Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 751 - 800 OF 15161 RESULTS

Prevalence and Progression of Macular Atrophy in Eyes with Neovascular Age-Related Macular Degeneration in the Phase 2 Ladder Trial of the Port Delivery System with Ranibizumab
Ophthalmology Retina, ISSN: 24686530
Glenn J. Jaffe; Briana Cameron; David Kardatzke; Jane Ives; Giulio Barteselli; Shamika Gune
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Sources of Cancer Neoantigens beyond Single-Nucleotide Variants
International Journal of Molecular Sciences, ISSN: 14220067 16616596
Aude-Hélène Capietto; Reyhane Hoshyar; Lélia Delamarre
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Atezolizumab versus chemotherapy in advanced or metastatic NSCLC with high blood-based tumor mutational burden: primary analysis of BFAST cohort C randomized phase 3 trial
Nature Medicine, ISSN: 1546170X 10788956
Solange Peters; Rafal Dziadziuszko; Alessandro Morabito; Enriqueta Felip; Shirish M. Gadgeel; Parneet Cheema; Manuel Cobo; Zoran Andric; Carlos H. Barrios; Masafumi Yamaguchi; Eric Dansin; Pongwut Danchaivijitr; Melissa L. Johnson; Silvia Novello; Michael Mathisen; Sarah M. Shagan; Erica Schleifman; Jin Wang; Mark Yan; Mocci; David Voong; David Fabrizio; David S. Shames; Todd Riehl; David R. Gandara; Tony Mok
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Scientific and Regulatory Policy Committee Points to Consider: Integration of Clinical Pathology Data With Anatomic Pathology Data in Nonclinical Toxicology Studies
Veterinary Clinical Pathology, ISSN: 1939165X 02756382
William Siska; A. Eric Schultze; Daniela Ennulat; Kathleen Biddle; Michael Logan; Adedeji; Tara Arndt; Adam Aulbach
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Population pharmacokinetic analysis of etrolizumab in patients with moderately-to-severely active ulcerative colitis
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Anita Moein; Tong Lu; Siv Jönsson; Jakob Ribbing; Nastya Kassir; Wenhui Zhang; Gizette Sperinde; Rong Zhang; Meina Tang; Young S. Oh; Rene Bruno; Rui Zhu
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Integrated systems modeling of severe asthma: Exploration of IL-33/ST2 antagonism
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Kapil Gadkar; Justin Feigelman; Siddharth Sukumaran; Manoj C. Rodrigo; Tracy Staton; Fang Cai; Rebecca N. Bauer; David F. Choy; Cynthia L. Stokes; Heleen Scheerens; Ramanujan
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Growth-rate model predicts in vivo tumor response from in vitro data
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Rocky Diegmiller; Laurent Salphati; Bruno Alicke; Wilson; Thomas J. Stout; Marc Hafner
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Changing the drug development and therapeutic paradigm with biologic drug combinations and bispecifics: How to choose between these two approaches?
