Scientists / Publications

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Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 51 - 100 OF 11542 RESULTS

Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration
EMBO Journal, ISSN: 14602075 02614189
David Castillo-Azofeifa; Elena N Fazio; Roy Nattiv; Hayley J Good; Tomas Wald; Michael A Pest; Frederic De Sauvage; Ophir D Klein; Samuel Asfaha
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Characterizing and enhancing virus removal by protein A chromatography
Biotechnology and Bioengineering, ISSN: 00063592
Chinwei Pan; Alejandro Becerra-Arteaga; Ben Tran; Michael Chinn; Hua Wang; Qi Chen; Herbert Lutz; Min Zhang
Continued access to investigational medicinal products for clinical trial participants-An industry approach
Cambridge Quarterly of Healthcare Ethics, ISSN: 14692147 09631801
Ariella Kelman; Anna Kang; Brian Crawford
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Discovery and Qualification of Candidate Urinary Biomarkers of Disease Activity in Lupus Nephritis
Journal of Proteome Research, ISSN: 15353907 15353893
Veronica Anania; Kebing Yu; Francesco Pingitore; Qingling Li; Christopher M. Rose; Peter Liu; Wendy Sandoval; Ann E. Herman; Jennie Lill; Rod Mathews
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Fatty acid recognition in the Frizzled receptor family
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Aaron Nile; Rami Hannoush
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Micro-CT imaging and structural analysis of glomeruli in a model of adriamycin-induced nephropathy
American Journal of Physiology - Renal Physiology, ISSN: 15221466 03636127
Luke Xie; Georgios Koukos; Kai Barck; Oded Foreman; Wyne P. Lee; Bob Brendza; Jeff Eastham; Brent S. McKenzie; Andy Peterson; Rick Carano
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Omalizumab effectiveness in asthma-COPD overlap: Post hoc analysis of PROSPERO
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Nicola A. Hanania; Bradley E. Chipps; Noelle Griffin; Bongin Yoo; Ahmar Iqbal; Thomas B. Casale
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Quantitative neuroimaging measures of myelin in the healthy brain and in multiple sclerosis
Human Brain Mapping, ISSN: 10659471
Jonathan O'Muircheartaigh; Irene Vavasour; Emil Ljungberg; David K. B. Li; Alexander Rauscher; Victoria Levesque; Hideki Garren; David Clayton; Roger Tam; Traboulsee; Shannon Kolind
The Escherichia coli -barrel assembly machinery is sensitized to perturbations under high membrane fluidity
Journal of Bacteriology, ISSN: 00219193
Kelly M. Storek; Rajesh Vij; Dawei Sun; Peter Smith; James T. Koerber; Steven T. Rutherford
Tumor-Infiltrating Lymphocytes in Patients Receiving Trastuzumab/Pertuzumab-Based Chemotherapy: A TRYPHAENA Substudy
Journal of the National Cancer Institute,
Michail Ignatiadis; Gert G.G.M. Van Den Eynden; Salgado Roberto; Marco Fornili; Yacine Bareche; Christine Desmedt; Rothé; Maetens; David Venet; Esther Holgado; Virginia McNally; Astrid Kiermaier; Heidi Savage; Tim Wilson; Javier Cortes; Andreas Schneeweiss; Karen Willard-Gallo; Elia Biganzoli; Christos Sotiriou
Utilizing a regulated targeted integration cell line development approach to systematically investigate what makes an antibody difficult to express
Biotechnology Progress, ISSN: 15206033 87567938
Tomofumi Tadauchi; Cynthia Lam; Laura Liu; Yizhou Zhou; Danming Tang; Salina Louie; Brad Snedecor; Shahram Misaghi
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Controlled Ice Nucleation using ControLyo® pressurization-depressurization method
Methods in Pharmacology and Toxicology, ISSN: 19406053 15572153
Jake Luoma; Graham Magill; Lokesh Kumar; Zakaria Yusoff
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Enantioselective synthesis of GNE-6688, a potent and selective inhibitor of interleukin-2 inducible T-cell kinase (ITK)
Tetrahedron Letters, ISSN: 00404039
Jared Moore; Kevin Lau; Xiaofeng Xu; Yamin Zhang; Jason Burch
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies
Neuron, ISSN: 10974199 08966273
Borislav Dejanovic; Melanie Huntley; Ann De Mazière; Bill Meilandt; Tiffany Wu; Karpagam Srinivasan; Zhiyu Jiang; Vineela Gandham; Brad Friedman; Hai Ngu; Oded Foreman; Rick Carano; Ben Chih; Judith Klumperman; Corey Bakalarski; Jesse Hanson; Morgan Sheng
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Serum periostin levels in adults of Chinese descent: An observational study ACTRN12614000122651 ACTRN 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology
Allergy, Asthma and Clinical Immunology, ISSN: 17101492 17101484
Evan Tan; Rachel Varughese; Ruth Semprini; Barney Montgomery; Cecile Holweg; Julie Olsson; Caswell-Smith; James Fingleton; Mark Weatherall; Beasley; Irene Braithwaite
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IFNg-induced Chemokines Are Required for CXCR3-mediated T-Cell Recruitment and Antitumor Efficacy of Anti-HER2/CD3 Bispecific Antibody
Clinical Cancer Research, ISSN: 15573265 10780432
Ji Li; Ryan Ybarra; Judy Mak; Aurelie Herault; Patricia De Almeida; Alfonso Arrazate; James Ziai; Klara Totpal; Melissa Junttila; Kevin B. Walsh; Teemu Junttila
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CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Xiangnan Du; Patricia de Almeida; Nicholas A. Manieri; Denise De Almeida Nagata; Thomas D. Wu; Kristin Harden Bowles; Vidhyalakshmi Arumugam; Jill Schartner; Rafael Cubas; Stephanie Mittman; Vincent Javinal; Keith R. Anderson; Soren Warming; Jane Grogan; Eugene Y. Chiang
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Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Yoong Wearn Lim; Haiyin Chen; Oleg Mayba; Steve Lianoglou; Art Wuster; Tushar Bhangale; Zia Khan; Sanjeev Mariathasan; Anneleen Daemen; Jens Reeder; Peter M. Haverty; Bill Forrest; Matt Brauer; Ira Mellman; Matthew Albert
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First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer
New England Journal of Medicine, ISSN: 15334406 00284793
Leora Horn; Mansfield; Szczȩsna; Havel; Maciej J Krzakowski; Hochmair; Huemer; György Losonczy; Melissa L. Johnson; Nishio; Martin Reck; Tony Mok; Lam; David Shames; Liu; Beiying Ding; Ariel Lopez-Chavez; Fairooz F. Kabbinavar; Lin; Alan Sandler; Liu
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Hippo pathway inhibition by blocking the YAP/TAZ–TEAD interface: a patent review
Expert Opinion on Therapeutic Patents, ISSN: 17447674 13543776
James Crawford; Sarah M. Bronner; Jason Zbieg
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2018 White Paper on Recent Issues in Bioanalysis: Focus on flow cytometry, gene therapy, cut points and key clarifications on BAV (Part 3 - LBA/cell-based assays: Immunogenicity, biomarkers and PK assays)
Bioanalysis, ISSN: 17576199 17576180
Lauren Stevenson; Richards; Renuka Pillutla; Albert Torri; John Kamerud; Devangi Mehta; Stephen Keller; Shobha Purushothama; Boris Gorovits; Virginia Litwin; Christopher Stebbins; Joseph Marini; Chris Beaver; Gizette Sperinde; Patty Siguenza; Roland F Staack; Yongchang Qiu; Lakshmi Amaravadi; Shashi Amur; Catherine Aversa Fleener; Daniel Baltrukonis; Ian Catlett; Elana Cherry; Shan Chung; Isabelle Cludts; Lorella Di Donato; Sally Fischer; Stephanie Fraser; Fabio Garofolo; Cherie Green; George R. Gunn; Sam Haidar; Jonathan Haulenbeek; Neil Henderson; Shirley Hopper; Akiko Ishii-Watabe; Rafiq Islam; Brian Janelsins; Vibha Jawa; Vellalore Kakkanaiah; Szilard Kamondi; Gerry Kolaitis; Robert J Kubiak; Seema Kumar; Pekka Kurki; Meina Liang; Patrick Liu; Kimberly Maxfield; Heather Myler; Nisha Palackal; Rachel Palmer; Joao Pedras-Vasconcelos; Steven Piccoli; Paul Rhyne; Yoshiro Saito; Natasha Savoie; Eginhard Schick; Becky Schweighardt; Judy Shih; An Song; Priya Sriraman; Ludovicus Staelens; Giane Sumner; Yongliang
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Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection
Genome Research, ISSN: 15495469
