Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 201 - 250 OF 15457 RESULTS

Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer
Cell Reports Medicine,
Matthew D. Galsky; Xiangnan Guan; Deepali Rishipathak; Aaron S. Rapaport; Hesham M. Shehata; Romain Banchereau; Kobe Yuen; Eugene Varfolomeev; Ruozhen Hu; Chia-Jung Han; Haocheng Li; Yuxin Liang; Domagoj Vucic; Li Wang; Jun Zhu; Haocheng Yu; Rebecca H. Herbst; Emma Hajaj; Evgeny Kiner; Aristotelis Bamias; Maria De Santis; Ian Davis; José Ángel Arranz; Eiji Kikuchi; Sandrine Bernhard; Patrick Williams; Chooi Lee; Ira Mellman; Shomyseh Sanjabi; Robert J. Johnston; Peter C. Black; Enrique Grande; Sanjeev Mariathasan
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Loss of CD20 expression as a mechanism of resistance to mosunetuzumab in relapsed/refractory B-cell lymphomas
Blood, ISSN: 00064971
Stephen J. Schuster; Huw; Christopher R. Bolen; Victor Maximov; Andrew G. Polson; Katerina Hatzi; Elisabeth A. Lasater; Sarit E. Assouline; Nancy L. Bartlett; Lihua E. Budde; Matthew Matasar; Koeppen; Emily C. Piccione; Deanna Wilson; Michael C. Wei; Shen Yin; Elicia M. Penuel
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Investigating the Origin of Epimerization Attenuation during Pd-Catalyzed Cross-Coupling Reactions
ACS Catalysis,
Isabelle Cai; Thomas C. Malig; Kenji L. Kurita; Joshua S. Derasp; Lauren E. Sirois; Jason E. Hein
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Exploring How Antibody Format Drives Clearance from the Brain
Molecular Pharmaceutics, ISSN: 15438384
Kelly Schwinghamer; Brian M. Kopec; Ebehiremen Ayewoh; Xun Tao; Shraddha Sadekar; Alavattam Sreedhara; Robert F. Kelley; Devin B. Tesar; Teruna J. Siahaan
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Care partner-informed meaningful change thresholds for the Clinical Dementia Rating-Sum of Boxes for trials of early Alzheimer's disease
Alzheimer's and Dementia, ISSN: 15525260
Lansdall; Edmond Teng; Jerome Chague; Rohan Palanganda; Paul Delmar; Janice Smith; Jeffrey L. Cummings; Fiona McDougall
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Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model
Alzheimer's and Dementia, ISSN: 15525260
Antoine Leuzy; Lars Lau Raket; Victor L Villemagne; Gregory Klein; Matteo Tonietto; Emily Olafson; Suzanne Baker; Ziad Saad; Santiago Bullich; Brian J Lopresti; Sandra Sanabria Bohorquez; Mercè Boada; Tobey J. Betthauser; Arnaud Charil; Emily Collins; Jessica A. Collins; Nicholas C. Cullen; Roger N Gunn; Makoto Higuchi; Eric Hostetler; R. Matthew Hutchison; Leonardo Iaccarino; Philip S. Insel; Michael C. Irizarry; Clifford R. Jack; William J. Jagust; Keith Johnson; Sterling C. Johnson; Yashmin Karten; Marta Marquié; Sulantha Mathotaarachchi; Mark A. Mintun; Rik Ossenkoppele; Ioannis Pappas; Ronald C. Petersen; Gil D. Rabinovici; Pedro Rosa-Neto; Christopher G. Schwarz; Ruben Smith; Andrew W Stephens; Alex Whittington; Maria C. Carrillo; Michael J. Pontecorvo; Samantha Budd Haeberlein; Billy Dunn; Hartmuth Kolb; Sudhir Sivakumaran; Christopher Rowe; Oskar Hansson; Vincent Dore
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Long-term Treatment Patterns for Diabetic Macular Edema: Up to 6-Year Follow-up in the IRIS® Registry
Ophthalmology Retina,
Blanche L. Kuo; David Tabano; Vincent Garmo; Eunice Kim; Theodore Leng; Meghan Hatfield; Andrew LaPrise; Rishi Singh
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Systematic Literature Reviews Comparing the Long-Term Safety Outcomes for the Port Delivery System with Ranibizumab (PDS) Versus Other Ocular Implants
Ophthalmology and Therapy, ISSN: 21938245
Nancy M. Holekamp; Manejeh Yaqub; Shrirang Ranade; Ronald A. Cantrell; Sheena Singh; Gus Gazzard