Clinical and Translational Science, ISSN: 17528062 17528054
Songmao Zheng; Prell; Jennifer Sheng; Yow-Ming C. Wang; Lora Hamuro
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Patient-reported outcomes provide prognostic information for survival in patients with diffuse large B-cell lymphoma: Analysis of 1239 patients from the GOYA study
Cancer Medicine, ISSN: 20457634
Huang Huang; Asim Datye; Ming Fan; Andrea Knapp; Tina Nielsen; Alessia Bottos; Joseph N. Paulson; Peter C. Trask; Fabio Efficace
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Differences in Glucose Readings Between Right Arm and Left Arm Using a Continuous Glucose Monitor
Journal of Diabetes Science and Technology, ISSN: 19322968
Sonoko Kawakatsu; Xiaohan Liu; Brandon Tran; Brittany P. Tran; Lucy Manzanero; Eric Shih; Allen Shek; Jeremy Lim
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Plasmid-Based Donor Templates for Nonviral CRISPR/Cas9-Mediated Gene Knock-In in Human T Cells
Current Protocols, ISSN: 26911299
Kate Senger; Ilseyar Akhmetzyanova; Benjamin Haley; Sascha Rutz; Soyoung A. Oh
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Plasmid-Based Donor Templates for Nonviral CRISPR/Cas9-Mediated Gene Knock-In in Human T Cells
Current Protocols,
Kate Senger; Ilseyar Akhmetzyanova; Benjamin Haley; Sascha Rutz; Soyoung A. Oh
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Physiologically Based Pharmacokinetic Models Can Be Used to Predict the Unique Nonlinear Absorption Profiles of Vismodegib
Drug Metabolism and Disposition,
Louis Lin; Matthew Wright; Cornelis E. Hop; Harvey Wong
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Hydroxypropyl methyl cellulose derivatives stabilize fragment antibody against aggregation in spray dried formulations at elevated temperature and resist pH changes
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 09396411
Purnendu K. Nayak; Karthikan Rajagopal; Debby P. Chang
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Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes
American Journal of Respiratory and Critical Care Medicine,
Pamela Jane McDowell; John Busby; Catherine E. Hanratty; Ratko Djukanovic; Ashley Woodcock; Samantha Walker; Tim Hardman; Joseph R. Arron; David F. Choy; Peter Bradding; Chris E. Brightling; Rekha Chaudhuri; Douglas Cowan; Adel Mansur; Stephen J. Fowler; Sarah Diver; Peter H. Howarth; James Lordan; Andrew Menzies-Gow; Timothy Harrison; Douglas S. Robinson; Cécile T.J. Holweg; Matthews; Ian D. Pavord; Liam G. Heaney
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Pharmacokinetics, Pharmacodynamics, and Safety of Etrolizumab in Children With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease: Results from a Phase 1 Randomized Trial
Inflammatory Bowel Diseases,
Wenhui Zhang; Astrid Scalori; Franklin Fuh; Jacqueline McBride; Gaohong She; Jaroslaw Kierkus; Bartosz Korczowksi; Regan Li; Mariam Abouhossein; Alysha Kadva; Park; Meina Tao Tang
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Physiologically Based Pharmacokinetic Models Can Be Used to Predict the Unique Nonlinear Absorption Profiles of Vismodegib
Drug Metabolism and Disposition, ISSN: 1521009X
Louis Lin; Matthew Wright; Cornelis E. Hop; Harvey Wong
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Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970
Pamela Jane McDowell; John Busby; Catherine E. Hanratty; Ratko Djukanovic; Ashley Woodcock; Samantha Walker; Tim Hardman; Joseph R. Arron; David F. Choy; Peter Bradding; Chris E. Brightling; Rekha Chaudhuri; Douglas Cowan; Adel Mansur; Stephen J. Fowler; Sarah Diver; Peter H. Howarth; James Lordan; Andrew Menzies-Gow; Timothy Harrison; Douglas S. Robinson; Cécile T.J. Holweg; Matthews; Ian D. Pavord; Liam G. Heaney
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Pharmacokinetics, Pharmacodynamics, and Safety of Etrolizumab in Children With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease: Results from a Phase 1 Randomized Trial