Chun Jimmie Ye; Jenny Chen; Alexandra-Chloé Villani; Rachel E. Gate; Meena Subramaniam; Tushar Bhangale; Mark N. Lee; Towfique Raj; Raktima Raychowdhury; Weibo Li; Noga Rogel; Sean Simmons; Selina H. Imboywa; Portia I. Chipendo; Cristin McCabe; Michelle H. Lee; Irene Y. Frohlich; Barbara E. Stranger; Philip L. De Jager; Aviv Regev; Tim Behrens; Nir Hacohen
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ASC- A nd caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages
Scientific Reports, ISSN: 20452322
Bettina L. Lee; Kathleen M. Mirrashidi; Irma Stowe; Sarah Kummerfeld; Colin Watanabe; Benjamin Haley; Trinna Cuellar; Mike Reichelt; Nobuhiko Kayagaki
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NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus
Nature Communications, ISSN: 20411723
Hans Brightbill; Eric Suto; Nicole Blaquiere; Nandhini Ramamoorthi; Swathi Sujatha-Bhaskar; Emily Gogol; Georgette Castanedo; Benjamin T. Jackson; Youngsu Kwon; Susan Haller; Justin Lesch; Karin Bents; Christine Everett; Pawan Bir Kohli; Sandra Linge; Laura Christian; Kathy Barrett; Allan Jaochico; Leo Berezhkovskiy; Peter W. Fan; Zora Modrusan; Kelli Veliz; Michael Townsend; Jason DeVoss; Adam Johnson; Robert Godemann; Wyne Lee; Cary Austin; Brent McKenzie; Jason Hackney; James J. Crawford; Steven Staben; Moulay Hicham Alaoui-Ismaili; Lawren Wu; Nico Ghilardi
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Calpain-mediated tau fragmentation is altered in Alzheimer’s disease progression
Scientific Reports, ISSN: 20452322
Hsu-Hsin Chen; Peter Liu; Paul Auger; Seung-Hye Lee; Oskar Adolfsson; Lorianne Rey-Bellet; Julien Lafrance-Vanasse; Brad Friedman; Maria Pihlgren; Andreas Muhs; Andrea Pfeifer; James Ernst; Gai Ayalon; Kristin Wildsmith; Thomas G. Beach; Marcel van der Brug
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Harnessing the Potential of Emerging Digital Health and Biological Sampling Technologies for Clinical Drug Development: Promise to Reality
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Prajakti A. Kothare; Pravin R. Jadhav; Pankaj Gupta; Jane Croft Harrelson; Leslie Dickmann
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Nonclinical safety assessment of a human interleukin-22FC IG fusion protein demonstrates in vitro to in vivo and cross-species translatability
Pharmacology Research and Perspectives,
Donna Lee; Shelly Zhong; Rama Pai; Julie Rae; Sid Sukumaran; Eric Stefanich; Jeff Lutman; Estelle Doudement; Xiaoting Wang; Brandon Harder; Annemarie N. Lekkerkerker; Ann Herman; Wenjun Ouyang; Dimitry Danilenko
Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events: Methods for item selection in industry-sponsored oncology clinical trials
Clinical Trials, ISSN: 17407753
Peter Trask; Amylou Dueck; Elisabeth Piault-Louis; Alicyn Campbell
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TBK1 and IKKε restrain cell death
Nature Cell Biology,
Klaus Heger; Vishva Dixit
89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer
Nature Medicine, ISSN: 1546170X 10788956
Frederike Bensch; Elly L. van der Veen; Marjolijn N. Lub-De Hooge; Annelies Jorritsma-Smit; Ronald Boellaard; Iris C. Kok; Sjoukje F. Oosting; Carolina P. Schröder; T. Jeroen N. Hiltermann; Anthonie J. van der Wekken; Harry J.M. Groen; Thomas C. Kwee; Sjoerd G. Elias; Jourik A. Gietema; Sandra Sanabria Bohorquez; De Crespigny; Simon P. Williams; Christoph Mancao; Adrienne H. Brouwers; Bernard Fine; Elisabeth G. E. De Vries
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Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
Nature Communications,
Lulu Yao; Teddy Grand; Jesse Hanson; Pierre Paoletti; Qiang Zhou
A targeted boost-and-sort immunization strategy using Escherichia coli BamA identifies rare growth inhibitory antibodies
Scientific Reports, ISSN: 20452322
Rajesh Vij; Zhonghua Lin; Nancy Chiang; Jean-Michel Vernes; Kelly M. Storek; Summer Park; Joyce Chan; Y. Gloria Meng; Laetitia Comps-Agrar; Tricia Luhn; Sophia Lee; Kellen Schneider; Jack Bevers; Inna Zilberleyb; Christine Tam; Chris Koth; Min Xu; Avinash Gill; Marcy Auerbach; Peter Smith; Steven T. Rutherford; Gerry Nakamura; Dhaya Seshasayee; Jian Payandeh; James T. Koerber
