Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 551 - 600 OF 15166 RESULTS

Development of a semi-automated MHC-associated peptide proteomics (MAPPs) method using streptavidin bead-based immunoaffinity capture and nano LC-MS/MS to support immunogenicity risk assessment in drug development
Frontiers in Immunology,
M. Violet Lee; Ola M. Saad; Sylvia Wong; Jason LaMar; Lynn Kamen; Benjamin A. Ordonia; Rachel Melendez; Azadeh Hassanzadeh; Shan Chung; Surinder Kaur
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Assessment of CYP3A-mediated drug interaction via cytokine (IL-6) elevation for mosunetuzumab using physiologically-based pharmacokinetic modeling
CPT: Pharmacometrics and Systems Pharmacology,
Yuan Chen; Fang Ma; Nicholas Steven Jones; Rong Deng; Chunze Li; Chi-Chung Li
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High-Throughput Analyses of Therapeutic Antibodies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry Combined with SampleStream and Intact Protein Mass Spectrometry
Analytical Chemistry, ISSN: 00032700
Rachel Liuqing Shi; Michael A. Dillon; Philip D. Compton; William S. Sawyer; John R. Thorup; Mandy Kwong; Pamela Chan; Cecilia Chiu; Ran Li; Rajbharan Yadav; Genee Y. Lee; Joshua G. Gober; Zhiyu Li; Adel ElSohly; Ayse Meric Ovacik; James T. Koerber; Christoph Spiess; Jonathan L. Josephs; John C. Tran
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Current Status and Future Directions: The Application of Artificial Intelligence/Machine Learning for Precision Medicine
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Kunal Naik; Rahul K. Goyal; Luca Foschini; Choi Wai Chak; Christian Thielscher; Hao Zhu; James Lu; Joseph Lehár; Michael A. Pacanoswki; Nadia Terranova; Neha Mehta; Niklas Korsbo; Tala Fakhouri; Qi Liu; Jogarao Gobburu
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Characterization of Dye-Loaded Poly(lactic-co-glycolic acid) Nanoparticles by Comprehensive Two-Dimensional Liquid Chromatography Combining Hydrodynamic and Reversed-Phase Liquid Chromatography
Analytical Chemistry, ISSN: 00032700
Joshka Verduin; Luca Tutiš; Alexander J. Becking; Amin Famili; Kelly Zhang; Bob W. J. Pirok; Govert W. Somsen
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PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models
Journal of Medicinal Chemistry, ISSN: 00222623
Michael Berlin; Jennifer Cantley; Mark Bookbinder; Elizabeth Bortolon; Broccatelli; Greg Cadelina; Emily Chan; Huifen Chen; Xin Chen; Yun-Xing Cheng; Tommy K. Cheung; Kim Davenport; Dean DiNicola; Debbie Gordon; Brian D. Hamman; Alicia Harbin; Roy Haskell; Mingtao He; Alison J. Hole; Thomas Januario; Philip S. Kerry; Stefan G. Koenig; Limei Li; Mark Merchant; Inmaculada Pérez-Dorado; Jennifer Pizzano; Connor Quinn; Christopher M. Rose; Emma Rousseau; Leofal Soto; Leanna Staben; Hongming Sun; Qingping Tian; Jing Wang; Weifeng Wang; Crystal S. Ye; Ye; Penghong Zhang; Yuhui Zhou; Robert Yauch; Peter Dragovich
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Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation
Journal of the American Chemical Society, ISSN: 00027863
Justin H. Faris; Emel Adaligil; Nataliya Popovych; Satoshi Ono; Mifune Takahashi; Huy Nguyen; Emile G. Plise; Jaru Taechalertpaisarn; Hsiau-Wei Lee; Michael F. T. Koehler; Christian N. Cunningham; R. Scott Lokey
