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Understanding Pemphigus Vulgaris


Back To Rare Disease
May 29, 2019

Pemphigus vulgaris is the most common type of a group of autoimmune disorders collectively called pemphigus. It is a painful, disfiguring and potentially fatal disease characterized by progressive blistering of skin and/or mucous membranes.

Pemphigus vulgaris occurs when the immune system mistakenly creates antibodies against proteins in healthy skin1

The cause of the disorder is uncertain1

The disease has a mortality rate between 5-15%2 mostly due to complications of infections1

It is a rare disease.

~3 in every 100,000

people are diagnosed with pemphigus vulgaris2

30-60

is the age range when the disease primarily appears3

Blisters in the mouth are typically the initial symptom, making it difficult to swallow or eat4

Blisters may also affect mucous membranes, which are found in the mouth, throat, nose, eyes, genitals and lungs1

Blisters form within the deep layer of the epidermis and often leave pigmented spots on the surface of the skin3

  •   References Down arrow

    1Healthline. Pemphigus Vulgaris. Last accessed: April 17, 2019 http://www.healthline.com/health/pemphigus-vulgaris#Overview1

    2Medscape. Pemphigus Vulgaris. Last accessed: April 17, 2019 http://emedicine.medscape.com/article/1064187-overview

    3International Pemphigus & Pemphigoid Foundation. Understanding P/P. Last accessed: April 17, 2019 http://www.pemphigus.org/living-with-pemphigus-pemphigoid/understanding-pemphigus-pemphigoid/

    4Mayo Clinic Pemphigus, Last accessed: April 17, 2019 http://www.mayoclinic.org/diseases-conditions/pemphigus/symptoms-causes/dxc-20157523

    5NIH National Institute of Arthritis and Musculoskeletal and Skin Disease. Pemphigus. Last accessed: April 17, 2019 http://www.niams.nih.gov/Health_Info/Pemphigus/


Tags:

  • Rare Disease,
  • Skin Health

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