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Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 1 - 50 OF 11343 RESULTS

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October 8, 2018

Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors

Cancer Cell, ISSN: 18783686 15356108

Ivana Yen; Frances Shanahan; Mark Merchant; Christine Orr; Thomas Hunsaker; Matthew Durk; Hank La; Xiaolin Zhang; Scott Martin; Eva Lin; John Chan; Yihong Yu; Dhara Amin; Rich Neve; Amy Gustafson; Avinashnarayan Venkatanarayan; Scott A. Foster; Joachim Rudolph; Christiaan Klijn; Shiva Malek

October 3, 2018

High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants

mAbs, ISSN: 19420870 19420862

Danielle DiCara; Nisana Andersen; Ruby Chan; James Ernst; Gai Ayalon; Greg A. Lazar; Nicholas J. Agard; Amy Hilderbrand; Isidro Hotzel

October 1, 2018

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

Nature Cell Biology, ISSN: 14764679 14657392

Kristiaan J. Lenos; Daniël M. Miedema; Sophie C. Lodestijn; Lisanne E. Nijman; Tom van den Bosch; Xavier Romero Ros; Filipe C. Lourenço; Maria C. Lecca; Maartje van der Heijden; Sanne M. van Neerven; Anita van Oort; Nicolas Leveille; Ronja S. Adam; Felipe de Sousa e Melo; Joy Otten; Patrick Veerman; Guillaume Hypolite; Lianne Koens; Scott K. Lyons; Stassi; Douglas J. Winton; Jan Paul Medema; Edward Morrissey; Maarten F. Bijlsma; Louis Vermeulen

October 1, 2018

An automated mapping method for Nissl-stained mouse brain histologic sections

Journal of Neuroscience Methods, ISSN: 1872678X 01650270

Smadar Shiffman; Sayantani Basak; Cleopatra Kozlowski; Reina Fuji

October 1, 2018

Applying a weight of evidence approach to the evaluation of developmental toxicity of biopharmaceuticals

Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300

Meredith Rocca; LaRonda L. Morford; Diann Blanset; Wendy Halpern; Joy A. Cavagnaro; Christopher J. Bowman

October 1, 2018

Buffer exchange path influences the stability and viscosity upon storage of a high concentration protein

European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411

Mary E. Krause; Ajit Narang; Gregory Barker; Sibylle Herzer; Smeet Deshmukh; Wenkui Lan; Daniel Fichana; John M. Wasylyk; Bahar Demirdirek; Limin Zhang; John Fiske; Matthew McGann; Monica L. Adams; Rajesh B. Gandhi

October 1, 2018

Development and validation of a novel semi-homogenous clinical assay for quantitation of Ranibizumab in human serum

Journal of Immunological Methods, ISSN: 18727905 00221759

John Lowe; Eric Wakshull; Theresa Shek; Anan Chuntharapai; Rebecca Elliott; Jeriza Rusit; Mauricio Maia

September 19, 2018

Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer's disease (BLAZE)

Alzheimer's Research and Therapy, ISSN: 17589193

Stephen Salloway; Lee Honigberg; William Cho; Michael Ward; Michel Friesenhahn; Flavia Brunstein; Angelica Quartino; David Clayton; Deborah L. Mortensen; Tobias Bittner; Carole Ho; Christina Rabe; Stephen Schauer; Kristin Wildsmith; Reina Fuji; Shehnaaz Suliman; Eric M. Reiman; Kewei Chen; Robert Paul

September 18, 2018

Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain

Cell Reports, ISSN: 22111247

Girish Bankar; Samuel J. Goodchild; Sarah Howard; Karen Nelkenbrecher; Matthew Waldbrook; Michelle Dourado; Noah Shuart; Sophia Lin; Clint Young; Zhiwei Xie; Kuldip Khakh; Elaine Chang; Luis E. Sojo; Andrea Lindgren; Sultan Chowdhury; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Christoph Dehnhardt; Jodie Pang; Jae H. Chang; Brian Safina; Dan Sutherlin; James P. Johnson; David Hackos; C. Lee Robinette; Charles J. Cohen

September 18, 2018

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities

Cell Reports, ISSN: 22111247

Stephanie Grabow; Andrew J. Kueh; Francine Ke; Hannah K. Vanyai; Bilal N. Sheikh; Michael A. Dengler; William Chiang; Samantha Eccles; Ian M. Smyth; Lynelle K. Jones; Frederic De Sauvage; Mark Scott; Lachlan Whitehead; Voss; Andreas Strasser