Inflammatory Bowel Diseases, ISSN: 15364844
Wenhui Zhang; Astrid Scalori; Franklin Fuh; Jacqueline McBride; Gaohong She; Jaroslaw Kierkus; Bartosz Korczowksi; Regan Li; Mariam Abouhossein; Alysha Kadva; Park; Meina Tao Tang
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Using a peptide-based mass spectrometry approach to quantitate proteolysis of an intact heterogeneous procollagen substrate by BMP1 for antagonistic antibody screening
Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642
Cong Wu; Ryan Cook; Ping Wu; Neha Srikumar; Elin Chee; William S. Sawyer; Hua Wang; Meredith Hazen; Isidro Hötzel; Elsa-Noah N’Diaye; Ning Ding; Yichin Liu; John C. Tran; Zhengmao Ye
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New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Kathleen M. Giacomini; Sook Wah Yee; Megan L. Koleske; Ling Zou; Pär Matsson; Eugene C. Chen; Deanna L. Kroetz; Miles A. Miller; Elnaz Gozalpour; Xiaoyan Chu
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Mechanisms underlying DMARD inefficacy in difficult-to-treat rheumatoid arthritis: a narrative review with systematic literature search
Rheumatology,
Nadia M T Roodenrijs; Paco M J Welsing; Joël van Roon; Jan L M Schoneveld; Marlies C. van der Goes; György Nagy; Michael J. Townsend; Jacob M. Van Laar
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Mechanisms underlying DMARD inefficacy in difficult-to-treat rheumatoid arthritis: a narrative review with systematic literature search
Rheumatology, ISSN: 14620332
Nadia M T Roodenrijs; Paco M J Welsing; Joël van Roon; Jan L M Schoneveld; Marlies C. van der Goes; György Nagy; Michael J. Townsend; Jacob M. Van Laar
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Enduring undetectable MRD and updated outcomes in relapsed/refractory CLL after fixed-duration venetoclax-rituximab
Blood, ISSN: 00064971
John F. Seymour; Thomas J. Kipps; Barbara Eichhorst; D'Rozario; Carolyn J. Owen; Sarit E. Assouline; Nicole Lamanna; Tadeusz Robak; Javier De La Serna; Jaeger; Guillaume Cartron; Marco Montillo; Clemens H. Mellink; Brenda Chyla; Anesh Panchal; Tong Lu; Jenny Q. Wu; Yanwen Jiang; Marcus Lefebure; Michelle Boyer; Kater
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Enduring undetectable MRD and updated outcomes in relapsed/refractory CLL after fixed-duration venetoclax-rituximab
Blood, ISSN: 15280020 00064971
John F. Seymour; Thomas J. Kipps; Barbara Eichhorst; D'Rozario; Carolyn J. Owen; Sarit E. Assouline; Nicole Lamanna; Tadeusz Robak; Javier De La Serna; Jaeger; Guillaume Cartron; Marco Montillo; Clemens H. Mellink; Brenda Chyla; Anesh Panchal; Tong Lu; Jenny Q. Wu; Yanwen Jiang; Marcus Lefebure; Michelle Boyer; Kater
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GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Alexander M. Taylor; Christopher Bailey; Lisa D. Belmont; Robert Campbell; Nico Cantone; Alexandre Côté; Terry Crawford; Richard T Cummings; Kevin Dement; Martin Duplessis; Megan Flynn; Andrew C. Good; Hon-Ren Huang; Shivangi Joshi; Yves Leblanc; Jeremy Murray; Christopher G. Nasveschuk; Adrianne Neiss; Florence Poy; F. Anthony Romero; Peter Sandy; Yong Tang; Vickie Tsui; Laura E. Zawadzke; Robert J. Sims; James E. Audia; Steve Bellon; Steven Magnuson; Brian K Albrecht; Andrea G Cochran
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Determination of BET Specific Surface Area of Hydrate-Anhydrate Systems Susceptible to Phase Transformation Using Inverse Gas Chromatography
AAPS PharmSciTech,
Minhthi Bui; Karthik Nagapudi; Paroma Chakravarty
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Disease-associated oligodendrocyte responses across neurodegenerative diseases
Cell Reports, ISSN: 22111247
