Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 851 - 900 OF 15166 RESULTS

Designing antibodies as therapeutics
Cell, ISSN: 10974172 00928674
Paul J. Carter; Arvind Rajpal
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Stress-induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration
EMBO Journal, ISSN: 14602075 02614189
Elena Tortosa; Arundhati Sengupta Ghosh; Qingling Li; Weng Ruh Wong; Trent Hinkle; Wendy N. Sandoval; Christopher M. Rose; Casper C Hoogenraad
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Transcriptional Regulation of the Hippo Pathway: Current Understanding and Insights from Single-Cell Technologies
Cells, ISSN: 20734409
Sayantanee Paul; Shiqi Xie; Xiaosai Yao; Anwesha Dey
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Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation
Journal of Medicinal Chemistry,
Richard Zang; Aline Barth; Harvey Wong; Jan Marik; Jie Shen; Julie Lade; Kerri Grove; Matthew Durk; Neil Parrott; Patrick J. Rudewicz; Sylvia Zhao; Tao Wang; Zhengyin Yan; Donglu Zhang
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Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation
Journal of Medicinal Chemistry, ISSN: 15204804
Richard Zang; Aline Barth; Harvey Wong; Jan Marik; Jie Shen; Julie Lade; Kerri Grove; Matthew Durk; Neil Parrott; Patrick J. Rudewicz; Sylvia Zhao; Tao Wang; Zhengyin Yan; Donglu Zhang
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Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Richard Zang; Aline Barth; Harvey Wong; Jan Marik; Jie Shen; Julie Lade; Kerri Grove; Matthew Durk; Neil Parrott; Patrick J. Rudewicz; Sylvia Zhao; Tao Wang; Zhengyin Yan; Donglu Zhang
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Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
Cancer immunology research, ISSN: 23266074
Kyung-Min Lee; Chang-Ching Lin; Alberto Servetto; Joonbeom Bae; Vishal Kandagatla; Dan Ye; GunMin Kim; Dhivya R. Sudhan; Saurabh Mendiratta; Paula I. Gonzalez-Ericsson; Justin M. Balko; Jeon Lee; Spencer Barnes; Venkat S. Malladi; Siamak Tabrizi; Sangeetha M. Reddy; Seoyun Yum; Ching-Wei Chang; Katherine E. Hutchinson; Susan E. Yost; Yuan Yuan; Zhijian J. Chen; Yang-Xin Fu; Ariella B. Hanker; Carlos L. Arteaga
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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-tune Virtual Microdissection
Journal of Visualized Experiments, ISSN: 1940087X
Veronica Ibarra-Lopez; Sangeeta Jayakar; Yeqing Angela Yang; Ciara Martin; Zora Modrusan; Sandra Rost
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Replication of Overall Survival, Progression-Free Survival, and Overall Response in Chemotherapy Arms of Non-Small Cell Lung Cancer Trials Using Real-World Data
Clinical Cancer Research, ISSN: 10780432
Ton; Navdeep Pal; Huong Trinh; Sami Mahrus; Michael T. Bretscher; Robson J. M. Machado; Natalia Sadetsky; Nayan Chaudhary; Michael W. Lu; Gregory J. Riely
View on Scopus
Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
Cancer immunology research,
Kyung-Min Lee; Chang-Ching Lin; Alberto Servetto; Joonbeom Bae; Vishal Kandagatla; Dan Ye; GunMin Kim; Dhivya R. Sudhan; Saurabh Mendiratta; Paula I. Gonzalez-Ericsson; Justin M. Balko; Jeon Lee; Spencer Barnes; Venkat S. Malladi; Siamak Tabrizi; Sangeetha M. Reddy; Seoyun Yum; Ching-Wei Chang; Katherine E. Hutchinson; Susan E. Yost; Yuan Yuan; Zhijian J. Chen; Yang-Xin Fu; Ariella B. Hanker; Carlos L. Arteaga
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Efficacy, safety, and tolerability of lebrikizumab in adolescent patients with uncontrolled asthma (ACOUSTICS)
Clinical and Translational Allergy,
