Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

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January 1, 2023

International consortium for innovation and quality: An industry perspective on the nonclinical and early clinical development of intravitreal drugs

Clinical and Translational Science, ISSN: 17528062 17528054

Ingrid M. Pruimboom-Brees; Swati Gupta; Nagendra V. Chemuturi; Helen Booler; Erik Nimz; Meg Ferrell Ramos; Antonello Caruso; Katie F. Maass; Vlad Bantseev; Qihong Huang; Mary P. Choules; Jesse C. Nussbaum; Jitendra Kanodia; Christopher Thompson; Chandrasekar Durairaj

January 1, 2023

High concentration formulation developability approaches and considerations

mAbs, ISSN: 19420862

Jonathan Zarzar; Tarik A. Khan; Maniraj Bhagawati; Benjamin Weiche; Jasmin Sydow-Andersen; Sreedhara Alavattam

January 1, 2023

Intraocular delivery considerations of ocular biologic products and key preclinical determinations

Expert Opinion on Drug Delivery, ISSN: 17447593 17425247

Patrick Hughes; Hongwen Rivers; Vlad Bantseev; Chun-Wan Yen; Hanns-Christian Mahler; Swati Gupta

January 1, 2023

Glycochenodeoxycholate and glycodeoxycholate 3-O-glucuronides, but not hexadecanedioate and tetradecanedioate, detected weak inhibition of OATP1B caused by GDC-0810 in humans

British Journal of Clinical Pharmacology, ISSN: 13652125 03065251

Yoshida; Allan Jaochico; Jialin Mao; Dewakar Sangaraju

January 1, 2023

Archway Phase 3 Trial of the Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration 2-Year Results

Ophthalmology, ISSN: 15494713 01616420

Carl D. Regillo; Brian Berger; Logan Brooks; W. Lloyd Clark; Robert Mittra; Charles C. Wykoff; Natalia F. Callaway; Stephanie DeGraaf; Han Ting Ding; Anne E. Fung; Shamika Gune; Sophie Le Pogam; Robert Smith; Jeffrey R. Willis; Giulio Barteselli

January 1, 2023

Physiologically-based pharmacokinetic/pharmacodynamic modeling to predict tumor growth inhibition and the efficacious dose of selective estrogen receptor degraders in humans

Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782

Anjani Ganti; Sijia Yu; Danielle Sharpnack; Ellen Ingalla; Tom De Bruyn

January 1, 2023

The oral selective estrogen receptor degrader GDC-0810 (ARN-810) in postmenopausal women with hormone receptor-positive HER2-negative (HR + /HER2 −) advanced/metastatic breast cancer

Breast Cancer Research and Treatment, ISSN: 15737217 01676806

Aditya Bardia; Ingrid A. Mayer; Eric P. Winer; Hannah M. Linden; Cynthia X. Ma; Barbara A. Parker; Meritxell Bellet; Carlos L. Arteaga; Sravanthi Cheeti; Mary Gates; Ching-Wei Chang; Jill Fredrickson; Jill M. Spoerke; Heather M. Moore; Jennifer M. Giltnane; Lori S. Friedman; Edna Chow-Maneval; Iris Chan; Komal Jhaveri

January 1, 2023

Prevalence of Macular Atrophy in the MARINA Study of Ranibizumab versus Sham for Neovascular Age-Related Macular Degeneration

Ophthalmology Retina, ISSN: 24686530

Barbara A. Blodi; Amitha Domalpally; Ellie Corkery; Aaron Osborne; Steven Blotner; Susanna M. Grzeschik; Shamika Gune

January 1, 2023

TACCO unifies annotation transfer and decomposition of cell identities for single-cell and spatial omics

Nature Biotechnology, ISSN: 15461696 10870156

Mages; Noa Moriel; Inbal Avraham-Davidi; Evan Murray; Jan Watter; Fei Chen; Orit Rozenblatt-Rosen; Johanna Klughammer; Aviv Regev; Mor Nitzan

January 1, 2023

Phase 1b study of cobimetinib plus atezolizumab in patients with advanced BRAFV600 wild-type melanoma progressing on prior anti–programmed death-1 therapy

European Journal of Cancer, ISSN: 18790852 09598049

Shahneen Sandhu; Victoria Atkinson; Maria González Cao; Theresa Medina; Ainara Soria Rivas; Alexander M. Menzies; Ivor Caro; Louise Roberts; Yuyao Song; Yibing Yan; Yu Guo; Cloris Xue; Georgina V. Long