Shristi Pandey; Kimberle Shen; Seung-Hye Lee; Yun-An A. Shen; Yuanyuan Wang; Marcos Otero-Garcia; Natalya Kotova; Stephen T. Vito; Benjamin I. Laufer; Dwight F. Newton; Mitchell G. Rezzonico; Jesse E. Hanson; Joshua S. Kaminker; Christopher J. Bohlen; Tracy J. Yuen; Brad A. Friedman
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Disease-associated oligodendrocyte responses across neurodegenerative diseases
Cell Reports,
Shristi Pandey; Kimberle Shen; Seung-Hye Lee; Yun-An A. Shen; Yuanyuan Wang; Marcos Otero-Garcia; Natalya Kotova; Stephen T. Vito; Benjamin I. Laufer; Dwight F. Newton; Mitchell G. Rezzonico; Jesse E. Hanson; Joshua S. Kaminker; Christopher J. Bohlen; Tracy J. Yuen; Brad A. Friedman
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EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation
eLife, ISSN: 2050084X
Ariel Pribluda; Anneleen Daemen; Anthony Lima; Xi Wang; Marc Hafner; Chungkee Poon; Zora Modrusan; Anand K. Katakam; Oded Foreman; Jeffrey Eastham; Jeffrey Hung; Benjamin Haley; Julia T. Garcia; Erica L. Jackson; Melissa Junttila
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Development of Dual Practical Manufacturing Routes to Cognate Pyrrolobenzodiazepine-Based Linker-Drugs
Organic Process Research and Development, ISSN: 1520586X 10836160
Stefan G. Koenig; Remy Angelaud; Christopher M. Crittenden; Kenji Kurita; David J. Russell; Jean-Francois Marcoux; Thomas Matt; Francis Gosselin
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Importance of Green and Sustainable Chemistry in the Chemical Industry
Organic Process Research and Development, ISSN: 1520586X 10836160
Juan Colberg; King Kuok Hii; Stefan G. Koenig
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EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation
eLife,
Ariel Pribluda; Anneleen Daemen; Anthony Lima; Xi Wang; Marc Hafner; Chungkee Poon; Zora Modrusan; Anand K. Katakam; Oded Foreman; Jeffrey Eastham; Jeffrey Hung; Benjamin Haley; Julia T. Garcia; Erica L. Jackson; Melissa Junttila
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Single-cell analysis reveals clonally expanded tumor-associated CD57 +CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Michael Fehlings; Leesun Kim; Xiangnan Guan; Kobe Yuen; Alireza Tafazzol; Shomyseh Sanjabi; Oliver A. Zill; Deepali Rishipathak; Andrew Wallace; Alessandra Nardin; Siming Ma; Ana Milojkovic; Evan W. Newell; Sanjeev Mariathasan; Mahesh Yadav
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Engineered Cytochrome P450-Catalyzed Oxidative Biaryl Coupling Reaction Provides a Scalable Entry into Arylomycin Antibiotics
Journal of the American Chemical Society, ISSN: 15205126 00027863
Carmela Molinaro; Yukie Kawasaki; George Wanyoike; Taiki Nishioka; Tsuyoshi Yamamoto; Snedecor; Sarah J. Robinson; Francis Gosselin
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The impact of low adsorption surfaces for the analysis of DNA and RNA oligonucleotides
Journal of Chromatography A, ISSN: 18733778 00219673
Honorine Lardeux; Alexandre Goyon; Kelly Zhang; Jennifer M Nguyen; Matthew A Lauber; Davy Guillarme; Valentina D'Atri
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Analytical techniques for characterizing diastereomers of phosphorothioated oligonucleotides
Journal of Chromatography A, ISSN: 18733778 00219673
Tao Chen; Shijia Tang; Yige Fu; José G. Napolitano; Kelly Zhang
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The impact of low adsorption surfaces for the analysis of DNA and RNA oligonucleotides
Journal of Chromatography A, ISSN: 00219673
Honorine Lardeux; Alexandre Goyon; Kelly Zhang; Jennifer M Nguyen; Matthew A Lauber; Davy Guillarme; Valentina D'Atri
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Liquid chromatography coupled with photodiode array and a multivariate curve resolution – Alternating least square algorithm for identification and quantification of co-eluting impurities in pharmaceutical analysis
