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Publications

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DISPLAYING 1201 - 1250 OF 15491 RESULTS

Real-time monitoring of antibody quality attributes for cell culture production processes in bioreactors via integration of an automated sampling technology with multi-dimensional liquid chromatography mass spectrometry
Journal of Chromatography A, ISSN: 18733778 00219673
Sanket Dahotre; Lu Dai; Karissa Kjenstad; Cinzia Stella; Julien Camperi
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Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490
Brandon Leonard; Kannan Sankar; Matthew G. Romei; Margaret J. Tse; Nina Do; Yanli Yang; Wadim L. Matochko; Jack Bevers; Sundeep Bollineni; Kiran Mukhyala; Kam Hon Hoi; Greg A. Lazar
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XIAP promotes melanoma growth by inducing tumour neutrophil infiltration
EMBO Reports, ISSN: 14693178 1469221X
Mila Daoud; Pia Nora Broxtermann; Fabian Schorn; J Paul Werthenbach; Jens Michael Seeger; Lars Schiffmann; Kerstin Brinkmann; Domagoj Vucic; Thomas Tüting; Cornelia Mauch; Dagmar Kulms; Paola Zigrino; Hamid Kashkar
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Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Brandon Leonard; Kannan Sankar; Matthew G. Romei; Margaret J. Tse; Nina Do; Yanli Yang; Wadim L. Matochko; Jack Bevers; Sundeep Bollineni; Kiran Mukhyala; Kam Hon Hoi; Greg A. Lazar
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Real-time monitoring of antibody quality attributes for cell culture production processes in bioreactors via integration of an automated sampling technology with multi-dimensional liquid chromatography mass spectrometry
Journal of Chromatography A, ISSN: 00219673
Sanket Dahotre; Lu Dai; Karissa Kjenstad; Cinzia Stella; Julien Camperi
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Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Journal of Cell Biology, ISSN: 15408140
Ofer Guttman; Adrien Le Thomas; Scot A. Marsters; David Lawrence; Lauren Gutgesell; Iratxe Zuazo-Gaztelu; Jonathan M. Harnoss; Simone M. Haag; Aditya Murthy; Geraldine Strasser; Zora Modrusan; Thomas Wu; Ira Mellman; Avi Ashkenazi
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Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Journal of Cell Biology, ISSN: 15408140
Ofer Guttman; Adrien Le Thomas; Scot A. Marsters; David Lawrence; Lauren Gutgesell; Iratxe Zuazo-Gaztelu; Jonathan M. Harnoss; Simone M. Haag; Aditya Murthy; Geraldine Strasser; Zora Modrusan; Thomas D Wu; Ira Mellman; Avi Ashkenazi
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Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Journal of Cell Biology,
Ofer Guttman; Adrien Le Thomas; Scot A. Marsters; David Lawrence; Lauren Gutgesell; Iratxe Zuazo-Gaztelu; Jonathan M. Harnoss; Simone M. Haag; Aditya Murthy; Geraldine Strasser; Zora Modrusan; Thomas Wu; Ira Mellman; Avi Ashkenazi
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Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Journal of Cell Biology, ISSN: 15408140 00219525
Ofer Guttman; Adrien Le Thomas; Scot A. Marsters; David Lawrence; Lauren Gutgesell; Iratxe Zuazo-Gaztelu; Jonathan M. Harnoss; Simone M. Haag; Aditya Murthy; Geraldine Strasser; Zora Modrusan; Thomas D Wu; Ira Mellman; Avi Ashkenazi
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Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
Molecular Cancer Research, ISSN: 15573125
Andrew Wallace; Sima P. Porten; Amy A. Lo; Daniel Oreper; Nicolas Lounsbury; Charles Havnar; Ximo Pechuan-Jorge; Oliver A. Zill; Maxwell V. Meng
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Coming of Age: Human Genomics and the Cancer-Immune Set Point
Cancer immunology research, ISSN: 23266074
Christian Hammer; Ira Mellman
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Corrigendum to a cross-industry collaboration to assess if acute toxicity (Q)SAR models are fit-for-purpose for GHS classification and labelling. Regulatory toxicology and pharmacology (2021) 104843 (Regulatory Toxicology and Pharmacology (2021) 120, (S0273230020302695), (10.1016/j.yrtph.2020.104843))
