Scientists / Publications

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Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 351 - 400 OF 11343 RESULTS

U-BIOPRED: evaluation of the value of a public–private partnership to industry
Drug Discovery Today, ISSN: 18785832 13596446
John Riley; Veit J. Erpenbeck; John Matthews; Cecile Holweg; Chris H. Compton; Wolfgang Seibold; Tim Higenbottam; Scott Wagers; Anthony Rowe; David Myles
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Cluster-Randomized Trial of a Behavioral Intervention to Incorporate a Treat-to-Target Approach to Care of US Patients With Rheumatoid Arthritis
Arthritis Care and Research, ISSN: 2151464X
Leslie R. Harrold; George W. Reed; Ani John; Christine J. Barr; Kevin Soe; Robert Magner; Katherine C. Saunders; Eric M. Ruderman; Tmirah Haselkorn; Greenberg; Allan Gibofsky; J. Timothy Harrington; Joel M. Kremer
Detection of PD-L1 in circulating tumor cells and white blood cells from patients with advanced non-small-cell lung cancer
Annals of Oncology, ISSN: 09237534
Marius Ilie; Edith Szafer-Glusman; Véronique Hofman; Chamorey; Salomé Lalvée; Eric Selva; Leroy; Charles-Hugo Marquette; Marcin Kowanetz; Priti Hedge; Elizabeth Punnoose; Paul Hofman
Predictive markers of anti-VEGF and emerging role of angiogenesis inhibitors as immunotherapeutics
Seminars in Cancer Biology, ISSN: 1044579X
Priti Hegde; Jeffrey Wallin; Christoph Mancao
Randomized Phase II Trial of Parsatuzumab (Anti-EGFL7) or Placebo in Combination with Carboplatin, Paclitaxel, and Bevacizumab for First-Line Nonsquamous Non-Small Cell Lung Cancer
Oncologist, ISSN: 10837159
Joachim Von Pawel; David Spigel; Thomas J. Ervin; György Losonczy; Fabrice Barlesi; Erzsébet Juhász; Maria Anderson; Bruce McCall; Eric Wakshull; Priti Hegde; Weilan Ye; Daniel Chen; Ilsung Chang; Ina Rhee; Martin Reck
A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Sarah M. Bronner; Jeremy Murray; Anthony Romero; Kwong Wah Lai; Vickie Tsui; Patrick Cyr; Maureen Beresini; Gladys Boenig; Zhongguo Chen; Edna Choo; Kevin Clark; Terry Crawford; Hariharan Jayaram; Susan Kaufman; Ruina Li; Yingjie Li; Jiangpeng Liao; Xiaorong Liang; Wenfeng Liu; Justin Ly; Jonathan M. Maher; John Wai; Fei Wang; Aijun Zheng; Xiaoyu Zhu; Steven Magnuson
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Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Paola Di Lello; Rich Pastor; Jeremy Murray; Robert Blake; Fred Cohen; Terry Crawford; Joy Drobnick; Jason Drummond; Kategaya; Tracy Kleinheinz; Till Maurer; Lionel Rouge; Xianrui Zhao; Ingrid Wertz; Chudi Ndubaku; Vickie Tsui
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Tumour lymph vessels boost immunotherapy
Nature, ISSN: 14764687 00280836
Christine Moussion; Shannon Turley
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Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Wei-Jen Chung; Anneleen Daemen; Jason Cheng; Jason E. Long; Jonathan E. Cooper; Bu-Er Wang; Christopher Tran; Mallika Singh; Florian Gnad; Zora Modrusan; Oded Foreman; Melissa Junttila; Anton Berns
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Structural and Functional Characterization of a Hole-Hole Homodimer Variant in a "knob-Into-Hole" Bispecific Antibody
Analytical Chemistry, ISSN: 15206882 00032700
Hui-Min Zhang; Charlene Li; Ming Lei; Victor Lundin; Ho Young Lee; Milady Ninonuevo; Kevin Lin; Guanghui Han; Wendy Sandoval; Dongsheng Lei; Gang Ren; Jennifer Zhang; Hongbin Liu
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Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Stephen J. Gregson; Luke Masterson; Binqing Wei; Thomas Pillow; Susan Spencer; Gyoung-Dong Kang; Shang-Fan Yu; Helga Raab; Jeffrey Lau; Ginny (Guangmin) Li; Gail Phillips; Janet Gunzner-Toste; Brian Safina; Rachana Ohri; Martine Darwish; Kathy Kozak; Josefa Dela Cruz Chuh; Andy Polson; John Flygare; Philip W. Howard