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Applying Natural Language Processing to ClinicalTrials.gov: mRNA cancer vaccine case study
Clinical and Translational Science, ISSN: 17528054
Bianca Vora; Denison Kuruvilla; Chloe Kim; Michael Wu; Colby S. Shemesh; Gillie A. Roth
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Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in- Class Therapy for Respiratory Disease
Journal of Medicinal Chemistry, ISSN: 00222623
Jack A. Terrett; Justin Ly; Paula Katavolos; Catrin Hasselgren; Steven Laing; Fiona Zhong; Elisia Villemure; Martin Déry; Larouche-Gauthier; Huifen Chen; Daniel G. Shore; Wyne P. Lee; Eric Suto; Kevin Johnson; Marjory B. Brooks; Alyssa Stablein; Francis Beaumier; Léa Constantineau-Forget; Chantal Grand-Maître; Luce Lépissier; Stéphane Ciblat; Claudio Sturino; Yong Chen; Baihua Hu; Justin Elstrott; Vineela D. Gandham; Victory Joseph; Helen Booler; Cain; Carolina Chou; Aaron Fullerton; Lepherd; Shannon Stainton; Elizabeth Torres; Konnie Urban; Lanlan Yu; Yu Zhong; Linda Bao; Kang-Jye Chou; Jessica Lin; Wei Zhang; Hank La; Liling Liu; Teresa Mulder; Jun Chen; Tania Chernov-Rogan; Adam R. Johnson; David Hackos; Rebecca Leahey; Shannon D. Shields; Alessia Balestrini; Lorena Riol-Blanco; Brian S. Safina; Matthew Volgraf; Steven Magnuson; Satoko Kakiuchi-Kiyota
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Multi-omic analysis of the tumor microenvironment shows clinical correlations in Ph1 study of atezolizumab +/- SoC in MM
Frontiers in Immunology, ISSN: 16643224
Sandy Wong; Habib Hamidi; Luciano J. Costa; Selma Bekri; Natalia Neparidze; Ravi Vij; Tina Nielsen; Aparna Raval; Rajan Sareen; Elisabeth Wassner-Fritsch; Hearn J. Cho
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Machine Learning-Based Quantification of Patient Factors Impacting Remission in Patients With Ulcerative Colitis: Insights from Etrolizumab Phase III Clinical Trials
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Rashed Harun; James Lu; Nastya Kassir; Wenhui Zhang
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Multiparametric Single-Vesicle Flow Cytometry Resolves Extracellular Vesicle Heterogeneity and Reveals Selective Regulation of Biogenesis and Cargo Distribution
ACS Nano, ISSN: 19360851
Ariana K. von Lersner; Fabiane Fernandes; Patricia MM Ozawa; Marques Jackson; Matthieu Masureel; Hoangdung Ho; Sierra M. Lima; Tatyana Vagner; Bong Hwan Sung; Mohamed Wehbe; Kai Franze; Heather H. Pua; John T. Wilson; Jonathan Irish; Alissa M. Weaver; Dolores Di Vizio; Andries Zijlstra
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Function-structure approach reveals novel insights on the interplay of Immunoglobulin G 1 proteoforms and Fc gamma receptor IIa allotypes
Frontiers in Immunology,
Steffen Lippold; Karishma Mistry; Sunidhi Lenka; Kevin Whang; Peilu Liu; Sebastian Pitschi; Felix Kuhne; Dietmar Reusch; Lance Cadang; Alexander Knaupp; Saeed Izadi; Alexis D. Dunkle; Feng Yang; Tilman Schlothauer
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A Continuing Clinical Education Course to Maintain Clinical Competencies and Foster New Clinical Knowledge During the Graduate School Years of MD-PhD Training
Journal of Clinical and Translational Science,
Graham D. Cochrane; Shima D. Anwar; Alice N. Weaver; Stephanie N. Brosius; Catherine H. Poholek; Heather Allen; Randy L. Seay; Robin G. Lorenz; Gregory Payne; William M. Geisler