Stanley J. Szefler; Graham Roberts; Adalberto S. Rubin; Stefan Zielen; Piotr Kuna; Oral Alpan; Judith Anzures-Cabrera; Qiang Chen; Cécile T.J. Holweg; Janusz Kaminski; Wendy Putnam; Matthews; Nikhil Kamath
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Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study
Haematologica, ISSN: 15928721 03906078
Lale Kostakoglu; Federico Mattiello; Maurizio Martelli; Laurie H. Sehn; David Belada; Chiara Ghiggi; Neil Chua; Eva González-Barca; Xiaonan Hong; Antonio Pinto; Yuan-Kai Shi; Yoichi Tatsumi; Christopher R. Bolen; Andrea Knapp; Gila Sellam; Tina Nielsen; Deniz Sahin; Umberto Vitolo; Marek Trneny
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A phase IV, multicentre, open-label study of emicizumab prophylaxis in people with haemophilia A with or without FVIII inhibitors undergoing minor surgical procedures
Haemophilia, ISSN: 13652516 13518216
Miguel Escobar; Amy Dunn; Doris Quon; Benjamin L. Trzaskoma; Lucy Lee; Richard H. Ko; Shannon L. Carpenter
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Transcriptional Regulation of the Hippo Pathway: Current Understanding and Insights from Single-Cell Technologies
Cells, ISSN: 20734409
Sayantanee Paul; Shiqi Xie; Xiaosai Yao; Anwesha Dey
View on Scopus
Immune contexture of paediatric cancers
European Journal of Cancer, ISSN: 18790852 09598049
Meghna Das Thakur; Carl Franz; Laura Brennan; Jurriaan Brouwer-Visser; Rachel Tam; Konstanty Korski; Koeppen; James Ziai; Galina Babitzki; Dominique Ranchere-Vince; Alexandre Vasiljevic; Frédérique Dijoud; Perrine Marec-Bérard; Isabelle Rochet; Michael A. Cannarile; Aurélien Marabelle
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Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Aprajita S. Yadav; Faith Stevison; Mika Kosaka; Susan C. Wong; Jane R. Kenny; John K. Amory; Nina Isoherranen
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Efficacy, safety, and tolerability of lebrikizumab in adolescent patients with uncontrolled asthma (ACOUSTICS)
Clinical and Translational Allergy, ISSN: 20457022
Stanley J. Szefler; Graham Roberts; Adalberto S. Rubin; Stefan Zielen; Piotr Kuna; Oral Alpan; Judith Anzures-Cabrera; Qiang Chen; Cécile T.J. Holweg; Janusz Kaminski; Wendy Putnam; Matthews; Nikhil Kamath
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Combinatorial Use of Therapeutic ELP-Based Micelle Particles in Tissue Engineering
Advanced Healthcare Materials, ISSN: 21922659 21922640
Beyza Bulutoglu; Aylin Acun; Sarah L. Deng; Safak Mert; Elise Lupon; Alexandre G. Lellouch; Curtis L. Cetrulo; Basak E. Uygun; Martin L. Yarmush
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Evaluating the IVIVC by Combining Tiny-tim Outputs and Compartmental PK Model to Predict Oral Exposure for Different Formulations of Ibuprofen
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Po-Chang Chiang; Jia Liu; Karthik Nagapudi; Ricky Wu; Michael J. Dolton; Niloufar Salehi; Gregory Amidon
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Best Practices for Aggregate Quantitation of Antibody Therapeutics by Sedimentation Velocity Analytical Ultracentrifugation
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
George M. Bou-Assaf; Ivan L. Budyak; Michael D. Brenowitz; Eric S. Day; David Hayes; John J. Hill; Ranajoy Majumdar; Paola Ringhieri; Peter Schuck; Jasper C. Lin
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Release Mechanisms and Practical Percolation Threshold for Long-acting Biodegradable Implants: An Image to Simulation Study
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Shawn Zhang; Karthik Nagapudi; Mike Shen; Joshua Lomeo; Yuri Qin; Aiden Zhu; Purnendu K. Nayak; Debby P. Chang; Rami N. Hannoush