January 1, 2023

Learning from data with structured missingness

Nature Machine Intelligence, ISSN: 25225839

Robin Mitra; Sarah F. McGough; Tapabrata Chakraborti; Chris Holmes; Ryan Copping; Niels Hagenbuch; Stefanie Biedermann; Jack Noonan; Brieuc Lehmann; Aditi Shenvi; Xuan Vinh Doan; David Leslie; Ginestra Bianconi; Ruben Sanchez-Garcia; Alisha Davies; Maxine Mackintosh; Eleni-Rosalina Andrinopoulou; Anahid Basiri; Chris Harbron; Ben D. MacArthur

January 1, 2023

Prognostic value of severe acute respiratory syndrome coronavirus-2 viral load and antibodies in patients hospitalized with COVID-19

Clinical and Translational Science, ISSN: 17528062 17528054

Rebecca N. Bauer; Anastasia Teterina; Haridha Shivram; Jacqueline McBride; Carrie M. Rosenberger; Fang Cai; Min Bao; Larry Tsai; Oliver Gordon; Ivan T. Lee; Jeffrey J. Wallin; Danielle Porter; Kavita Juneja; Gregory Camus; Ivan O. Rosas; Steffen Wildum

January 1, 2023

Astegolimab or Efmarodocokin Alfa in Patients with Severe COVID-19 Pneumonia: A Randomized, Phase 2 Trial∗

Critical Care Medicine, ISSN: 15300293 00903493

Michael Waters; James A. McKinnell; Andre C. Kalil; Greg S. Martin; Timothy G. Buchman; Wiebke Theess; Xiaoying Yang; Annemarie N. Lekkerkerker; Tracy Staton; Carrie M. Rosenberger; Rajita Pappu; Yehong Wang; Wenhui Zhang; Logan Brooks; Dorothy Cheung; Joshua Galanter; Hubert Chen; Divya Mohan; Melicent Peck

January 1, 2023

Publisher Correction: Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial (Nature Medicine, (2019), 25, 11, (1706-1714), 10.1038/s41591-019-0628-7)

Nature Medicine, ISSN: 1546170X 10788956

Thomas Powles; Mark Kockx; Alejo Rodriguez-Vida; Ignacio Durán; Simon J. Crabb; Michiel S Van Der Heijden; Bernadett Szabados; Albert Font Pous; Gwenaëlle Gravis; Urbano Anido Herranz; Andrew Protheroe; Alain Ravaud; Denis Maillet; Maria Jose Mendez; Cristina Suarez; Mark Linch; Aaron Prendergast; Pieter-Jan van Dam; Diana Stanoeva; Sofie Daelemans; Sanjeev Mariathasan; Joy S. Tea; Kelly Mousa; Romain Banchereau; Daniel Castellano

January 1, 2023

Exploring the Use of a Kinetic pH Calculation to Correct the ACAT Model with a Single Stomach Compartment Setting: Impact of Stomach Setting on Food Effect Prediction for Basic Compounds

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Po-Chang Chiang; Michael J. Dolton; Karthik Nagapudi; Jia Liu

January 1, 2023

Mass spectrometry-based multi-attribute method in protein therapeutics product quality monitoring and quality control

mAbs, ISSN: 19420870 19420862

Feng Yang; Jennifer Zhang; Alexander Buettner; Eva Vosika; Monica Sadek; Zhiqi Hao; Dietmar Reusch; Maximiliane Koenig; Wayman Chan; Anja Bathke; Hilary Pallat; Victor Lundin; Kepert; Patrick Bulau; Galahad Deperalta; Christopher Yu; Richard L Beardsley; Tura Camilli; Reed J. Harris; Stults

January 1, 2023

Combining regulated and constitutive protein expression significantly boosts protein expression by increasing productivity without affecting CHO cell growth

Biotechnology Progress, ISSN: 15206033 87567938

Cynthia Lam; Joe Carver; Domingos Ng; Dejin Zhan; Danming Tang; Thara Kandamkalam; Snedecor; Gavin Barnard; Amy Shen; Shahram Misaghi

January 1, 2023

Shared learning from a physiologically based pharmacokinetic modeling strategy for human pharmacokinetics prediction through retrospective analysis of Genentech compounds

Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782

Jialin Mao; Fang Ma; Jesse Yu; Tom De Bruyn; Miaoran Ning; Christine M. Bowman; Yuan Chen