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Joel P. Bercu; Melisa J. Masuda‐Herrera; Alejandra Trejo-Martin; Catrin Hasselgren; Jean Lord; Jessica Graham; Matthew Schmitz; Lawrence Milchak; Colin Owens; Surya Hari Lal; Richard Marchese Robinson; Sarah Whalley; Phillip Bellion; Anna Vuorinen; Kamila Gromek; William A. Hawkins; Iris van de Gevel; Kathleen Vriens; Raymond Kemper; Russell Naven; Pierre Ferrer; Glenn J. Myatt
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Extracellular Histones Trigger Disseminated Intravascular Coagulation by Lytic Cell Death
International Journal of Molecular Sciences, ISSN: 16616596
Yan Zhang; Congqing Wu; Lan Li; Ankit Pandeya; Guoying Zhang; Jian Cui; Daniel Kirchhofer; Jeremy P. Wood; Susan S. Smyth; Yinan Wei; Zhenyu Li
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Untargeted metabolomics identifies the potential role of monocarboxylate transporter 6 (MCT6/SLC16A5) in lipid and amino acid metabolism pathways
Pharmacology Research and Perspectives, ISSN: 20521707
Tianjing Ren; Robert S. Jones; Marilyn E. Morris
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2021 White Paper on Recent Issues in Bioanalysis: TAb/NAb, Viral Vector CDx, Shedding Assays; CRISPR/Cas9 & CAR-T Immunogenicity; PCR & Vaccine Assay Performance; ADA Assay Comparability & Cut Point Appropriateness (Part 3 - Recommendations on Gene Therapy, Cell Therapy, Vaccine Assays; Immunogenicity of Biotherapeutics and Novel Modalities; Integrated Summary of Immunogenicity Harmonization)
Bioanalysis, ISSN: 17576199 17576180
Lina Loo; Shannon Harris; Milton; Meena; Wibke Lembke; Flora Berisha; Sylvie Bertholet; Francis Dessy; Robert Dodge; Xiaodong Fang; Michele Fiscella; Fabio Garofolo; Boris Gorovits; Soumi Gupta; Vibha Jawa; Akiko Ishii-Watabe; Brian Long; Yanmei Lu; Timothy Mack; Kristina McGuire; Katrina Nolan; Luying Pan; Bernd Potthoff; Shobha Purushothama; Dean Smith; Therese Solstad; Ivo Sonderegger; Frank Taddeo; Shabnam Tangri; Leslie Wagner; Bonnie Wu; Yuanxin Xu; Susan Kirshner; Verthelyi; Haoheng Yan; Kimberly Maxfield; Joao Pedras-Vasconcelos; Mohsen Rajabi Abhari; Swati Gupta; Yuling Wu; Manoj Rajadhyaksha; Matthew Andisik; Daniel Baltrukonis; Elana Cherry; Isabelle Cludts; George R. Gunn; Anders Holm Millner; Gregor Jordan; Sumit Kar; Robert J Kubiak; Gregor P Lotz; Rachel Palmer; Kun Peng; Johann Poetzl; Richards; Natasha Savoie; Roland F Staack; Kay Stubenrauch; Meenu Wadhwa; Günter Waxenecker; Tong-Yuan Yang; Lucia Zhang
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Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis
Cardiovascular Research, ISSN: 17553245 00086363
Marco Witkowski; Mario Witkowski; Julian Friebel; Jennifer A. Buffa; Xinmin S. Li; Zeneng Wang; Naseer Sangwan; Lin Li; Joseph A. DiDonato; Caroline Tizian; Arash Haghikia; Daniel Kirchhofer; François Mach; Lorenz Räber; Christian M. Matter; Wilson Tang; Ulf Landmesser; Thomas F. Lüscher; Ursula Rauch; Stanley L. Hazen
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Novel Anti-LY6G6D/CD3 T-Cell–Dependent Bispecific Antibody for the Treatment of Colorectal Cancer
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Peiyin Wang; Liping L. Sun; Robyn Clark; Maria Hristopoulos; Cecilia P.C. Chiu; Michael Dillon; WeiYu Lin; Amy A. Lo; Sreedevi Chalsani; Meghna Das Thakur; Kristin M. Zimmerman Savill; Lionel Rouge; Patrick J. Lupardus; Robert Piskol; Bushra Husain; Diego Ellerman; Vittal Shivva; Steven R. Leong; Meric A. Ovacik; Klara Totpal; Yan Wu; Christoph Spiess; Genee Y. Lee; Douglas Leipold; Andrew G. Polson
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Extracellular Histones Trigger Disseminated Intravascular Coagulation by Lytic Cell Death
International Journal of Molecular Sciences, ISSN: 14220067 16616596
Yan Zhang; Congqing Wu; Lan Li; Ankit Pandeya; Guoying Zhang; Jian Cui; Daniel Kirchhofer; Jeremy P. Wood; Susan S. Smyth; Yinan Wei; Zhenyu Li
View on Scopus