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TRP’ing up chronic kidney disease
Science, ISSN: 10959203 00368075
Jun-Jae Chung; Andrey Shaw
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Characterization of PD-L1 expression in Chinese non-small cell lung cancer patients with PTEN expression as a means for tissue quality screening
Cancer Immunology, Immunotherapy, ISSN: 14320851 03407004
Xu-chao Zhang; Xu Cao; Chun Sun; Zhi Xie; Jian-jun Guo; Jin-ji Yang; Xue-ning Yang; Hang-jun Dai; Su-chun Li; Xin-ran Xu; Yun-xia Zuo; Meng Chen; Hartmut Koeppen; Jing He; Astrid Kiermaier; David Shames; Gang Cheng; Yi-Long Wu
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2017 White Paper on recent issues in bioanalysis: A global perspective on immunogenicity guidelines & biomarker assay performance (Part 3-LBA: Immunogenicity, biomarkers and PK assays)
Bioanalysis, ISSN: 17576199 17576180
Shalini Gupta; Richards; Lakshmi Amaravadi; Steven Piccoli; Binodh DeSilva; Renuka Pillutla; Lauren Stevenson; Devangi Mehta; Montse Carrasco-Triguero; Robert J. Neely; Michael A. Partridge; Roland F Staack; Xuemei Zhao; Boris Gorovits; Gerry Kolaitis; Giane Sumner; Kay Stubenrauch; Zou; Shashi Amur; Chris Beaver; Isabella Berger; Flora Berisha; Herbert Birnboeck; Joe Bower; Seongeun Julia Cho; Isabelle Cludts; Cocea; Lorella Di Donato; Sally Fischer; Stephanie Fraser; Fabio Garofolo; Sam Haidar; Jonathan Haulenbeek; Charles Hottenstein; Jenny Hu; Akiko Ishii-Watabe; Rafiq Islam; Darshana Jani; John Kadavil; John Kamerud; Daniel Kramer; Pekka Kurki; Stephen MacMannis; Jim McNally; Ashley Mullan; Apollon Papadimitriou; Joao Pedras-Vasconcelos; Soma Ray; Afshin Safavi; Yoshiro Saito; Natasha Savoie; Marianne Scheel Fjording; Kara Scheibner; John Smeraglia; An Song; Bruce C. Stouffer; Nilufer Tampal; Barry Van Der Strate; Thorsten Verch; Jan Welink; Yuanxin Xu; Tong-Yuan Yang; Lilian Yengi; Jianing Zeng; Yan
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A phase i dose-escalation study of the safety and pharmacokinetics of pictilisib in combination with erlotinib in patients with advanced solid tumors
Oncologist, ISSN: 1549490X 10837159
Stephen Leong; Rebecca A. Moss; Daniel W. Bowles; Joseph A. Ware; Jing Zhou; Jill Spoerke; Mark Lackner; Geetha Shankar; Jennifer L. Schutzman; Ruud van der Noll; Emile E. Voest; Jan H. M. Schellens
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Found in translation: How preclinical research is guiding the clinical development of the BCL2-selective inhibitor venetoclax
Cancer Discovery, ISSN: 21598290 21598274
Joel D. Leverson; Deepak Sampath; Andrew J. Souers; Saul H. Rosenberg; Wayne Fairbrother; Amiot; Marina Konopleva; Anthony Letai
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Identification of Small-Molecule Noncovalent Binders Utilizing SAMDI Technology
SALAS Discovery, ISSN: 24725560 24725552
Erica VanderPorten; Michael D. Scholle; John Sherrill; John C. Tran; Yichin Liu
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Tissue Localization of Glycosphingolipid Accumulation in a Gaucher Disease Mouse Brain by LC-ESI-MS/MS and High-Resolution MALDI Imaging Mass Spectrometry
SALAS Discovery, ISSN: 24725560 24725552
E. Ellen Jones; Wujuan Zhang; Xueheng Zhao; Cristine Quiason-Huynh; Stephanie Dale; Sheerin Latham; Gregory A. Grabowski; Kenneth D.R. Setchell; Richard R. Drake; Ying Sun
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Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes
Nature Communications, ISSN: 20411723
Vagheesh M. Narasimhan; Raheleh Rahbari; Aylwyn Scally; Art Wuster; Dan Mason; Yali Xue; John Wright; Richard C. Trembath; Eamonn R Maher; David A. van Heel; Adam Auton; Matthew E. Hurles; Chris Tyler-Smith; Richard Durbin
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Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity
Scientific Reports, ISSN: 20452322
Simon Hansen; Jakob C. Stüber; Patrick Ernst; Alexander Koch; Daniel Bojar; Alexander Batyuk; Pluckthun
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Non-canonical reader modules of BAZ1A promote recovery from DNA damage
Nature Communications, ISSN: 20411723
Mariano Oppikofer; Meredith Sagolla; Benjamin Haley; Hui-Min Zhang; Sarah Kummerfeld; Sudhamsu Sudhamsu; Megan Flynn; Tianyi Bai; Jennifer Zhang; Claudio Ciferri; Andrea Cochran
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Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP)
Scientific Reports, ISSN: 20452322
Travis Bainbridge; Diana Ronai Dunshee; Noelyn Kljavin; Nicholas Skelton; Jun Sonoda; James Ernst
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Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Li Di; Christopher Breen; Rob Chambers; Sean T. Eckley; Robert Fricke; Avijit Ghosh; Paul Harradine; Kalvass; Stacy Ho; Caroline A. Lee; Punit H. Marathe; Everett J. Perkins; Mark Qian; Susanna Tse; Zhengyin Yan; Zamek-Gliszczynski
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Clinical responses to ERK inhibition in BRAFV600E-mutant colorectal cancer predicted using a computational model
npj Systems Biology and Applications,
Kirouac; Gabriele Schaefer; Jocelyn Chan; Mark Merchant; Christine Orr; Shih-Min A. Huang; John Moffat; Lichuan Liu; Kapil Gadkar; Saroja Ramanujan
Erratum to: Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model (npj Systems Biology and Applications, (2017), 3, 1, (14), 10.1038/s41540-017-0016-1)
npj Systems Biology and Applications,
Kirouac; Gabriele Schaefer; Jocelyn Chan; Mark Merchant; Christine Orr; Shih-Min A. Huang; John Moffat; Lichuan Liu; Kapil Gadkar; Saroja Ramanujan
Statistical characterization of therapeutic protein modifications
Scientific Reports, ISSN: 20452322
Tsung-Heng Tsai; Zhiqi Hao; Qiuting Hong; Benjamin Moore; Cinzia Stella; Jeffrey H. Zhang; Yan Chen; Michael Kim; Theo Koulis; Gregory Ryslik; Erik Verschueren; Fred Jacobson; William E. Haskins; Olga Vitek
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Reversed-phase chromatography with large pore superficially porous particles for high throughput immunoglobulin G2disulfide isoform separation
Journal of Chromatography A, ISSN: 00219673
Bingchuan Wei; Bing Zhang; Barry E. Boyes; Yonghua (Taylor) Zhang
Correction to: Population pharmacokinetics of trastuzumab emtansine in previously treated patients with HER2-positive advanced gastric cancer (AGC)
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Shang-Chiung Chen; Kagedal; Yuying Gao; Wang; Marie-Laurence Harle-Yge; Sandhya Girish; Jin Jin; Chunze Li
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GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Anthony Romero; Jeremy Murray; Kwong Wah Lai; Vickie Tsui; Brian K Albrecht; Le An; Maureen Beresini; Gladys Boenig; Sarah M. Bronner; Emily Chan; Kevin Chen; Zhongguo Chen; Edna Choo; Kyle Clagg; Kevin Clark; Terry Crawford; Patrick Cyr; Denise De Almeida Nagata; Karen Gascoigne; Jane Grogan; Georgia Hatzivassiliou; Wei Huang; Thomas Hunsaker; Susan Kaufman; Stefan G. Koenig; Ruina Li; Yingjie Li; Xiaorong Liang; Jiangpeng Liao; Wenfeng Liu; Justin Ly; Jonathan M. Maher; Colin Masui; Mark Merchant; Yingqing Ran; Alexander M. Taylor; John Wai; Fei Wang; Xiaocang Wei; Dong Yu; Bing-Yan Zhu; Xiaoyu Zhu; Steven Magnuson
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Treatment Patterns and Outcomes in Patients with KRAS Wild-Type Metastatic Colorectal Cancer Treated in First Line with Bevacizumab- or Cetuximab-Containing Regimens
Journal of Gastrointestinal Cancer, ISSN: 19416636 19416628
Arthur C. Houts; Sarika Ogale; Nicolas Sommer; Sacha Satram-Hoang; Mark S. Walker
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What evidence do we need for biomarker qualification?
