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Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

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An Integrated Genomic, Proteomic, and Immunopeptidomic Approach to Discover Treatment-Induced Neoantigens
Frontiers in Immunology,
Niclas Olsson; Marlene L. Heberling; Lichao Zhang; Suchit Jhunjhunwala; Qui Phung; Sarah Lin; Veronica Anania; Jennie Lill; Joshua E. Elias
Multiplexed small molecule impurity monitoring in antibody-based therapeutics by mixed-mode chromatography paired with charged aerosol detection
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
Steven Chin; Xin Xin Lin; Bethany Santarra; Jason Gruenhagen; Peter Yehl; Tao Chen
Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Locally Advanced or Metastatic ROS1 Fusion-Positive Non-Small-Cell Lung Cancer
Journal of Clinical Oncology,
Rafal Dziadziuszko; Matthew G Krebs; Filippo De Braud; Siena; Alexander Drilon; Robert C Doebele; Manish R. Patel; Byoung Chul Cho; Stephen V. Liu; Ahn; Chao-Hua Chiu; Anna F Farago; Chia-Chi Lin; Karapetis; Yu-Chung Li; Bann-Mo Day; David Chen; Tim Wilson; Fabrice Barlesi
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3H)-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor
Journal of Medicinal Chemistry,
Malcolm Huestis; Darlene Dela Cruz; Antonio DiPasquale; Matthew Durk; Charles Eigenbrot; Paul Gibbons; Alberto Gobbi; Thomas Hunsaker; Hank La; Dennis H. Leung; Wendy Liu; Shiva Malek; Mark Merchant; John Moffat; Christine S. Muli; Christine Orr; Brendan T. Parr; Frances Shanahan; Christopher Sneeringer; Weiru Wang; Ivana Yen; Peter Yin; Mike Siu; Joachim Rudolph
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy
Journal of Medicinal Chemistry,
Jack A. Terrett; Huifen Chen; Daniel Shore; Elisia Villemure; Larouche-Gauthier; Martin Déry; Francis Beaumier; Léa Constantineau-Forget; Chantal Grand-Maître; Luce Lépissier; Stéphane Ciblat; Claudio Sturino; Yong Chen; Baihua Hu; Aijun Lu; Yunli Wang; Andrew P. Cridland; Stuart I. Ward; David Hackos; Rebecca M. Reese; Shannon Shields; Jun Chen; Alessia Balestrini; Lorena Riol Blanco; Wyne P. Lee; John Liu; Eric Suto; Xiumin Wu; Juan Zhang; Justin Q. Ly; Hank La; Kevin Johnson; Matt Baumgardner; Kang-Jye Chou; Alexis Rohou; Lionel Rouge; Brian Safina; Steven Magnuson; Matthew Volgraf
Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade
Journal for ImmunoTherapy of Cancer,
Romain Banchereau; Avantika S. Chitre; Alexis Scherl; Thomas Wu; Namrata S. Patil; Patricia De Almeida; Edward E. Kadel III; Shravan Madireddi; Amelia Au-Yeung; Chikara Takahashi; Jasmine Chen; Zora Modrusan; Jacqueline McBride; Rhea Nersesian; Ehab A. El-Gabry; Mark D. Robida; Jeffrey Hung; Marcin Kowanetz; Wei Zou; Mark McCleland; Patrick Caplazi; Shadi Toghi Eshgi; Hartmut Koeppen; Priti Hegde; Ira Mellman; Rod Mathews; Thomas Powles; Sanjeev Mariathasan; Jane Grogan; William E. O'Gorman
BMJ Open, ISSN: 20446055
Devin Incerti; Shemra Rizzo; Xiao Li; Lisa Lindsay; Vince Yau; Daniel Keebler; Jenny Chia; Larry Tsai
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