Theragnostic significance of tumor-infiltrating lymphocytes and Ki67 in BRAFV600-mutant metastatic melanoma (BRIM-3 trial)
Current Problems in Cancer, ISSN: 15356345 01470272
Paul B. Googe; Stamatios Theocharis; Alexandros Pergaris; Haocheng Li; Yibing Yan; Edward McKenna; Stergios J. Moschos
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Development of an SPR-based binding assay for characterization of anti-CD20 antibodies to CD20 expressed on extracellular vesicles
Analytical Biochemistry, ISSN: 10960309 00032697
Xiangdan Wang; Minh Michael Phan; Yonglian Sun; James T. Koerber; Hoangdung Ho; Yongmei Chen; Yang
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2021 White Paper on Recent Issues in Bioanalysis: TAb/NAb, Viral Vector CDx, Shedding Assays; CRISPR/Cas9 & CAR-T Immunogenicity; PCR & Vaccine Assay Performance; ADA Assay Comparability & Cut Point Appropriateness (Part 3 - Recommendations on Gene Therapy, Cell Therapy, Vaccine Assays; Immunogenicity of Biotherapeutics and Novel Modalities; Integrated Summary of Immunogenicity Harmonization)
Bioanalysis,
Lina Loo; Shannon Harris; Milton; Meena; Wibke Lembke; Flora Berisha; Sylvie Bertholet; Francis Dessy; Robert Dodge; Xiaodong Fang; Michele Fiscella; Fabio Garofolo; Boris Gorovits; Soumi Gupta; Vibha Jawa; Akiko Ishii-Watabe; Brian Long; Yanmei Lu; Timothy Mack; Kristina McGuire; Katrina Nolan; Luying Pan; Bernd Potthoff; Shobha Purushothama; Dean Smith; Therese Solstad; Ivo Sonderegger; Frank Taddeo; Shabnam Tangri; Leslie Wagner; Bonnie Wu; Yuanxin Xu; Susan Kirshner; Verthelyi; Haoheng Yan; Kimberly Maxfield; Joao Pedras-Vasconcelos; Mohsen Rajabi Abhari; Swati Gupta; Yuling Wu; Manoj Rajadhyaksha; Matthew Andisik; Daniel Baltrukonis; Elana Cherry; Isabelle Cludts; George R. Gunn; Anders Holm Millner; Gregor Jordan; Sumit Kar; Robert J Kubiak; Gregor P Lotz; Rachel Palmer; Kun Peng; Johann Poetzl; Richards; Natasha Savoie; Roland F Staack; Kay Stubenrauch; Meenu Wadhwa; Günter Waxenecker; Tong-Yuan Yang; Lucia Zhang
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Assessment of Clinical Response Following Atezolizumab and Bevacizumab Treatment in Patients With Neuroendocrine Tumors A Nonrandomized Clinical Trial
JAMA Oncology, ISSN: 23742445 23742437
Daniel M. Halperin; Suyu Liu; Arvind Dasari; David Fogelman; Priya Bhosale; Armeen Mahvash; Jeannelyn S. Estrella; Laura Rubin; Ajaykumar C. Morani; Mark Knafl; Tim A. Overeem; Szu-Chin Fu; Luisa M. Solis; Edwin R. Parra Cuentas; Anuj Verma; Honglei Chen; Swati Gite; Priya Subashchandrabose; Shannon Dervin; Katja Schulze; Darbonne; Cindy Yun; Ignacio I. Wistuba; Andrew Futreal; Scott E. Woodman; James C. Yao
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An efficient and scalable data analysis solution for automated electrophysiology platforms
SALAS Discovery, ISSN: 24725560
Tianbo Li; Martin Ginkel; Ada X. Yee; Leigh Foster; Jun Chen; Stephan Heyse; Stephan Steigele
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Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma
Molecular Cancer Research, ISSN: 15573125 15417786
Andrew Wallace; Sima P. Porten; Amy A. Lo; Daniel Oreper; Nicolas Lounsbury; Charles Havnar; Ximo Pechuan-Jorge; Oliver A. Zill; Maxwell V. Meng
View on Scopus
Coming of Age: Human Genomics and the Cancer–Immune Set Point
Cancer immunology research, ISSN: 23266074 23266066
Christian Hammer; Ira Mellman
View on Scopus
Correlation of Optical Coherence Tomography Angiography of Type 3 Macular Neovascularization With Corresponding Histology
JAMA Ophthalmology, ISSN: 21686173 21686165
Andreas Berlin; Diogo Cabral; Ling Chen; Jeffrey D. Messinger; Chandrakumar Balaratnasingam; Randev Mendis; Daniela Ferrara; K. Bailey Freund; Christine A. Curcio
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Allelic variation in HLA-DRB1 is associated with development of antidrug antibodies in cancer patients treated with atezolizumab that are neutralizing in vitro
Clinical and Translational Science, ISSN: 17528062 17528054
Christian Hammer; Jane Ruppel; Lynn Kamen; Julie Hunkapiller; Ira Mellman; Quarmby