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Investigation of Quantitative X-ray Microscopy for Assessment of API and Excipient Microstructure Evolution in Solid Dosage Processing
AAPS PharmSciTech, ISSN: 15309932
Aiden Zhu; Chen Mao; Paul E. Luner; Joshua Lomeo; Chi So; Stephanie Marchal; Shawn Zhang
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Magnetic Resonance Enterography and Histology in Patients With Fibrostenotic Crohn's Disease: A Multicenter Study
Clinical and Translational Gastroenterology,
Coimbra; Rimola; Miriam Cuatrecasas; Gert De Hertogh; Gert A. Van Assche; Vanslembrouck; Henning Glerup; Agnete Hedemann Nielsen; Rikke Hagemann-Madsen; Yoram Bouhnik; Magaly Zappa; Dominique Cazals-Hatem; Geert R.A.M. D'Haens; Jaap Stoker; Sybren Meijer; Gerhard Rogler; Andreas Boss; Achim Weber; Rui Zhao; Mary E. Keir; Alexis Scherl; De Crespigny; Timothy T. Lu; Julián Panés
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Standardized Processing for Formalin-Fixed, Paraffin-Embedded Cell Pellet Immunohistochemistry Controls
Journal of Visualized Experiments, ISSN: 1940087X
Charles Havnar; Kathy Hötzel; Carmina Espiritu; Amy A. Lo; Webster
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Correction to: Assessment of the Cost-Effectiveness of HER2-Targeted Treatment Pathways in the Neoadjuvant Treatment of High-Risk HER2-Positive Early-Stage Breast Cancer (Advances in Therapy, (2022), 39, 3, (1375-1392), 10.1007/s12325-022-02047-y)
Advances in Therapy, ISSN: 18658652 0741238X
Jesse Sussell; Joshua A. Roth; Craig S. Meyer; Fung; Svenn A. Hansen
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ortho-Quinone drugs go pro
Nature Chemistry, ISSN: 17554330
Thomas H. Pillow
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Spontaneous Findings in the Reproductive System of Sexually Mature Male Cynomolgus Macaques
Toxicologic Pathology, ISSN: 15331601 01926233
Justin D. Vidal; Manoj Bhaskaran; Mary Carsillo; Steve Denham; Olivia Dubay; Steven T. Laing; Balasubramanian Manickam; Stephanie Phillips; Jonathan Werner; Armando R. Irizarry Rovira
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Channeling effects in the prescription of new therapies: the case of emicizumab for hemophilia A
Journal of Comparative Effectiveness Research, ISSN: 20426305
Arash Mahajerin; Imi Faghmous; Peter Kuebler; Monet Howard; Tao Xu; Carlos Flores; Tiffany Chang; Francis Nissen
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Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition
Gut, ISSN: 14683288
Raghav Sundar; Kie-Kyon Huang; Vikrant Kumar; Kalpana Ramnarayanan; Deniz Demircioglu; Zhisheng Her; Xuewen Ong; Zul Fazreen Bin Adam Isa; Manjie Xing; Angie Lay-Keng Tan; David Wai Meng Tai; Su Pin Choo; Weiwei Zhai; Jia Qi Lim; Meghna Das Thakur; Luciana L. Molinero; Edward Cha; Marcella Fassò; Monica Niger; Filippo Pietrantonio; Jeeyun Lee; Anand D. Jeyasekharan; Aditi Qamra; Radhika Patnala; Arne Fabritius; Mark De Simone; Joe Yeong; Cedric Chuan Young Ng; Sun Young Rha; Yukiya Narita; Kei Muro; Yu Amanda Guo; Anders Jacobsen Skanderup; Jimmy Bok Yan So; Wei Peng Yong; Qingfeng Chen; Jonathan Göke; Patrick Tan
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Population Pharmacokinetics and Exposure-Response Relationships of Astegolimab in Patients With Severe Asthma
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Naoki Kotani; Michael J. Dolton; Robin J Svensson; Jakob Ribbing; Lena E. Friberg; Shweta Vadhavkar; Dorothy S. Cheung; Tracy Staton; Gizette Sperinde; Jin Jin; Wendy Putnam; Angelica Quartino