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cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation
EMBO Journal, ISSN: 02614189
Fabian Schorn; J Paul Werthenbach; Mattes Hoffmann; Mila Daoud; Johanna Stachelscheid; Lars Schiffmann; Ximena Hildebrandt; Su Ir Lyu; Nieves Peltzer; Alexander Quaas; Domagoj Vucic; John Silke; Manolis Pasparakis; Hamid Kashkar
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Allosteric Inhibitors of the SARS-COV-2 Papain-like Protease Domain Induce Proteasomal Degradation of Its Parent Protein NSP3
ACS Chemical Biology, ISSN: 15548929
Peter E. Cockram; Benjamin T. Walters; Aaron Lictao; Frances Shanahan; Ingrid E. Wertz; Scott A. Foster; Joachim Rudolph
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Manufacturing Process for 6-Bromo-N,N-bis(4-methoxybenzyl)-4-methyl-5-(trifluoromethyl)pyridin-2-amine, a Key Intermediate in the Synthesis of KRAS G12C Inhibitor Divarasib
Organic Process Research and Development, ISSN: 10836160
Jeff Shen; Nicholas A. White; Qingping Tian; Lauren E. Sirois; Haiming Zhang; Francis Gosselin
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Probing the Protein-Excipient Interaction in the Orally Delivered Protein by Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry and Molecular Dynamics
Analytical Chemistry, ISSN: 00032700
Xiao Pan; Sunidhi Lenka; Jeff Davis; Karthik Nagapudi; Priscilla Mantik; Miguel Saggu; Lulu Dai; Lance Cadang; Hui-Min Zhang; Jennifer Zhang; Saeed Izadi; Feng Yang; Bingchuan Wei
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Real-world adherence and discontinuation among Medicare beneficiaries initiating venetoclax vs. BTKis in relapsed/refractory chronic lymphocytic leukemia
Leukemia and Lymphoma, ISSN: 10428194
Scott F Huntington; Beenish S. Manzoor; Justin T Puckett; Sachin Kamal-Bahl; Hasan Alhasani; Arliene Ravelo; Dureshahwar Jawaid; Jalpa A Doshi
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Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types
Nature Biotechnology, ISSN: 10870156
Hem R. Gurung; Amy Heidersbach; Martine Darwish; Pamela Pui Fung Chan; Jenny Li; Beresini; Oliver A. Zill; Andrew Wallace; Ann-Jay Tong; Daniel Hascall; Eric Torres; Andy Chang; Kenny ‘Hei-Wai’ Lou; Yassan Abdolazimi; Christian Hammer; Ana Xavier-Magalhães; Ana Marcu; Samir Vaidya; Daniel D. Le; Ilseyar Akhmetzyanova; Soyoung A. Oh; Amanda J. Moore; Uzodinma N. Uche; Melanie B. Laur; Richard J. Notturno; Peter J. R. Ebert; Craig D. Blanchette; Benjamin Haley; Christopher M. Rose
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Matrix effect in bioanalytical assay development using supercritical fluid chromatography-mass spectrometry
Biomedical chromatography : BMC, ISSN: 02693879
Liuxi Chen; Yuxiang Cui; Brian J. Dean; Xiaorong Liang
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Comparative effectiveness between mosunetuzumab monotherapy clinical trial and real-world data in relapsed/refractory follicular lymphoma in third or subsequent lines of systemic therapy
Leukemia and Lymphoma, ISSN: 10428194
Sarah F. McGough; Natasha Shamas; Jue Wang; Mahmoud Jaber; Binay Swarup; Marie-Hélène Blanchet Zumofen; Bertrand Lautié; Joana Parreira; Michael C. Wei; Ashwini Shewade