January 1, 2023

Overall survival with first-line atezolizumab in combination with vemurafenib and cobimetinib in BRAFV600 mutation-positive advanced melanoma (IMspire150): second interim analysis of a multicentre, randomised, phase 3 study

The Lancet Oncology, ISSN: 14745488 14702045

Paolo A. Ascierto; Daniil Stroyakovskiy; Helen Gogas; Caroline Robert; Karl Lewis; Svetlana Protsenko; Rodrigo P Pereira; Thomas Eigentler; Piotr Rutkowski; Lev Demidov; Natalia Zhukova; Jacob Schachter; Yibing Yan; Ivor Caro; Christian Hertig; Cloris Xue; Lieke Kusters; Grant A McArthur; Ralf Gutzmer

January 1, 2023

Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis

Gut, ISSN: 14683288 00175749

Frank Wagner; John C. Mansfield; Annemarie N. Lekkerkerker; Yehong Wang; Mary E. Keir; Ajit Dash; Brandon Butcher; Brandon Harder; Luz D. Orozco; Jordan S. Mar; Hao Chen; Michael E. Rothenberg

January 1, 2023

From Logic-Respecting Efficacy Estimands to Logic-Ensuring Analysis Principle for Time-to-Event Endpoint in Randomized Clinical Trials with Subgroups

Statistics in Biopharmaceutical Research, ISSN: 19466315

Yi Liu; Miao Yang; Siyoen Kil; Jiang Li; Shoubhik Mondal; Yue Shentu; Hong Tian; Liwei Wang; Godwin Yung

January 1, 2023

ER+, HER2− advanced breast cancer treated with taselisib and fulvestrant: genomic landscape and associated clinical outcomes

Molecular Oncology, ISSN: 18780261 15747891

Jessica W. Chen; William Jacot; Javier Cortés; Ian E. Krop; Susan Dent; Nadia Harbeck; De Laurentiis; Diéras; Young-Hyuck Im; Thomas J. Stout; Frauke Schimmoller; Heidi Savage; Katherine E. Hutchinson; Wilson

January 1, 2023

Activation of the PERK branch of the unfolded protein response during production reduces specific productivity in CHO cells via downregulation of PDGFRa and IRE1a signaling

Biotechnology Progress, ISSN: 87567938

Brian M. Castellano; Danming Tang; Scot A. Marsters; Cynthia Lam; Peter S. Liu; Christopher M. Rose; Wendy N. Sandoval; Avi Ashkenazi; Snedecor; Shahram Misaghi

January 1, 2023

Green Chemistry Articles of Interest to the Pharmaceutical Industry

Organic Process Research and Development, ISSN: 1520586X 10836160

Marian C. Bryan; Charlotte Dalton; Alba Díaz-Rodríguez; Jaika Doerfler; Oliver D. Engl; Alejandro Gimenez Molina; Vanessa Harawa; Christopher B. Kelly; Wei Li; Rachel Munday; Jan Pawlas; Paul Richardson; William J. Smith; Alan Steven; Balaram S. Takale; Jack A. Terrett; Daniel S. Treitler; Mingshuo Zeng

January 1, 2023

Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer

Nature, ISSN: 00280836

Luis A. Rojas; Zachary Sethna; Kevin C. Soares; Cristina Olcese; Nan Pang; Erin Patterson; Jayon Lihm; Nicholas Ceglia; Pablo Guasp; Alexander Chu; Rebecca Yu; Adrienne Kaya Chandra; Theresa Waters; Jennifer Ruan; Masataka Amisaki; Abderezak Zebboudj; Zagaa Odgerel; George Payne; Evelyna Derhovanessian; Felicitas Müller; Ina Rhee; Mahesh Yadav; Anton Dobrin; Michel Sadelain; Marta Łuksza; Noah Cohen; Laura Tang; Olca Basturk; Mithat Gonen; Seth S. Katz; Richard Kinh Do; Andrew S. Epstein; Parisa Momtaz; Wungki Park; Ryan Sugarman; Anna M. Varghese; Elizabeth Won; Avni Desai; Alice C. Wei; Michael I. D’Angelica; T. Peter Kingham; Ira Mellman; Taha Merghoub; Jedd D Wolchok; Ugur Sahin; Özlem Türeci; Benjamin D. Greenbaum; William R. Jarnagin; Jeffrey Drebin; O'Reilly; Vinod P. Balachandran