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Supplemental Intravitreal Ranibizumab Injections in Eyes Treated with the Port Delivery System with Ranibizumab in the Archway Trial
Ophthalmology Retina,
Jared Nielsen; Andrew Chang; Nancy M. Holekamp; Melina Cavichini-Cordeiro; Stephanie L. Lin; Dominic Heinrich; Katie F. Maass; Alicia R. Menezes; Natasha Singh; Dante Joseph Pieramici
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High Resolution Ion Mobility Enables the Structural Characterization of Atropisomers of GDC-6036, a KRAS G12C Covalent Inhibitor
Journal of the American Society for Mass Spectrometry, ISSN: 10440305
Marcelino Varona; Daniel P. Dobson; José G. Napolitano; Rekha Thomas; Jessica L. Ochoa; David J. Russell; Christopher M. Crittenden
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Cost-effectiveness analysis of mosunetuzumab for treatment of relapsed or refractory follicular lymphoma after two or more lines of systemic therapy in the United States
Journal of Medical Economics, ISSN: 13696998
Matthew Matasar; Javier Sanchez Alvarez; Hélène Parisé; Eric Zuk; Danilo Di Maio; Sheila Shapouri; Eunice Kim; Shih Wen Lin
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Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions
Developmental Cell, ISSN: 15345807
Max Koppers; Nazmiye Özkan; Ha H. Nguyen; Daphne Jurriens; Janine McCaughey; Dan T.M. Nguyen; Chun Hei Li; Riccardo Stucchi; Maarten Altelaar; Harold MacGillavry; Lukas C. Kapitein; Casper C Hoogenraad; Ginny G. Farías
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Meta-Analysis of 49 Roche Oncology Trials Comparing Blinded Independent Central Review (BICR) and Local Evaluation to Assess the Value of BICR
Oncologist, ISSN: 10837159
Qinshu Lian; Jill Fredrickson; Kamila Boudier; Christiane Rothkegel; Magalie Hilton; Alexander Hillebrecht; Andrew McDonald; Xu
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Quantitative characterization of the effects of fulvestrant alone or in combination with taselisib (PI3Kinase inhibitor) on longitudinal tumor growth in patients with estrogen receptor-positive, HER2-negative, PIK3CA-mutant, advanced or metastatic breast cancer
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Anita Moein; Jin Yan Jin; Matthew Wright; Harvey Wong
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Semorinemab Pharmacokinetics and The Effect on Plasma Total Tau Pharmacodynamics in Clinical Studies
Journal of Prevention of Alzheimer's Disease, ISSN: 22745807
Vidya Ramakrishnan; Brendan C. Bender; Jurgen Langenhorst; Mats O. Magnusson; Michael J. Dolton; Shim; Reina N. Fuji; Cecilia Monteiro; Edmond Teng; Nastya Kassir; Jin Yan Jin
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Characteristics of patients with chronic spontaneous urticaria who are late-responders to omalizumab
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
Giselle Mosnaim; Thomas B. Casale; Michael Holden; Benjamin L. Trzaskoma; Jonathan A. Bernstein
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Microfluidic Sample Preparation for Multiplexed Single-Cell Proteomics Using a Nested Nanowell Chip
Methods in Molecular Biology,
Junho Park; Tommy K. Cheung; Ying Zhu
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The receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumour suppression
Journal of Cell Science, ISSN: 00219533
Katherine A. Young; Katarzyna Wojdyla; Tiffany Lai; Katie E. Mulholland; Silvia Aldaz Casanova; Robin Antrobus; Simon Andrews; Laura Biggins; Betania Mahler-Araujo; Philippa R. Barton; Keith R. Anderson; Gareth W. Fearnley; Hayley J. Sharpe
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Investigation of the state of hydration of a non-stoichiometric hydrate in a low dose formulation using 19F solid-state NMR