Trina Mouchahoir; John Schiel; Richard S. Rogers; Alan Heckert; Benjamin J. Place; Aaron Ammerman; Xiaoxiao Li; Tom Robinson; Brian Schmidt; Chris M. Chumsae; Xinbi Li; Anton V. Manuilov; Bo Yan; Gregory O. Staples; Da Ren; Alexander J. Veach; Dongdong Wang; Wael Yared; Zoran Sosic; Yan Wang; Li Zang; Anthony M. Leone; Peiran Liu; Richard Ludwig; Li Tao; Wei Wu; Ahmet Cansizoglu; Andrew Hanneman; Greg W. Adams; Irina Perdivara; Hunter Walker; Margo Wilson; Arnd Brandenburg; Nick Degraan-Weber; Stefano Gotta; Joe Shambaugh; Melissa Alvarez; Christopher Yu (PAC); Li Cao; Chun Shao; Andrew Mahan; Hirsh Nanda; Kristen Nields; Nancy Nightlinger; Helena Maria Barysz; Michael Jahn; Ben Niu; Jihong Wang; Gabriella Leo; Nunzio Sepe; Yan-Hui Liu; Bhumit A. Patel; Douglas D. Richardson; Yi Wang; Daniela Tizabi; Oleg V. Borisov; Yali Lu; Ernest L. Maynard; Albrecht Gruhler; Kim F. Haselmann; Thomas N. Krogh; Carsten P. Sönksen; Simon Letarte; Sean Shen; Kristin Boggio; Keith Johnson; Wenqin Ni; Himakshi Patel; David Rip
Monoclonal antibody aggregation associated with free radical induced oxidation
International Journal of Molecular Sciences, ISSN: 16616596
Kai Zheng; Diya Ren; John Wang; Wayne Lilyestrom; Tom Scherer; Justin K. Y. Hong; Junyan A. Ji
Anti-LYPD1/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Ovarian Cancer
Molecular Cancer Therapeutics,
Amy A. Lo; Jennifer Johnston; Ji Li; Danielle Mandikian; Maria Hristopoulos; Robyn Clark; Dorothee Nickles; Wei-Ching Liang; Kathy Hotzel; Debra Dunlap; Thinh Pham; Hao Cai; Meric Ovacik; Daniel Bravo-Perez; Elaine Mai; Dion Slaga; Diego Ellerman; James Ziai; Klara Totpal; Genee Lee; Andy Boswell; Jian Payandeh; Yan Wu; Teemu Junttila
Cigarette smoke–induced effects on airway basal cells: Taking it up a NOTCH
American Journal of Respiratory Cell and Molecular Biology, ISSN: 10441549
Daniel Lafkas
Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury
Cell Death and Disease,
Kimberly Stark; Tanya Goncharov; Eugene Varfolomeev; Luke Xie; Hai Ngu; Ivan Peng; Keith Anderson; Erik Verschueren; Meena Choi; Donald S. Kirkpatrick; Amy Easton; Webster; Brent McKenzie; Domagoj Vucic; Baris Bingol
Journal of Molecular Diagnostics, ISSN: 19437811 15251578
Manana Javey; Christina Reinsch; Mirjam Feldkamp; Sandra Siemann; Anja Blüher; Corinna Woestmann; Lingling Cai; Ian Tran; Theresa May; Charles Havnar; Amy A. Lo; Bernd Hinzmann; Gabrielle Heilek; John F. Palma
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN: 15221490 03636119
Keri M. Kemp; Jackson Colson; Robin Lorenz; Craig L. Maynard; Jennifer S. Pollock
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Yinzhi Lang; Nirav R. Shah; Xun Tao; Stephanie M. Reeve; Jieqiang Zhou; Bartolome Moya; Alaa R. M. Sayed; Suresh Dharuman; Jeremiah L. Oyer; Alicja J. Copik; Brett A. Fleischer; Eunjeong Shin; Carolin Werkman; Kari B. Basso; Deanna Deveson Lucas; Dhruvit Sutaria; Marianne Mégroz; Tae Hwan Kim; Victoria Loudon-Hossler; Amy Wright; Rossie H. Jimenez-Nieves; Miranda J. Wallace; Keisha C. Cadet; Yuanyuan Jiao; John D. Boyce; Eric D. LoVullo; Herbert P. Schweizer; Robert A. Bonomo; Nagakumar Bharatham; Brian T. Tsuji; Cornelia B. Landersdorfer; Michael H. Norris; Beom Soo Shin; Arnold Louie; Venkataraman Balasubramanian; Richard E. Lee; George L. Drusano; Jürgen B. Bulitta
Cancer Discovery, ISSN: 21598290 21598274
Joachim Rudolph; Jeffrey Settleman; Shiva Malek
