Cecile Chalouni; Melanie Ebersold; Hani Bou-Reslan; Richard A. D. Carano; Ira Mellman; Lélia Delamarre
Immunobiology, ISSN: 01712985
Steven M. Becker; Lélia Delamarre; Ira Mellman; Norma W. Andrews
Journal of Cell Biology, ISSN: 00219525 00219525
Ona Bloom; Juli Unternaehrer; Aimin Jiang; Jeoung-Sook Shin; Lélia Delamarre; Patrick Allen; Ira Mellman
Education
- University Paris, France, Ph.D. in Virology – 1996