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Massively parallel phenotyping of coding variants in cancer with Perturb-seq
Nature Biotechnology, ISSN: 15461696 10870156
Oana Ursu; James T. Neal; Emily Shea; Pratiksha I. Thakore; Livnat Jerby-Arnon; Lan Nguyen; Danielle Dionne; Celeste Diaz; Julia Bauman; Mariam Mounir Mosaad; Christian Fagre; April Lo; Maria McSharry; Andrew O. Giacomelli; Seav Huong Ly; Orit Rozenblatt-Rosen; William C. Hahn; Andrew J. Aguirre; Alice H. Berger; Aviv Regev; Jesse S. Boehm
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INVESTIGATION OF THE USE OF SERUM BIOMARKERS FOR THE DETECTION OF CARDIAC DISEASE IN MARINE MAMMALS
Journal of Zoo and Wildlife Medicine, ISSN: 10427260
Melissa J. Joblon; Jennifer E. Flower; Laura A. Thompson; Kathleen Biddle; Deborah A. Burt; Tanja S. Zabka; Michael J. Adkesson; Barbie Halaska; Caroline E. C. Goertz; Natalie Rouse; Sion N. Cahoon; Kristen Jetzke; Richard Giovanelli; Allison D. Tuttle
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Assessment of Clinical Response Following Atezolizumab and Bevacizumab Treatment in Patients With Neuroendocrine Tumors A Nonrandomized Clinical Trial
JAMA Oncology, ISSN: 23742445 23742437
Daniel M. Halperin; Suyu Liu; Arvind Dasari; David Fogelman; Priya Bhosale; Armeen Mahvash; Jeannelyn S. Estrella; Laura Rubin; Ajaykumar C. Morani; Mark Knafl; Tim A. Overeem; Szu-Chin Fu; Luisa M. Solis; Edwin R. Parra Cuentas; Anuj Verma; Honglei Chen; Swati Gite; Priya Subashchandrabose; Shannon Dervin; Katja Schulze; Darbonne; Cindy Yun; Ignacio I. Wistuba; P. Andrew Futreal; Scott E. Woodman; James C. Yao
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Molecular classification of hormone-sensitive and castration-resistant prostate cancer, using nonnegative matrix factorization molecular subtyping of primary and metastatic specimens
Prostate, ISSN: 10970045 02704137
Kobe Yuen; Ben Tran; Angelyn Anton; Habib Hamidi; Anthony J. Costello; Niall M. Corcoran; Nathan Lawrentschuk; Natalie Rainey; Marie C. G. Semira; Peter Gibbs; Sanjeev Mariathasan; Shahneen Sandhu; Edward E. Kadel III
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Theragnostic significance of tumor-infiltrating lymphocytes and Ki67 in BRAFV600-mutant metastatic melanoma (BRIM-3 trial)
Current Problems in Cancer, ISSN: 01470272
Paul B. Googe; Stamatios Theocharis; Alexandros Pergaris; Haocheng Li; Yibing Yan; Edward McKenna; Stergios J. Moschos
View on Scopus
Assessment of Clinical Response Following Atezolizumab and Bevacizumab Treatment in Patients With Neuroendocrine Tumors A Nonrandomized Clinical Trial
JAMA Oncology, ISSN: 23742445 23742437
Daniel M. Halperin; Suyu Liu; Arvind Dasari; David Fogelman; Priya Bhosale; Armeen Mahvash; Jeannelyn S. Estrella; Laura Rubin; Ajaykumar C. Morani; Mark Knafl; Tim A. Overeem; Szu-Chin Fu; Luisa M. Solis; Edwin R. Parra Cuentas; Anuj Verma; Hong-Lei Chen; Swati Gite; Priya Subashchandrabose; Shannon Dervin; Katja Schulze; Darbonne; Cindy Yun; Ignacio I. Wistuba; P. Andrew Futreal; Scott E. Woodman; James C. Yao
View on Scopus
Fostering a diverse regional community of physician-scientist trainees
Journal of the National Medical Association, ISSN: 19434693 00279684
Mark E. Pepin; J. Paige Souder; Alice N. Weaver; Robin G. Lorenz; Talene Yacoubian; Randy L. Seay
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Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers
eLife, ISSN: 2050084X
Vladislav Belyy; Iratxe Zuazo-Gaztelu; Andrew Alamban; Avi Ashkenazi; Peter Walter
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Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Jayaprakasam Bolleddula; Kevin Brady; Gerard Bruin; Anthony J. Lee; Jennifer A. Martin; Markus Walles; Keyang Xu; Tong-Yuan Yang; Xiaochun Zhu; Hongbin Yu
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A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Markus Walles; Michael Berna; Wenying Jian; Simon Hauri; Shawna Hengel; Lloyd King; John C. Tran; Cong Wei; Keyang Xu; Xiaochun Zhu
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Degrader-antibody conjugates