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Combination of Atezolizumab and Tazemetostat in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Results From a Phase Ib Study
Clinical Lymphoma, Myeloma and Leukemia, ISSN: 21522669 21522650
M. Lia Palomba; Guillaume Cartron; Leslie L. Popplewell; Vincent Ribrag; Jason Westin; Huw; Shefali Agarwal; Mahesh Shivhare; Wan-Jen Hong; Aparna Raval; Alice C. Chang; Elicia M. Penuel; Morschhauser
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Combination of Atezolizumab and Obinutuzumab in Patients with Relapsed/Refractory Follicular Lymphoma and Diffuse Large B‐Cell Lymphoma: Results from a Phase 1b Study
Clinical Lymphoma, Myeloma and Leukemia, ISSN: 21522669 21522650
M. Lia Palomba; Brian G. Till; Steven I. Park; Morschhauser; Guillaume Cartron; Reinhard Marks; Mahesh Shivhare; Wan-Jen Hong; Aparna Raval; Alice C. Chang; Elicia M. Penuel; Leslie L. Popplewell
View on Scopus
Magnetic Resonance Enterography and Histology in Patients With Fibrostenotic Crohn's Disease: A Multicenter Study
Clinical and Translational Gastroenterology, ISSN: 2155384X
Coimbra; Rimola; Miriam Cuatrecasas; Gert De Hertogh; Gert A. Van Assche; Vanslembrouck; Henning Glerup; Agnete Hedemann Nielsen; Rikke Hagemann-Madsen; Yoram Bouhnik; Magaly Zappa; Dominique Cazals-Hatem; Geert R.A.M. D'Haens; Jaap Stoker; Sybren Meijer; Gerhard Rogler; Andreas Boss; Achim Weber; Rui Zhao; Mary E. Keir; Alexis Scherl; De Crespigny; Timothy T. Lu; Julián Panés
View on Scopus
Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
Cancer immunology research, ISSN: 23266074 23266066
Kyung-Min Lee; Chang-Ching Lin; Alberto Servetto; Joonbeom Bae; Vishal Kandagatla; Dan Ye; GunMin Kim; Dhivya R. Sudhan; Saurabh Mendiratta; Paula I. González Ericsson; Justin M. Balko; Jeon Lee; Spencer Barnes; Venkat S. Malladi; Siamak Tabrizi; Sangeetha M. Reddy; Seoyun Yum; Ching-Wei Chang; Katherine E. Hutchinson; Susan E. Yost; Yuan Yuan; Zhijian J. Chen; Yang-Xin Fu; Ariella B. Hanker; Carlos L. Arteaga
View on Scopus
Channeling effects in the prescription of new therapies: the case of emicizumab for hemophilia A
Journal of Comparative Effectiveness Research, ISSN: 20426313 20426305
Arash Mahajerin; Imi Faghmous; Peter Kuebler; Monet Howard; Tao Xu; Carlos Flores; Tiffany Chang; Francis Nissen
View on Scopus
Correction to: Assessment of the Cost-Effectiveness of HER2-Targeted Treatment Pathways in the Neoadjuvant Treatment of High-Risk HER2-Positive Early-Stage Breast Cancer (Advances in Therapy, (2022), 39, 3, (1375-1392), 10.1007/s12325-022-02047-y)
Advances in Therapy, ISSN: 18658652 0741238X
Jesse A. Sussell; Joshua A. Roth; Craig S. Meyer; Fung; Svenn A. Hansen
View on Scopus
Replication of Overall Survival, Progression-Free Survival, and Overall Response in Chemotherapy Arms of Non-Small Cell Lung Cancer Trials Using Real-World Data
Clinical Cancer Research, ISSN: 15573265 10780432
Ton; Navdeep Pal; Huong Trinh; Sami Mahrus; Michael T. Bretscher; Robson J. M. Machado; Natalia Sadetsky; Nayan Chaudhary; Michael W. Lu; Gregory J. Riely
View on Scopus
ortho-Quinone drugs go pro
Nature Chemistry, ISSN: 17554349 17554330
Thomas H. Pillow
View on Scopus
Spectroscopy-Based Local Modeling Method for High-Throughput Quantification of Nucleic Acid Loading in Lipid Nanoparticles
Analytical Chemistry, ISSN: 00032700
Yuchen Fan; Zhenqi Shi; Shengli Ma; Sayyeda Zeenat A. Razvi; Yige Fu; Tao Chen; Jason Gruenhagen; Kelly Zhang
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Spectroscopy-Based Local Modeling Method for High-Throughput Quantification of Nucleic Acid Loading in Lipid Nanoparticles
Analytical Chemistry, ISSN: 15206882 00032700
Yuchen Fan; Zhenqi Shi; Shengli Ma; Sayyeda Zeenat A. Razvi; Yige Fu; Tao Chen; Jason Gruenhagen; Kelly Zhang