Science Translational Medicine, ISSN: 19466242 19466234
Chris Leptak; Joseph P. Menetski; John A. Wagner; Jiri Aubrecht; Linda Brady; Martha Brumfield; William W. Chin; Steve Hoffmann; Gary J. Kelloff; Gabriela Lavezzari; Rajesh Ranganathan; John-Michael Sauer; Frank D. Sistare; Tanja Zabka; David Wholley
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Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach
Organic Letters, ISSN: 15237052 15237060
Ngiap-Kie Lim; Patrick Weiss; Beryl X. Li; Christina H. McCulley; Stephanie R. Hare; Bronwyn L. Bensema; Teresa A. Palazzo; Dean J. Tantillo; Haiming Zhang; Francis Gosselin
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PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Tom Januario; Ye; Russell Bainer; Bruno Alicke; Tunde Smith; Benjamin Haley; Zora Modrusan; Stephen Gould; Bob Yauch
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Overall survival in patients with glioblastoma before and after bevacizumab approval
Current Medical Research and Opinion, ISSN: 14734877 03007995
Derek R. Johnson; Antonio M. P. Omuro; Arliene Ravelo; Nicolas Sommer; Annie Guérin; Raluca Ionescu-Ittu; Sherry Shi; Alex Macalalad; Joon H. Uhm
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An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD
Blood, ISSN: 00064971
Jonathan C. Poe; Wei Jia; Hsuan Su; Sarah Anand; Jeremy J. Rose; Prasanthi V. Tata; Amy N. Suthers; Corbin D. Jones; Pei Fen Kuan; Benjamin G. Vincent; Jonathan S. Serody; Mitchell E. Horwitz; Vincent T. Ho; Steve Pavletic; Fran Hakim; Kouros Owzar; Dadong Zhang; Bruce R. Blazar; Chris Siebel; Nelson J. Chao; Ivan Maillard; Stefanie Sarantopoulos
Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8)
Journal of Medicinal Chemistry, ISSN: 00222623
Yong Ma; Yue Fu; Cyrus Khojasteh; Deepak Dalvie; Donglu Zhang
FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia
Cell Metabolism, ISSN: 19327420 15504131
Tian Lan; Donald A. Morgan; Kamal Rahmouni; Jun Sonoda; Xiaorong Fu; Shawn C. Burgess; William L. Holland; Steven A. Kliewer; David J. Mangelsdorf
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Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control
Cell, ISSN: 10974172 00928674
Richard G. Yau; Kerstin Doerner; Erick Castellanos; Diane L. Haakonsen; Achim Werner; Nan Wang; X. William Yang; Nadia Martinez Martin; Marissa Matsumoto; Vishva Dixit; Michael Rape
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Tumor Microvessel Density as a Potential Predictive Marker for Bevacizumab Benefit: GOG-0218 Biomarker Analyses
Journal of the National Cancer Institute, ISSN: 00278874
Carlos Bais; Barbara Mueller; Mark F. Brady; Robert S. Mannel; Robert A. Burger; Wei Wei; Koen M. Marien; Mark Kockx; Amreen Husain; Michael J. Birrer
Combining "bottom-up" and "top-down" approaches to assess the impact of food and gastric pH on pictilisib (GDC-0941) pharmacokinetics
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Tong Lu; Grazyna Fraczkiewicz; Laurent Salphati; Nageshwar Budha; Gena Dalziel; Gillian S. Smelick; Kari Morrissey; John Davis; Jin Y. Jin; Joseph A. Ware
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Concordance between plasma-based and tissue-based next-generation sequencing in LOTUS
The Lancet Oncology, ISSN: 14745488 14702045
Sung-Bae Kim; Rebecca Dent; Matthew Wongchenko; Stina Singel; José Baselga
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Monitoring and Targeting Anti-VEGF Induced Hypoxia within the Viable Tumor by 19F–MRI and Multispectral Analysis
Neoplasia (United States), ISSN: 14765586 15228002
Yunzhou Shi; Jason Oeh; Anna Hitz; Maj Hedehus; Jeff Eastham Anderson; Frank Peale; Patricia Hamilton; Thomas O'Brien; Deepak Sampath; Rick Carano
