Understanding Lupus Nephritis

Lupus nephritis is a severe and potentially life-threatening complication of systemic lupus erythematosus (SLE) resulting from inflammation in the kidney.


are affected by lupus, and about 70% have the systemic form, SLE.1,2

Up to 60%

with SLE will develop lupus nephritis.3

Lupus nephritis overwhelmingly impacts women

particularly young women of color.2,4

It is more prevalent in certain populations.

African American, Hispanic, Native American, and Asian American women are 2 to 3 times more likely than Caucasian women to get lupus.2,4

Asian, African Caribbean, African American, and Hispanic

ethnicities are most likely to present with more severe lupus nephritis than other ethnic groups.3

Up to 25% of proliferative lupus nephritis patients will develop potentially life-threatening end-stage renal disease.5

Lupus nephritis develops early in the course of SLE, therefore becoming a major predictor of poor prognosis.5

We're taking action to recruit a broader, more diverse population of participants into clinical trials, including diseases such as lupus nephritis, to ensure clinical trial participants more closely reflect those impacted by the disease for which a medicine is being studied. To learn more about our efforts in this area, please visit http://www.gene.com/inclusiveresearch.


1A. de Zubiria Salgado and C. Herrera-Diaz, "Lupus Nephritis: An Overview of Recent Findings. Autoimmune Diseases," vol. 2012, Article ID 849684, 221 pages, 2012. doi:10.1155/2012/849684

2Lupus Foundation of America. Lupus Facts and Statistics. Last accessed October 24, 2019
Available at: https://www.lupus.org/resources/lupus-facts-and-statistics

3Ramesh Saxena, Tina Mahaian and Chandra Mohan, "Lupus Nephritis: Current Update," Arthritis Research & Therapy, 2011, 13:240. doi:10.1186/ar3378

4Lupus Research Alliance. Lupus Fact Sheet. Last accessed October 24, 2019
Available at: http://www.lupusresearch.org/wp-content/uploads/2017/09/Lupus-Fact-Sheet.pdf

5Alberto de Zubiria Salgado and Catalina Herrera-Diaz, "Lupus Nephritis: An Overview of Recent Findings," Autoimmune Diseases, vol. 2012, Article ID 849684, 21 pages, 2012. doi:10.1155/2012/849684