Journal of Chromatography A, ISSN: 18733778 00219673
Davide Vecchietti; Akira Nishio; Yuichiro Fujita; Takeshi Yoshida; Toshinobu Yanagisawa; Dawen Kou
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Liquid chromatography coupled with photodiode array and a multivariate curve resolution – Alternating least square algorithm for identification and quantification of co-eluting impurities in pharmaceutical analysis
Journal of Chromatography A, ISSN: 00219673
Davide Vecchietti; Akira Nishio; Yuichiro Fujita; Takeshi Yoshida; Toshinobu Yanagisawa; Dawen Kou
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First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors
Clinical Cancer Research, ISSN: 15573265 10780432
Tae Won Kim; Howard A. Burris; Maria J. de Miguel Luken; Pishvaian; Bang; Michael S. Gordon; Ahmad Awada; D. Ross Camidge; F. Stephen Hodi; Grant A. McArthur; Miller; Andrés Cervantes; Laura Q.M. Chow; Alexander M. Lesokhin; Annemie Rutten; Mario Sznol; Deepali Rishipathak; Shang-Chiung Chen; Stefanich; Tony Pourmohamad; Maria Anderson; Jeong Kim; Mahrukh Huseni; Ina Rhee; Siu
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Monitoring multiple quality attributes of a complex Fc-fusion protein during cell culture production processes by mD-LC-MS peptide mapping
Talanta, ISSN: 00399140
Julien Camperi; Sanket Dahotre; Davy Guillarme; Cinzia Stella
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First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors
Clinical Cancer Research, ISSN: 10780432
Tae Won Kim; Howard A. Burris; Maria J. de Miguel Luken; Pishvaian; Bang; Michael S. Gordon; Ahmad Awada; D. Ross Camidge; F. Stephen Hodi; Grant A. McArthur; Miller; Andrés Cervantes; Laura Q.M. Chow; Alexander M. Lesokhin; Annemie Rutten; Mario Sznol; Deepali Rishipathak; Shang-Chiung Chen; Stefanich; Tony Pourmohamad; Maria Anderson; Jeong Kim; Mahrukh Huseni; Ina Rhee; Siu
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Attached Nitrogen Test by 13C-14N Solid-State NMR Spectroscopy for the Structure Determination of Heterocyclic Isomers
Organic Letters, ISSN: 15237052 15237060
Rick W. Dorn; Brendan J. Wall; Sarah B. Ference; Sean R. Norris; Joseph W. Lubach; Aaron J. Rossini; Brett VanVeller
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Immune microenvironment characteristics in multiple myeloma progression from transcriptome profiling
Frontiers in Oncology, ISSN: 2234943X
Jin Wang; Yi Hu; Habib Hamidi; Cedric Dos Santos; Jingyu Zhang; Elizabeth A. Punnoose; Wenjin Li
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The “η-sweet-spot” (ηmax) in liquid-assisted mechanochemistry: polymorph control and the role of a liquid additive as either a catalyst or an inhibitor in resonant acoustic mixing (RAM)
Faraday Discussions, ISSN: 13645498 13596640
Lori Gonnet; Tristan H. Borchers; Cameron B. Lennox; Jogirdas Vainauskas; Yong Teoh; Hatem M. Titi; Christopher J. Barrett; Stefan G. Koenig; Karthik Nagapudi; Tomislav Friščić
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mRNA Display and Its Growing Potential in the Discovery of de Novo Therapeutic Peptide Candidates
ACS Symposium Series, ISSN: 19475918 00976156
Christina Helmling; Christian N. Cunningham
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mRNA Display and Its Growing Potential in the Discovery of de Novo Therapeutic Peptide Candidates
ACS Symposium Series, ISSN: 00976156
Christina Helmling; Christian N. Cunningham
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Preface
ACS Symposium Series, ISSN: 19475918 00976156
Swapnil V. Ghodge; Kaustav Biswas; Andrei A. Golosov
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NMR Spectroscopy for Studying Peptide Conformations and Cell Permeability
ACS Symposium Series, ISSN: 00976156
Kaustav Biswas; Andrei A. Golosov; Emel Adaligil; Wayne J. Fairbrother
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