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Utilizing targeted integration CHO pools to potentially accelerate the GMP manufacturing of monoclonal and bispecific antibodies
Biotechnology Progress, ISSN: 87567938
Gavin Barnard; Michelle Zhou; Amy Shen; Inn H. Yuk; Mike Laird
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Population pharmacokinetics and pharmacodynamics of efmarodocokin alfa (IL-22Fc)
Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 1567567X
Yanke Yu; Michael E. Rothenberg; Han Ting Ding; Ari Brekkan; Gizette Sperinde; Brandon Harder; Rong Zhang; Ryan Owen; Nastya Kassir; Annemarie N. Lekkerkerker
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Evaluating hybrid controls methodology in early-phase oncology trials: A simulation study based on the MORPHEUS-UC trial
Pharmaceutical Statistics, ISSN: 15391604
Guanbo Wang; Melanie Poulin-Costello; Herbert Pang; Jiawen Zhu; Hans-Joachim Helms; Reyes-Rivera; Robert W. Platt; Menglan Pang; Artemis Koukounari
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Comprehensive Impurity Profiling of mRNA: Evaluating Current Technologies and Advanced Analytical Techniques
Analytical Chemistry, ISSN: 00032700
Julien Camperi; Steffen Lippold; Luladey Ayalew; Brian Roper; Stephanie Shao; Emily Freund; Ariane Nissenbaum; Carolina Galan; Qinjingwen Cao; Feng Yang; Christopher Yu; Axel Guilbaud
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No Recipe for Quantitative Systems Pharmacology Model Validation, but a Balancing Act Between Risk and Cost
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Vincent Lemaire; Chuanpu Hu; Van Der Graaf; Steve Chang; Weirong Wang
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Atezolizumab plus bevacizumab versus active surveillance in patients with resected or ablated high-risk hepatocellular carcinoma (IMbrave050): a randomised, open-label, multicentre, phase 3 trial
The Lancet, ISSN: 01406736
Shukui Qin; Minshan Chen; Ann-Lii Cheng; Ahmed O Kaseb; Masatoshi Kudo; Han Chu Lee; Adam Yopp; Jian Zhou; Lu Wang; Xiaoyu Wen; Jeong Heo; Won Young Tak; Shinichiro Nakamura; Numata; Thomas Uguen; David Hsiehchen; Edward Cha; Stephen P. Hack; Qinshu Lian; Ning Ma; Spahn; Wang; Chun Wu; Pierce Chow; Alexander Thompson; Mark Danta; Pirooz Poursoltan; Andrew Kiberu; Renuka Chittajallu; Siddarth Sood; Rudolf Stauber; Matthias Pinter; Markus Peck-Radosavljevic; Jochen Decaestecker; Cuyle; Gontran Verset; Hans Van Vlierberghe; Sergio De Azevedo; Livia Andrade; Ademar Cunha Júnior; Luiza Faria; Cheng Tzu Yen; Leandro Colli; Jamil Asselah; Petr Kavan; Vladimir Marquez; Mayur Brahmania; Qiang Li; Baocai Xing; Yabing Guo; Zhendong Chen; Haitao Zhao; Tao Peng; Liming Wang; Hongming Liu; Feixiang Wu; Lunxiu Qin; Qichang Zheng; Jieer Ying; Haitao Li; Tianfu Wen; Yunpeng Liu; Boqing Wang; Yuxian Bai; Yifu He; Hong Zhao; Dong Zhou; Chaoliu Dai; Gaojun Teng; Shuzhong Cui; Yi Gao; Xizhi Zhang; Zheng Lu; Tao Yin; Youming Ding; Weidong Jia; Yongxiang Xia; Beicheng Sun; Qiang Xia; Yufeng Yuan; Hui-Chan Sun; Xuetao Shi; Adrián Guzmán; Luis Corrales; Zdenek Kral; Priester; Eugen Kubala; Jean Frederic Blanc; Marc Bourliere; Jean Marie Peron; Borg; Jean-Pierre Bronowicki; Nathalie Ganne; Thomas Decaens; Alexandra Heurgue; Joerg Trojan; Maria Angeles Gonzalez-Carmona; Christoph Roderburg; Thomas Ettrich; Clemens Schotten; Arne Kandulski; Thomas