Chemical Society Reviews, ISSN: 14604744
Peter Dragovich
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Establishment of baseline profiles of 50 bile acids in preclinical toxicity species: A comprehensive assessment of translational differences and study design considerations for biomarker development
Toxicology and Applied Pharmacology, ISSN: 10960333 0041008X
Dewakar Sangaraju; Paula Katavolos; Xiaorong Liang; Carolina Chou; Tanja S. Zabka; Brian J. Dean; Jonathan M. Maher
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Establishment of baseline profiles of 50 bile acids in preclinical toxicity species: A comprehensive assessment of translational differences and study design considerations for biomarker development
Toxicology and Applied Pharmacology, ISSN: 0041008X
Dewakar Sangaraju; Paula Katavolos; Xiaorong Liang; Carolina Chou; Tanja S. Zabka; Brian J. Dean; Jonathan M. Maher
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Challenges in the structure determination of a dimeric impurity found during development of GDC-0326
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
Nathaniel Segraves; Stefan G. Koenig; Jeffrey Stults; Shengli Ma; Antonio G. DiPasquale; Sarah J. Robinson; David J. Russell
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Challenges in the structure determination of a dimeric impurity found during development of GDC-0326
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Nathaniel Segraves; Stefan G. Koenig; Jeffrey Stults; Shengli Ma; Antonio G. DiPasquale; Sarah J. Robinson; David J. Russell
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Degrader-antibody conjugates
Chemical Society Reviews, ISSN: 14604744 03060012
Peter Dragovich
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Evaluating human genetic support for hypothesized metabolic disease genes
Cell Metabolism, ISSN: 19327420 15504131
Peter Dornbos; Preeti Singh; Dong-Keun Jang; Anubha Mahajan; Sudha B. Biddinger; Jerome I Rotter; Mark I. McCarthy; Jason Flannick
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A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRASG12C inhibitors
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490
Siyu Feng; Marinella G. Callow; Jean-Philippe Fortin; Zia Khan; David Bray; Michael Costa; Zhen Shi; Weiru Wang; Marie Evangelista
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A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRASG12C inhibitors
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Siyu Feng; Marinella G. Callow; Jean-Philippe Fortin; Zia Khan; David Bray; Michael Costa; Shi; Weiru Wang; Marie Evangelista
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A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRASG12C inhibitors
Proceedings of the National Academy of Sciences of the United States of America,
Siyu Feng; Marinella G. Callow; Jean-Philippe Fortin; Zia Khan; David Bray; Michael Costa; Zhen Shi; Weiru Wang; Marie Evangelista
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High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA
Journal of Experimental Medicine, ISSN: 15409538
Soyoung A. Oh; Kate Senger; Shravan Madireddi; Ilseyar Akhmetzyanova; Isabel E. Ishizuka; Somayeh S. Tarighat; Jerry H. Lo; David Shaw; Benjamin Haley; Sascha Rutz
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Generation of a Porcine Antibody Fab Fragment Using Protein Engineering to Facilitate the Evaluation of Ocular Sustained Delivery Technology
Molecular Pharmaceutics, ISSN: 15438392 15438384
Robert F. Kelley; Devin B. Tesar; Yue Wang; Nick Agard; Patrick Holder; Joyce Chan; Laetitia Comps-Agrar; Judit Horvath; Joshua Horvath; Susan R. Crowell
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High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA
Journal of Experimental Medicine, ISSN: 15409538 00221007
Soyoung A. Oh; Kate Senger; Shravan Madireddi; Ilseyar Akhmetzyanova; Isabel E. Ishizuka; Somayeh S. Tarighat; Jerry H. Lo; David Shaw; Benjamin Haley; Sascha Rutz
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