January 1, 2023

Tetramer-aided sorting and single-cell RNA sequencing facilitate transcriptional profiling of antigen-specific CD8+ T cells

Translational Oncology, ISSN: 19365233

Kamalakannan Rajasekaran; Xiangnan Guan; Alireza Tafazzol; Habib Hamidi; Martine Darwish; Mahesh Yadav

January 1, 2023

Integrated summary of immunogenicity of polatuzumab vedotin in patients with relapsed or refractory B-cell non-Hodgkin’s lymphoma

Frontiers in Immunology, ISSN: 16643224

Randall Dere; Richard L. Beardsley; Dan Lu; Tong Lu; Grace Ku; Gabriel Man; Van Nguyen; Surinder Kaur

January 1, 2023

Advanced Technologies and Automation in mES Cell Workflow

Methods in Molecular Biology, ISSN: 19406029 10643745

Charles Yu; Roger Caothien; Marques Jackson; Brian Nakao; Anna Pham; Lucinda Tam; Merone Roose-Girma

January 1, 2023

Safety of adjuvant atezolizumab after pneumonectomy/bilobectomy in stage II-IIIA non–small cell lung cancer in the randomized phase III IMpower010 trial

Journal of Thoracic and Cardiovascular Surgery, ISSN: 1097685X 00225223

Jay M. Lee; Eric Vallières; Beiying Ding; Ann Johnson; Jan Bhagwakar; Sanam Rashidi; Qian (Cindy) Zhu; Barbara Gitlitz; Benny Weksler; Kimberly Costas; Nasser Altorki

January 1, 2023

Toward Quantitative Models in Safety Assessment: A Case Study to Show Impact of Dose–Response Inference on hERG Inhibition Models

International Journal of Molecular Sciences, ISSN: 14220067 16616596

Fjodor Melnikov; Lennart T. Anger; Catrin Hasselgren

January 1, 2023

Fostering a High-Functioning Team in Cancer Care Using the 4R Oncology Model: Assessment in a Large Health System and a Blueprint for Other Institutions

JCO Oncology Practice, ISSN: 26881535 26881527

Raymond Liu; Christine B. Weldon; Elizabeth Linehan; Nancy Gordon; Thea Abbe; Marti Hennings; Henie James; Jed Katzel; Chun Ng; Megumi Tomita; Jeffrey B. Velotta; Stephanie Ossowski; Lori C. Sakoda; Sharon Likely Sprague; Anna Dowling; Kimberly Beringer; Arliene Ravelo; Elaine Yu; Julia R. Trosman

January 1, 2023

Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling

Clinical and Translational Science, ISSN: 17528062 17528054

Stephanie N. Liu; Priya Agarwal; Katja Heinig; Asim Datye; Carolina Sturm-Pellanda; Andrea Crugnola; Marc Arca; Dale Miles

January 1, 2023

ASIS-Seq: Transgene Insertion Site Mapping by Nanopore Adaptive Sampling

Methods in Molecular Biology, ISSN: 19406029 10643745

Charles Yu; Roger Caothien; Anna Pham; Lucinda Tam; Tuija M. Alcantar; Natasha Bacarro; Juan Reyes; Marques Jackson; Brian Nakao; Merone Roose-Girma

January 1, 2023

MSstatsPTM: Statistical Relative Quantification of Posttranslational Modifications in Bottom-Up Mass Spectrometry-Based Proteomics

Molecular and Cellular Proteomics, ISSN: 15359484 15359476

Devon Kohler; Tsung-Heng Tsai; Erik Verschueren; Ting Huang; Trent Hinkle; Lilian Phu; Meena Choi; Olga Vitek

January 1, 2023

Psychometrics of patient-reported bother from side effects of treatment single-items in industry-sponsored oncology trials

Quality of Life Research, ISSN: 15732649 09629343

Peter C. Trask; Tracy Holt; Timothy Pearman

January 1, 2023

A frequentist approach to dynamic borrowing

Biometrical Journal, ISSN: 03233847

Ruilin Li; Ray S. Lin; Jiangeng Huang; Lu Tian; Jiawen Zhu

January 1, 2023

Mass Spectrometry-Based Tissue Imaging of the Tumor Microenvironment

Methods in Molecular Biology,

Tyler Risom; Patrick Chang; Sandra Rost; James Ziai

January 1, 2023

The role of bacterial membrane vesicles in antibiotic resistance

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Craig R. MacNair; Man-Wah Tan