September 15, 2018

Phase II study of Taselisib (GDC-0032) in combination with fulvestrant in patients with HER2-negative, hormone receptor–positive advanced breast cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Maura N. Dickler; Saura; Donald A. Richards; Ian E. Krop; Andrés Cervantes; Philippe L. Bedard; Manish R. Patel; Pusztai; Oliveira; Alison Cardenas; Na Cui; Tim Wilson; Thomas J. Stout; Michael C. Wei; Jerry Hsu; Baselga

September 15, 2018

Tumor elastography and its association with collagen and the tumor microenvironment

Clinical Cancer Research, ISSN: 15573265 10780432

Johannes Riegler; Yassin Labyed; Stephen Rosenzweig; Vincent Javinal; Alessandra Castiglioni; Claudia Dominguez; Jason E. Long; Qingling Li; Wendy Sandoval; Melissa Junttila; Shannon Turley; Jill Schartner; Rick Carano

September 13, 2018

Optimized arylomycins are a new class of Gram-negative antibiotics

Nature, ISSN: 14764687 00280836

Peter Smith; Michael F. T. Koehler; Hany S. Girgis; Donghong Yan; Yongsheng Chen; Yuan Chen; James J. Crawford; Matthew Durk; Robert I. Higuchi; Jing Kang; Jeremy Murray; Prasuna Paraselli; Summer Park; Wilson Phung; John Quinn; Tucker C. Roberts; Lionel Rouge; Jacob B. Schwarz; Elizabeth Skippington; John Wai; Min Xu; Zhiyong Yu; Hua Zhang; Man Wah Tan; Chris Heise

September 11, 2018

The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors

Science Signaling, ISSN: 19379145 19450877

Thijs Hagenbeek; Webster; Noelyn Kljavin; Matthew T. Chang; Trang Pham; Ho-June Lee; Christiaan Klijn; Allen G. Cai; Klara Totpal; Buvana Ravishankar; Naiying Yang; Da-Hye Lee; Kevin B. Walsh; Georgia Hatzivassiliou; Cecile de la Cruz; Stephen Gould; Xiumin Wu; Wyne P. Lee; Shuqun Yang; Zhixiang Zhang; Qingyang Gu; Qunsheng Ji; Erica Jackson; Dae-Sik Lim; Anwesha Dey

September 6, 2018

Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: A new treatment strategy for ibrutinib-resistant CLL

Blood, ISSN: 15280020 00064971

Sean D. Reiff; Elizabeth M. Muhowski; Daphne Guinn; Amy Lehman; Catherine A. Fabian; Carolyn Cheney; Rose Mantel; Lisa Smith; Amy J. Johnson; Wendy Young; Adam Johnson; Lichuan Liu; John C. Byrd; Jennifer A. Woyach

September 5, 2018

A phase Ib study of pictilisib (GDC-0941) in combination with paclitaxel, with and without bevacizumab or trastuzumab, and with letrozole in advanced breast cancer

Breast Cancer Research, ISSN: 1465542X 14655411

Patrick Schöffski; Sara Cresta; Ingrid A. Mayer; Hans Wildiers; Silvia Damian; Steven Gendreau; Isabelle Rooney; Kari Morrissey; Jill Spoerke; Vivian Ng; Stina Singel; Eric Winer

September 5, 2018

Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus

Science Translational Medicine, ISSN: 19466242 19466234

Emmanuel Clave; Itauá Leston Araujo; Cécile Alanio; Etienne Patin; Jacob Bergstedt; Alejandra Urrutia; Silvia Lopez-Lastra; Yan Li; Bruno Charbit; Cameron R. MacPherson; Milena Hasan; Breno Luiz Melo-Lima; Corinne Douay; Noémie Saut; Marine Germain; David-Alexandre Trégouët; Pierre-Emmanuel Morange; Magnus Fontes; Darragh Duffy; James P. Di Santo; Lluis Quintana-Murci; Matthew Albert; Antoine Toubert; Laurent Abel; Andres Alcover; Hugues Aschard; Kalle Aström; Philippe Bousso; Pierre Bruhns; Ana Cumano; Caroline Demangel; Ludovic Deriano; James Di Santo; Françoise Dromer; Darragh Duffy; Gérard Eberl; Jost Enninga; Jacques Fellay; Magnus Fontes; Antonio Freitas; Odile Gelpi; Ivo Gomperts-Boneca; Milena Hasan; Serge Hercberg; Olivier Lantz; Claude Leclerc; Hugo Mouquet; Etienne Patin; Sandra Pellegrini; Stanislas Pol; Antonio Rausell; Lars Rogge; Anavaj Sakuntabhai; Olivier Schwartz; Benno Schwikowski; Spencer Shorte; Vassili Soumelis; Frédéric Tangy; Eric Tartour; Antoine Toubert; Mathilde Touvier; M

