Understanding GPA

Granulomatosis with polyangiitis (GPA) is a rare type of blood vessel inflammation (called vasculitis) that most often affects the sinuses, lungs and kidneys. GPA is a potentially serious disease that can reduce blood supply to vital organs and, if left untreated, can lead to kidney failure and lung complications.

It is a rare disease.

GPA affects an estimated three out of every 100,000 people.1

It affects men and women equally. It can occur at any age, but occurs most often between the ages of 40 and 65.1

Early treatment is important.

GPA causes ongoing inflammation and the disease can worsen rapidly. If left untreated, GPA can cause potentially life-threatening organ damage or organ failure.1

Medications are available that can effectively treat GPA and reduce complications.1

Treatment used depends on many factors including the affected organs and disease severity.1

GPA causes a wide range of symptoms.

GPA can potentially affect many different organs and symptoms may develop over days to months. Common symptoms include:1

Other symptoms can include joint pain, decreased hearing, skin rashes, eye redness and/or vision changes, fatigue, fever, appetite and weight loss night sweats, numbness or loss of movement in the fingers, toes or limbs.1