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Frederick Hsu; Ivy Chen; Fabio Broccatelli
Journal of Thoracic Oncology, ISSN: 15561380 15560864
Makoto Nishio; Fabrice Barlesi; Howard West; Simon Ball; Rodolfo Bordoni; Manuel Cobo; Pascale Dubray Longeras; Jerome H Goldschmidt; Silvia Novello; Orlandi; Rachel E. Sanborn; Zsuzsanna Szalai; Grigoriy Ursol; Diana Mendus; Lijia Wang; Wen; Mark McCleland; Tien Hoang; See Phan; Mark A. Socinski
Toxicologic Pathology, ISSN: 15331601 01926233
Nardos G. Tassew; Steven T. Laing; Jeffrey Aaronson; Isabella de Jong; Chris Schuetz; Florence Lorget
Haematologica, ISSN: 15928721 03906078
Raghuveer Singh Mali; Qi Zhang; Rosaanna Defilippis; Antonio Cavazos; Vinitha Mary Kuruvilla; Jayant Raman; Vidhi Mody; Edna Choo; Monique Dail; Neil P. Shah; Marina Konopleva; Deepak Sampath; Elisabeth A. Lasater
Toxicologic Pathology, ISSN: 15331601 01926233
Helen Booler; Thomas Larsen; Amy Shelton; Vladimir Bansteev; Mayur Mitra
Toxicologic Pathology, ISSN: 15331601 01926233
Steven Laing; Marie M. Bockenstedt; Helen Booler
American Journal of Hematology, ISSN: 10968652 03618609
Jonathan L. Kaufman; Cristina Gasparetto; Fredrik H. Schjesvold; Moreau; Touzeau; Thierry Facon; Lawrence H. Boise; Yanwen Jiang; Xiaoqing Yang; Fengjiao Dunbar; Deeksha Vishwamitra; Stefanie Unger; Tammy Macartney; John Pesko; Yao Yu; Ahmed Hamed Salem; Jeremy A. Ross; Wan-Jen Hong; Paulo C. Maciag; James M. Pauff; Shaji Kumar
JCI insight, ISSN: 23793708
Daryle DePianto; Jason A. Vander Heiden; Katrina B. Morshead; Kai-Hui Sun; Zora Modrusan; Grace Teng; Paul J. Wolters; Joe Arron
Nature Immunology, ISSN: 15292916 15292908
Meidi Gu; Xiaofei Zhou; Jee Hyung Sohn; Lele Zhu; Zuliang Jie; Jin-Young Yang; Xiaofeng Zheng; Xiaoping Xie; Jie Yang; Yaoyao Shi; Hans Brightbill; Jae Bum Kim; Jing Wang; Xuhong Cheng; Shao-Cong Sun
EBioMedicine, ISSN: 23523964
Feng Xu; Naoya Tanabe; Dragos M. Vasilescu; John E. McDonough; Harvey C. Coxson; Kohei Ikezoe; Daisuke Kinose; Kevin W. Ng; Stijn E. Verleden; Wim Wuyts; Bart M. Vanaudenaerde; Johny Verschakelen; Joel D. Cooper; Marc E. Lenburg; Katrina B. Morshead; Alexander Abbas; Joe Arron; Avrum Spira; Tillie-Louise Hackett; Thomas V. Colby; Christopher J. Ryerson; Raymond T. Ng; James C. Hogg
Journal of Visualized Experiments, ISSN: 1940087X
Charles Havnar; Oliver Zill; Jeffrey Eastham; Jeffrey Hung; Manana Javey; Emmanuel Naouri; Jennifer Giltnane; Justin M. Balko; Andrew Wallace; Nicolas Lounsbury; Daniel Oreper; Sarajane Saturnio; G-Y Yang; Amy A. Lo
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Christopher W. Davies; Irma Stowe; Qui Phung; Hoangdung Ho; Corey Bakalarski; Aaron Gupta; Yingnan Zhang; Jennie Lill; Jian Payandeh; Nobuhiko Kayagaki; JT Koerber
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
David R. Gandara; Martin Reck; Moro-Sibilot; Julien Mazieres; Shirish M. Gadgeel; Morris; Andres Cardona; Diana Mendus; Marcus Ballinger; Achim Rittmeyer; Solange Peters
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Andrea Ardizzoni; Sergio Azevedo; Belen Rubio-Viqueira; Rodriguez-Abreu; Jorge Alatorre-Alexander; Hans J M Smit; Jinming Yu; Konstantinos Syrigos; Kerstin Trunzer; Hina Patel; Jonathan Tolson; Andres Cardona; Pablo Perez-Moreno; Tom Newsom-Davis