Yau; Lam Chan; Mario Scartozzi; Gianluca Masi; Silvia Fanello; Pier Maria Battezzati; Francesco Leonardi; Michele Ghidini; Morimoto; Hisashi Hidaka; Kaoru Tsuchiya; Tatsuya Yamashita; Naoya Kato; Atsushi Hagihara; Hironori Koga; Tomohiro Arakawa; Ikuo Nakamura; Yusuke Kawamura; Tomokazu Kawaoka; Mitsuo Shimada; Kiyoshi Hasegawa; Hiroyuki Marusawa; Shinchiro Nakamura; Atsushi Hiraoka; Hiromitsu Hayashi; Shin Takeda; Seung Woon Paik; Do Young Kim; Jung Il Lee; Sook-Hyang Jeong; Won Kim; Hyeyeong Kim; Hong Jae Chon; Jaeyoun Cheong; Seung Kew Yoon; Jung-Hwan Yoon; Ricardo Villalobos; Jorge Luis Martinez Rodriguez; Victor Oyervides Juarez; Carlos Alberto Hernandez; Heinz-Josef Klumpen; Judith de Vos-Geelen; Edward J. Gane; Paola Montenegro; Cesar Torres Mattos; Ewa Janczewska; Maciej Kawecki; Ewa Nowakowska-Zajdel; Alexander Fedenko; Dmitrii Granov; Anna Alyasova; Marina Sekacheva; Evgeny Ledin; Jens Samol; Han Chong Toh; Mariona Calvo Campos; Carlos Gomez Martin; Carlos Lopez Lopez; Andres Jesus Muñoz Martin; Jose Luis Calleja Panero; Jose Luis Montero Alvarez; Maria Reig Monzón; Ignacio Delgado Mingorance; Beatriz Minguez Rosique; Ann Lii Cheng; Yi-Hsiang Huang; Shi-Ming Lin; Jee-Fu Huang; Ming-Lung Yu; Wei-Wen Su; Krittiya Korphaisarn; Kunlatida Maneenil; Chayanee Samdaengpan; Ekkapong Tharavichitkul; Mustafa Özgüroğlu; Kose; Hakan Harputluoglu; Gary L Buchschacher; Paul Thuluvath; Henry Xiong; Mital Patel; Philip Gold; Daneng Li; Gabriel Brooks; Ashiq Masood; Reema Patel; Ben George; Reena Salgia; Manji; Mary Crow; Ahmed Kaseb; Matthew Dugan; Kunal Kadakia; Adel Kardosh; John Gibbs; Ashesh Shah; Howard Burris III
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Lipid Tales: Optimizing Arylomycin Membrane Anchors
ACS Medicinal Chemistry Letters,
Michael F. T. Koehler; Yi-Chen Chen; Yongsheng Chen; Yuan Chen; James J. Crawford; Matthew Durk; Keira Garland; Emily J. Hanan; Robert I. Higuchi; Huiyong Hu; Cuong Q. Ly; Prasuna Paraselli; Tucker C. Roberts; Jacob B. Schwarz; Peter A. Smith; Zhiyong Yu; Christopher E. Heise
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Spatial host–microbiome sequencing reveals niches in the mouse gut
Nature Biotechnology, ISSN: 10870156
Britta Lötstedt; Martin Stražar; Ramnik J. Xavier; Aviv Regev; Sanja Vickovic
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Label-Free Composition Analysis of Supramolecular Polymer-Nanoparticle Hydrogels by Reversed-Phase Liquid Chromatography Coupled with a Charged Aerosol Detector
Analytical Chemistry, ISSN: 00032700
Shijia Tang; Zachary Pederson; Emily L. Meany; Chun-Wan Yen; Andrew K. Swansiger; James S. Prell; Bifan Chen; Abigail K. Grosskopf; Noah Eckman; Grace Jiang; Julie Baillet; Jackson D. Pellett; Eric A. Appel
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High-throughput protein binding assay using cross-sample pooling in combination with high-resolution mass spectrometry
Rapid Communications in Mass Spectrometry, ISSN: 10970231 09514198
Jingwei Cai; Julie Huang; Zhengyin Yan
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Surgical outcomes in people with hemophilia A taking emicizumab prophylaxis: experience from the HAVEN 1-4 studies
Blood advances, ISSN: 24739537 24739529