Journal of Pharmaceutical Sciences, ISSN: 00223549
Jonathan Hau; Antonio G. DiPasquale; Joseph W. Lubach; Paroma Chakravarty
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Exploring the Impact of In Vitro-Transcribed mRNA Impurities on Cellular Responses
Analytical Chemistry, ISSN: 00032700
Julien Camperi; Brian Roper; Emily C. Freund; Rebecca Leylek; Ariane Nissenbaum; Carolina Galan; Roger Caothien; Zhilan Hu; Peggy Ko; Allison Lee; Kamalakar Chatla; Luladey Ayalew; Feng Yang; Steffen Lippold; Axel Guilbaud
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RIP1 inhibition protects retinal ganglion cells in glaucoma models of ocular injury
Cell Death and Differentiation, ISSN: 13509047
Bo Kyoung Kim; Tatiana Goncharov; Sébastien A. Archaimbault; Filip Roudnicky; Webster; Peter D. Westenskow; Domagoj Vucic
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Immunogenicity risk assessment and mitigation for engineered antibody and protein therapeutics
Nature Reviews Drug Discovery, ISSN: 14741776
Paul J. Carter; Quarmby
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Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification
Nature Genetics, ISSN: 10614036
Simone M. Haag; Shiqi Xie; Celine Eidenschenk; Jean-Philippe Fortin; Marinella G. Callow; Michael Costa; Aaron T. L. Lun; Christian Cox; Sunny Z. Wu; Rachana Pradhan; Jaclyn Y. Lock; Julia A. Kuhn; Loryn Holokai; Minh Thai; Emily C. Freund; Ariane Nissenbaum; Mary E. Keir; Christopher J. Bohlen; Scott E. Martin; Kathryn R. Geiger-Schuller; Hussein A. Hejase; Brian L. Yaspan; Sandra Melo Carlos; Shannon J. Turley; Aditya Murthy
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Development of a Robust Pd-Catalyzed C-S Coupling for the Synthesis of Janus Kinase Inhibitor GDC-9918
Organic Process Research and Development, ISSN: 10836160
Derek M. Dalton; Juno Castillo Siu; Marcelino Varona-Ortiz; C. Gregory Sowell; Francis Gosselin
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A comparison of data visualization tools: A case study in health-related research
Information Visualization, ISSN: 14738716
Hongtai Huang; Sreedevi Ravi; Timothy Warrington; Howe Cui; Carlson Wang; Mark McCreary; Benjamin E. Lauffer; Christina Lu
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Considerations for Industry—Preparing for the FDA Model-Informed Drug Development (MIDD) Paired Meeting Program
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Gerald R. Galluppi; Malidi Ahamadi; Souvik Bhattacharya; Nageshwar Budha; Ferdous Gheyas; Chi-Chung Li; Yuan Chen; Anne-Gaëlle Dosne; Niels Rode Kristensen; Mindy Magee; Mahesh N. Samtani; Vikram Sinha; Kunal S. Taskar; Vijay V. Upreti; Jianning Yang; Jack Cook
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Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development
Xenobiotica, ISSN: 00498254
Michael Z. Liao; Douglas Leipold; Shang-Chiung Chen; Zao Li; Amrita Kamath; Chunze Li
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Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species
Xenobiotica, ISSN: 00498254
Victor Yip; Ola M. Saad; Douglas Leipold; Chunze Li; Amrita Kamath; Shen
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A Novel Step-Up Dosage Regimen for Enhancing the Benefit-to-Risk Ratio of Mosunetuzumab in Relapsed or Refractory Follicular Lymphoma
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Chi-Chung Li; Brendan C. Bender; Justin Wilkins; Feifei Li; Turner; Wang; Rong Deng; Shweta Vadhavkar; Zao Li; Antonia Kwan; Huang Huang; Kun Peng; Elicia M. Penuel; Huw; Pascal Chanu; Chunze Li; Shen Yin; Michael C. Wei
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Interim Results of the Phase III Portal Extension Trial of the Port Delivery System with Ranibizumab in Neovascular Age-Related Macular Degeneration
