Understanding Lupus Nephritis
Lupus nephritis is a severe and potentially life-threatening manifestation of systemic lupus erythematosus (SLE) resulting from inflammation in the kidney.
It is a common manifestation.
of SLE patients will develop clinically relevant lupus nephritis1.
It is more prevalent in certain populations.
PATIENTS YOUNGER THAN 55
are more likely to develop lupus nephritis, and severe nephritis is most prominent in children1
Asian, African Caribbean, and African American
ethnicities are most likely to present with more severe lupus nephritis than other ethnic groups1
It is brought on by the presence of an autoimmune disease.
More than half of SLE patients have not had other symptoms of the disease before being diagnosed with lupus nephritis2
Up to 25% of lupus nephritis patients will develop end-stage renal disease3
Lupus nephritis develops early in the course of SLE, therefore becoming a major predictor of poor prognosis3
It can affect multiple areas of the body.
Swelling around the eyes, legs, ankles or fingers is typically the first noticeable symptom of lupus nephritis4
Other symptoms include blood in one's urine or the constant need to urinate in the middle of the night2,5
Lupus nephritis can cause abnormal sounds in the heart and lungs2
The condition can also lead to high blood pressure2
Severe cases of lupus nephritis can result in kidney failure4
1Ramesh Saxena, Tina Mahaian and Chandra Mohan, "Lupus Nephritis: Current Update," Arthritis Research & Therapy, 2011, 13:240. doi:10.1186/ar3378
2MedlinePlus, Lupus Nephritis. Last accessed: April 5, 2016Available at: https://www.nlm.nih.gov/medlineplus/ency/article/000481.htm
3Alberto de Zubiria Salgado and Catalina Herrera-Diaz, "Lupus Nephritis: An Overview of Recent Findings," Autoimmune Diseases, vol. 2012, Article ID 849684, 21 pages, 2012. doi:10.1155/2012/849684
4Cedars-Sinai, Lupus Nephritis Last Accessed: April 5, 2016Available at: https://www.cedars-sinai.edu/Patients/Health-Conditions/Lupus-Nephritis.aspx
5National Kidney Foundation. Lupus and Kidney Disease (Lupus Nephritis). Last accessed: April 5, 2016 Available at: https://www.kidney.org/atoz/content/lupus