Kruse-Jarres; Flora Peyvandi; Johannes Oldenburg; Tiffany Chang; Sammy Chebon; Michelle Y. Doral; Stacy E. Croteau; Thierry Lambert; Kempton; Steven W Pipe; Richard H. Ko; Benjamin L. Trzaskoma; Dhalluin; Nives Selak Bienz; Markus Niggli; Michaela Lehle; Paz-Priel; Guy Young; Jiménez-Yuste
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Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Emily J. Hanan; Marie-Gabrielle Braun; Robert Heald; Calum Macleod; Connie Chan; Saundra Clausen; Kyle A. Edgar; Eigenbrot; Richard Elliott; Nicholas F. Endres; Lori S. Friedman; Emily Gogol; Xiao-Hui Gu; Rebecca Hong Thibodeau; Philip Jackson; James R. Kiefer; Jamie Knight; Michelle Nannini; Raman Narukulla; Amanda Pace; Jodie Pang; Hans E. Purkey; Laurent Salphati; Deepak Sampath; Stephen Schmidt; Steve Sideris; Kyung Song; Swathi Sujatha-Bhaskar; Ultsch; Heidi J. A. Wallweber; Jianfeng Xin; Siew Kuen Yeap; Amy Young; Yu Zhong; Steven T. Staben
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Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Matthew T. Cifone; Yongle He; Rajeswari Basu; Nan Wang; Shabnam Davoodi; Lauren A. Spagnuolo; Yuanyuan Si; Taraneh Daryaee; Craig E. Stivala; Stephen G. Walker; Peter J. Tonge
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Automated segmentation of lungs and lung tumors in mouse micro-CT scans
iScience, ISSN: 25890042
Gregory Z. Ferl; Kai H. Barck; Jasmine Patil; Skander Jemaa; Evelyn J. Malamut; Anthony Lima; Jason E. Long; Jason H. Cheng; Melissa Junttila; Richard A. D. Carano
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Impact of drug loading on the compaction properties of itraconazole-PVPVA amorphous solid dispersions
International Journal of Pharmaceutics, ISSN: 18733476 03785173
Wei Zhang; Kellie Sluga; Edward Yost; Jerry Phan; Karthik Nagapudi; Hao Helen Hou
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Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis
Science Translational Medicine, ISSN: 19466242 19466234
Joseph Chavarria-Smith; Cecilia P.C. Chiu; Janet Jackman; Jianping Yin; Juan Zhang; Jason A. Hackney; Wei-Yu Lin; Tulika Tyagi; Yonglian Sun; Janet Tao; Debra Dunlap; William D. Morton; Swapnil V. Ghodge; Henry R. Maun; Hong Li; Hilda Hernandez-Barry; Kelly M. Loyet; Emily Chen; John Liu; Christine Tam; Brian L. Yaspan; Hao Cai; Mercedesz Balazs; Joseph R. Arron; Jing Li; Arthur J. Wittwer; Rajita Pappu; Cary D. Austin; Wyne P. Lee; Robert A. Lazarus; Jawahar Sudhamsu; James T. Koerber; Tangsheng Yi
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Atezolizumab plus Bevacizumab versus Sorafenib for Unresectable Hepatocellular Carcinoma: Results from Older Adults Enrolled in the IMbrave150 Randomized Clinical Trial
Liver Cancer, ISSN: 16645553 22351795
Daneng Li; Han Chong Toh; Philippe Merle; Kaoru Tsuchiya; Sairy Hernandez; Wendy Verret; Alan Nicholas; Masatoshi Kudo
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Resonant acoustic mixing (RAM) for efficient mechanoredox catalysis without grinding or impact media
Chemical Communications, ISSN: 1364548X 13597345
Farshid Effaty; Lori Gonnet; Stefan G. Koenig; Karthik Nagapudi; Xavier Ottenwaelder; Tomislav Friščić
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Computationally-guided design and selection of high performing ribosomal active site mutants
Nucleic Acids Research, ISSN: 03051048
Camila Kofman; Andrew Watkins; Do Soon Kim; Jessica A Willi; Alexandra C Wooldredge; Ashty S Karim; Rhiju Das; Michael C Jewett