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A new lead to NLRP3 inhibition
Journal of Experimental Medicine, ISSN: 00221007
Mohamed Lamkanfi; Vishva Dixit
A phase IB dose-escalation study of the safety and pharmacokinetics of pictilisib in combination with either paclitaxel and carboplatin (with or without bevacizumab) or pemetrexed and cisplatin (with or without bevacizumab) in patients with advanced non–small cell lung cancer
European Journal of Cancer, ISSN: 18790852 09598049
Jean-Charles Soria; Alex Adjei; Rastilav Bahleda; Benjamin Besse; Charles Ferte; David Planchard; Jing Zhou; Joseph Ware; Kari Morrissey; Geetha Shankar; Wei Lin; Jennifer L. Schutzman; Grace Dy; Harry J.M. Groen
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High-Throughput and Sensitive Quantification of Circulating Tumor DNA by Microfluidic-Based Multiplex PCR and Next-Generation Sequencing
Journal of Molecular Diagnostics, ISSN: 19437811 15251578
Ying Guan; Oleg Mayba; Thomas Sandmann; Shan Lu; YJ Choi; Walter Darbonne; Vincent Leveque; Lisa Ryner; Eric Humke; Nga W.R. Tam; Sundari Sujathasarma; Anna Cheung; Richard Bourgon; Mark Lackner; Yulei Wang
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Obinutuzumab or rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in previously untreated diffuse large b-cell lymphoma
Journal of Clinical Oncology, ISSN: 15277755 0732183X
Umberto Vitolo; Marek Trneny; David Belada; John M. Burke; Angelo Michele Carella; Neil Chua; Pau Abrisqueta; Judit Demeter; Ian Flinn; Xiaonan Hong; Won Seog Kim; Antonio Pinto; Yuan-Kai Shi; Yoichi Tatsumi; Mikkel Z. Oestergaard; Michael Wenger; Guenter Fingerle-Rowson; Olivier Catalani; Tina Nielsen; Maurizio Martelli; Laurie H. Sehn
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Phase 2 randomized trial of the safety and efficacy of MHAA4549A, a broadly neutralizing monoclonal antibody, in a human influenza a virus challenge model
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Jacqueline McBride; Jeremy Lim; Tracy Burgess; Rong Deng; Michael Derby; Mauricio Maia; Priscilla Horn; Omer Siddiqui; Daniel Sheinson; Haiyin Chen; Elizabeth Newton; Dimitri Fillos; Denise Nazzal; Carrie Rosenberger; Maikke B. Ohlson; Rob Lambkin-Williams; Hosnieh Fathi; Jeffrey M. Harris; Jorge A. Tavela
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Silencing of retrotransposons by SET DB1 inhibits the interferon response in acute myeloid leukemia
Journal of Cell Biology, ISSN: 00219525
Cuellar; Anna-Maria Herzner; Xiaotian Zhang; Yogesh Goyal; Colin Watanabe; Brad Friedman; Vasant Janakiraman; Steffen Durinck; Jeremy Stinson; David Arnott; Tommy K Cheung; Subhra Chaudhuri; Zora Modrusan; Jonas Martin Doerr; Marie Classon; Benjamin Haley
Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates
British Journal of Pharmacology, ISSN: 14765381 00071188
Daniela Yadav; Janice Maloney; Kristin Wildsmith; Reina Fuji; Bill Meilandt; Hilda Solanoy; Yanmei Lu; Kate Peng; Blair Wilson; Pamela Chan; Kapil Gadkar; Andrew Kosky; Marisa Goo; Ann Daugherty; Jessica Couch; Thomas Keene; Karen Hayes; Lisa Jungbauer Nikolas; Deanna Lane; Robert Switzer; Eric L. Adams; Ryan Watts; Kimberly Scearce-Levie; Saileta Prabhu; Lisa Shafer; Deepak R Thakker; Keith Hildebrand; Jasi Atwal
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Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database
Toxicology and Applied Pharmacology, ISSN: 0041008X
Thomas M. Monticello; Thomas W. Jones; Donna Dambach; David M. Potter; Michael W. Bolt; Maggie Liu; Douglas A. Keller; Timothy K. Hart; Vivek J. Kadambi

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