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Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers
eLife,
Vladislav Belyy; Iratxe Zuazo-Gaztelu; Andrew Alamban; Avi Ashkenazi; Peter Walter
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Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers
eLife, ISSN: 2050084X
Vladislav Belyy; Iratxe Zuazo-Gaztelu; Andrew Alamban; Avi Ashkenazi; Peter Walter
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Activation-Induced Cytidine Deaminase Impacts the Primary Antibody Repertoire in Naive Mice
Journal of Immunology, ISSN: 00221767
Katherine Bao; Juan Zhang; Alexis Scherl; James Ziai; Azi Hadadianpour; Daqi Xu; Christopher Dela Cruz; John Liu; Yuxin Liang; Lucinda Tam; Cesar A. Corzo; Merone Roose-Girma; Søren Warming; Zora Modrusan; Wyne P. Lee; Kam Hon Hoi; Ali A. Zarrin
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Activation-Induced Cytidine Deaminase Impacts the Primary Antibody Repertoire in Naive Mice
Journal of Immunology, ISSN: 15506606 00221767
Katherine Bao; Juan Zhang; Alexis Scherl; James Ziai; Azi Hadadianpour; Daqi Xu; Christopher Dela Cruz; John Liu; Yuxin Liang; Lucinda Tam; Cesar A. Corzo; Merone Roose-Girma; Søren Warming; Zora Modrusan; Wyne P. Lee; Kam Hon Hoi; Ali A. Zarrin
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Marital Status, Living Arrangement, and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings from CALGB 89803 (Alliance)
Oncologist,
Seohyuk Lee; Chao Ma; Sui Zhang; Fang-Shu Ou; Tiffany M. Bainter; Donna Niedzwiecki; Leonard Saltz; Robert J. Mayer; Renaud Whittom; Alexander Hantel; Al B. Benson; Daniel Atienza; Hedy L. Kindler; Cary P. Gross; Melinda L. Irwin; Jeffrey A. Meyerhardt; Charles Fuchs
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Marital Status, Living Arrangement, and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings from CALGB 89803 (Alliance)
Oncologist, ISSN: 1549490X
Seohyuk Lee; Chao Ma; Sui Zhang; Fang-Shu Ou; Tiffany M. Bainter; Donna Niedzwiecki; Leonard Saltz; Robert J. Mayer; Renaud Whittom; Alexander Hantel; Al B. Benson; Daniel Atienza; Hedy L. Kindler; Cary P. Gross; Melinda L. Irwin; Jeffrey A. Meyerhardt; Charles Fuchs
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Real-time monitoring of antibody quality attributes for cell culture production processes in bioreactors via integration of an automated sampling technology with multi-dimensional liquid chromatography mass spectrometry
Journal of Chromatography A, ISSN: 18733778 00219673
Sanket Dahotre; Lu Dai; Karissa Kjenstad; Cinzia Stella; Julien Camperi
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Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490
Brandon Leonard; Kannan Sankar; Matthew G. Romei; Margaret J. Tse; Nina Do; Yanli Yang; Wadim L. Matochko; Jack Bevers; Sundeep Bollineni; Kiran Mukhyala; Kam Hon Hoi; Greg A. Lazar
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XIAP promotes melanoma growth by inducing tumour neutrophil infiltration
EMBO Reports, ISSN: 14693178 1469221X
Mila Daoud; Pia Nora Broxtermann; Fabian Schorn; J Paul Werthenbach; Jens Michael Seeger; Lars Schiffmann; Kerstin Brinkmann; Domagoj Vucic; Thomas Tüting; Cornelia Mauch; Dagmar Kulms; Paola Zigrino; Hamid Kashkar
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Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Brandon Leonard; Kannan Sankar; Matthew G. Romei; Margaret J. Tse; Nina Do; Yanli Yang; Wadim L. Matochko; Jack Bevers; Sundeep Bollineni; Kiran Mukhyala; Kam Hon Hoi; Greg A. Lazar
View on Scopus
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