September 4, 2018

Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates

Molecular Pharmaceutics, ISSN: 15438392 15438384

Zhonghua Pei; Chunjiao Chen; Jinhua Chen; Josefa Dela Cruz-Chuh; Reginald Delarosa; Yuzhong Deng; Aimee Fourie-O'Donohue; Isabel Figueroa; Jun Guo; Weiwei Jin; Cyrus Khojasteh; Kathy Kozak; Brandon Latifi; James Lee; Ginny Li; Eva Lin; Liling Liu; Jiawei Lu; Scott Martin; Carl Ng; Trung Nguyen; Rachana Ohri; Gail Phillips; Thomas Pillow; Rebecca K. Rowntree; Nicola Stagg; David Stokoe; Sheila Ulufatu; Vishal Verma; John Wai; Jing Wang; Keyang Xu; Zijin Xu; Hui Yao; Shang-Fan Yu; Donglu Zhang; Peter Dragovich

September 1, 2018

An empirical approach leveraging tumorgrafts to dissect the tumor microenvironment in renal cell carcinoma identifies missing link to prognostic inflammatory factors

Cancer Discovery, ISSN: 21598290 21598274

Tao Wang; Rong Lu; Payal Kapur; Bijay Jaiswal; Raquibul Hannan; Ze Zhang; Ivan Pedrosa; Jason Luke; He Zhang; Leonard Goldstein; Qurratulain Yousuf; Yi-Feng Gu; Tiffani McKenzie; Allison Joyce; Min S. Kim; Xinlei Wang; Danni Luo; Oreoluwa Onabolu; Christina Stevens; Zhiqun Xie; Mingyi Chen; Alexander Filatenkov; Jose Torrealba; Xin Luo; Wenbin Guo; Jingxuan He; Eric Stawiski; Zora Modrusan; Steffen Durinck; Somasekar Seshagiri; James Brugarolas

September 1, 2018

MicroRNA–mRNA regulatory networks underlying chronic mucus hypersecretion in COPD

European Respiratory Journal, ISSN: 13993003 09031936

Hataitip Tasena; Alen Faiz; Timens; Jacobien Noordhoek; Machteld N. Hylkema; Reinoud Gosens; Pieter S. Hiemstra; Avrum Spira; Dirkje S. Postma; Wei Tew; Michele A. Grimbaldeston; van den Berge; Irene H. Heijink; Brandsma

September 1, 2018

Progress in understanding slow inactivation speeds up

Journal of General Physiology, ISSN: 00221295

Jian Payandeh

September 1, 2018

Analytical Validation of a Hybrid Capture–Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA

Journal of Molecular Diagnostics, ISSN: 19437811 15251578

Travis Clark; Jon H. Chung; Mark Kennedy; Jason D. Hughes; Niru Chennagiri; Daniel S. Lieber; Bernard Fendler; Lauren Young; Mandy Zhao; Michael Coyne; Virginia Breese; Geneva Young; Amy Donahue; Dean Pavlick; Alyssa Tsiros; Timothy Brennan; Shan Zhong; Tariq Mughal; Mark Bailey; Jie He; Steven Roels; Garrett M Frampton; Jill Spoerke; Steven Gendreau; Mark Lackner; Erica Schleifman; Peters; Jeffrey S. Ross; Siraj M. Ali; Vincent A. Miller; Jeffrey P. Gregg; Phillip J. Stephens; Allison Welsh; Geoff A. Otto; Doron Lipson

September 1, 2018

Considerations from the innovation and quality induction working group in response to drug-drug interaction guidances from regulatory agencies: Focus on CYP3A4 mRNA in vitro response thresholds, variability, and clinical relevances

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Jane Kenny; Diane Ramsden; David Buckley; Shannon Dallas; Conrad Fung; Michael A. Mohutsky; Heidi J. Einolf; Liangfu Chen; Joshua G. DeKeyser; Maria Fitzgerald; Theunis C Goosen; Amy Siu; Robert L. Walsky; George Zhang; Donald J. Tweedie; Niresh Hariparsad

September 1, 2018

Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species

Analytical Biochemistry, ISSN: 10960309 00032697

Jing Wang; Ryan Takahashi; Kevin DeMent; Amy Gustafson; Jane Kenny; Simon G. Wong; Zhengyin Yan