Ophthalmology Retina,
Peter A. Campochiaro; David Eichenbaum; Margaret A. Chang; W. Lloyd Clark; Jordan M. Graff; Sophie Le Pogam; Melina Cavichini-Cordeiro; Shamika Gune; Melvin D. Rabena; Natasha Singh; Stephanie L. Lin; Natalia F. Callaway
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A Refined Thin-Film Model for Drug Dissolution Considering Radial Diffusion – Simulating Powder Dissolution
Pharmaceutical Research, ISSN: 07248741
Karthik Salish; Chi So; Seong Hoon Jeong; Hao Helen Hou; Chen Mao
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Automated tumor immunophenotyping predicts clinical benefit from anti-PD-L1 immunotherapy
Journal of Pathology, ISSN: 00223417
Xiao Li; Jeffrey Eastham; Jennifer M. Giltnane; Wei Zou; Andries Zijlstra; Evgeniy Tabatsky; Romain Banchereau; Ching-Wei Chang; Barzin Y. Nabet; Namrata S. Patil; Luciana L. Molinero; Steve Chui; Maureen Harryman; Shari Lau; Linda Rangell; Yannick Waumans; Mark Kockx; Darya Y. Orlova; Koeppen
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Macular Sensitivity Endpoints in Geographic Atrophy: Exploratory Analysis of Chroma and Spectri Clinical Trials
Ophthalmology Science,
Dolly Chang; Natalia F. Callaway; Verena Steffen; Karl G. Csaky; Robyn H. Guymer; David G. Birch; Praveen J. Patel; Michael S. Ip; Simon S. Gao; Jayla Briggs; Lee Honigberg; Phillip Lai; Daniela Ferrara; Yasir J. Sepah
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Inhibitors targeting BamA in gram-negative bacteria
Biochimica et Biophysica Acta - Molecular Cell Research, ISSN: 01674889
Kelly M. Storek; Dawei Sun; Steven T. Rutherford
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Lymphoid System
Toxicologic Pathology: a Primer,
Steven T. Laing
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Dose Optimization in Oncology Drug Development: An International Consortium for Innovation and Quality in Pharmaceutical Development White Paper
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Divya Samineni; Karthik Venkatakrishnan; Ahmed A. Othman; Yazdi K. Pithavala; Srinivasu Poondru; Chirag Patel; Pavan Vaddady; Wendy Ankrom; Ramanujan; Nageshwar Budha; Michael Wu; Nahor Haddish-Berhane; Holger Fritsch; Azher Hussain; Jitendra Kanodia; Meng Li; Mengyao Li; Murad Melhem; Apurvasena Parikh; Vijay V. Upreti; Neeraj Gupta
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Patient preferences for chronic lymphocytic leukemia treatments: a discrete-choice experiment
Future Oncology, ISSN: 14796694
Arliene Ravelo; Kelley Myers; Robyn Brumble; Cooper Bussberg; Brian Koffman; Beenish S. Manzoor; Juliana M L Biondo; Carol Mansfield
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Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model
Journal of Medicinal Chemistry, ISSN: 00222623
Marie-Gabrielle Braun; Avi Ashkenazi; Ramsay E. Beveridge; Georgette M. Castanedo; Heidi J. A. Wallweber; Beresini; Clark; Tom De Bruyn; Liqiang Fu; Paul Gibbons; Fan Jiang; Susan Kaufman; David Kan; James R. Kiefer; Jean-Philippe Leclerc; Alexandre Lemire; Cuong Q. Ly; Ehud Segal; Jessica Sims; Weiru Wang; Wentao Wei; Zhao; Jacob B. Schwarz; Joachim Rudolph
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A novel biomarker assay qualification strategy for rare human matrices–a case study of biomarkers in aqueous humor
Bioanalysis, ISSN: 17576180
Jennifer A. Getz; Trung Nguy; Randall Dere; Mauricio Maia
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Role of NaV1.7 in postganglionic sympathetic nerve function in human and guinea-pig arteries
Journal of Physiology, ISSN: 00223751
Joyce S. Kim; Sonya Meeker; Fei Ru; Minh Tran; Tanja S. Zabka; David Hackos; Bradley J. Undem