Nature, ISSN: 14764687 00280836
Hannah Wand; Samuel A. Lambert; Cecelia Tamburro; Michael A. Iacocca; Jack W. O’Sullivan; Catherine Sillari; Iftikhar J. Kullo; Robb Rowley; Jacqueline S. Dron; Deanna Brockman; Eric Venner; Mark McCarthy; Antonis C. Antoniou; Douglas F. Easton; Robert A. Hegele; Amit V. Khera; Hugh Watkins; Charles Kooperberg; Karen Edwards; Katherine Vlessis; Kim Kinnear; John Danesh; Helen Parkinson; Erin M. Ramos; Megan C. Roberts; Kelly E. Ormond; Muin J. Khoury; A. Cecile J. W. Janssens; Katrina A. B. Goddard; Peter Kraft; Jaqueline A. L. MacArthur; Michael Inouye; Genevieve L. Wojcik
Cell Reports, ISSN: 22111247
Kimberle Shen; Mike Reichelt; Roxanne Kyauk; Hai Ngu; Yun-An A. Shen; Oded Foreman; Zora Modrusan; Brad A. Friedman; Morgan Sheng; Tracy J. Yuen
Cell, ISSN: 10974172 00928674
Marc Kschonsak; Lionel Rouge; Chris Arthur; Ho Hoangdung; Nidhi Patel; Ingrid Kim; Matthew C. Johnson; Edward Kraft; Alexis Rohou; Avinash Gill; Nadia Martinez-Martin; Jian Payandeh; Claudio Ciferri
Cell, ISSN: 10974172 00928674
Nathan D. Mathewson; Orr Ashenberg; Itay Tirosh; Simon Gritsch; Elizabeth M. Perez; Sascha Marx; Livnat Jerby-Arnon; Rony Chanoch-Myers; Toshiro Hara; Alyssa R. Richman; Yoshinaga Ito; Jason Pyrdol; Mirco Friedrich; Kathrin Schumann; Michael J. Poitras; Prafulla C. Gokhale; L. Nicolas Gonzalez Castro; Marni E. Shore; Christine M. Hebert; Brian Shaw; Heather L. Cahill; Matthew Drummond; Wubing Zhang; Olamide Olawoyin; Hiroaki Wakimoto; Orit Rozenblatt-Rosen; Priscilla Kaliopi Brastianos; X. Shirley Liu; Pamela S. Jones; Daniel P. Cahill; Matthew P. Frosch; David N. Louis; Gordon J. Freeman; Keith L. Ligon; Alexander Marson; E. Antonio Chiocca; David A. Reardon; Aviv Regev; Mario L. Suvà; Kai W. Wucherpfennig
Durability of Response to Tocilizumab Therapy in Rheumatoid Arthritis: Data from the US-Based Corrona Rheumatoid Arthritis Registry
Rheumatology and Therapy, ISSN: 21986576
Dimitrios A. Pappas; Taylor Blachley; Jennie Best; Steve Zlotnick; Bill Reiss; Kelechi Emeanuru; Joel M. Kremer
Free Radical Biology and Medicine, ISSN: 18734596 08915849
Mary Mohrin
Nature Genetics, ISSN: 15461718 10614036
Chris J. Frangieh; Johannes C. Melms; Pratiksha I. Thakore; Kathryn R. Geiger-Schuller; Patricia Ho; Adrienne M. Luoma; Brian Cleary; Livnat Jerby-Arnon; Shruti Malu; Michael S. Cuoco; Maryann Zhao; Casey R. Ager; Meri Rogava; Lila Hovey; Asaf Rotem; Chantale Bernatchez; Kai W. Wucherpfennig; Bruce E. Johnson; Orit Rozenblatt-Rosen; Dirk Schadendorf; Aviv Regev; Benjamin Izar
Diabetes Care, ISSN: 19355548 01495992
Charles C. Wykoff; Rahul N. Khurana; Quan Dong Nguyen; Scott P. Kelly; Flora Lum; Rebecca Hall; Ibrahim Abbass; Anna M. Abolian; Ivo Stoilov; Tu My To; Vincent Garmo
Treatment Patterns, Disease Burden, and Outcomes in Patients with Giant Cell Arteritis and Polymyalgia Rheumatica: A Real-World, Electronic Health Record-Based Study of Patients in Clinical Practice
Rheumatology and Therapy, ISSN: 21986576
Gary Craig; Keith Knapp; Bob Salim; Shalini V. Mohan; Margaret Michalska
Annals of Clinical and Translational Neurology, ISSN: 23289503
Robert A. Bermel; Waubant; Gabriel Pardo; Ann Bass; Pavle Repovic; Scott Newsome; John W. Lindsey; Deidre Kile; Ashish Pradhan; Bruno Musch; Aram Zabeti