January 1, 2023

Liposomal Permeation Assay for Droplet-Scale Pharmacokinetic Screening

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Juan Hu; Alix I Chan; Emel Adaligil; Ivy Kekessie; Mifune Takahashi; Aimin Song; Christian N. Cunningham; Brian M. Paegel

January 1, 2023

Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Jocelyn Chan; Joyce Chan; Lily Shao; Scott Stawicki; Victoria Pham; Robert W. Akita; Marc Hafner; Lisa Crocker; Kebing Yu; James T. Koerber; Gabriele Schaefer; Laetitia Comps-Agrar

January 1, 2023

An Interlaboratory Study to Identify Potential Visible Protein-Like Particle Standards

AAPS PharmSciTech, ISSN: 15309932

Srivalli N. Telikepalli; Michael J. Carrier; Dean C. Ripple; Greg Barnett; Ashwinkumar Bhirde; Donna Bolton; George M. Bou-Assaf; Erica Ferrari; Scott Leigh; Sophia Levitskaya-Seaman; Tim Menzen; Felix Nikels; Anna Riley; Miguel Saggu; Neha Sahni; Eric Vernooij; Klaus Wuchner

January 1, 2023

Effect of Buffer pH and Concentration on the Dissolution Rates of Sodium Indomethacin-Copovidone and Indomethacin-Copovidone Amorphous Solid Dispersions

Molecular Pharmaceutics, ISSN: 15438384

Cheng W. Chiang; Shijia Tang; Chen Mao; Yinshan Chen

January 1, 2023

Risks of Powder Flow Obstruction in Hopper and Bin Discharge in Solid Dosage Form Manufacture should be Predicted Under The Active Stress State

Journal of Pharmaceutical Sciences, ISSN: 00223549

Karthik Salish; Reto Maurer; Chen Mao

January 1, 2023

Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences

Xenobiotica, ISSN: 00498254

Michael J. Doerksen; Denny Seo; Alexander D. Smith; Robert S. Jones; Michael W. H. Coughtrie; Abby C. Collier

January 1, 2023

Estimation of conditional power in the presence of auxiliary data

Statistics in Medicine, ISSN: 02776715

Xin Li; Godwin Yung; Jianchang Lin; Jian Zhu

January 1, 2023

Totality of evidence of the effectiveness of repurposed therapies for COVID-19: Can we use real-world studies alongside randomized controlled trials?

Clinical and Translational Science, ISSN: 17528054

Jaap W. Mandema; Hugh Montgomery; Louis Dron; Shuai Fu; Estelle Russek-Cohen; Christina Bromley; Samer Mouksassi; Amy Lalonde; Aaron Springford; Larry Tsai; Phil Ambery; Doug McNair; Nawab Qizilbash; Stuart Pocock; Névine Zariffa

January 1, 2023

Synthesis of 3-Functionalized 4-Quinolones from Readily Available Anthranilic Acids

Organic Letters, ISSN: 15237060

Lin Deng; Julie A. Deichert; Sierra C. Nguyen; Ian S. Young; Chong Han

January 1, 2023

Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial

Nature Medicine, ISSN: 10788956

Jayesh Desai; Guzman Alonso; Se Hyun Kim; Andrés Cervantes; Thomas Karasic; Laura Medina; Einat Shacham-Shmueli; Rasha Cosman; Alejandro Falcon; Eelke Gort; Guren; Erminia Massarelli; Miller; Luis Paz-Ares; Hans Prenen; Alessio Amatu; Chiara Cremolini; Tae Won Kim; Victor Moreno; Sai-Hong I. Ou; Alessandro Passardi; Adrian Sacher; Armando Santoro; Rafal Stec; Susanna Ulahannan; Kathryn Arbour; Patricia M. LoRusso; Jia Luo; Manish R. Patel; Yoonha Choi; Shi; Sandhya Mandlekar; Mark T. Lin; Stephanie Royer-Joo; Julie Chang; Tomi Jun; Neekesh V. Dharia; Jennifer L. Schutzman; Sae-Won Han

January 1, 2023

Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)

Organic Process Research and Development, ISSN: 10836160

Paroma Chakravarty; Jie Xu; Brandon Scott; Sarah J. Robinson; Karthik Nagapudi

January 1, 2023

Alternative therapeutic strategies to treat antibiotic-resistant pathogens

Nature Reviews Microbiology, ISSN: 17401526

Craig R. MacNair; Steven T. Rutherford; Man-Wah Tan

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