September 1, 2018

Long-term survival follow-up of atezolizumab in combination with platinum-based doublet chemotherapy in patients with advanced non–small-cell lung cancer

European Journal of Cancer, ISSN: 18790852 09598049

Stephen V. Liu; D. Ross Camidge; Scott Gettinger; Giuseppe Giaccone; Rebecca S. Heist; F. Stephen Hodi; Neal E. Ready; Wei Zhang; Jeffrey Wallin; Roel Funke; Waterkamp; Paul Foster; Koho Iizuka; John D. Powderly

September 1, 2018

Safety and clinical activity of atezolizumab monotherapy in metastatic non-small-cell lung cancer: final results from a phase I study

European Journal of Cancer, ISSN: 18790852 09598049

Leora Horn; Scott Gettinger; Michael S. Gordon; Roy S. Herbst; Leena Gandhi; Enriqueta Felip; Lecia V. Sequist; David Spigel; Scott J. Antonia; Ani Balmanoukian; Philippe A. Cassier; Bo Liu; Marcin Kowanetz; Carol E. O'Hear; Marcella Fasso; William Grossman; Alan Sandler; Jean-Charles Soria

September 1, 2018

Zinc finger protein 521 regulates early hematopoiesis through cell-extrinsic mechanisms in the bone marrow microenvironment

Molecular and Cellular Biology, ISSN: 02707306

Courtney J. Fleenor; Tessa Arends; Hong Lei; Josefine Ahsberg; Kazuki Okuyama; Jacob Kuruvilla; Susana Cristobal; Jennifer L. Rabe; Ahwan Pandey; Thomas Danhorn; Desiree Straign; Joaquin M. Espinosa; Soren Warming; Eric Pietras; Mikael Sigvardsson; James R. Hagman

September 1, 2018

Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: Insights from the faSScinate clinical trial in systemic sclerosis

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

Christopher P. Denton; Voon H Ong; Shiwen Xu; Haiyin Chen; Zora Modrusan; Robert Lafyatis; Dinesh Khanna; Angelika Jahreis; Jeffrey Siegel; Thierry Sornasse

September 1, 2018

Comparative effectiveness of tocilizumab versus TNF inhibitors as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis after the use of at least one biologic disease-modifying antirheumatic drug: Analyses from the pan-European TOCERRA register collaboration

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

Kim Lauper; Dan C. Nordström; Karel Pavelka; Maria Victoria Hernández; Tore K. Kvien; Eirik Klami Kristianslund; Maria Jose Santos; Žiga Rotar; Florenzo Iannone; Catalin Codreanu; Galina Lukina; Sara Gale; Khaled Sarsour; Yves Luder; Delphine Sophie Courvoisier; Cem Gabay

September 1, 2018

Erratum to: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells (Nature Chemical Biology, (2018), 14, 6, (582-590), 10.1038/s41589-018-0035-2)

Nature Chemical Biology, ISSN: 15524469 15524450

Aaron Nile; Felipe de Sousa e Melo; Susmith Mukund; Robert Piskol; Simon Hansen; Lijuan Zhou; Yingnan Zhang; Yue Fu; Emily Gogol; László Kömüves; Zora Modrusan; Stephane Angers; Yvonne Franke; Chris Koth; Wayne Fairbrother; Weiru Wang; Frederic De Sauvage; Rami Hannoush

September 1, 2018

Patient-Reported Outcomes in OAK: A Phase III Study of Atezolizumab Versus Docetaxel in Advanced Non–Small-cell Lung Cancer

Clinical Lung Cancer, ISSN: 19380690 15257304

Rodolfo Bordoni; Fortunato Ciardiello; Joachim Von Pawel; Diego L Cortinovis; Thomas Karagiannis; Marcus Ballinger; Alan Sandler; Wei Yu; Pei He; Christina Matheny; Federico Felizzi; Achim Rittmeyer

August 21, 2018

Kinase domain dimerization drives RIPK3-dependent necroptosis

Science Signaling, ISSN: 19450877

Saravanan Raju; Dan Whalen; Meron Mengistu; Carter J. Swanson; John G. Quinn; Susan Taylor; Webster; Kim Newton; Andrey Shaw

August 17, 2018

Development of an Efficient Manufacturing Process for Reversible Bruton's Tyrosine Kinase Inhibitor GDC-0853

Organic Process Research and Development, ISSN: 10836160

Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Qingping Tian; Danial Beaudry; Jessica L. Defreese; Alec Fettes; Philippe James; David Linder; Sushant Malhotra; Chong Han; Remy Angelaud; Francis Gosselin

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