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Online Nucleotide Mapping of mRNAs
Analytical Chemistry, ISSN: 00032700
Alexandre Goyon; Brandon Scott; Peter M. Yehl; Kelly Zhang
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A New Approach for Preparing Stable High-Concentration Peptide Nanoparticle Formulations
Pharmaceuticals,
Chloe Hu; Nanzhi Zang; Yu Tong Tam; Desmond Dizon; Kaylee Lee; Jodie Pang; Elizabeth Torres; Yusi Cui; Chun-Wan Yen; Dennis H. Leung
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Model-based comparisons of post-treatment free IgE and FEV1 between omalizumab asthma dosing tables in the United States and European Union
British Journal of Clinical Pharmacology, ISSN: 03065251
Rui Zhu; Rik Schoemaker; Aurelie Gautier; Xianbin Tian; Cheryl HooiMing Sim; Theodore A. Omachi; Amita Joshi; Jin Jin; Ryan Owen
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Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy
Frontiers in Pharmacology,
Rajbharan Yadav; Suzanne Schubbert; Patrick Holder; Eugene Y. Chiang; Nargess Kiabi; Liz Bogaert; Irene Leung; Rumana Rashid; Kendra N. Avery; Christine Bonzon; John Desjarlais; Shomyseh Sanjabi; Amy Sharma; Lepherd; Amy Shelton; Pamela Chan; Yanqiu Liu; Louis R. Joslyn; Iraj Hosseini; Stefanich; Amrita Kamath; Matthew Bernett; Vittal Shivva
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Bioproduction Platform to Generate Functionalized Disulfide-Constrained Peptide Analogues
ACS Bio and Med Chem Au,
Sunhee Hwang; Aaron T. Balana; Bryan Martin; Michael Clarkson; Paola Di Lello; Hao Wu; Yanjie Li; Jakob Fuhrmann; Yavuz S. Dagdas; Patrick Holder; Christina I. Schroeder; Stephen E. Miller; Xinxin Gao
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PROTEIN DISCOVERY WITH DISCRETE WALK-JUMP SAMPLING
12th International Conference on Learning Representations, ICLR 2024,
Nathan C. Frey; Daniel Berenberg; Karina Zadorozhny; Joseph Kleinhenz; Julien Lafrance-Vanasse; Isidro Hötzel; Yan Wu; Stephen Ra; Richard Bonneau; Kyunghyun Cho; Andreas Loukas; Vladimir Gligorijevic; Saeed Saremi
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Fit-for-Purpose Synthesis of a KRASG12C Covalent Inhibitor, via a Diastereoselective Hayashi Arylation
Organic Process Research and Development, ISSN: 10836160
Carmela Molinaro; Nicholas Wong; Nicholas A. White; Lauren E. Sirois; Raphael Bigler; Quentin P. Bindschaedler; Steven Do; Sushant Malhotra; Francis Gosselin
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Efficacy of Faricimab versus Aflibercept in Diabetic Macular Edema in the 20/50 or Worse Vision Subgroup in Phase III YOSEMITE and RHINE Trials
Ophthalmology, ISSN: 01616420
Marco A. Zarbin; David Tabano; Ayesha Ahmed; Manuel Amador; Allan Ding; Nancy M. Holekamp; Xiao-Yu Lu; Ivaylo Stoilov; Ming Yang
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Faricimab for neovascular age-related macular degeneration and diabetic macular edema: from preclinical studies to phase 3 outcomes
Graefe's Archive for Clinical and Experimental Ophthalmology, ISSN: 0721832X
Hansjurgen Agostini; Francis Abreu; Caroline R. Baumal; Dolly Chang; Karl G. Csaky; Anna M. Demetriades; Laurent Kodjikian; Jennifer I. Lim; Philippe Margaron; Jordi Monés; Tunde Peto; Federico Ricci; Matthias Rüth; Rishi Singh; Ivaylo Stoilov; Balakumar Swaminathan; Jeffrey R. Willis; Peter D. Westenskow
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Development of an advanced separation and characterization platform for mRNA and lipid nanoparticles using multi-detector asymmetrical flow field-flow fractionation
Analytical and Bioanalytical Chemistry, ISSN: 16182642
Ziting Gao; Jessica Lin; Wan-Chih Su; Kelly Zhang; Jason Gruenhagen; Wenwan Zhong; Yuchen Fan; Juan Bian
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