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Population-wide gene disruption in the murine lung epithelium via AAV-mediated delivery of CRISPR-Cas9 components
Molecular Therapy - Methods and Clinical Development, ISSN: 23290501
Chen; Durinck; Hetal Patel; Oded Foreman; Kathryn Mesh; Jeffrey Eastham; Roger Caothien; Robert J. Newman; Merone Roose-Girma; Spyros Darmanis; Søren Warming; Annalisa Lattanzi; Yuxin Liang; Benjamin Haley
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Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation
Nature, ISSN: 14764687 00280836
Mark Schmitt; Fatih Ceteci; Jalaj Gupta; Marina Pesic; Tim W. Böttger; Adele Nicolas; Kilian B. Kennel; Esther Engel; Matthias Schewe; Asude Callak Kirisözü; Valentina Petrocelli; Yasamin Dabiri; Julia Varga; Mallika Ramakrishnan; Madina Karimova; Andrea Ablasser; Toshiro Sato; Melek C. Arkan; Frederic J. De Sauvage; Florian R. Greten
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Characterization of Impurities in Therapeutic RNAs at the Single Nucleotide Level
Analytical Chemistry, ISSN: 15206882 00032700
Alexandre Goyon; Daniel Nguyen; Sara Boulanouar; Peter M. Yehl; Kelly Zhang
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Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration
Nature Communications, ISSN: 20411723
Gerhardy; Ultsch; Wanjian Tang; Evan M. Green; Jeffrey K. Holden; Wei Li; Alberto Estevez; Christopher P. Arthur; Irene Tom; Alexis Rohou; Daniel Kirchhofer
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Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors
Nature Communications,
Paul Beroza; James J. Crawford; Oleg Ganichkin; Leo Gendelev; Seth F. Harris; Raphael Klein; Anh Miu; Stefan Steinbacher; Franca-Maria Klingler; Christian Lemmen
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Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors
Nature Communications, ISSN: 20411723
Kristin M. Zimmerman Savill; Brian B. Lee; Jason Oeh; Jie Lin; Eva Lin; Wei-Jen Chung; Amy Young; Wennie Chen; Monika Miś; Kathryn Mesh; Jeffrey Eastham; Florian Gnad; Zhaoshi Jiang; Eric Stawiski; Benjamin Haley; Anneleen Daemen; Xiaojing Wang; Koeppen; Zora Modrusan; Scott E. Martin; Deepak Sampath; Kui Lin
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BMP1 is not required for lung fibrosis in mice
Scientific Reports, ISSN: 20452322
Hsiao-Yen Ma; Elsa-Noah N’Diaye; Patrick Caplazi; Zhiyu Huang; Alexander Arlantico; Surinc Er Jeet; Aaron Wong; Hans D. Brightbill; Qingling Li; Weng Wong; Wendy N. Sandoval; Lucinda Tam; Robert J. Newman; Merone Roose-Girma; Ning Ding
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Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors
Nature Communications, ISSN: 20411723
Paul Beroza; James J. Crawford; Oleg Ganichkin; Leo Gendelev; Seth F. Harris; Raphael Klein; Anh Miu; Stefan Steinbacher; Franca-Maria Klingler; Christian Lemmen
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Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel
Nature Communications, ISSN: 20411723
Cameron Noland; Han Chow Chua; Marc Kschonsak; Stephanie Andrea Heusser; Nina Braun; Timothy Chang; Christine Tam; Jia Tang; Christopher P. Arthur; Claudio Ciferri; Stephan Alexander Pless; Jian Payandeh
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