Bioanalysis, ISSN: 17576199
Susan Spitz; Yan Zhang; Sally Fischer; Kristina McGuire; Ulrike Sommer; Lakshmi Amaravadi; Abbas Bandukwala; Steven Eck; Fabio Garofolo; Rafiqul Islam; Gregor Jordan; Lindsay King; Yoshiro Saito; Giane Sumner; Linda Terry; Alessandra Vitaliti; Yow-Ming C. Wang; Grimaldi; Alison Joyce; Rachel Palmer; Matthew Andisik; Marcela Araya; Mitra Azadeh; Daniel Baltrukonis; Rebecca Elliott; Sam Haidar; Seema Kumar; Andrew Mayer; Florian Neff; Nisha Palackal; Kun Peng; Mohsen Rajabi Abhari; Christina Satterwhite; Natasha Savoie; Catherine Soo; Stephen Vinter; Jan Welink; Weili Yan; Kevin Maher; David Lanham; Sylvie Bertholet; Naveen Dakappagari; Christèle Gonneau; Cherie Green; Fabian Junker; Sumit Kar; Lisa Patti-Diaz; Shyam Sarikonda; Megan McCausland; Priscila Camillo Teixeira; Vilma Decman; Jose Estevam; Michael Hedrick; Alberto Hidalgo Robert; Gregory Hopkins; Sandra Nuti; Shabnam Tangri; Richard Wnek; Suman Dandamudi; Arindam Dasgupta; Anna Edmison; Patrick Faustino; Michael McGuinness; Gustavo Mendes Lima Santo
eLife, ISSN: 2050084X
Helen Tauc; Imilce A. Rodriguez-Fernandez; Jason Hackney; Michal Pawlak; Tal Ronnen Oron; Jerome Korzelius; Hagar F. Moussa; Subhra Chaudhuri; Zora Modrusan; Bruce A. Edgar; Heinrich Jasper
Cancer Discovery, ISSN: 21598290 21598274
Trang Pham; Thijs Hagenbeek; Ho-June Lee; Jason Li; Christopher M. Rose; Eva Lin; Mamie Yu; Scott E. Martin; Robert Piskol; Jennifer Lacap; Deepak Sampath; Victoria Pham; Zora Modrusan; Jennie Lill; Christiaan Klijn; Shiva Malek; Matthew T. Chang; Anwesha Dey
Pharmaceutical Research, ISSN: 1573904X 07248741
Nidhi Doshi; Jamie Giddings; Lin M. Luis; Arthur Wu; Kyle Ritchie; Wenqiang Liu; Wayman Chan; Rosalynn Taing; Jeff Chu; Sreedhara Alavattam; Aadithya Kannan; Pervina Kei; Ian Shieh; Tobias Graf; Mark Hu
Ophthalmology Retina, ISSN: 24686530
Allen Chiang; Sunir Garg; Michael A. Klufas; Allen C. Ho; Lauren Hill; Min Tsuboi; Ivo Stoilov
Pharmaceutical Research, ISSN: 1573904X 07248741
Adithi C. Bhargava; Kathryn Mains; Albert Siu; Jie Gu; Jonathan Zarzar; Li Yi; Inn Yuk
Pharmaceutical Research, ISSN: 1573904X 07248741
Ming Lei; Cynthia Quan; John Wang; Yung-Hsiang Kao; Christian Schöneich
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Michael J. Dolton; Po-Chang Chiang; Yuan Chen
The use of emerging safety biomarkers in nonclinical and clinical safety assessment – The current and future state: An IQ DruSafe industry survey
Regulatory Toxicology and Pharmacology, ISSN: 02732300
Tanja Zabka; John Burkhardt; William J. Reagan; Jean-Charles Gautier; Warren E. Glaab; Magali Guffroy; Joanna Harding; Dominique Brees; Eric McDuffie; Lila Ramaiah; A. Eric Schultze; James Smith; Alison Wolfreys; Deidre A. Dalmas
Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Yixuan Zhou; Ingmar Niels Bastian; Mark D. Long; Michelle Dow; Weihua Li; Tao Liu; Rachael Katie Ngu; Laura Antonucci; Jian Yu Huang; Qui T. Phung; Xi-He Zhao; Sourav Banerjee; Xue-Jia Lin; Hongxia Wang; Brian Dang; Sylvia Choi; Daniel Karin; Hua Su; Mark H. Ellisman; Christina Jamieson; Marcus Bosenberg; Zhang Cheng; Johannes Haybaeck; Lukas Kenner; Kathleen M. Fisch; Richard Bourgon; Genevive Hernandez; Jennie Lill; Song Liu; Hannah Carter; Ira Mellman; Michael Karin; Shabnam Shalapour