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A Tet-Off gene expression system for validation of antifungal drug targets in a murine invasive pulmonary aspergillosis model
Scientific Reports, ISSN: 20452322
Yutian Peng; Hua Zhang; Min Xu; Man Wah Tan
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Antibody-mediated stabilization of NRG1 induces behavioral and electrophysiological alterations in adult mice
Scientific Reports, ISSN: 20452322
Sara Dominguez; Ganapati Hegde; Jesse Hanson; Hong Xiang; Danielle Mandikian; Andy Boswell; Cecilia Chiu; Yan Wu; Siao Ping Tsai; Daniel Fleck; Martin Weber; Hai Ngu; Kimberly Scearce-Levie; Erica Jackson
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Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy
Scientific Reports, ISSN: 20452322
Ken Katschke; Hongkang Xi; Christian Cox; Tom Truong; Yann Malato; Wyne Lee; Brent McKenzie; Rommel Arceo; Janet Tao; Linda Rangell; Mike Reichelt; Lauri Diehl; Justin Elstrott; Robby Weimer; Menno van Lookeren Campagne
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Comprehensive analysis of single molecule sequencing-derived complete genome and whole transcriptome of Hyposidra talaca nuclear polyhedrosis virus
Scientific Reports, ISSN: 20452322
Thong Tom Nguyen; Kushal Suryamohan; Boney Kuriakose; Vasant Janakiraman; Mike Reichelt; Subhra Chaudhuri; Joe Guillory; Neethu Divakaran; Rabins; Ridhi Goel; Bhabesh Deka; Suman Sarkar; Preety Ekka; Yu-Chih Tsai; Derek Vargas; Sam Santhosh; Sangeetha Mohan; Chen-Shan Chin; Jonas Korlach; George Thomas; Azariah Babu; Somasekar Seshagiri
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Erratum to: Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy (Scientific Reports, (2018), 8, 1, (7348), 10.1038/s41598-018-25557-8)
Scientific Reports,
Ken Katschke; Hongkang Xi; Christian Cox; Tom Truong; Yann Malato; Wyne P. Lee; Brent McKenzie; Rommel Arceo; Janet Tao; Linda Rangell; Mike Reichelt; Lauri Diehl; Justin Elstrott; Robby Weimer; Menno van Lookeren Campagne
Erratum to: Comprehensive analysis of single molecule sequencing-derived complete genome and whole transcriptome of Hyposidra talaca nuclear polyhedrosis virus (Scientific Reports, (2018), 8, 1, (8924), 10.1038/s41598-018-27084-y)
Scientific Reports,
Thong Tom Nguyen; Kushal Suryamohan; Boney Kuriakose; Vasant Janakiraman; Mike Reichelt; Subhra Chaudhuri; Joe Guillory; Neethu Divakaran; Rabins; Ridhi Goel; Bhabesh Deka; Suman Sarkar; Preety Ekka; Yu-Chih Tsai; Derek Vargas; Sam Santhosh; Sangeetha Mohan; Chen-Shan Chin; Jonas Korlach; George Thomas; Azariah Babu; Somasekar Seshagiri
Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
Nature Communications, ISSN: 20411723
Erika López-Arribillaga; Verónica Rodilla; Carlota Colomer; Anna Vert; Amy Shelton; Jason Cheng; Bing Yan; Abel Gonzalez-Perez; Melissa Junttila; Mar Iglesias; Ferran Torres; Joan Albanell; Alberto Villanueva; Anna Bigas; Chris Siebel; Lluis Espinosa
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Next generation sequencing identifies novel diseaseassociated BEST1 mutations in Bestrophinopathy patients
Scientific Reports, ISSN: 20452322
Thong Tom Nguyen; Poornachandra; Anshuman Verma; Ruchir A. Mehta; Sameer Phalke; Rajani Battu; Vedam Laxmi Ramprasad; Andy Peterson; Arkasubhra Ghosh; Somasekar Seshagiri
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Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes
Nature Communications, ISSN: 20411723
David S. Hewings; Johanna Heideker; Taylur Ma; Andrew P. Ahyoung; Farid El Oualid; Alessia Amore; Gregory T. Costakes; Daniel Kirchhofer; Bradley Brasher; Thomas Pillow; Nataliya Popovych; Till Maurer; Carsten Schwerdtfeger; Bill Forrest; Kebing Yu; John Flygare; Matthew Bogyo; Ingrid Wertz
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Testosterone is an endogenous regulator of BAFF and splenic B cell number
Nature Communications, ISSN: 20411723
Anna S. Wilhelmson; Marta Lantero Rodriguez; Alexandra Stubelius; Per Fogelstrand; Inger Johansson; Matthew B. Buechler; Steve Lianoglou; Varun N. Kapoor; Maria E. Johansson; Johan B. Fagman; Amanda Duhlin; Prabhanshu Tripathi; Alessandro Camponeschi; Bo T. Porse; Antonius G. Rolink; Hans Nissbrandt; Shannon Turley; Hans Carlsten; Inga-Lill Mårtensson; Mikael C. I. Karlsson; Åsa Tivesten
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Clinical utility of a blood-based EGFR mutation test in patients receiving first-line erlotinib therapy in the ENSURE, FASTACT-2, and ASPIRATION studies
Lung Cancer, ISSN: 01695002
Yi-Long Wu; Victor Lee; Chong-Kin Liam; Shun Lu; Keunchil Park; Vichien Srimuninnimit; Jie Wang; Caicun Zhou; Anita Appius; Peter Button; Gregory Hooper; John F. Palma; Katja Schulze; Sidney Scudder; David Shames; Anny-Yue Yin; Guili Zhang; Tony Mok
Correction to: Application of a Novel ‘Make and Test in Parallel’ Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects (Pharmaceutical Research, (2018), 35, 12, (233), 10.1007/s11095-018-2516-0)
Pharmaceutical Research, ISSN: 07248741
Sravanthi Cheeti; Hao Helen Hou; Eric Nelson; Helen Walker; Buyun Chen; Roland Morley; Mary Gates; Luna Musib; Sandhya Girish; Srikumar Sahasranaman; Lichuan Liu
Application of a Novel ‘Make and Test in Parallel’ Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects
Pharmaceutical Research, ISSN: 1573904X 07248741
Sravanthi Cheeti; Hao Helen Hou; Eric Nelson; Helen Walker; Buyun Chen; Roland Morley; Mary Gates; Luna Musib; Sandhya Girish; Srikumar Sahasranaman; Lichuan Liu
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Development and Validation of a High-Quality Composite Real-World Mortality Endpoint
Health Services Research, ISSN: 14756773 00179124
Melissa D. Curtis; Sandra D. Griffith; Melisa Tucker; Michael D. Taylor; William B. Capra; Gillis Carrigan; Ben Holzman; Aracelis Z. Torres; Paul You; Brandon Arnieri; Amy P. Abernethy
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First inter-laboratory study of a Supercritical Fluid Chromatography method for the determination of pharmaceutical impurities
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Amandine Dispas; Roland Marini; Vincent Desfontaine; Jean-Luc Veuthey; Dorina Kotoni; Luca Gioacchino Losacco; Adrian Clarke; Charlene Muscat Galea; Debby Mangelings; Brandon M. Jocher; Erik L. Regalado; Katerina Plachká; Lucie Nováková; Benjamin Wuyts; Isabelle François; Michael Gray; Andrew J. Aubin; Abhijit Tarafder; Maxime Cazes; Christophe Desvignes; Loic Villemet; Morgan Sarrut; Adrien Raimbault; Elise Lemasson; Eric Lesellier; Caroline West; Tomas Leek; Mengling Wong; Lulu Dai; Kelly Zhang; Alexandre Grand-Guillaume Perrenoud; Claudio Brunelli; Philippe Hennig; Sophie Bertin; Fabien Mauge; Nathalie Da Costa; William P. Farrell; Madeleine Hill; Niranjan Desphande; Manish Grangrade; Santosh Sadaphule; Ravi Yadav; Sandesh Rane; Shankar Shringare; Marion Iguiniz; Sabine Heinisch; Julien Lefevre; Estelle Corbel; Nicolas Roques; Yvan Vander Heyden; Davy Guillarme; Philippe Hubert
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Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer
New England Journal of Medicine, ISSN: 15334406 00284793
Schmid; Sylvia Adams; Hope S. Rugo; Andreas Schneeweiss; Carlos H. Barrios; Iwata; Diéras; Roberto Hegg; Seock-Ah Im; Shaw Wright; Henschel; Luciana Molinero; Chui; Roel Funke; Husain; Eric P. Winer; Sherene Loi; Leisha A. Emens
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Preanalytical approaches to improve recovery of amyloid-β peptides from CSF as measured by immunological or mass spectrometry-based assays
Alzheimer's Research and Therapy, ISSN: 17589193
Stephen Schauer; William R. Mylott; Moucun Yuan; Rand Jenkins; Rodney Mathews; Lee Honigberg; Kristin Wildsmith
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Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors
Journal of Neuroscience,
Shannon Shields; Lunbin Deng; Rebecca M. Reese; Michelle Dourado; Janet Tao; Oded Foreman; Jae H. Chang; David Hackos

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